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Network neighborhood for query Sequence : HMCS1_MOUSE

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HMCS1_MOUSE
SwissProt Accessions	Q8JZK9, Q3UXI4	Gene names	Hmgcs1
Domain Architecture	No domain graphic available
Description	Hydroxymethylglutaryl-CoA synthase, cytoplasmic (EC 2.3.3.10) (HMG-CoA synthase) (3-hydroxy-3-methylglutaryl coenzyme A synthase).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HMCS1_HUMAN
θ value	0 (rank : 1)	NC score	0.999566 (rank : 2)
Query Neighborhood Hits	8	Target Neighborhood Hits	5	Shared Neighborhood Hits	5
SwissProt Accessions	Q01581	Gene names	HMGCS1, HMGCS
Domain Architecture
Description	Hydroxymethylglutaryl-CoA synthase, cytoplasmic (EC 2.3.3.10) (HMG-CoA synthase) (3-hydroxy-3-methylglutaryl coenzyme A synthase).

HMCS1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	8	Target Neighborhood Hits	8	Shared Neighborhood Hits	8
SwissProt Accessions	Q8JZK9, Q3UXI4	Gene names	Hmgcs1
Domain Architecture	No domain graphic available
Description	Hydroxymethylglutaryl-CoA synthase, cytoplasmic (EC 2.3.3.10) (HMG-CoA synthase) (3-hydroxy-3-methylglutaryl coenzyme A synthase).

HMCS2_HUMAN
θ value	0 (rank : 3)	NC score	0.991633 (rank : 3)
Query Neighborhood Hits	8	Target Neighborhood Hits	7	Shared Neighborhood Hits	4
SwissProt Accessions	P54868	Gene names	HMGCS2
Domain Architecture
Description	Hydroxymethylglutaryl-CoA synthase, mitochondrial precursor (EC 2.3.3.10) (HMG-CoA synthase) (3-hydroxy-3-methylglutaryl coenzyme A synthase).

HMCS2_MOUSE
θ value	0 (rank : 4)	NC score	0.991356 (rank : 4)
Query Neighborhood Hits	8	Target Neighborhood Hits	5	Shared Neighborhood Hits	4
SwissProt Accessions	P54869, Q64740, Q9DBK1, Q9DBM4	Gene names	Hmgcs2
Domain Architecture	No domain graphic available
Description	Hydroxymethylglutaryl-CoA synthase, mitochondrial precursor (EC 2.3.3.10) (HMG-CoA synthase) (3-hydroxy-3-methylglutaryl coenzyme A synthase).

G6PD1_MOUSE
θ value	2.36792 (rank : 5)	NC score	0.018473 (rank : 5)
Query Neighborhood Hits	8	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q00612	Gene names	G6pdx, G6pd, G6pd-1
Domain Architecture
Description	Glucose-6-phosphate 1-dehydrogenase X (EC 1.1.1.49) (G6PD).

FATH_HUMAN
θ value	3.0926 (rank : 6)	NC score	0.005280 (rank : 8)
Query Neighborhood Hits	8	Target Neighborhood Hits	570	Shared Neighborhood Hits	3
SwissProt Accessions	Q14517	Gene names	FAT
Domain Architecture
Description	Cadherin-related tumor suppressor homolog precursor (Protein fat homolog).

RHG06_HUMAN
θ value	3.0926 (rank : 7)	NC score	0.012118 (rank : 6)
Query Neighborhood Hits	8	Target Neighborhood Hits	114	Shared Neighborhood Hits	2
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RNF34_HUMAN
θ value	6.88961 (rank : 8)	NC score	0.010086 (rank : 7)
Query Neighborhood Hits	8	Target Neighborhood Hits	153	Shared Neighborhood Hits	2
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

Hits sorted by NC score

HMCS1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	8	Target Neighborhood Hits	8	Shared Neighborhood Hits	8
SwissProt Accessions	Q8JZK9, Q3UXI4	Gene names	Hmgcs1
Domain Architecture	No domain graphic available
Description	Hydroxymethylglutaryl-CoA synthase, cytoplasmic (EC 2.3.3.10) (HMG-CoA synthase) (3-hydroxy-3-methylglutaryl coenzyme A synthase).

HMCS1_HUMAN
NC score	0.999566 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	8	Target Neighborhood Hits	5	Shared Neighborhood Hits	5
SwissProt Accessions	Q01581	Gene names	HMGCS1, HMGCS
Domain Architecture
Description	Hydroxymethylglutaryl-CoA synthase, cytoplasmic (EC 2.3.3.10) (HMG-CoA synthase) (3-hydroxy-3-methylglutaryl coenzyme A synthase).

HMCS2_HUMAN
NC score	0.991633 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	8	Target Neighborhood Hits	7	Shared Neighborhood Hits	4
SwissProt Accessions	P54868	Gene names	HMGCS2
Domain Architecture
Description	Hydroxymethylglutaryl-CoA synthase, mitochondrial precursor (EC 2.3.3.10) (HMG-CoA synthase) (3-hydroxy-3-methylglutaryl coenzyme A synthase).

HMCS2_MOUSE
NC score	0.991356 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	8	Target Neighborhood Hits	5	Shared Neighborhood Hits	4
SwissProt Accessions	P54869, Q64740, Q9DBK1, Q9DBM4	Gene names	Hmgcs2
Domain Architecture	No domain graphic available
Description	Hydroxymethylglutaryl-CoA synthase, mitochondrial precursor (EC 2.3.3.10) (HMG-CoA synthase) (3-hydroxy-3-methylglutaryl coenzyme A synthase).

G6PD1_MOUSE
NC score	0.018473 (rank : 5)	θ value	2.36792 (rank : 5)
Query Neighborhood Hits	8	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q00612	Gene names	G6pdx, G6pd, G6pd-1
Domain Architecture
Description	Glucose-6-phosphate 1-dehydrogenase X (EC 1.1.1.49) (G6PD).

RHG06_HUMAN
NC score	0.012118 (rank : 6)	θ value	3.0926 (rank : 7)
Query Neighborhood Hits	8	Target Neighborhood Hits	114	Shared Neighborhood Hits	2
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RNF34_HUMAN
NC score	0.010086 (rank : 7)	θ value	6.88961 (rank : 8)
Query Neighborhood Hits	8	Target Neighborhood Hits	153	Shared Neighborhood Hits	2
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

FATH_HUMAN
NC score	0.005280 (rank : 8)	θ value	3.0926 (rank : 6)
Query Neighborhood Hits	8	Target Neighborhood Hits	570	Shared Neighborhood Hits	3
SwissProt Accessions	Q14517	Gene names	FAT
Domain Architecture
Description	Cadherin-related tumor suppressor homolog precursor (Protein fat homolog).