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Network neighborhood for query Sequence : ARRD2_HUMAN

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ARRD2_HUMAN
SwissProt Accessions	Q8TBH0, O95895, Q6ZRV9, Q8WYG6	Gene names	ARRDC2
Domain Architecture	No domain graphic available
Description	Arrestin domain-containing protein 2.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ARRD2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	Q8TBH0, O95895, Q6ZRV9, Q8WYG6	Gene names	ARRDC2
Domain Architecture	No domain graphic available
Description	Arrestin domain-containing protein 2.

ARRD2_MOUSE
θ value	3.71755e-171 (rank : 2)	NC score	0.993828 (rank : 2)
Query Neighborhood Hits	22	Target Neighborhood Hits	20	Shared Neighborhood Hits	13
SwissProt Accessions	Q9D668, Q3UVK8, Q3UXC6	Gene names	Arrdc2
Domain Architecture	No domain graphic available
Description	Arrestin domain-containing protein 2.

ARRD3_HUMAN
θ value	7.86017e-121 (rank : 3)	NC score	0.983540 (rank : 3)
Query Neighborhood Hits	22	Target Neighborhood Hits	13	Shared Neighborhood Hits	11
SwissProt Accessions	Q96B67, Q9P2H1	Gene names	ARRDC3, KIAA1376
Domain Architecture	No domain graphic available
Description	Arrestin domain-containing protein 3.

ARRD3_MOUSE
θ value	2.80211e-110 (rank : 4)	NC score	0.982644 (rank : 4)
Query Neighborhood Hits	22	Target Neighborhood Hits	12	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TPQ9, Q4KMN0, Q80TE6, Q8K0L7	Gene names	Arrdc3, Kiaa1376
Domain Architecture	No domain graphic available
Description	Arrestin domain-containing protein 3.

ARRD4_HUMAN
θ value	5.86991e-92 (rank : 5)	NC score	0.976515 (rank : 5)
Query Neighborhood Hits	22	Target Neighborhood Hits	27	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NCT1, Q6NSI9	Gene names	ARRDC4
Domain Architecture	No domain graphic available
Description	Arrestin domain-containing protein 4.

TXNIP_HUMAN
θ value	6.76295e-64 (rank : 6)	NC score	0.942542 (rank : 6)
Query Neighborhood Hits	22	Target Neighborhood Hits	12	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H3M7, Q16226, Q6PML0, Q9BXG9	Gene names	TXNIP, VDUP1
Domain Architecture	No domain graphic available
Description	Thioredoxin-interacting protein (Vitamin D3 up-regulated protein 1) (Thioredoxin-binding protein 2).

TXNIP_MOUSE
θ value	5.7252e-63 (rank : 7)	NC score	0.942213 (rank : 7)
Query Neighborhood Hits	22	Target Neighborhood Hits	11	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BG60, Q8BGQ0, Q8K2B2, Q9DC00, Q9EP90, Q9R115	Gene names	Txnip, Vdup1
Domain Architecture	No domain graphic available
Description	Thioredoxin-interacting protein (Vitamin D3 up-regulated protein 1).

ARRD1_MOUSE
θ value	8.93572e-24 (rank : 8)	NC score	0.743817 (rank : 8)
Query Neighborhood Hits	22	Target Neighborhood Hits	90	Shared Neighborhood Hits	13
SwissProt Accessions	Q99KN1, Q3TDT6, Q8VEG7	Gene names	Arrdc1
Domain Architecture	No domain graphic available
Description	Arrestin domain-containing protein 1.

ARRD1_HUMAN
θ value	1.86321e-21 (rank : 9)	NC score	0.743263 (rank : 9)
Query Neighborhood Hits	22	Target Neighborhood Hits	75	Shared Neighborhood Hits	13
SwissProt Accessions	Q8N5I2	Gene names	ARRDC1
Domain Architecture	No domain graphic available
Description	Arrestin domain-containing protein 1.

ARRD5_MOUSE
θ value	1.133e-10 (rank : 10)	NC score	0.564994 (rank : 10)
Query Neighborhood Hits	22	Target Neighborhood Hits	12	Shared Neighborhood Hits	10
SwissProt Accessions	Q497K5	Gene names	Arrdc5
Domain Architecture	No domain graphic available
Description	Arrestin domain-containing protein 5.

FGD1_MOUSE
θ value	0.00228821 (rank : 11)	NC score	0.041009 (rank : 13)
Query Neighborhood Hits	22	Target Neighborhood Hits	387	Shared Neighborhood Hits	4
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_HUMAN
θ value	0.0148317 (rank : 12)	NC score	0.038723 (rank : 14)
Query Neighborhood Hits	22	Target Neighborhood Hits	367	Shared Neighborhood Hits	3
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ZN553_MOUSE
θ value	1.38821 (rank : 13)	NC score	-0.000138 (rank : 21)
Query Neighborhood Hits	22	Target Neighborhood Hits	744	Shared Neighborhood Hits	2
SwissProt Accessions	Q3US17, Q3UFP3, Q8R0V0, Q921H7	Gene names	Znf553, Zfp553
Domain Architecture	No domain graphic available
Description	Zinc finger protein 553.

ARRB1_HUMAN
θ value	1.81305 (rank : 14)	NC score	0.047133 (rank : 12)
Query Neighborhood Hits	22	Target Neighborhood Hits	19	Shared Neighborhood Hits	9
SwissProt Accessions	P49407, O75625, O75630, Q2PP20, Q9BTK8	Gene names	ARRB1, ARR1
Domain Architecture
Description	Beta-arrestin-1 (Arrestin beta 1).

MLL2_HUMAN
θ value	1.81305 (rank : 15)	NC score	0.020086 (rank : 16)
Query Neighborhood Hits	22	Target Neighborhood Hits	1788	Shared Neighborhood Hits	8
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

ARRC_MOUSE
θ value	4.03905 (rank : 16)	NC score	0.057267 (rank : 11)
Query Neighborhood Hits	22	Target Neighborhood Hits	12	Shared Neighborhood Hits	7
SwissProt Accessions	Q9EQP6	Gene names	Arr3
Domain Architecture
Description	Arrestin-C (Cone arrestin) (cArr) (Retinal cone arrestin-3).

TITIN_HUMAN
θ value	4.03905 (rank : 17)	NC score	-0.000161 (rank : 22)
Query Neighborhood Hits	22	Target Neighborhood Hits	2923	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

ARRB1_MOUSE
θ value	6.88961 (rank : 18)	NC score	0.033251 (rank : 15)
Query Neighborhood Hits	22	Target Neighborhood Hits	18	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BWG8, Q3UH95, Q8BTJ5	Gene names	Arrb1
Domain Architecture	No domain graphic available
Description	Beta-arrestin-1 (Arrestin beta 1).

DOT1L_HUMAN
θ value	6.88961 (rank : 19)	NC score	0.010131 (rank : 18)
Query Neighborhood Hits	22	Target Neighborhood Hits	660	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

AKP8L_MOUSE
θ value	8.99809 (rank : 20)	NC score	0.007727 (rank : 19)
Query Neighborhood Hits	22	Target Neighborhood Hits	95	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R0L7	Gene names	Akap8l, Nakap95
Domain Architecture
Description	A-kinase anchor protein 8-like (AKAP8-like protein) (Neighbor of A- kinase-anchoring protein 95) (Neighbor of AKAP95).

METH_HUMAN
θ value	8.99809 (rank : 21)	NC score	0.012725 (rank : 17)
Query Neighborhood Hits	22	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q99707, Q99713, Q99723	Gene names	MTR
Domain Architecture
Description	Methionine synthase (EC 2.1.1.13) (5-methyltetrahydrofolate-- homocysteine methyltransferase) (Methionine synthase, vitamin-B12 dependent) (MS).

S6A13_MOUSE
θ value	8.99809 (rank : 22)	NC score	0.002299 (rank : 20)
Query Neighborhood Hits	22	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	P31649	Gene names	Slc6a13, Gabt3, Gat-3
Domain Architecture
Description	Sodium- and chloride-dependent GABA transporter 3 (GAT3).

Hits sorted by NC score

ARRD2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	Q8TBH0, O95895, Q6ZRV9, Q8WYG6	Gene names	ARRDC2
Domain Architecture	No domain graphic available
Description	Arrestin domain-containing protein 2.

ARRD2_MOUSE
NC score	0.993828 (rank : 2)	θ value	3.71755e-171 (rank : 2)
Query Neighborhood Hits	22	Target Neighborhood Hits	20	Shared Neighborhood Hits	13
SwissProt Accessions	Q9D668, Q3UVK8, Q3UXC6	Gene names	Arrdc2
Domain Architecture	No domain graphic available
Description	Arrestin domain-containing protein 2.

ARRD3_HUMAN
NC score	0.983540 (rank : 3)	θ value	7.86017e-121 (rank : 3)
Query Neighborhood Hits	22	Target Neighborhood Hits	13	Shared Neighborhood Hits	11
SwissProt Accessions	Q96B67, Q9P2H1	Gene names	ARRDC3, KIAA1376
Domain Architecture	No domain graphic available
Description	Arrestin domain-containing protein 3.

ARRD3_MOUSE
NC score	0.982644 (rank : 4)	θ value	2.80211e-110 (rank : 4)
Query Neighborhood Hits	22	Target Neighborhood Hits	12	Shared Neighborhood Hits	11
SwissProt Accessions	Q7TPQ9, Q4KMN0, Q80TE6, Q8K0L7	Gene names	Arrdc3, Kiaa1376
Domain Architecture	No domain graphic available
Description	Arrestin domain-containing protein 3.

ARRD4_HUMAN
NC score	0.976515 (rank : 5)	θ value	5.86991e-92 (rank : 5)
Query Neighborhood Hits	22	Target Neighborhood Hits	27	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NCT1, Q6NSI9	Gene names	ARRDC4
Domain Architecture	No domain graphic available
Description	Arrestin domain-containing protein 4.

TXNIP_HUMAN
NC score	0.942542 (rank : 6)	θ value	6.76295e-64 (rank : 6)
Query Neighborhood Hits	22	Target Neighborhood Hits	12	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H3M7, Q16226, Q6PML0, Q9BXG9	Gene names	TXNIP, VDUP1
Domain Architecture	No domain graphic available
Description	Thioredoxin-interacting protein (Vitamin D3 up-regulated protein 1) (Thioredoxin-binding protein 2).

TXNIP_MOUSE
NC score	0.942213 (rank : 7)	θ value	5.7252e-63 (rank : 7)
Query Neighborhood Hits	22	Target Neighborhood Hits	11	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BG60, Q8BGQ0, Q8K2B2, Q9DC00, Q9EP90, Q9R115	Gene names	Txnip, Vdup1
Domain Architecture	No domain graphic available
Description	Thioredoxin-interacting protein (Vitamin D3 up-regulated protein 1).

ARRD1_MOUSE
NC score	0.743817 (rank : 8)	θ value	8.93572e-24 (rank : 8)
Query Neighborhood Hits	22	Target Neighborhood Hits	90	Shared Neighborhood Hits	13
SwissProt Accessions	Q99KN1, Q3TDT6, Q8VEG7	Gene names	Arrdc1
Domain Architecture	No domain graphic available
Description	Arrestin domain-containing protein 1.

ARRD1_HUMAN
NC score	0.743263 (rank : 9)	θ value	1.86321e-21 (rank : 9)
Query Neighborhood Hits	22	Target Neighborhood Hits	75	Shared Neighborhood Hits	13
SwissProt Accessions	Q8N5I2	Gene names	ARRDC1
Domain Architecture	No domain graphic available
Description	Arrestin domain-containing protein 1.

ARRD5_MOUSE
NC score	0.564994 (rank : 10)	θ value	1.133e-10 (rank : 10)
Query Neighborhood Hits	22	Target Neighborhood Hits	12	Shared Neighborhood Hits	10
SwissProt Accessions	Q497K5	Gene names	Arrdc5
Domain Architecture	No domain graphic available
Description	Arrestin domain-containing protein 5.

ARRC_MOUSE
NC score	0.057267 (rank : 11)	θ value	4.03905 (rank : 16)
Query Neighborhood Hits	22	Target Neighborhood Hits	12	Shared Neighborhood Hits	7
SwissProt Accessions	Q9EQP6	Gene names	Arr3
Domain Architecture
Description	Arrestin-C (Cone arrestin) (cArr) (Retinal cone arrestin-3).

ARRB1_HUMAN
NC score	0.047133 (rank : 12)	θ value	1.81305 (rank : 14)
Query Neighborhood Hits	22	Target Neighborhood Hits	19	Shared Neighborhood Hits	9
SwissProt Accessions	P49407, O75625, O75630, Q2PP20, Q9BTK8	Gene names	ARRB1, ARR1
Domain Architecture
Description	Beta-arrestin-1 (Arrestin beta 1).

FGD1_MOUSE
NC score	0.041009 (rank : 13)	θ value	0.00228821 (rank : 11)
Query Neighborhood Hits	22	Target Neighborhood Hits	387	Shared Neighborhood Hits	4
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_HUMAN
NC score	0.038723 (rank : 14)	θ value	0.0148317 (rank : 12)
Query Neighborhood Hits	22	Target Neighborhood Hits	367	Shared Neighborhood Hits	3
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

ARRB1_MOUSE
NC score	0.033251 (rank : 15)	θ value	6.88961 (rank : 18)
Query Neighborhood Hits	22	Target Neighborhood Hits	18	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BWG8, Q3UH95, Q8BTJ5	Gene names	Arrb1
Domain Architecture	No domain graphic available
Description	Beta-arrestin-1 (Arrestin beta 1).

MLL2_HUMAN
NC score	0.020086 (rank : 16)	θ value	1.81305 (rank : 15)
Query Neighborhood Hits	22	Target Neighborhood Hits	1788	Shared Neighborhood Hits	8
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

METH_HUMAN
NC score	0.012725 (rank : 17)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	22	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q99707, Q99713, Q99723	Gene names	MTR
Domain Architecture
Description	Methionine synthase (EC 2.1.1.13) (5-methyltetrahydrofolate-- homocysteine methyltransferase) (Methionine synthase, vitamin-B12 dependent) (MS).

DOT1L_HUMAN
NC score	0.010131 (rank : 18)	θ value	6.88961 (rank : 19)
Query Neighborhood Hits	22	Target Neighborhood Hits	660	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

AKP8L_MOUSE
NC score	0.007727 (rank : 19)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	22	Target Neighborhood Hits	95	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R0L7	Gene names	Akap8l, Nakap95
Domain Architecture
Description	A-kinase anchor protein 8-like (AKAP8-like protein) (Neighbor of A- kinase-anchoring protein 95) (Neighbor of AKAP95).

S6A13_MOUSE
NC score	0.002299 (rank : 20)	θ value	8.99809 (rank : 22)
Query Neighborhood Hits	22	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	P31649	Gene names	Slc6a13, Gabt3, Gat-3
Domain Architecture
Description	Sodium- and chloride-dependent GABA transporter 3 (GAT3).

ZN553_MOUSE
NC score	-0.000138 (rank : 21)	θ value	1.38821 (rank : 13)
Query Neighborhood Hits	22	Target Neighborhood Hits	744	Shared Neighborhood Hits	2
SwissProt Accessions	Q3US17, Q3UFP3, Q8R0V0, Q921H7	Gene names	Znf553, Zfp553
Domain Architecture	No domain graphic available
Description	Zinc finger protein 553.

TITIN_HUMAN
NC score	-0.000161 (rank : 22)	θ value	4.03905 (rank : 17)
Query Neighborhood Hits	22	Target Neighborhood Hits	2923	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).