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Network neighborhood for query Sequence : IF37_HUMAN

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IF37_HUMAN
SwissProt Accessions	O15371, Q5M9Q6	Gene names	EIF3S7
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 7 (eIF-3 zeta) (eIF3 p66) (eIF3d).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

IF37_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	50	Target Neighborhood Hits	50	Shared Neighborhood Hits	50
SwissProt Accessions	O15371, Q5M9Q6	Gene names	EIF3S7
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 7 (eIF-3 zeta) (eIF3 p66) (eIF3d).

IF37_MOUSE
θ value	0 (rank : 2)	NC score	0.993368 (rank : 2)
Query Neighborhood Hits	50	Target Neighborhood Hits	45	Shared Neighborhood Hits	37
SwissProt Accessions	O70194	Gene names	Eif3s7
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 7 (eIF-3 zeta) (eIF3 p66) (eIF3d).

IF3A_HUMAN
θ value	0.0431538 (rank : 3)	NC score	0.075953 (rank : 4)
Query Neighborhood Hits	50	Target Neighborhood Hits	875	Shared Neighborhood Hits	31
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

RBM25_HUMAN
θ value	0.0961366 (rank : 4)	NC score	0.058968 (rank : 7)
Query Neighborhood Hits	50	Target Neighborhood Hits	682	Shared Neighborhood Hits	13
SwissProt Accessions	P49756, Q9UEQ5, Q9UIE9	Gene names	RBM25, RNPC7
Domain Architecture	No domain graphic available
Description	Probable RNA-binding protein 25 (RNA-binding motif protein 25) (RNA- binding region-containing protein 7) (Protein S164).

CD2L1_HUMAN
θ value	0.125558 (rank : 5)	NC score	0.027958 (rank : 24)
Query Neighborhood Hits	50	Target Neighborhood Hits	1467	Shared Neighborhood Hits	18
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

CD2L2_HUMAN
θ value	0.163984 (rank : 6)	NC score	0.022816 (rank : 33)
Query Neighborhood Hits	50	Target Neighborhood Hits	1439	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

IF3A_MOUSE
θ value	0.163984 (rank : 7)	NC score	0.069387 (rank : 6)
Query Neighborhood Hits	50	Target Neighborhood Hits	871	Shared Neighborhood Hits	31
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

ZC313_HUMAN
θ value	0.21417 (rank : 8)	NC score	0.077550 (rank : 3)
Query Neighborhood Hits	50	Target Neighborhood Hits	772	Shared Neighborhood Hits	28
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

CLK4_HUMAN
θ value	0.279714 (rank : 9)	NC score	0.024063 (rank : 30)
Query Neighborhood Hits	50	Target Neighborhood Hits	759	Shared Neighborhood Hits	9
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

ZRF1_MOUSE
θ value	0.365318 (rank : 10)	NC score	0.070950 (rank : 5)
Query Neighborhood Hits	50	Target Neighborhood Hits	414	Shared Neighborhood Hits	10
SwissProt Accessions	P54103	Gene names	Zrf1, Dnajc2
Domain Architecture
Description	Zuotin-related factor 1.

CD2L1_MOUSE
θ value	0.62314 (rank : 11)	NC score	0.022947 (rank : 32)
Query Neighborhood Hits	50	Target Neighborhood Hits	1463	Shared Neighborhood Hits	17
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

IF2P_HUMAN
θ value	0.62314 (rank : 12)	NC score	0.034468 (rank : 17)
Query Neighborhood Hits	50	Target Neighborhood Hits	889	Shared Neighborhood Hits	17
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

CDC5L_MOUSE
θ value	0.813845 (rank : 13)	NC score	0.057903 (rank : 8)
Query Neighborhood Hits	50	Target Neighborhood Hits	205	Shared Neighborhood Hits	10
SwissProt Accessions	Q6A068, Q8K1J9	Gene names	Cdc5l, Kiaa0432
Domain Architecture	No domain graphic available
Description	Cell division cycle 5-related protein (Cdc5-like protein).

TRHY_HUMAN
θ value	0.813845 (rank : 14)	NC score	0.024623 (rank : 28)
Query Neighborhood Hits	50	Target Neighborhood Hits	1385	Shared Neighborhood Hits	19
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

U2AFM_HUMAN
θ value	0.813845 (rank : 15)	NC score	0.044031 (rank : 12)
Query Neighborhood Hits	50	Target Neighborhood Hits	577	Shared Neighborhood Hits	13
SwissProt Accessions	Q15696	Gene names	ZRSR2, U2AF1-RS2, U2AF1L2, U2AF1RS2
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (NY-REN-20 antigen).

CDC5L_HUMAN
θ value	1.06291 (rank : 16)	NC score	0.057775 (rank : 9)
Query Neighborhood Hits	50	Target Neighborhood Hits	197	Shared Neighborhood Hits	10
SwissProt Accessions	Q99459, Q76N46, Q99974	Gene names	CDC5L, KIAA0432, PCDC5RP
Domain Architecture	No domain graphic available
Description	Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5- related protein).

GOGA4_HUMAN
θ value	1.06291 (rank : 17)	NC score	0.029591 (rank : 21)
Query Neighborhood Hits	50	Target Neighborhood Hits	2034	Shared Neighborhood Hits	41
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

HOOK2_MOUSE
θ value	1.38821 (rank : 18)	NC score	0.030438 (rank : 20)
Query Neighborhood Hits	50	Target Neighborhood Hits	736	Shared Neighborhood Hits	24
SwissProt Accessions	Q7TMK6, Q8BY47, Q8R347, Q8VCN4, Q99LU2	Gene names	Hook2
Domain Architecture
Description	Hook homolog 2.

TOP1_MOUSE
θ value	1.38821 (rank : 19)	NC score	0.051634 (rank : 10)
Query Neighborhood Hits	50	Target Neighborhood Hits	213	Shared Neighborhood Hits	5
SwissProt Accessions	Q04750	Gene names	Top1, Top-1
Domain Architecture
Description	DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I).

BAZ2B_HUMAN
θ value	1.81305 (rank : 20)	NC score	0.028617 (rank : 23)
Query Neighborhood Hits	50	Target Neighborhood Hits	803	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

FA50A_HUMAN
θ value	1.81305 (rank : 21)	NC score	0.040092 (rank : 13)
Query Neighborhood Hits	50	Target Neighborhood Hits	264	Shared Neighborhood Hits	6
SwissProt Accessions	Q14320, Q5HY37	Gene names	FAM50A, DXS9928E, HXC26, XAP5
Domain Architecture
Description	Protein FAM50A (Protein XAP-5) (Protein HXC-26).

PCY1A_MOUSE
θ value	2.36792 (rank : 22)	NC score	0.046421 (rank : 11)
Query Neighborhood Hits	50	Target Neighborhood Hits	35	Shared Neighborhood Hits	5
SwissProt Accessions	P49586, Q542W4	Gene names	Pcyt1a, Ctpct, Pcyt1
Domain Architecture
Description	Choline-phosphate cytidylyltransferase A (EC 2.7.7.15) (Phosphorylcholine transferase A) (CTP:phosphocholine cytidylyltransferase A) (CT A) (CCT A) (CCT-alpha).

CLK4_MOUSE
θ value	3.0926 (rank : 23)	NC score	0.017924 (rank : 38)
Query Neighborhood Hits	50	Target Neighborhood Hits	759	Shared Neighborhood Hits	10
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

M4K4_HUMAN
θ value	3.0926 (rank : 24)	NC score	0.013965 (rank : 45)
Query Neighborhood Hits	50	Target Neighborhood Hits	1589	Shared Neighborhood Hits	22
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

ZRF1_HUMAN
θ value	3.0926 (rank : 25)	NC score	0.039834 (rank : 14)
Query Neighborhood Hits	50	Target Neighborhood Hits	457	Shared Neighborhood Hits	9
SwissProt Accessions	Q99543	Gene names	ZRF1, DNAJC2, MPHOSPH11, MPP11
Domain Architecture
Description	Zuotin-related factor 1 (M-phase phosphoprotein 11).

CHP2_MOUSE
θ value	4.03905 (rank : 26)	NC score	0.015596 (rank : 41)
Query Neighborhood Hits	50	Target Neighborhood Hits	122	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D869	Gene names	Chp2, Hca520
Domain Architecture
Description	Calcineurin B homologous protein 2 (Hepatocellular carcinoma- associated antigen 520 homolog).

DDX23_HUMAN
θ value	4.03905 (rank : 27)	NC score	0.014188 (rank : 44)
Query Neighborhood Hits	50	Target Neighborhood Hits	486	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BUQ8, O43188	Gene names	DDX23
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX23 (EC 3.6.1.-) (DEAD box protein 23) (100 kDa U5 snRNP-specific protein) (U5-100kD) (PRP28 homolog).

ITSN2_MOUSE
θ value	4.03905 (rank : 28)	NC score	0.024128 (rank : 29)
Query Neighborhood Hits	50	Target Neighborhood Hits	1371	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

M4K4_MOUSE
θ value	4.03905 (rank : 29)	NC score	0.013548 (rank : 47)
Query Neighborhood Hits	50	Target Neighborhood Hits	1560	Shared Neighborhood Hits	21
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

TPR_HUMAN
θ value	4.03905 (rank : 30)	NC score	0.023238 (rank : 31)
Query Neighborhood Hits	50	Target Neighborhood Hits	1921	Shared Neighborhood Hits	37
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

DHX16_HUMAN
θ value	5.27518 (rank : 31)	NC score	0.017650 (rank : 39)
Query Neighborhood Hits	50	Target Neighborhood Hits	356	Shared Neighborhood Hits	14
SwissProt Accessions	O60231, O60322, Q969X7, Q96QC1	Gene names	DHX16, DBP2, DDX16, KIAA0577
Domain Architecture
Description	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.1.-) (DEAH-box protein 16) (ATP-dependent RNA helicase #3).

ITSN2_HUMAN
θ value	5.27518 (rank : 32)	NC score	0.017526 (rank : 40)
Query Neighborhood Hits	50	Target Neighborhood Hits	1173	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

NFM_MOUSE
θ value	5.27518 (rank : 33)	NC score	0.014327 (rank : 43)
Query Neighborhood Hits	50	Target Neighborhood Hits	1159	Shared Neighborhood Hits	27
SwissProt Accessions	P08553, Q61961	Gene names	Nef3, Nefm, Nfm
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M).

PCY1A_HUMAN
θ value	5.27518 (rank : 34)	NC score	0.038055 (rank : 15)
Query Neighborhood Hits	50	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	P49585	Gene names	PCYT1A, CTPCT, PCYT1
Domain Architecture
Description	Choline-phosphate cytidylyltransferase A (EC 2.7.7.15) (Phosphorylcholine transferase A) (CTP:phosphocholine cytidylyltransferase A) (CT A) (CCT A) (CCT-alpha).

TAF3_MOUSE
θ value	5.27518 (rank : 35)	NC score	0.020166 (rank : 35)
Query Neighborhood Hits	50	Target Neighborhood Hits	463	Shared Neighborhood Hits	9
SwissProt Accessions	Q5HZG4, Q3U490, Q3UWX2, Q8BIU8, Q99JH4	Gene names	Taf3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

5HT2C_MOUSE
θ value	6.88961 (rank : 36)	NC score	0.003875 (rank : 50)
Query Neighborhood Hits	50	Target Neighborhood Hits	876	Shared Neighborhood Hits	3
SwissProt Accessions	P34968	Gene names	Htr2c, 5ht1c, Htr1c
Domain Architecture
Description	5-hydroxytryptamine 2C receptor (5-HT-2C) (Serotonin receptor 2C) (5- HT2C) (5-HTR2C) (5HT-1C).

CCD39_HUMAN
θ value	6.88961 (rank : 37)	NC score	0.019983 (rank : 36)
Query Neighborhood Hits	50	Target Neighborhood Hits	868	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

CF057_MOUSE
θ value	6.88961 (rank : 38)	NC score	0.028665 (rank : 22)
Query Neighborhood Hits	50	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BTE0, Q9CQN5, Q9D537	Gene names
Domain Architecture	No domain graphic available
Description	UPF0369 protein C6orf57 homolog precursor.

INCE_HUMAN
θ value	6.88961 (rank : 39)	NC score	0.025596 (rank : 26)
Query Neighborhood Hits	50	Target Neighborhood Hits	978	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

INCE_MOUSE
θ value	6.88961 (rank : 40)	NC score	0.026458 (rank : 25)
Query Neighborhood Hits	50	Target Neighborhood Hits	903	Shared Neighborhood Hits	21
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

PCNT_MOUSE
θ value	6.88961 (rank : 41)	NC score	0.034095 (rank : 18)
Query Neighborhood Hits	50	Target Neighborhood Hits	1207	Shared Neighborhood Hits	32
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

SAFB2_HUMAN
θ value	6.88961 (rank : 42)	NC score	0.015425 (rank : 42)
Query Neighborhood Hits	50	Target Neighborhood Hits	720	Shared Neighborhood Hits	12
SwissProt Accessions	Q14151, Q8TB13	Gene names	SAFB2, KIAA0138
Domain Architecture
Description	Scaffold attachment factor B2.

CCD50_MOUSE
θ value	8.99809 (rank : 43)	NC score	0.035439 (rank : 16)
Query Neighborhood Hits	50	Target Neighborhood Hits	172	Shared Neighborhood Hits	14
SwissProt Accessions	Q810U5, Q3TRW1, Q8BP82, Q9CZT1, Q9D436	Gene names	Ccdc50
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 50 (Protein Ymer).

FA50A_MOUSE
θ value	8.99809 (rank : 44)	NC score	0.021912 (rank : 34)
Query Neighborhood Hits	50	Target Neighborhood Hits	293	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WV03, Q9D866	Gene names	Fam50a, D0HXS9928E, Xap5
Domain Architecture
Description	Protein FAM50A (XAP-5 protein).

GNL3_MOUSE
θ value	8.99809 (rank : 45)	NC score	0.025158 (rank : 27)
Query Neighborhood Hits	50	Target Neighborhood Hits	99	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CI11, Q811R9, Q811S8, Q8BK21	Gene names	Gnl3, Ns
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein-like 3 (Nucleolar GTP-binding protein 3) (Nucleostemin).

HRX_HUMAN
θ value	8.99809 (rank : 46)	NC score	0.019036 (rank : 37)
Query Neighborhood Hits	50	Target Neighborhood Hits	825	Shared Neighborhood Hits	9
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

NFH_HUMAN
θ value	8.99809 (rank : 47)	NC score	0.009677 (rank : 48)
Query Neighborhood Hits	50	Target Neighborhood Hits	1242	Shared Neighborhood Hits	19
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

RADI_HUMAN
θ value	8.99809 (rank : 48)	NC score	0.013664 (rank : 46)
Query Neighborhood Hits	50	Target Neighborhood Hits	741	Shared Neighborhood Hits	15
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

TOP1_HUMAN
θ value	8.99809 (rank : 49)	NC score	0.031900 (rank : 19)
Query Neighborhood Hits	50	Target Neighborhood Hits	207	Shared Neighborhood Hits	6
SwissProt Accessions	P11387, O43256, Q12855, Q12856, Q15610, Q5TFY3, Q9UJN0	Gene names	TOP1
Domain Architecture
Description	DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I).

USH1C_MOUSE
θ value	8.99809 (rank : 50)	NC score	0.009395 (rank : 49)
Query Neighborhood Hits	50	Target Neighborhood Hits	557	Shared Neighborhood Hits	6
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

Hits sorted by NC score

IF37_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	50	Target Neighborhood Hits	50	Shared Neighborhood Hits	50
SwissProt Accessions	O15371, Q5M9Q6	Gene names	EIF3S7
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 7 (eIF-3 zeta) (eIF3 p66) (eIF3d).

IF37_MOUSE
NC score	0.993368 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	50	Target Neighborhood Hits	45	Shared Neighborhood Hits	37
SwissProt Accessions	O70194	Gene names	Eif3s7
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 7 (eIF-3 zeta) (eIF3 p66) (eIF3d).

ZC313_HUMAN
NC score	0.077550 (rank : 3)	θ value	0.21417 (rank : 8)
Query Neighborhood Hits	50	Target Neighborhood Hits	772	Shared Neighborhood Hits	28
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

IF3A_HUMAN
NC score	0.075953 (rank : 4)	θ value	0.0431538 (rank : 3)
Query Neighborhood Hits	50	Target Neighborhood Hits	875	Shared Neighborhood Hits	31
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

ZRF1_MOUSE
NC score	0.070950 (rank : 5)	θ value	0.365318 (rank : 10)
Query Neighborhood Hits	50	Target Neighborhood Hits	414	Shared Neighborhood Hits	10
SwissProt Accessions	P54103	Gene names	Zrf1, Dnajc2
Domain Architecture
Description	Zuotin-related factor 1.

IF3A_MOUSE
NC score	0.069387 (rank : 6)	θ value	0.163984 (rank : 7)
Query Neighborhood Hits	50	Target Neighborhood Hits	871	Shared Neighborhood Hits	31
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

RBM25_HUMAN
NC score	0.058968 (rank : 7)	θ value	0.0961366 (rank : 4)
Query Neighborhood Hits	50	Target Neighborhood Hits	682	Shared Neighborhood Hits	13
SwissProt Accessions	P49756, Q9UEQ5, Q9UIE9	Gene names	RBM25, RNPC7
Domain Architecture	No domain graphic available
Description	Probable RNA-binding protein 25 (RNA-binding motif protein 25) (RNA- binding region-containing protein 7) (Protein S164).

CDC5L_MOUSE
NC score	0.057903 (rank : 8)	θ value	0.813845 (rank : 13)
Query Neighborhood Hits	50	Target Neighborhood Hits	205	Shared Neighborhood Hits	10
SwissProt Accessions	Q6A068, Q8K1J9	Gene names	Cdc5l, Kiaa0432
Domain Architecture	No domain graphic available
Description	Cell division cycle 5-related protein (Cdc5-like protein).

CDC5L_HUMAN
NC score	0.057775 (rank : 9)	θ value	1.06291 (rank : 16)
Query Neighborhood Hits	50	Target Neighborhood Hits	197	Shared Neighborhood Hits	10
SwissProt Accessions	Q99459, Q76N46, Q99974	Gene names	CDC5L, KIAA0432, PCDC5RP
Domain Architecture	No domain graphic available
Description	Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5- related protein).

TOP1_MOUSE
NC score	0.051634 (rank : 10)	θ value	1.38821 (rank : 19)
Query Neighborhood Hits	50	Target Neighborhood Hits	213	Shared Neighborhood Hits	5
SwissProt Accessions	Q04750	Gene names	Top1, Top-1
Domain Architecture
Description	DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I).

PCY1A_MOUSE
NC score	0.046421 (rank : 11)	θ value	2.36792 (rank : 22)
Query Neighborhood Hits	50	Target Neighborhood Hits	35	Shared Neighborhood Hits	5
SwissProt Accessions	P49586, Q542W4	Gene names	Pcyt1a, Ctpct, Pcyt1
Domain Architecture
Description	Choline-phosphate cytidylyltransferase A (EC 2.7.7.15) (Phosphorylcholine transferase A) (CTP:phosphocholine cytidylyltransferase A) (CT A) (CCT A) (CCT-alpha).

U2AFM_HUMAN
NC score	0.044031 (rank : 12)	θ value	0.813845 (rank : 15)
Query Neighborhood Hits	50	Target Neighborhood Hits	577	Shared Neighborhood Hits	13
SwissProt Accessions	Q15696	Gene names	ZRSR2, U2AF1-RS2, U2AF1L2, U2AF1RS2
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (NY-REN-20 antigen).

FA50A_HUMAN
NC score	0.040092 (rank : 13)	θ value	1.81305 (rank : 21)
Query Neighborhood Hits	50	Target Neighborhood Hits	264	Shared Neighborhood Hits	6
SwissProt Accessions	Q14320, Q5HY37	Gene names	FAM50A, DXS9928E, HXC26, XAP5
Domain Architecture
Description	Protein FAM50A (Protein XAP-5) (Protein HXC-26).

ZRF1_HUMAN
NC score	0.039834 (rank : 14)	θ value	3.0926 (rank : 25)
Query Neighborhood Hits	50	Target Neighborhood Hits	457	Shared Neighborhood Hits	9
SwissProt Accessions	Q99543	Gene names	ZRF1, DNAJC2, MPHOSPH11, MPP11
Domain Architecture
Description	Zuotin-related factor 1 (M-phase phosphoprotein 11).

PCY1A_HUMAN
NC score	0.038055 (rank : 15)	θ value	5.27518 (rank : 34)
Query Neighborhood Hits	50	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	P49585	Gene names	PCYT1A, CTPCT, PCYT1
Domain Architecture
Description	Choline-phosphate cytidylyltransferase A (EC 2.7.7.15) (Phosphorylcholine transferase A) (CTP:phosphocholine cytidylyltransferase A) (CT A) (CCT A) (CCT-alpha).

CCD50_MOUSE
NC score	0.035439 (rank : 16)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	50	Target Neighborhood Hits	172	Shared Neighborhood Hits	14
SwissProt Accessions	Q810U5, Q3TRW1, Q8BP82, Q9CZT1, Q9D436	Gene names	Ccdc50
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 50 (Protein Ymer).

IF2P_HUMAN
NC score	0.034468 (rank : 17)	θ value	0.62314 (rank : 12)
Query Neighborhood Hits	50	Target Neighborhood Hits	889	Shared Neighborhood Hits	17
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

PCNT_MOUSE
NC score	0.034095 (rank : 18)	θ value	6.88961 (rank : 41)
Query Neighborhood Hits	50	Target Neighborhood Hits	1207	Shared Neighborhood Hits	32
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

TOP1_HUMAN
NC score	0.031900 (rank : 19)	θ value	8.99809 (rank : 49)
Query Neighborhood Hits	50	Target Neighborhood Hits	207	Shared Neighborhood Hits	6
SwissProt Accessions	P11387, O43256, Q12855, Q12856, Q15610, Q5TFY3, Q9UJN0	Gene names	TOP1
Domain Architecture
Description	DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I).

HOOK2_MOUSE
NC score	0.030438 (rank : 20)	θ value	1.38821 (rank : 18)
Query Neighborhood Hits	50	Target Neighborhood Hits	736	Shared Neighborhood Hits	24
SwissProt Accessions	Q7TMK6, Q8BY47, Q8R347, Q8VCN4, Q99LU2	Gene names	Hook2
Domain Architecture
Description	Hook homolog 2.

GOGA4_HUMAN
NC score	0.029591 (rank : 21)	θ value	1.06291 (rank : 17)
Query Neighborhood Hits	50	Target Neighborhood Hits	2034	Shared Neighborhood Hits	41
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

CF057_MOUSE
NC score	0.028665 (rank : 22)	θ value	6.88961 (rank : 38)
Query Neighborhood Hits	50	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BTE0, Q9CQN5, Q9D537	Gene names
Domain Architecture	No domain graphic available
Description	UPF0369 protein C6orf57 homolog precursor.

BAZ2B_HUMAN
NC score	0.028617 (rank : 23)	θ value	1.81305 (rank : 20)
Query Neighborhood Hits	50	Target Neighborhood Hits	803	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

CD2L1_HUMAN
NC score	0.027958 (rank : 24)	θ value	0.125558 (rank : 5)
Query Neighborhood Hits	50	Target Neighborhood Hits	1467	Shared Neighborhood Hits	18
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

INCE_MOUSE
NC score	0.026458 (rank : 25)	θ value	6.88961 (rank : 40)
Query Neighborhood Hits	50	Target Neighborhood Hits	903	Shared Neighborhood Hits	21
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

INCE_HUMAN
NC score	0.025596 (rank : 26)	θ value	6.88961 (rank : 39)
Query Neighborhood Hits	50	Target Neighborhood Hits	978	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

GNL3_MOUSE
NC score	0.025158 (rank : 27)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	50	Target Neighborhood Hits	99	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CI11, Q811R9, Q811S8, Q8BK21	Gene names	Gnl3, Ns
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein-like 3 (Nucleolar GTP-binding protein 3) (Nucleostemin).

TRHY_HUMAN
NC score	0.024623 (rank : 28)	θ value	0.813845 (rank : 14)
Query Neighborhood Hits	50	Target Neighborhood Hits	1385	Shared Neighborhood Hits	19
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

ITSN2_MOUSE
NC score	0.024128 (rank : 29)	θ value	4.03905 (rank : 28)
Query Neighborhood Hits	50	Target Neighborhood Hits	1371	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

CLK4_HUMAN
NC score	0.024063 (rank : 30)	θ value	0.279714 (rank : 9)
Query Neighborhood Hits	50	Target Neighborhood Hits	759	Shared Neighborhood Hits	9
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

TPR_HUMAN
NC score	0.023238 (rank : 31)	θ value	4.03905 (rank : 30)
Query Neighborhood Hits	50	Target Neighborhood Hits	1921	Shared Neighborhood Hits	37
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

CD2L1_MOUSE
NC score	0.022947 (rank : 32)	θ value	0.62314 (rank : 11)
Query Neighborhood Hits	50	Target Neighborhood Hits	1463	Shared Neighborhood Hits	17
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

CD2L2_HUMAN
NC score	0.022816 (rank : 33)	θ value	0.163984 (rank : 6)
Query Neighborhood Hits	50	Target Neighborhood Hits	1439	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

FA50A_MOUSE
NC score	0.021912 (rank : 34)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	50	Target Neighborhood Hits	293	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WV03, Q9D866	Gene names	Fam50a, D0HXS9928E, Xap5
Domain Architecture
Description	Protein FAM50A (XAP-5 protein).

TAF3_MOUSE
NC score	0.020166 (rank : 35)	θ value	5.27518 (rank : 35)
Query Neighborhood Hits	50	Target Neighborhood Hits	463	Shared Neighborhood Hits	9
SwissProt Accessions	Q5HZG4, Q3U490, Q3UWX2, Q8BIU8, Q99JH4	Gene names	Taf3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

CCD39_HUMAN
NC score	0.019983 (rank : 36)	θ value	6.88961 (rank : 37)
Query Neighborhood Hits	50	Target Neighborhood Hits	868	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

HRX_HUMAN
NC score	0.019036 (rank : 37)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	50	Target Neighborhood Hits	825	Shared Neighborhood Hits	9
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

CLK4_MOUSE
NC score	0.017924 (rank : 38)	θ value	3.0926 (rank : 23)
Query Neighborhood Hits	50	Target Neighborhood Hits	759	Shared Neighborhood Hits	10
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

DHX16_HUMAN
NC score	0.017650 (rank : 39)	θ value	5.27518 (rank : 31)
Query Neighborhood Hits	50	Target Neighborhood Hits	356	Shared Neighborhood Hits	14
SwissProt Accessions	O60231, O60322, Q969X7, Q96QC1	Gene names	DHX16, DBP2, DDX16, KIAA0577
Domain Architecture
Description	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.1.-) (DEAH-box protein 16) (ATP-dependent RNA helicase #3).

ITSN2_HUMAN
NC score	0.017526 (rank : 40)	θ value	5.27518 (rank : 32)
Query Neighborhood Hits	50	Target Neighborhood Hits	1173	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

CHP2_MOUSE
NC score	0.015596 (rank : 41)	θ value	4.03905 (rank : 26)
Query Neighborhood Hits	50	Target Neighborhood Hits	122	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D869	Gene names	Chp2, Hca520
Domain Architecture
Description	Calcineurin B homologous protein 2 (Hepatocellular carcinoma- associated antigen 520 homolog).

SAFB2_HUMAN
NC score	0.015425 (rank : 42)	θ value	6.88961 (rank : 42)
Query Neighborhood Hits	50	Target Neighborhood Hits	720	Shared Neighborhood Hits	12
SwissProt Accessions	Q14151, Q8TB13	Gene names	SAFB2, KIAA0138
Domain Architecture
Description	Scaffold attachment factor B2.

NFM_MOUSE
NC score	0.014327 (rank : 43)	θ value	5.27518 (rank : 33)
Query Neighborhood Hits	50	Target Neighborhood Hits	1159	Shared Neighborhood Hits	27
SwissProt Accessions	P08553, Q61961	Gene names	Nef3, Nefm, Nfm
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M).

DDX23_HUMAN
NC score	0.014188 (rank : 44)	θ value	4.03905 (rank : 27)
Query Neighborhood Hits	50	Target Neighborhood Hits	486	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BUQ8, O43188	Gene names	DDX23
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX23 (EC 3.6.1.-) (DEAD box protein 23) (100 kDa U5 snRNP-specific protein) (U5-100kD) (PRP28 homolog).

M4K4_HUMAN
NC score	0.013965 (rank : 45)	θ value	3.0926 (rank : 24)
Query Neighborhood Hits	50	Target Neighborhood Hits	1589	Shared Neighborhood Hits	22
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

RADI_HUMAN
NC score	0.013664 (rank : 46)	θ value	8.99809 (rank : 48)
Query Neighborhood Hits	50	Target Neighborhood Hits	741	Shared Neighborhood Hits	15
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

M4K4_MOUSE
NC score	0.013548 (rank : 47)	θ value	4.03905 (rank : 29)
Query Neighborhood Hits	50	Target Neighborhood Hits	1560	Shared Neighborhood Hits	21
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

NFH_HUMAN
NC score	0.009677 (rank : 48)	θ value	8.99809 (rank : 47)
Query Neighborhood Hits	50	Target Neighborhood Hits	1242	Shared Neighborhood Hits	19
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

USH1C_MOUSE
NC score	0.009395 (rank : 49)	θ value	8.99809 (rank : 50)
Query Neighborhood Hits	50	Target Neighborhood Hits	557	Shared Neighborhood Hits	6
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

5HT2C_MOUSE
NC score	0.003875 (rank : 50)	θ value	6.88961 (rank : 36)
Query Neighborhood Hits	50	Target Neighborhood Hits	876	Shared Neighborhood Hits	3
SwissProt Accessions	P34968	Gene names	Htr2c, 5ht1c, Htr1c
Domain Architecture
Description	5-hydroxytryptamine 2C receptor (5-HT-2C) (Serotonin receptor 2C) (5- HT2C) (5-HTR2C) (5HT-1C).