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Network neighborhood for query Sequence : CASQ2_HUMAN

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CASQ2_HUMAN
SwissProt Accessions	O14958, Q8TBW8	Gene names	CASQ2
Domain Architecture
Description	Calsequestrin-2 precursor (Calsequestrin, cardiac muscle isoform).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CASQ2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	O14958, Q8TBW8	Gene names	CASQ2
Domain Architecture
Description	Calsequestrin-2 precursor (Calsequestrin, cardiac muscle isoform).

CASQ2_MOUSE
θ value	0 (rank : 2)	NC score	0.994456 (rank : 2)
Query Neighborhood Hits	20	Target Neighborhood Hits	34	Shared Neighborhood Hits	17
SwissProt Accessions	O09161, O88505	Gene names	Casq2
Domain Architecture
Description	Calsequestrin-2 precursor (Calsequestrin, cardiac muscle isoform).

CASQ1_HUMAN
θ value	2.05413e-145 (rank : 3)	NC score	0.989743 (rank : 3)
Query Neighborhood Hits	20	Target Neighborhood Hits	22	Shared Neighborhood Hits	13
SwissProt Accessions	P31415, Q8TBW7	Gene names	CASQ1, CASQ
Domain Architecture
Description	Calsequestrin-1 precursor (Calsequestrin, skeletal muscle isoform) (Calmitin).

CASQ1_MOUSE
θ value	4.57613e-145 (rank : 4)	NC score	0.988887 (rank : 4)
Query Neighborhood Hits	20	Target Neighborhood Hits	24	Shared Neighborhood Hits	13
SwissProt Accessions	O09165	Gene names	Casq1
Domain Architecture
Description	Calsequestrin-1 precursor (Calsequestrin, skeletal muscle isoform).

PDIA4_HUMAN
θ value	2.13673e-09 (rank : 5)	NC score	0.346058 (rank : 7)
Query Neighborhood Hits	20	Target Neighborhood Hits	60	Shared Neighborhood Hits	13
SwissProt Accessions	P13667	Gene names	PDIA4, ERP70, ERP72
Domain Architecture
Description	Protein disulfide-isomerase A4 precursor (EC 5.3.4.1) (Protein ERp-72) (ERp72).

TXND4_MOUSE
θ value	4.76016e-09 (rank : 6)	NC score	0.440572 (rank : 5)
Query Neighborhood Hits	20	Target Neighborhood Hits	44	Shared Neighborhood Hits	13
SwissProt Accessions	Q9D1Q6, Q3TVI1, Q6A045	Gene names	Txndc4, Erp44, Kiaa0573
Domain Architecture
Description	Thioredoxin domain-containing protein 4 precursor (Endoplasmic reticulum resident protein ERp44).

PDIA1_MOUSE
θ value	6.21693e-09 (rank : 7)	NC score	0.334704 (rank : 9)
Query Neighborhood Hits	20	Target Neighborhood Hits	50	Shared Neighborhood Hits	13
SwissProt Accessions	P09103	Gene names	P4hb, Pdia1
Domain Architecture
Description	Protein disulfide-isomerase precursor (EC 5.3.4.1) (PDI) (Prolyl 4- hydroxylase subunit beta) (Cellular thyroid hormone-binding protein) (p55) (Erp59).

PDIA4_MOUSE
θ value	1.80886e-08 (rank : 8)	NC score	0.337189 (rank : 8)
Query Neighborhood Hits	20	Target Neighborhood Hits	57	Shared Neighborhood Hits	13
SwissProt Accessions	P08003, P15841	Gene names	Pdia4, Cai, Erp72
Domain Architecture
Description	Protein disulfide-isomerase A4 precursor (EC 5.3.4.1) (Protein ERp-72) (ERp72).

TXND4_HUMAN
θ value	3.08544e-08 (rank : 9)	NC score	0.438917 (rank : 6)
Query Neighborhood Hits	20	Target Neighborhood Hits	43	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BS26, O60319, Q5VWZ7, Q6UW14, Q8WX67	Gene names	TXNDC4, ERP44, KIAA0573
Domain Architecture
Description	Thioredoxin domain-containing protein 4 precursor (Endoplasmic reticulum resident protein ERp44).

PDIA1_HUMAN
θ value	2.21117e-06 (rank : 10)	NC score	0.312997 (rank : 11)
Query Neighborhood Hits	20	Target Neighborhood Hits	56	Shared Neighborhood Hits	13
SwissProt Accessions	P07237, P30037, P32079, Q15205, Q6LDE5	Gene names	P4HB, PDI, PDIA1, PO4DB
Domain Architecture
Description	Protein disulfide-isomerase precursor (EC 5.3.4.1) (PDI) (Prolyl 4- hydroxylase subunit beta) (Cellular thyroid hormone-binding protein) (p55).

TXD10_HUMAN
θ value	0.000121331 (rank : 11)	NC score	0.316214 (rank : 10)
Query Neighborhood Hits	20	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	Q96JJ7, Q8N5J0, Q9NWJ9	Gene names	TXNDC10, KIAA1830, TMX3
Domain Architecture	No domain graphic available
Description	Protein disulfide-isomerase TXNDC10 precursor (EC 5.3.4.1) (Thioredoxin domain-containing protein 10) (Thioredoxin-related transmembrane protein 3).

PDIA3_HUMAN
θ value	0.279714 (rank : 12)	NC score	0.216094 (rank : 13)
Query Neighborhood Hits	20	Target Neighborhood Hits	57	Shared Neighborhood Hits	12
SwissProt Accessions	P30101, Q13453, Q14255, Q8IYF8, Q9UMU7	Gene names	PDIA3, ERP60, GRP58
Domain Architecture
Description	Protein disulfide-isomerase A3 precursor (EC 5.3.4.1) (Disulfide isomerase ER-60) (ERp60) (58 kDa microsomal protein) (p58) (ERp57) (58 kDa glucose-regulated protein).

TXD10_MOUSE
θ value	0.365318 (rank : 13)	NC score	0.261510 (rank : 12)
Query Neighborhood Hits	20	Target Neighborhood Hits	48	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BXZ1, Q3US84, Q6PGA1, Q6ZPH5, Q8BZB8	Gene names	Txndc10, Kiaa1830
Domain Architecture	No domain graphic available
Description	Protein disulfide-isomerase TXNDC10 precursor (EC 5.3.4.1) (Thioredoxin domain-containing protein 10).

VPS72_HUMAN
θ value	1.38821 (rank : 14)	NC score	0.054630 (rank : 33)
Query Neighborhood Hits	20	Target Neighborhood Hits	274	Shared Neighborhood Hits	7
SwissProt Accessions	Q15906, Q53GJ2, Q5U0R4	Gene names	VPS72, TCFL1, YL1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

VPS72_MOUSE
θ value	1.38821 (rank : 15)	NC score	0.054363 (rank : 34)
Query Neighborhood Hits	20	Target Neighborhood Hits	286	Shared Neighborhood Hits	7
SwissProt Accessions	Q62481, Q3U2N4, Q810A9, Q99K81	Gene names	Vps72, Tcfl1, Yl1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

LEO1_MOUSE
θ value	3.0926 (rank : 16)	NC score	0.033143 (rank : 39)
Query Neighborhood Hits	20	Target Neighborhood Hits	946	Shared Neighborhood Hits	8
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

OSBL8_HUMAN
θ value	4.03905 (rank : 17)	NC score	0.011631 (rank : 42)
Query Neighborhood Hits	20	Target Neighborhood Hits	289	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BZF1, Q8WXP8, Q9P277	Gene names	OSBPL8, KIAA1451, ORP8, OSBP10
Domain Architecture
Description	Oxysterol-binding protein-related protein 8 (OSBP-related protein 8) (ORP-8).

LEO1_HUMAN
θ value	5.27518 (rank : 18)	NC score	0.024683 (rank : 40)
Query Neighborhood Hits	20	Target Neighborhood Hits	958	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

ANLN_HUMAN
θ value	6.88961 (rank : 19)	NC score	0.011594 (rank : 43)
Query Neighborhood Hits	20	Target Neighborhood Hits	222	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

SEC63_HUMAN
θ value	6.88961 (rank : 20)	NC score	0.020787 (rank : 41)
Query Neighborhood Hits	20	Target Neighborhood Hits	586	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UGP8, O95380, Q86VS9, Q8IWL0, Q9NTE0	Gene names	SEC63, SEC63L
Domain Architecture
Description	Translocation protein SEC63 homolog.

PDIA2_HUMAN
θ value	θ > 10 (rank : 21)	NC score	0.189297 (rank : 15)
Query Neighborhood Hits	20	Target Neighborhood Hits	49	Shared Neighborhood Hits	9
SwissProt Accessions	Q13087, Q96KJ6, Q9BW95	Gene names	PDIA2, PDIP
Domain Architecture
Description	Protein disulfide-isomerase A2 precursor (EC 5.3.4.1) (PDIp).

PDIA3_MOUSE
θ value	θ > 10 (rank : 22)	NC score	0.206574 (rank : 14)
Query Neighborhood Hits	20	Target Neighborhood Hits	58	Shared Neighborhood Hits	11
SwissProt Accessions	P27773	Gene names	Pdia3, Erp, Erp60, Grp58
Domain Architecture
Description	Protein disulfide-isomerase A3 precursor (EC 5.3.4.1) (Disulfide isomerase ER-60) (ERp60) (58 kDa microsomal protein) (p58) (ERp57).

PDIA5_HUMAN
θ value	θ > 10 (rank : 23)	NC score	0.122147 (rank : 20)
Query Neighborhood Hits	20	Target Neighborhood Hits	42	Shared Neighborhood Hits	9
SwissProt Accessions	Q14554	Gene names	PDIA5, PDIR
Domain Architecture
Description	Protein disulfide-isomerase A5 precursor (EC 5.3.4.1) (Protein disulfide isomerase-related protein).

PDIA5_MOUSE
θ value	θ > 10 (rank : 24)	NC score	0.120430 (rank : 21)
Query Neighborhood Hits	20	Target Neighborhood Hits	46	Shared Neighborhood Hits	9
SwissProt Accessions	Q921X9	Gene names	Pdia5, Pdir
Domain Architecture	No domain graphic available
Description	Protein disulfide-isomerase A5 precursor (EC 5.3.4.1) (Protein disulfide isomerase-related protein).

PDIA6_HUMAN
θ value	θ > 10 (rank : 25)	NC score	0.154416 (rank : 16)
Query Neighborhood Hits	20	Target Neighborhood Hits	46	Shared Neighborhood Hits	11
SwissProt Accessions	Q15084, Q99778	Gene names	PDIA6, TXNDC7
Domain Architecture
Description	Protein disulfide-isomerase A6 precursor (EC 5.3.4.1) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7).

PDIA6_MOUSE
θ value	θ > 10 (rank : 26)	NC score	0.151202 (rank : 17)
Query Neighborhood Hits	20	Target Neighborhood Hits	47	Shared Neighborhood Hits	11
SwissProt Accessions	Q922R8, Q8BK54	Gene names	Pdia6, Txndc7
Domain Architecture	No domain graphic available
Description	Protein disulfide-isomerase A6 precursor (EC 5.3.4.1) (Thioredoxin domain-containing protein 7).

QSC6L_HUMAN
θ value	θ > 10 (rank : 27)	NC score	0.062600 (rank : 30)
Query Neighborhood Hits	20	Target Neighborhood Hits	35	Shared Neighborhood Hits	9
SwissProt Accessions	Q6ZRP7, Q5TB37, Q7Z7B6, Q86VV7, Q8N3G2	Gene names	QSCN6L1, QSOX2, SOXN
Domain Architecture	No domain graphic available
Description	Sulfhydryl oxidase 2 precursor (EC 1.8.3.2) (Quiescin Q6-like protein 1) (Neuroblastoma-derived sulfhydryl oxidase).

QSC6L_MOUSE
θ value	θ > 10 (rank : 28)	NC score	0.052615 (rank : 35)
Query Neighborhood Hits	20	Target Neighborhood Hits	36	Shared Neighborhood Hits	7
SwissProt Accessions	Q3TMX7, Q3TZA5, Q8C9I4, Q8K0M2	Gene names	Qscn6l1
Domain Architecture	No domain graphic available
Description	Sulfhydryl oxidase 2 precursor (EC 1.8.3.2) (Quiescin Q6-like protein 1).

QSCN6_HUMAN
θ value	θ > 10 (rank : 29)	NC score	0.061078 (rank : 31)
Query Neighborhood Hits	20	Target Neighborhood Hits	98	Shared Neighborhood Hits	9
SwissProt Accessions	O00391, Q59G29, Q5T2X0, Q8TDL6, Q8WVP4	Gene names	QSCN6, QSOX1
Domain Architecture	No domain graphic available
Description	Sulfhydryl oxidase 1 precursor (EC 1.8.3.2) (Quiescin Q6) (hQSOX).

QSCN6_MOUSE
θ value	θ > 10 (rank : 30)	NC score	0.071276 (rank : 29)
Query Neighborhood Hits	20	Target Neighborhood Hits	62	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BND5, Q3TDY9, Q3TE19, Q3TR29, Q3UEL4, Q8K041, Q9DBL6	Gene names	Qscn6, Sox
Domain Architecture	No domain graphic available
Description	Sulfhydryl oxidase 1 precursor (EC 1.8.3.2) (Quiescin Q6) (Skin sulfhydryl oxidase) (mSOx).

THIOM_HUMAN
θ value	θ > 10 (rank : 31)	NC score	0.118974 (rank : 22)
Query Neighborhood Hits	20	Target Neighborhood Hits	46	Shared Neighborhood Hits	9
SwissProt Accessions	Q99757, Q5JZA0, Q9UH29	Gene names	TXN2, TRX2
Domain Architecture
Description	Thioredoxin, mitochondrial precursor (Mt-Trx) (MTRX) (Thioredoxin-2).

THIOM_MOUSE
θ value	θ > 10 (rank : 32)	NC score	0.118222 (rank : 23)
Query Neighborhood Hits	20	Target Neighborhood Hits	45	Shared Neighborhood Hits	9
SwissProt Accessions	P97493, Q545D5	Gene names	Txn2
Domain Architecture
Description	Thioredoxin, mitochondrial precursor (Mt-Trx) (MTRX) (Thioredoxin-2).

THIO_HUMAN
θ value	θ > 10 (rank : 33)	NC score	0.078026 (rank : 27)
Query Neighborhood Hits	20	Target Neighborhood Hits	43	Shared Neighborhood Hits	9
SwissProt Accessions	P10599, Q96KI3	Gene names	TXN, TRDX, TRX, TRX1
Domain Architecture
Description	Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP).

THIO_MOUSE
θ value	θ > 10 (rank : 34)	NC score	0.073461 (rank : 28)
Query Neighborhood Hits	20	Target Neighborhood Hits	39	Shared Neighborhood Hits	9
SwissProt Accessions	P10639, Q52KC4, Q9D8R0	Gene names	Txn, Txn1
Domain Architecture
Description	Thioredoxin (Trx) (ATL-derived factor) (ADF).

TXD11_HUMAN
θ value	θ > 10 (rank : 35)	NC score	0.052440 (rank : 36)
Query Neighborhood Hits	20	Target Neighborhood Hits	402	Shared Neighborhood Hits	9
SwissProt Accessions	Q6PKC3, O95887, Q6PJA6, Q8N2Q4, Q96K45, Q96K53	Gene names	TXNDC11, EFP1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 11 (EF-hand-binding protein 1).

TXD11_MOUSE
θ value	θ > 10 (rank : 36)	NC score	0.059272 (rank : 32)
Query Neighborhood Hits	20	Target Neighborhood Hits	81	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K2W3, Q8BMR8, Q8VCK9	Gene names	Txndc11
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 11.

TXD13_MOUSE
θ value	θ > 10 (rank : 37)	NC score	0.051364 (rank : 37)
Query Neighborhood Hits	20	Target Neighborhood Hits	61	Shared Neighborhood Hits	11
SwissProt Accessions	Q8C0L0, Q3UHC6, Q6ZPW7, Q80X49	Gene names	Txndc13, D2Bwg1356e, Kiaa1162
Domain Architecture
Description	Thioredoxin domain-containing protein 13 precursor.

TXND1_HUMAN
θ value	θ > 10 (rank : 38)	NC score	0.102088 (rank : 24)
Query Neighborhood Hits	20	Target Neighborhood Hits	38	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H3N1, Q8N487, Q8NBN5, Q9Y4T6	Gene names	TXNDC1, TMX, TXNDC
Domain Architecture
Description	Thioredoxin domain-containing protein 1 precursor (Transmembrane Trx- related protein) (Thioredoxin-related transmembrane protein).

TXND1_MOUSE
θ value	θ > 10 (rank : 39)	NC score	0.099155 (rank : 25)
Query Neighborhood Hits	20	Target Neighborhood Hits	36	Shared Neighborhood Hits	9
SwissProt Accessions	Q8VBT0, Q3UCI8, Q9CSD5	Gene names	Txndc1, Txndc
Domain Architecture
Description	Thioredoxin domain-containing protein 1 precursor.

TXND5_HUMAN
θ value	θ > 10 (rank : 40)	NC score	0.132893 (rank : 19)
Query Neighborhood Hits	20	Target Neighborhood Hits	54	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NBS9, Q8ND33, Q8TCT2, Q9BVH9	Gene names	TXNDC5, TLP46
Domain Architecture
Description	Thioredoxin domain-containing protein 5 precursor (Thioredoxin-like protein p46) (Endoplasmic reticulum protein ERp46).

TXND5_MOUSE
θ value	θ > 10 (rank : 41)	NC score	0.142051 (rank : 18)
Query Neighborhood Hits	20	Target Neighborhood Hits	52	Shared Neighborhood Hits	11
SwissProt Accessions	Q91W90, Q8R1I6	Gene names	Txndc5, Tlp46
Domain Architecture
Description	Thioredoxin domain-containing protein 5 precursor (Thioredoxin-like protein p46) (Endoplasmic reticulum protein ERp46) (Plasma cell- specific thioredoxin-related protein) (PC-TRP).

TXND8_MOUSE
θ value	θ > 10 (rank : 42)	NC score	0.082446 (rank : 26)
Query Neighborhood Hits	20	Target Neighborhood Hits	41	Shared Neighborhood Hits	9
SwissProt Accessions	Q69AB2, Q78Y03, Q80YE0, Q9CQ96	Gene names	Txndc8, Sptrx3, Trx6
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 8 (Spermatid-specific thioredoxin-3) (Sptrx-3) (Thioredoxin-6).

TXNL2_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.050210 (rank : 38)
Query Neighborhood Hits	20	Target Neighborhood Hits	59	Shared Neighborhood Hits	9
SwissProt Accessions	O76003, Q96CE0, Q9P1B0, Q9P1B1	Gene names	TXNL2, PICOT
Domain Architecture
Description	Thioredoxin-like protein 2 (PKC-interacting cousin of thioredoxin) (PKC-theta-interacting protein) (PKCq-interacting protein).

Hits sorted by NC score

CASQ2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	O14958, Q8TBW8	Gene names	CASQ2
Domain Architecture
Description	Calsequestrin-2 precursor (Calsequestrin, cardiac muscle isoform).

CASQ2_MOUSE
NC score	0.994456 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	20	Target Neighborhood Hits	34	Shared Neighborhood Hits	17
SwissProt Accessions	O09161, O88505	Gene names	Casq2
Domain Architecture
Description	Calsequestrin-2 precursor (Calsequestrin, cardiac muscle isoform).

CASQ1_HUMAN
NC score	0.989743 (rank : 3)	θ value	2.05413e-145 (rank : 3)
Query Neighborhood Hits	20	Target Neighborhood Hits	22	Shared Neighborhood Hits	13
SwissProt Accessions	P31415, Q8TBW7	Gene names	CASQ1, CASQ
Domain Architecture
Description	Calsequestrin-1 precursor (Calsequestrin, skeletal muscle isoform) (Calmitin).

CASQ1_MOUSE
NC score	0.988887 (rank : 4)	θ value	4.57613e-145 (rank : 4)
Query Neighborhood Hits	20	Target Neighborhood Hits	24	Shared Neighborhood Hits	13
SwissProt Accessions	O09165	Gene names	Casq1
Domain Architecture
Description	Calsequestrin-1 precursor (Calsequestrin, skeletal muscle isoform).

TXND4_MOUSE
NC score	0.440572 (rank : 5)	θ value	4.76016e-09 (rank : 6)
Query Neighborhood Hits	20	Target Neighborhood Hits	44	Shared Neighborhood Hits	13
SwissProt Accessions	Q9D1Q6, Q3TVI1, Q6A045	Gene names	Txndc4, Erp44, Kiaa0573
Domain Architecture
Description	Thioredoxin domain-containing protein 4 precursor (Endoplasmic reticulum resident protein ERp44).

TXND4_HUMAN
NC score	0.438917 (rank : 6)	θ value	3.08544e-08 (rank : 9)
Query Neighborhood Hits	20	Target Neighborhood Hits	43	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BS26, O60319, Q5VWZ7, Q6UW14, Q8WX67	Gene names	TXNDC4, ERP44, KIAA0573
Domain Architecture
Description	Thioredoxin domain-containing protein 4 precursor (Endoplasmic reticulum resident protein ERp44).

PDIA4_HUMAN
NC score	0.346058 (rank : 7)	θ value	2.13673e-09 (rank : 5)
Query Neighborhood Hits	20	Target Neighborhood Hits	60	Shared Neighborhood Hits	13
SwissProt Accessions	P13667	Gene names	PDIA4, ERP70, ERP72
Domain Architecture
Description	Protein disulfide-isomerase A4 precursor (EC 5.3.4.1) (Protein ERp-72) (ERp72).

PDIA4_MOUSE
NC score	0.337189 (rank : 8)	θ value	1.80886e-08 (rank : 8)
Query Neighborhood Hits	20	Target Neighborhood Hits	57	Shared Neighborhood Hits	13
SwissProt Accessions	P08003, P15841	Gene names	Pdia4, Cai, Erp72
Domain Architecture
Description	Protein disulfide-isomerase A4 precursor (EC 5.3.4.1) (Protein ERp-72) (ERp72).

PDIA1_MOUSE
NC score	0.334704 (rank : 9)	θ value	6.21693e-09 (rank : 7)
Query Neighborhood Hits	20	Target Neighborhood Hits	50	Shared Neighborhood Hits	13
SwissProt Accessions	P09103	Gene names	P4hb, Pdia1
Domain Architecture
Description	Protein disulfide-isomerase precursor (EC 5.3.4.1) (PDI) (Prolyl 4- hydroxylase subunit beta) (Cellular thyroid hormone-binding protein) (p55) (Erp59).

TXD10_HUMAN
NC score	0.316214 (rank : 10)	θ value	0.000121331 (rank : 11)
Query Neighborhood Hits	20	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	Q96JJ7, Q8N5J0, Q9NWJ9	Gene names	TXNDC10, KIAA1830, TMX3
Domain Architecture	No domain graphic available
Description	Protein disulfide-isomerase TXNDC10 precursor (EC 5.3.4.1) (Thioredoxin domain-containing protein 10) (Thioredoxin-related transmembrane protein 3).

PDIA1_HUMAN
NC score	0.312997 (rank : 11)	θ value	2.21117e-06 (rank : 10)
Query Neighborhood Hits	20	Target Neighborhood Hits	56	Shared Neighborhood Hits	13
SwissProt Accessions	P07237, P30037, P32079, Q15205, Q6LDE5	Gene names	P4HB, PDI, PDIA1, PO4DB
Domain Architecture
Description	Protein disulfide-isomerase precursor (EC 5.3.4.1) (PDI) (Prolyl 4- hydroxylase subunit beta) (Cellular thyroid hormone-binding protein) (p55).

TXD10_MOUSE
NC score	0.261510 (rank : 12)	θ value	0.365318 (rank : 13)
Query Neighborhood Hits	20	Target Neighborhood Hits	48	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BXZ1, Q3US84, Q6PGA1, Q6ZPH5, Q8BZB8	Gene names	Txndc10, Kiaa1830
Domain Architecture	No domain graphic available
Description	Protein disulfide-isomerase TXNDC10 precursor (EC 5.3.4.1) (Thioredoxin domain-containing protein 10).

PDIA3_HUMAN
NC score	0.216094 (rank : 13)	θ value	0.279714 (rank : 12)
Query Neighborhood Hits	20	Target Neighborhood Hits	57	Shared Neighborhood Hits	12
SwissProt Accessions	P30101, Q13453, Q14255, Q8IYF8, Q9UMU7	Gene names	PDIA3, ERP60, GRP58
Domain Architecture
Description	Protein disulfide-isomerase A3 precursor (EC 5.3.4.1) (Disulfide isomerase ER-60) (ERp60) (58 kDa microsomal protein) (p58) (ERp57) (58 kDa glucose-regulated protein).

PDIA3_MOUSE
NC score	0.206574 (rank : 14)	θ value	θ > 10 (rank : 22)
Query Neighborhood Hits	20	Target Neighborhood Hits	58	Shared Neighborhood Hits	11
SwissProt Accessions	P27773	Gene names	Pdia3, Erp, Erp60, Grp58
Domain Architecture
Description	Protein disulfide-isomerase A3 precursor (EC 5.3.4.1) (Disulfide isomerase ER-60) (ERp60) (58 kDa microsomal protein) (p58) (ERp57).

PDIA2_HUMAN
NC score	0.189297 (rank : 15)	θ value	θ > 10 (rank : 21)
Query Neighborhood Hits	20	Target Neighborhood Hits	49	Shared Neighborhood Hits	9
SwissProt Accessions	Q13087, Q96KJ6, Q9BW95	Gene names	PDIA2, PDIP
Domain Architecture
Description	Protein disulfide-isomerase A2 precursor (EC 5.3.4.1) (PDIp).

PDIA6_HUMAN
NC score	0.154416 (rank : 16)	θ value	θ > 10 (rank : 25)
Query Neighborhood Hits	20	Target Neighborhood Hits	46	Shared Neighborhood Hits	11
SwissProt Accessions	Q15084, Q99778	Gene names	PDIA6, TXNDC7
Domain Architecture
Description	Protein disulfide-isomerase A6 precursor (EC 5.3.4.1) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7).

PDIA6_MOUSE
NC score	0.151202 (rank : 17)	θ value	θ > 10 (rank : 26)
Query Neighborhood Hits	20	Target Neighborhood Hits	47	Shared Neighborhood Hits	11
SwissProt Accessions	Q922R8, Q8BK54	Gene names	Pdia6, Txndc7
Domain Architecture	No domain graphic available
Description	Protein disulfide-isomerase A6 precursor (EC 5.3.4.1) (Thioredoxin domain-containing protein 7).

TXND5_MOUSE
NC score	0.142051 (rank : 18)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	20	Target Neighborhood Hits	52	Shared Neighborhood Hits	11
SwissProt Accessions	Q91W90, Q8R1I6	Gene names	Txndc5, Tlp46
Domain Architecture
Description	Thioredoxin domain-containing protein 5 precursor (Thioredoxin-like protein p46) (Endoplasmic reticulum protein ERp46) (Plasma cell- specific thioredoxin-related protein) (PC-TRP).

TXND5_HUMAN
NC score	0.132893 (rank : 19)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	20	Target Neighborhood Hits	54	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NBS9, Q8ND33, Q8TCT2, Q9BVH9	Gene names	TXNDC5, TLP46
Domain Architecture
Description	Thioredoxin domain-containing protein 5 precursor (Thioredoxin-like protein p46) (Endoplasmic reticulum protein ERp46).

PDIA5_HUMAN
NC score	0.122147 (rank : 20)	θ value	θ > 10 (rank : 23)
Query Neighborhood Hits	20	Target Neighborhood Hits	42	Shared Neighborhood Hits	9
SwissProt Accessions	Q14554	Gene names	PDIA5, PDIR
Domain Architecture
Description	Protein disulfide-isomerase A5 precursor (EC 5.3.4.1) (Protein disulfide isomerase-related protein).

PDIA5_MOUSE
NC score	0.120430 (rank : 21)	θ value	θ > 10 (rank : 24)
Query Neighborhood Hits	20	Target Neighborhood Hits	46	Shared Neighborhood Hits	9
SwissProt Accessions	Q921X9	Gene names	Pdia5, Pdir
Domain Architecture	No domain graphic available
Description	Protein disulfide-isomerase A5 precursor (EC 5.3.4.1) (Protein disulfide isomerase-related protein).

THIOM_HUMAN
NC score	0.118974 (rank : 22)	θ value	θ > 10 (rank : 31)
Query Neighborhood Hits	20	Target Neighborhood Hits	46	Shared Neighborhood Hits	9
SwissProt Accessions	Q99757, Q5JZA0, Q9UH29	Gene names	TXN2, TRX2
Domain Architecture
Description	Thioredoxin, mitochondrial precursor (Mt-Trx) (MTRX) (Thioredoxin-2).

THIOM_MOUSE
NC score	0.118222 (rank : 23)	θ value	θ > 10 (rank : 32)
Query Neighborhood Hits	20	Target Neighborhood Hits	45	Shared Neighborhood Hits	9
SwissProt Accessions	P97493, Q545D5	Gene names	Txn2
Domain Architecture
Description	Thioredoxin, mitochondrial precursor (Mt-Trx) (MTRX) (Thioredoxin-2).

TXND1_HUMAN
NC score	0.102088 (rank : 24)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	20	Target Neighborhood Hits	38	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H3N1, Q8N487, Q8NBN5, Q9Y4T6	Gene names	TXNDC1, TMX, TXNDC
Domain Architecture
Description	Thioredoxin domain-containing protein 1 precursor (Transmembrane Trx- related protein) (Thioredoxin-related transmembrane protein).

TXND1_MOUSE
NC score	0.099155 (rank : 25)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	20	Target Neighborhood Hits	36	Shared Neighborhood Hits	9
SwissProt Accessions	Q8VBT0, Q3UCI8, Q9CSD5	Gene names	Txndc1, Txndc
Domain Architecture
Description	Thioredoxin domain-containing protein 1 precursor.

TXND8_MOUSE
NC score	0.082446 (rank : 26)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	20	Target Neighborhood Hits	41	Shared Neighborhood Hits	9
SwissProt Accessions	Q69AB2, Q78Y03, Q80YE0, Q9CQ96	Gene names	Txndc8, Sptrx3, Trx6
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 8 (Spermatid-specific thioredoxin-3) (Sptrx-3) (Thioredoxin-6).

THIO_HUMAN
NC score	0.078026 (rank : 27)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	20	Target Neighborhood Hits	43	Shared Neighborhood Hits	9
SwissProt Accessions	P10599, Q96KI3	Gene names	TXN, TRDX, TRX, TRX1
Domain Architecture
Description	Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP).

THIO_MOUSE
NC score	0.073461 (rank : 28)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	20	Target Neighborhood Hits	39	Shared Neighborhood Hits	9
SwissProt Accessions	P10639, Q52KC4, Q9D8R0	Gene names	Txn, Txn1
Domain Architecture
Description	Thioredoxin (Trx) (ATL-derived factor) (ADF).

QSCN6_MOUSE
NC score	0.071276 (rank : 29)	θ value	θ > 10 (rank : 30)
Query Neighborhood Hits	20	Target Neighborhood Hits	62	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BND5, Q3TDY9, Q3TE19, Q3TR29, Q3UEL4, Q8K041, Q9DBL6	Gene names	Qscn6, Sox
Domain Architecture	No domain graphic available
Description	Sulfhydryl oxidase 1 precursor (EC 1.8.3.2) (Quiescin Q6) (Skin sulfhydryl oxidase) (mSOx).

QSC6L_HUMAN
NC score	0.062600 (rank : 30)	θ value	θ > 10 (rank : 27)
Query Neighborhood Hits	20	Target Neighborhood Hits	35	Shared Neighborhood Hits	9
SwissProt Accessions	Q6ZRP7, Q5TB37, Q7Z7B6, Q86VV7, Q8N3G2	Gene names	QSCN6L1, QSOX2, SOXN
Domain Architecture	No domain graphic available
Description	Sulfhydryl oxidase 2 precursor (EC 1.8.3.2) (Quiescin Q6-like protein 1) (Neuroblastoma-derived sulfhydryl oxidase).

QSCN6_HUMAN
NC score	0.061078 (rank : 31)	θ value	θ > 10 (rank : 29)
Query Neighborhood Hits	20	Target Neighborhood Hits	98	Shared Neighborhood Hits	9
SwissProt Accessions	O00391, Q59G29, Q5T2X0, Q8TDL6, Q8WVP4	Gene names	QSCN6, QSOX1
Domain Architecture	No domain graphic available
Description	Sulfhydryl oxidase 1 precursor (EC 1.8.3.2) (Quiescin Q6) (hQSOX).

TXD11_MOUSE
NC score	0.059272 (rank : 32)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	20	Target Neighborhood Hits	81	Shared Neighborhood Hits	9
SwissProt Accessions	Q8K2W3, Q8BMR8, Q8VCK9	Gene names	Txndc11
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 11.

VPS72_HUMAN
NC score	0.054630 (rank : 33)	θ value	1.38821 (rank : 14)
Query Neighborhood Hits	20	Target Neighborhood Hits	274	Shared Neighborhood Hits	7
SwissProt Accessions	Q15906, Q53GJ2, Q5U0R4	Gene names	VPS72, TCFL1, YL1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

VPS72_MOUSE
NC score	0.054363 (rank : 34)	θ value	1.38821 (rank : 15)
Query Neighborhood Hits	20	Target Neighborhood Hits	286	Shared Neighborhood Hits	7
SwissProt Accessions	Q62481, Q3U2N4, Q810A9, Q99K81	Gene names	Vps72, Tcfl1, Yl1
Domain Architecture
Description	Vacuolar protein sorting-associated protein 72 homolog (Transcription factor-like 1) (Protein YL-1).

QSC6L_MOUSE
NC score	0.052615 (rank : 35)	θ value	θ > 10 (rank : 28)
Query Neighborhood Hits	20	Target Neighborhood Hits	36	Shared Neighborhood Hits	7
SwissProt Accessions	Q3TMX7, Q3TZA5, Q8C9I4, Q8K0M2	Gene names	Qscn6l1
Domain Architecture	No domain graphic available
Description	Sulfhydryl oxidase 2 precursor (EC 1.8.3.2) (Quiescin Q6-like protein 1).

TXD11_HUMAN
NC score	0.052440 (rank : 36)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	20	Target Neighborhood Hits	402	Shared Neighborhood Hits	9
SwissProt Accessions	Q6PKC3, O95887, Q6PJA6, Q8N2Q4, Q96K45, Q96K53	Gene names	TXNDC11, EFP1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 11 (EF-hand-binding protein 1).

TXD13_MOUSE
NC score	0.051364 (rank : 37)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	20	Target Neighborhood Hits	61	Shared Neighborhood Hits	11
SwissProt Accessions	Q8C0L0, Q3UHC6, Q6ZPW7, Q80X49	Gene names	Txndc13, D2Bwg1356e, Kiaa1162
Domain Architecture
Description	Thioredoxin domain-containing protein 13 precursor.

TXNL2_HUMAN
NC score	0.050210 (rank : 38)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	20	Target Neighborhood Hits	59	Shared Neighborhood Hits	9
SwissProt Accessions	O76003, Q96CE0, Q9P1B0, Q9P1B1	Gene names	TXNL2, PICOT
Domain Architecture
Description	Thioredoxin-like protein 2 (PKC-interacting cousin of thioredoxin) (PKC-theta-interacting protein) (PKCq-interacting protein).

LEO1_MOUSE
NC score	0.033143 (rank : 39)	θ value	3.0926 (rank : 16)
Query Neighborhood Hits	20	Target Neighborhood Hits	946	Shared Neighborhood Hits	8
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

LEO1_HUMAN
NC score	0.024683 (rank : 40)	θ value	5.27518 (rank : 18)
Query Neighborhood Hits	20	Target Neighborhood Hits	958	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

SEC63_HUMAN
NC score	0.020787 (rank : 41)	θ value	6.88961 (rank : 20)
Query Neighborhood Hits	20	Target Neighborhood Hits	586	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UGP8, O95380, Q86VS9, Q8IWL0, Q9NTE0	Gene names	SEC63, SEC63L
Domain Architecture
Description	Translocation protein SEC63 homolog.

OSBL8_HUMAN
NC score	0.011631 (rank : 42)	θ value	4.03905 (rank : 17)
Query Neighborhood Hits	20	Target Neighborhood Hits	289	Shared Neighborhood Hits	5
SwissProt Accessions	Q9BZF1, Q8WXP8, Q9P277	Gene names	OSBPL8, KIAA1451, ORP8, OSBP10
Domain Architecture
Description	Oxysterol-binding protein-related protein 8 (OSBP-related protein 8) (ORP-8).

ANLN_HUMAN
NC score	0.011594 (rank : 43)	θ value	6.88961 (rank : 19)
Query Neighborhood Hits	20	Target Neighborhood Hits	222	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NQW6, Q5CZ78, Q6NSK5, Q9H8Y4, Q9NVN9, Q9NVP0	Gene names	ANLN
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.