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Network neighborhood for query Sequence : DEDD2_HUMAN

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DEDD2_HUMAN
SwissProt Accessions	Q8WXF8, Q8NBR2, Q8NES1, Q8TAA8, Q96D35	Gene names	DEDD2, FLAME3
Domain Architecture	No domain graphic available
Description	DNA-binding death effector domain-containing protein 2 (FADD-like anti-apoptotic molecule 3) (DED-containing protein FLAME-3).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DEDD2_HUMAN
θ value	3.91003e-112 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	19
SwissProt Accessions	Q8WXF8, Q8NBR2, Q8NES1, Q8TAA8, Q96D35	Gene names	DEDD2, FLAME3
Domain Architecture	No domain graphic available
Description	DNA-binding death effector domain-containing protein 2 (FADD-like anti-apoptotic molecule 3) (DED-containing protein FLAME-3).

DEDD2_MOUSE
θ value	7.37397e-111 (rank : 2)	NC score	0.993516 (rank : 2)
Query Neighborhood Hits	19	Target Neighborhood Hits	14	Shared Neighborhood Hits	6
SwissProt Accessions	Q8QZV0, Q569Y9, Q8JZV1	Gene names	Dedd2, Flame3
Domain Architecture	No domain graphic available
Description	DNA-binding death effector domain-containing protein 2 (FADD-like anti-apoptotic molecule 3) (DED-containing protein FLAME-3).

DEDD_HUMAN
θ value	3.24342e-66 (rank : 3)	NC score	0.948255 (rank : 4)
Query Neighborhood Hits	19	Target Neighborhood Hits	40	Shared Neighborhood Hits	4
SwissProt Accessions	O75618, O60737	Gene names	DEDD, DEDPRO1, DEFT
Domain Architecture
Description	Death effector domain-containing protein (Death effector domain- containing testicular molecule) (DEDPro1) (FLDED-1).

DEDD_MOUSE
θ value	1.2325e-65 (rank : 4)	NC score	0.949690 (rank : 3)
Query Neighborhood Hits	19	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z1L3, Q7TQH8, Q9R227	Gene names	Dedd
Domain Architecture
Description	Death effector domain-containing protein (DEDPro1).

RPTN_MOUSE
θ value	0.163984 (rank : 5)	NC score	0.036921 (rank : 6)
Query Neighborhood Hits	19	Target Neighborhood Hits	650	Shared Neighborhood Hits	7
SwissProt Accessions	P97347	Gene names	Rptn
Domain Architecture
Description	Repetin.

OBSCN_HUMAN
θ value	0.279714 (rank : 6)	NC score	0.008581 (rank : 17)
Query Neighborhood Hits	19	Target Neighborhood Hits	1931	Shared Neighborhood Hits	6
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

US6NL_HUMAN
θ value	0.47712 (rank : 7)	NC score	0.039844 (rank : 5)
Query Neighborhood Hits	19	Target Neighborhood Hits	201	Shared Neighborhood Hits	4
SwissProt Accessions	Q92738, Q15400, Q7L0K9	Gene names	USP6NL, KIAA0019
Domain Architecture	No domain graphic available
Description	USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN- tre).

TTC16_HUMAN
θ value	0.62314 (rank : 8)	NC score	0.034223 (rank : 8)
Query Neighborhood Hits	19	Target Neighborhood Hits	417	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NEE8, Q5JU66, Q96M72	Gene names	TTC16
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 16 (TPR repeat protein 16).

ANK2_HUMAN
θ value	2.36792 (rank : 9)	NC score	0.010646 (rank : 15)
Query Neighborhood Hits	19	Target Neighborhood Hits	1615	Shared Neighborhood Hits	9
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

R4RL2_MOUSE
θ value	2.36792 (rank : 10)	NC score	0.007681 (rank : 18)
Query Neighborhood Hits	19	Target Neighborhood Hits	279	Shared Neighborhood Hits	2
SwissProt Accessions	Q7M6Z0, Q3UQ62	Gene names	Rtn4rl2, Ngrl3
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 2 precursor (Nogo-66 receptor homolog 1) (Nogo-66 receptor-related protein 2) (NgR2) (Nogo receptor-like 3).

US6NL_MOUSE
θ value	3.0926 (rank : 11)	NC score	0.035291 (rank : 7)
Query Neighborhood Hits	19	Target Neighborhood Hits	157	Shared Neighborhood Hits	4
SwissProt Accessions	Q80XC3, Q6ZQK8	Gene names	Usp6nl, Kiaa0019
Domain Architecture	No domain graphic available
Description	USP6 N-terminal-like protein.

RRBP1_HUMAN
θ value	4.03905 (rank : 12)	NC score	0.011017 (rank : 14)
Query Neighborhood Hits	19	Target Neighborhood Hits	1306	Shared Neighborhood Hits	5
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

SMBP2_HUMAN
θ value	4.03905 (rank : 13)	NC score	0.016831 (rank : 11)
Query Neighborhood Hits	19	Target Neighborhood Hits	107	Shared Neighborhood Hits	2
SwissProt Accessions	P38935, Q00443, Q14177	Gene names	IGHMBP2, SMBP2, SMUBP2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Glial factor 1) (GF-1).

ASML_HUMAN
θ value	5.27518 (rank : 14)	NC score	0.024605 (rank : 9)
Query Neighborhood Hits	19	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	O95671, Q8NBH5, Q96G02, Q9BUL6	Gene names	ASMTL
Domain Architecture
Description	N-acetylserotonin O-methyltransferase-like protein (ASMTL).

DDX51_HUMAN
θ value	5.27518 (rank : 15)	NC score	0.008694 (rank : 16)
Query Neighborhood Hits	19	Target Neighborhood Hits	332	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

AFF1_HUMAN
θ value	6.88961 (rank : 16)	NC score	0.015157 (rank : 13)
Query Neighborhood Hits	19	Target Neighborhood Hits	506	Shared Neighborhood Hits	7
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

HIRP3_HUMAN
θ value	6.88961 (rank : 17)	NC score	0.021957 (rank : 10)
Query Neighborhood Hits	19	Target Neighborhood Hits	323	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BW71, O75707, O75708	Gene names	HIRIP3
Domain Architecture	No domain graphic available
Description	HIRA-interacting protein 3.

PROP_HUMAN
θ value	6.88961 (rank : 18)	NC score	0.007389 (rank : 19)
Query Neighborhood Hits	19	Target Neighborhood Hits	126	Shared Neighborhood Hits	2
SwissProt Accessions	P27918, O15134, O15135, O15136, O75826	Gene names	CFP, PFC
Domain Architecture
Description	Properdin precursor (Factor P).

NEIL1_MOUSE
θ value	8.99809 (rank : 19)	NC score	0.015358 (rank : 12)
Query Neighborhood Hits	19	Target Neighborhood Hits	52	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K4Q6, Q80V58, Q9CYT9	Gene names	Neil1, Nei1
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (Nei-like 1) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (NEH1).

Hits sorted by NC score

DEDD2_HUMAN
NC score	0.999962 (rank : 1)	θ value	3.91003e-112 (rank : 1)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	19
SwissProt Accessions	Q8WXF8, Q8NBR2, Q8NES1, Q8TAA8, Q96D35	Gene names	DEDD2, FLAME3
Domain Architecture	No domain graphic available
Description	DNA-binding death effector domain-containing protein 2 (FADD-like anti-apoptotic molecule 3) (DED-containing protein FLAME-3).

DEDD2_MOUSE
NC score	0.993516 (rank : 2)	θ value	7.37397e-111 (rank : 2)
Query Neighborhood Hits	19	Target Neighborhood Hits	14	Shared Neighborhood Hits	6
SwissProt Accessions	Q8QZV0, Q569Y9, Q8JZV1	Gene names	Dedd2, Flame3
Domain Architecture	No domain graphic available
Description	DNA-binding death effector domain-containing protein 2 (FADD-like anti-apoptotic molecule 3) (DED-containing protein FLAME-3).

DEDD_MOUSE
NC score	0.949690 (rank : 3)	θ value	1.2325e-65 (rank : 4)
Query Neighborhood Hits	19	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z1L3, Q7TQH8, Q9R227	Gene names	Dedd
Domain Architecture
Description	Death effector domain-containing protein (DEDPro1).

DEDD_HUMAN
NC score	0.948255 (rank : 4)	θ value	3.24342e-66 (rank : 3)
Query Neighborhood Hits	19	Target Neighborhood Hits	40	Shared Neighborhood Hits	4
SwissProt Accessions	O75618, O60737	Gene names	DEDD, DEDPRO1, DEFT
Domain Architecture
Description	Death effector domain-containing protein (Death effector domain- containing testicular molecule) (DEDPro1) (FLDED-1).

US6NL_HUMAN
NC score	0.039844 (rank : 5)	θ value	0.47712 (rank : 7)
Query Neighborhood Hits	19	Target Neighborhood Hits	201	Shared Neighborhood Hits	4
SwissProt Accessions	Q92738, Q15400, Q7L0K9	Gene names	USP6NL, KIAA0019
Domain Architecture	No domain graphic available
Description	USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN- tre).

RPTN_MOUSE
NC score	0.036921 (rank : 6)	θ value	0.163984 (rank : 5)
Query Neighborhood Hits	19	Target Neighborhood Hits	650	Shared Neighborhood Hits	7
SwissProt Accessions	P97347	Gene names	Rptn
Domain Architecture
Description	Repetin.

US6NL_MOUSE
NC score	0.035291 (rank : 7)	θ value	3.0926 (rank : 11)
Query Neighborhood Hits	19	Target Neighborhood Hits	157	Shared Neighborhood Hits	4
SwissProt Accessions	Q80XC3, Q6ZQK8	Gene names	Usp6nl, Kiaa0019
Domain Architecture	No domain graphic available
Description	USP6 N-terminal-like protein.

TTC16_HUMAN
NC score	0.034223 (rank : 8)	θ value	0.62314 (rank : 8)
Query Neighborhood Hits	19	Target Neighborhood Hits	417	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NEE8, Q5JU66, Q96M72	Gene names	TTC16
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 16 (TPR repeat protein 16).

ASML_HUMAN
NC score	0.024605 (rank : 9)	θ value	5.27518 (rank : 14)
Query Neighborhood Hits	19	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	O95671, Q8NBH5, Q96G02, Q9BUL6	Gene names	ASMTL
Domain Architecture
Description	N-acetylserotonin O-methyltransferase-like protein (ASMTL).

HIRP3_HUMAN
NC score	0.021957 (rank : 10)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	19	Target Neighborhood Hits	323	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BW71, O75707, O75708	Gene names	HIRIP3
Domain Architecture	No domain graphic available
Description	HIRA-interacting protein 3.

SMBP2_HUMAN
NC score	0.016831 (rank : 11)	θ value	4.03905 (rank : 13)
Query Neighborhood Hits	19	Target Neighborhood Hits	107	Shared Neighborhood Hits	2
SwissProt Accessions	P38935, Q00443, Q14177	Gene names	IGHMBP2, SMBP2, SMUBP2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Glial factor 1) (GF-1).

NEIL1_MOUSE
NC score	0.015358 (rank : 12)	θ value	8.99809 (rank : 19)
Query Neighborhood Hits	19	Target Neighborhood Hits	52	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K4Q6, Q80V58, Q9CYT9	Gene names	Neil1, Nei1
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (Nei-like 1) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (NEH1).

AFF1_HUMAN
NC score	0.015157 (rank : 13)	θ value	6.88961 (rank : 16)
Query Neighborhood Hits	19	Target Neighborhood Hits	506	Shared Neighborhood Hits	7
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

RRBP1_HUMAN
NC score	0.011017 (rank : 14)	θ value	4.03905 (rank : 12)
Query Neighborhood Hits	19	Target Neighborhood Hits	1306	Shared Neighborhood Hits	5
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

ANK2_HUMAN
NC score	0.010646 (rank : 15)	θ value	2.36792 (rank : 9)
Query Neighborhood Hits	19	Target Neighborhood Hits	1615	Shared Neighborhood Hits	9
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

DDX51_HUMAN
NC score	0.008694 (rank : 16)	θ value	5.27518 (rank : 15)
Query Neighborhood Hits	19	Target Neighborhood Hits	332	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

OBSCN_HUMAN
NC score	0.008581 (rank : 17)	θ value	0.279714 (rank : 6)
Query Neighborhood Hits	19	Target Neighborhood Hits	1931	Shared Neighborhood Hits	6
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

R4RL2_MOUSE
NC score	0.007681 (rank : 18)	θ value	2.36792 (rank : 10)
Query Neighborhood Hits	19	Target Neighborhood Hits	279	Shared Neighborhood Hits	2
SwissProt Accessions	Q7M6Z0, Q3UQ62	Gene names	Rtn4rl2, Ngrl3
Domain Architecture	No domain graphic available
Description	Reticulon-4 receptor-like 2 precursor (Nogo-66 receptor homolog 1) (Nogo-66 receptor-related protein 2) (NgR2) (Nogo receptor-like 3).

PROP_HUMAN
NC score	0.007389 (rank : 19)	θ value	6.88961 (rank : 18)
Query Neighborhood Hits	19	Target Neighborhood Hits	126	Shared Neighborhood Hits	2
SwissProt Accessions	P27918, O15134, O15135, O15136, O75826	Gene names	CFP, PFC
Domain Architecture
Description	Properdin precursor (Factor P).