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Network neighborhood for query Sequence : PENK_MOUSE

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PENK_MOUSE
SwissProt Accessions	P22005	Gene names	Penk, Penk1
Domain Architecture
Description	Proenkephalin A precursor [Contains: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); Met-enkephalin-Arg-Ser-Leu; Leu- enkephalin; Met-enkephalin-Arg-Phe].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PENK_MOUSE
θ value	1.32529e-160 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	P22005	Gene names	Penk, Penk1
Domain Architecture
Description	Proenkephalin A precursor [Contains: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); Met-enkephalin-Arg-Ser-Leu; Leu- enkephalin; Met-enkephalin-Arg-Phe].

PENK_HUMAN
θ value	1.20984e-129 (rank : 2)	NC score	0.979072 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	29	Shared Neighborhood Hits	9
SwissProt Accessions	P01210	Gene names	PENK
Domain Architecture
Description	Proenkephalin A precursor [Contains: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); Met-enkephalin-Arg-Gly-Leu; Leu- enkephalin; Met-enkephalin-Arg-Phe].

PDYN_MOUSE
θ value	2.13179e-17 (rank : 3)	NC score	0.707710 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	11	Shared Neighborhood Hits	6
SwissProt Accessions	O35417	Gene names	Pdyn
Domain Architecture
Description	Beta-neoendorphin-dynorphin precursor (Proenkephalin B) (Preprodynorphin) [Contains: Alpha-neoendorphin; Dynorphin A; Leu- enkephalin; Dynorphin B].

PDYN_HUMAN
θ value	3.63628e-17 (rank : 4)	NC score	0.700636 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	17	Shared Neighborhood Hits	6
SwissProt Accessions	P01213	Gene names	PDYN
Domain Architecture
Description	Beta-neoendorphin-dynorphin precursor (Proenkephalin B) (Preprodynorphin) [Contains: Beta-neoendorphin; Dynorphin; Leu- enkephalin; Rimorphin; Leumorphin].

PNOC_MOUSE
θ value	0.0961366 (rank : 5)	NC score	0.266673 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	Q64387, Q61105, Q61938	Gene names	Pnoc, Npnc1
Domain Architecture
Description	Nociceptin precursor (N23K/N27K) [Contains: Neuropeptide 1; Nociceptin (Orphanin FQ) (PPNOC); Neuropeptide 2].

PNOC_HUMAN
θ value	0.21417 (rank : 6)	NC score	0.280521 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	9	Shared Neighborhood Hits	6
SwissProt Accessions	Q13519	Gene names	PNOC, OFQ
Domain Architecture
Description	Nociceptin precursor [Contains: Neuropeptide 1; Nociceptin (Orphanin FQ) (PPNOC); Neuropeptide 2].

KE4_MOUSE
θ value	0.47712 (rank : 7)	NC score	0.057637 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q31125, Q3TVU6, Q9Z1W1	Gene names	Slc39a7, H2-Ke4, Hke4
Domain Architecture
Description	Zinc transporter SLC39A7 (Solute carrier family 39 member 7) (Histidine-rich membrane protein Ke4).

COLI_HUMAN
θ value	1.81305 (rank : 8)	NC score	0.058232 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	P01189, P78442, Q9UD39, Q9UD40	Gene names	POMC
Domain Architecture
Description	Corticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC) [Contains: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide; Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanotropin alpha (Alpha-MSH); Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropin beta (Beta-MSH); Beta-endorphin; Met-enkephalin].

PARP8_HUMAN
θ value	2.36792 (rank : 9)	NC score	0.041139 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N3A8, Q3KRB7, Q6DHZ1, Q9H754	Gene names	PARP8
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 8 (EC 2.4.2.30) (PARP-8).

PARP8_MOUSE
θ value	2.36792 (rank : 10)	NC score	0.041030 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	Q3UD82, Q3UDE4, Q3UDU5, Q8VCB5, Q9CYY3	Gene names	Parp8, D13Ertd275e
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 8 (EC 2.4.2.30) (PARP-8).

ARS2_MOUSE
θ value	4.03905 (rank : 11)	NC score	0.025170 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	212	Shared Neighborhood Hits	6
SwissProt Accessions	Q99MR6, Q99MR4, Q99MR5, Q99MR7	Gene names	Ars2, Asr2
Domain Architecture
Description	Arsenite-resistance protein 2.

MY18A_MOUSE
θ value	4.03905 (rank : 12)	NC score	0.006259 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	1989	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

ANR11_HUMAN
θ value	8.99809 (rank : 13)	NC score	0.006195 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	1289	Shared Neighborhood Hits	5
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

ERCC6_HUMAN
θ value	8.99809 (rank : 14)	NC score	0.009910 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	247	Shared Neighborhood Hits	6
SwissProt Accessions	Q03468	Gene names	ERCC6, CSB
Domain Architecture
Description	DNA excision repair protein ERCC-6 (EC 3.6.1.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB).

MY18A_HUMAN
θ value	8.99809 (rank : 15)	NC score	0.005258 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	1929	Shared Neighborhood Hits	6
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

PGBM_MOUSE
θ value	8.99809 (rank : 16)	NC score	0.002398 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	1073	Shared Neighborhood Hits	2
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

Hits sorted by NC score

PENK_MOUSE
NC score	0.999962 (rank : 1)	θ value	1.32529e-160 (rank : 1)
Query Neighborhood Hits	16	Target Neighborhood Hits	16	Shared Neighborhood Hits	16
SwissProt Accessions	P22005	Gene names	Penk, Penk1
Domain Architecture
Description	Proenkephalin A precursor [Contains: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); Met-enkephalin-Arg-Ser-Leu; Leu- enkephalin; Met-enkephalin-Arg-Phe].

PENK_HUMAN
NC score	0.979072 (rank : 2)	θ value	1.20984e-129 (rank : 2)
Query Neighborhood Hits	16	Target Neighborhood Hits	29	Shared Neighborhood Hits	9
SwissProt Accessions	P01210	Gene names	PENK
Domain Architecture
Description	Proenkephalin A precursor [Contains: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); Met-enkephalin-Arg-Gly-Leu; Leu- enkephalin; Met-enkephalin-Arg-Phe].

PDYN_MOUSE
NC score	0.707710 (rank : 3)	θ value	2.13179e-17 (rank : 3)
Query Neighborhood Hits	16	Target Neighborhood Hits	11	Shared Neighborhood Hits	6
SwissProt Accessions	O35417	Gene names	Pdyn
Domain Architecture
Description	Beta-neoendorphin-dynorphin precursor (Proenkephalin B) (Preprodynorphin) [Contains: Alpha-neoendorphin; Dynorphin A; Leu- enkephalin; Dynorphin B].

PDYN_HUMAN
NC score	0.700636 (rank : 4)	θ value	3.63628e-17 (rank : 4)
Query Neighborhood Hits	16	Target Neighborhood Hits	17	Shared Neighborhood Hits	6
SwissProt Accessions	P01213	Gene names	PDYN
Domain Architecture
Description	Beta-neoendorphin-dynorphin precursor (Proenkephalin B) (Preprodynorphin) [Contains: Beta-neoendorphin; Dynorphin; Leu- enkephalin; Rimorphin; Leumorphin].

PNOC_HUMAN
NC score	0.280521 (rank : 5)	θ value	0.21417 (rank : 6)
Query Neighborhood Hits	16	Target Neighborhood Hits	9	Shared Neighborhood Hits	6
SwissProt Accessions	Q13519	Gene names	PNOC, OFQ
Domain Architecture
Description	Nociceptin precursor [Contains: Neuropeptide 1; Nociceptin (Orphanin FQ) (PPNOC); Neuropeptide 2].

PNOC_MOUSE
NC score	0.266673 (rank : 6)	θ value	0.0961366 (rank : 5)
Query Neighborhood Hits	16	Target Neighborhood Hits	10	Shared Neighborhood Hits	6
SwissProt Accessions	Q64387, Q61105, Q61938	Gene names	Pnoc, Npnc1
Domain Architecture
Description	Nociceptin precursor (N23K/N27K) [Contains: Neuropeptide 1; Nociceptin (Orphanin FQ) (PPNOC); Neuropeptide 2].

COLI_HUMAN
NC score	0.058232 (rank : 7)	θ value	1.81305 (rank : 8)
Query Neighborhood Hits	16	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	P01189, P78442, Q9UD39, Q9UD40	Gene names	POMC
Domain Architecture
Description	Corticotropin-lipotropin precursor (Pro-opiomelanocortin) (POMC) [Contains: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide; Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanotropin alpha (Alpha-MSH); Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanotropin beta (Beta-MSH); Beta-endorphin; Met-enkephalin].

KE4_MOUSE
NC score	0.057637 (rank : 8)	θ value	0.47712 (rank : 7)
Query Neighborhood Hits	16	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q31125, Q3TVU6, Q9Z1W1	Gene names	Slc39a7, H2-Ke4, Hke4
Domain Architecture
Description	Zinc transporter SLC39A7 (Solute carrier family 39 member 7) (Histidine-rich membrane protein Ke4).

PARP8_HUMAN
NC score	0.041139 (rank : 9)	θ value	2.36792 (rank : 9)
Query Neighborhood Hits	16	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N3A8, Q3KRB7, Q6DHZ1, Q9H754	Gene names	PARP8
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 8 (EC 2.4.2.30) (PARP-8).

PARP8_MOUSE
NC score	0.041030 (rank : 10)	θ value	2.36792 (rank : 10)
Query Neighborhood Hits	16	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	Q3UD82, Q3UDE4, Q3UDU5, Q8VCB5, Q9CYY3	Gene names	Parp8, D13Ertd275e
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 8 (EC 2.4.2.30) (PARP-8).

ARS2_MOUSE
NC score	0.025170 (rank : 11)	θ value	4.03905 (rank : 11)
Query Neighborhood Hits	16	Target Neighborhood Hits	212	Shared Neighborhood Hits	6
SwissProt Accessions	Q99MR6, Q99MR4, Q99MR5, Q99MR7	Gene names	Ars2, Asr2
Domain Architecture
Description	Arsenite-resistance protein 2.

ERCC6_HUMAN
NC score	0.009910 (rank : 12)	θ value	8.99809 (rank : 14)
Query Neighborhood Hits	16	Target Neighborhood Hits	247	Shared Neighborhood Hits	6
SwissProt Accessions	Q03468	Gene names	ERCC6, CSB
Domain Architecture
Description	DNA excision repair protein ERCC-6 (EC 3.6.1.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB).

MY18A_MOUSE
NC score	0.006259 (rank : 13)	θ value	4.03905 (rank : 12)
Query Neighborhood Hits	16	Target Neighborhood Hits	1989	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

ANR11_HUMAN
NC score	0.006195 (rank : 14)	θ value	8.99809 (rank : 13)
Query Neighborhood Hits	16	Target Neighborhood Hits	1289	Shared Neighborhood Hits	5
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

MY18A_HUMAN
NC score	0.005258 (rank : 15)	θ value	8.99809 (rank : 15)
Query Neighborhood Hits	16	Target Neighborhood Hits	1929	Shared Neighborhood Hits	6
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

PGBM_MOUSE
NC score	0.002398 (rank : 16)	θ value	8.99809 (rank : 16)
Query Neighborhood Hits	16	Target Neighborhood Hits	1073	Shared Neighborhood Hits	2
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).