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Network neighborhood for query Sequence : AL2SE_HUMAN

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AL2SE_HUMAN
SwissProt Accessions	Q8NDH6, Q53P45, Q53QZ4, Q53T97, Q96N47, Q96Q32, Q9BVQ2	Gene names	ALS2CR15
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

AL2SE_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	42
SwissProt Accessions	Q8NDH6, Q53P45, Q53QZ4, Q53T97, Q96N47, Q96Q32, Q9BVQ2	Gene names	ALS2CR15
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein.

AL2SE_MOUSE
θ value	2.83983e-179 (rank : 2)	NC score	0.980671 (rank : 2)
Query Neighborhood Hits	42	Target Neighborhood Hits	55	Shared Neighborhood Hits	23
SwissProt Accessions	Q3TY65, Q6AXB8, Q6PD23, Q8C0R6, Q9D9S5	Gene names	Als2cr15
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein homolog (Ica69-related protein).

ICA69_HUMAN
θ value	4.1775e-114 (rank : 3)	NC score	0.952641 (rank : 3)
Query Neighborhood Hits	42	Target Neighborhood Hits	35	Shared Neighborhood Hits	10
SwissProt Accessions	Q05084, P78506, Q13824	Gene names	ICA1
Domain Architecture
Description	Islet cell autoantigen 1 (69 kDa islet cell autoantigen) (ICA69) (p69) (Islet cell autoantigen p69) (ICAp69).

ICA69_MOUSE
θ value	1.34386e-112 (rank : 4)	NC score	0.952214 (rank : 4)
Query Neighborhood Hits	42	Target Neighborhood Hits	27	Shared Neighborhood Hits	9
SwissProt Accessions	P97411, P97362, P97954, Q99M40, Q9R2C4	Gene names	Ica1, Icap69
Domain Architecture	No domain graphic available
Description	Islet cell autoantigen 1 (69 kDa islet cell autoantigen) (ICA69) (p69) (Islet cell autoantigen p69) (ICAp69).

ARFP1_HUMAN
θ value	1.99992e-07 (rank : 5)	NC score	0.343216 (rank : 5)
Query Neighborhood Hits	42	Target Neighborhood Hits	37	Shared Neighborhood Hits	13
SwissProt Accessions	P53367, Q9Y2X6	Gene names	ARFIP1
Domain Architecture
Description	Arfaptin-1 (ADP-ribosylation factor-interacting protein 1).

ARFP2_MOUSE
θ value	0.000270298 (rank : 6)	NC score	0.284334 (rank : 6)
Query Neighborhood Hits	42	Target Neighborhood Hits	20	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K221, Q3U3G6, Q9D7M3	Gene names	Arfip2
Domain Architecture	No domain graphic available
Description	Arfaptin-2 (ADP-ribosylation factor-interacting protein 2).

ARFP2_HUMAN
θ value	0.000461057 (rank : 7)	NC score	0.279777 (rank : 7)
Query Neighborhood Hits	42	Target Neighborhood Hits	20	Shared Neighborhood Hits	8
SwissProt Accessions	P53365	Gene names	ARFIP2, POR1
Domain Architecture
Description	Arfaptin-2 (ADP-ribosylation factor-interacting protein 2) (Partner of RAC1) (Protein POR1).

REST_HUMAN
θ value	0.00390308 (rank : 8)	NC score	0.069126 (rank : 8)
Query Neighborhood Hits	42	Target Neighborhood Hits	1605	Shared Neighborhood Hits	31
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

EEA1_HUMAN
θ value	0.00869519 (rank : 9)	NC score	0.059990 (rank : 10)
Query Neighborhood Hits	42	Target Neighborhood Hits	1796	Shared Neighborhood Hits	30
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

REST_MOUSE
θ value	0.0563607 (rank : 10)	NC score	0.060418 (rank : 9)
Query Neighborhood Hits	42	Target Neighborhood Hits	1506	Shared Neighborhood Hits	29
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

SYCP1_MOUSE
θ value	0.0961366 (rank : 11)	NC score	0.052926 (rank : 15)
Query Neighborhood Hits	42	Target Neighborhood Hits	1456	Shared Neighborhood Hits	32
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

CP250_MOUSE
θ value	0.163984 (rank : 12)	NC score	0.051922 (rank : 19)
Query Neighborhood Hits	42	Target Neighborhood Hits	1583	Shared Neighborhood Hits	29
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

MYH14_MOUSE
θ value	0.21417 (rank : 13)	NC score	0.047332 (rank : 26)
Query Neighborhood Hits	42	Target Neighborhood Hits	1225	Shared Neighborhood Hits	29
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

CENPE_HUMAN
θ value	0.279714 (rank : 14)	NC score	0.044452 (rank : 31)
Query Neighborhood Hits	42	Target Neighborhood Hits	2060	Shared Neighborhood Hits	32
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

ERC2_HUMAN
θ value	0.365318 (rank : 15)	NC score	0.055678 (rank : 12)
Query Neighborhood Hits	42	Target Neighborhood Hits	1156	Shared Neighborhood Hits	28
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

CP135_HUMAN
θ value	0.47712 (rank : 16)	NC score	0.056501 (rank : 11)
Query Neighborhood Hits	42	Target Neighborhood Hits	1290	Shared Neighborhood Hits	28
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

SYNE1_HUMAN
θ value	0.47712 (rank : 17)	NC score	0.052193 (rank : 16)
Query Neighborhood Hits	42	Target Neighborhood Hits	1484	Shared Neighborhood Hits	29
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

CING_MOUSE
θ value	0.62314 (rank : 18)	NC score	0.052188 (rank : 17)
Query Neighborhood Hits	42	Target Neighborhood Hits	1432	Shared Neighborhood Hits	30
SwissProt Accessions	P59242	Gene names	Cgn
Domain Architecture
Description	Cingulin.

ERC2_MOUSE
θ value	0.62314 (rank : 19)	NC score	0.055169 (rank : 13)
Query Neighborhood Hits	42	Target Neighborhood Hits	1166	Shared Neighborhood Hits	28
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

MYH11_MOUSE
θ value	0.813845 (rank : 20)	NC score	0.044585 (rank : 30)
Query Neighborhood Hits	42	Target Neighborhood Hits	1777	Shared Neighborhood Hits	30
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH11_HUMAN
θ value	1.06291 (rank : 21)	NC score	0.043219 (rank : 32)
Query Neighborhood Hits	42	Target Neighborhood Hits	1806	Shared Neighborhood Hits	30
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

ROCK1_MOUSE
θ value	1.81305 (rank : 22)	NC score	0.022311 (rank : 36)
Query Neighborhood Hits	42	Target Neighborhood Hits	2126	Shared Neighborhood Hits	32
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

GOGA4_MOUSE
θ value	2.36792 (rank : 23)	NC score	0.049565 (rank : 24)
Query Neighborhood Hits	42	Target Neighborhood Hits	1939	Shared Neighborhood Hits	31
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

SDCG8_HUMAN
θ value	2.36792 (rank : 24)	NC score	0.046430 (rank : 28)
Query Neighborhood Hits	42	Target Neighborhood Hits	1002	Shared Neighborhood Hits	28
SwissProt Accessions	Q86SQ7, O60527, Q3ZCR6, Q8N5F2, Q9P0F1	Gene names	SDCCAG8, CCCAP
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (hCCCAP) (Antigen NY-CO-8).

CAR14_MOUSE
θ value	3.0926 (rank : 25)	NC score	0.052032 (rank : 18)
Query Neighborhood Hits	42	Target Neighborhood Hits	526	Shared Neighborhood Hits	28
SwissProt Accessions	Q99KF0	Gene names	Card14, Bimp2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (Bcl10-interacting MAGUK protein 2) (Bimp2).

GOGA4_HUMAN
θ value	3.0926 (rank : 26)	NC score	0.046679 (rank : 27)
Query Neighborhood Hits	42	Target Neighborhood Hits	2034	Shared Neighborhood Hits	29
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

PRS10_HUMAN
θ value	3.0926 (rank : 27)	NC score	0.013002 (rank : 41)
Query Neighborhood Hits	42	Target Neighborhood Hits	95	Shared Neighborhood Hits	6
SwissProt Accessions	P62333, P49719, Q6IBU3, Q92524	Gene names	PSMC6, SUG2
Domain Architecture
Description	26S protease regulatory subunit S10B (Proteasome subunit p42) (Proteasome 26S subunit ATPase 6).

PRS10_MOUSE
θ value	3.0926 (rank : 28)	NC score	0.013002 (rank : 42)
Query Neighborhood Hits	42	Target Neighborhood Hits	95	Shared Neighborhood Hits	6
SwissProt Accessions	P62334, P49719, Q3TKK1, Q810A6, Q92524, Q9CXH9	Gene names	Psmc6, Sug2
Domain Architecture
Description	26S protease regulatory subunit S10B (Proteasome subunit p42) (Proteasome 26S subunit ATPase 6).

TMC1_HUMAN
θ value	3.0926 (rank : 29)	NC score	0.021011 (rank : 37)
Query Neighborhood Hits	42	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	Q8TDI8	Gene names	TMC1
Domain Architecture	No domain graphic available
Description	Transmembrane cochlear-expressed protein 1.

CENPF_HUMAN
θ value	4.03905 (rank : 30)	NC score	0.044598 (rank : 29)
Query Neighborhood Hits	42	Target Neighborhood Hits	1932	Shared Neighborhood Hits	28
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

CTF1_MOUSE
θ value	4.03905 (rank : 31)	NC score	0.025638 (rank : 35)
Query Neighborhood Hits	42	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q60753	Gene names	Ctf1
Domain Architecture	No domain graphic available
Description	Cardiotrophin-1 (CT-1).

MYH14_HUMAN
θ value	5.27518 (rank : 32)	NC score	0.042854 (rank : 33)
Query Neighborhood Hits	42	Target Neighborhood Hits	995	Shared Neighborhood Hits	29
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

RAD50_MOUSE
θ value	5.27518 (rank : 33)	NC score	0.048367 (rank : 25)
Query Neighborhood Hits	42	Target Neighborhood Hits	1366	Shared Neighborhood Hits	31
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

FANCM_HUMAN
θ value	6.88961 (rank : 34)	NC score	0.011144 (rank : 45)
Query Neighborhood Hits	42	Target Neighborhood Hits	210	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

KIF11_HUMAN
θ value	6.88961 (rank : 35)	NC score	0.028602 (rank : 34)
Query Neighborhood Hits	42	Target Neighborhood Hits	583	Shared Neighborhood Hits	25
SwissProt Accessions	P52732, Q15716, Q5VWX0	Gene names	KIF11, EG5, KNSL1
Domain Architecture
Description	Kinesin-like protein KIF11 (Kinesin-related motor protein Eg5) (Kinesin-like spindle protein HKSP) (Thyroid receptor-interacting protein 5) (TRIP5) (Kinesin-like protein 1).

MFN1_HUMAN
θ value	6.88961 (rank : 36)	NC score	0.012551 (rank : 43)
Query Neighborhood Hits	42	Target Neighborhood Hits	71	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IWA4, O15323, O60639, Q9BZB5, Q9NWQ2	Gene names	MFN1
Domain Architecture
Description	Transmembrane GTPase MFN1 (EC 3.6.5.-) (Mitofusin-1) (Fzo homolog).

TAOK1_HUMAN
θ value	6.88961 (rank : 37)	NC score	0.011711 (rank : 44)
Query Neighborhood Hits	42	Target Neighborhood Hits	1734	Shared Neighborhood Hits	25
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

ATE1_MOUSE
θ value	8.99809 (rank : 38)	NC score	0.014299 (rank : 40)
Query Neighborhood Hits	42	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z2A5, Q9Z2A4	Gene names	Ate1
Domain Architecture
Description	Arginyl-tRNA--protein transferase 1 (EC 2.3.2.8) (R-transferase 1) (Arginyltransferase 1) (Arginine-tRNA--protein transferase 1).

EEA1_MOUSE
θ value	8.99809 (rank : 39)	NC score	0.053157 (rank : 14)
Query Neighborhood Hits	42	Target Neighborhood Hits	1637	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

LAMC2_MOUSE
θ value	8.99809 (rank : 40)	NC score	0.015160 (rank : 39)
Query Neighborhood Hits	42	Target Neighborhood Hits	614	Shared Neighborhood Hits	20
SwissProt Accessions	Q61092	Gene names	Lamc2
Domain Architecture
Description	Laminin gamma-2 chain precursor (Laminin 5 gamma 2 subunit) (Kalinin/nicein/epiligrin 100 kDa subunit) (Laminin B2t chain).

MPIP3_HUMAN
θ value	8.99809 (rank : 41)	NC score	0.009695 (rank : 46)
Query Neighborhood Hits	42	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	P30307, Q96PL3, Q9H168, Q9H2E8, Q9H2E9, Q9H2F1	Gene names	CDC25C
Domain Architecture
Description	M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C).

ROCK1_HUMAN
θ value	8.99809 (rank : 42)	NC score	0.020307 (rank : 38)
Query Neighborhood Hits	42	Target Neighborhood Hits	2000	Shared Neighborhood Hits	31
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

CP135_MOUSE
θ value	θ > 10 (rank : 43)	NC score	0.050920 (rank : 22)
Query Neighborhood Hits	42	Target Neighborhood Hits	1278	Shared Neighborhood Hits	28
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

CYLN2_HUMAN
θ value	θ > 10 (rank : 44)	NC score	0.050822 (rank : 23)
Query Neighborhood Hits	42	Target Neighborhood Hits	1004	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UDT6, O14527, O43611	Gene names	CYLN2, KIAA0291, WBSCR4, WSCR4
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115) (Williams-Beuren syndrome chromosome region 4 protein).

CYLN2_MOUSE
θ value	θ > 10 (rank : 45)	NC score	0.051021 (rank : 21)
Query Neighborhood Hits	42	Target Neighborhood Hits	1002	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z0H8, Q7TSI9, Q8CHU1, Q9EP81	Gene names	Cyln2, Kiaa0291
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115).

SYCP1_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.051198 (rank : 20)
Query Neighborhood Hits	42	Target Neighborhood Hits	1313	Shared Neighborhood Hits	32
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

Hits sorted by NC score

AL2SE_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	42
SwissProt Accessions	Q8NDH6, Q53P45, Q53QZ4, Q53T97, Q96N47, Q96Q32, Q9BVQ2	Gene names	ALS2CR15
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein.

AL2SE_MOUSE
NC score	0.980671 (rank : 2)	θ value	2.83983e-179 (rank : 2)
Query Neighborhood Hits	42	Target Neighborhood Hits	55	Shared Neighborhood Hits	23
SwissProt Accessions	Q3TY65, Q6AXB8, Q6PD23, Q8C0R6, Q9D9S5	Gene names	Als2cr15
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein homolog (Ica69-related protein).

ICA69_HUMAN
NC score	0.952641 (rank : 3)	θ value	4.1775e-114 (rank : 3)
Query Neighborhood Hits	42	Target Neighborhood Hits	35	Shared Neighborhood Hits	10
SwissProt Accessions	Q05084, P78506, Q13824	Gene names	ICA1
Domain Architecture
Description	Islet cell autoantigen 1 (69 kDa islet cell autoantigen) (ICA69) (p69) (Islet cell autoantigen p69) (ICAp69).

ICA69_MOUSE
NC score	0.952214 (rank : 4)	θ value	1.34386e-112 (rank : 4)
Query Neighborhood Hits	42	Target Neighborhood Hits	27	Shared Neighborhood Hits	9
SwissProt Accessions	P97411, P97362, P97954, Q99M40, Q9R2C4	Gene names	Ica1, Icap69
Domain Architecture	No domain graphic available
Description	Islet cell autoantigen 1 (69 kDa islet cell autoantigen) (ICA69) (p69) (Islet cell autoantigen p69) (ICAp69).

ARFP1_HUMAN
NC score	0.343216 (rank : 5)	θ value	1.99992e-07 (rank : 5)
Query Neighborhood Hits	42	Target Neighborhood Hits	37	Shared Neighborhood Hits	13
SwissProt Accessions	P53367, Q9Y2X6	Gene names	ARFIP1
Domain Architecture
Description	Arfaptin-1 (ADP-ribosylation factor-interacting protein 1).

ARFP2_MOUSE
NC score	0.284334 (rank : 6)	θ value	0.000270298 (rank : 6)
Query Neighborhood Hits	42	Target Neighborhood Hits	20	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K221, Q3U3G6, Q9D7M3	Gene names	Arfip2
Domain Architecture	No domain graphic available
Description	Arfaptin-2 (ADP-ribosylation factor-interacting protein 2).

ARFP2_HUMAN
NC score	0.279777 (rank : 7)	θ value	0.000461057 (rank : 7)
Query Neighborhood Hits	42	Target Neighborhood Hits	20	Shared Neighborhood Hits	8
SwissProt Accessions	P53365	Gene names	ARFIP2, POR1
Domain Architecture
Description	Arfaptin-2 (ADP-ribosylation factor-interacting protein 2) (Partner of RAC1) (Protein POR1).

REST_HUMAN
NC score	0.069126 (rank : 8)	θ value	0.00390308 (rank : 8)
Query Neighborhood Hits	42	Target Neighborhood Hits	1605	Shared Neighborhood Hits	31
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

REST_MOUSE
NC score	0.060418 (rank : 9)	θ value	0.0563607 (rank : 10)
Query Neighborhood Hits	42	Target Neighborhood Hits	1506	Shared Neighborhood Hits	29
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

EEA1_HUMAN
NC score	0.059990 (rank : 10)	θ value	0.00869519 (rank : 9)
Query Neighborhood Hits	42	Target Neighborhood Hits	1796	Shared Neighborhood Hits	30
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

CP135_HUMAN
NC score	0.056501 (rank : 11)	θ value	0.47712 (rank : 16)
Query Neighborhood Hits	42	Target Neighborhood Hits	1290	Shared Neighborhood Hits	28
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

ERC2_HUMAN
NC score	0.055678 (rank : 12)	θ value	0.365318 (rank : 15)
Query Neighborhood Hits	42	Target Neighborhood Hits	1156	Shared Neighborhood Hits	28
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

ERC2_MOUSE
NC score	0.055169 (rank : 13)	θ value	0.62314 (rank : 19)
Query Neighborhood Hits	42	Target Neighborhood Hits	1166	Shared Neighborhood Hits	28
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

EEA1_MOUSE
NC score	0.053157 (rank : 14)	θ value	8.99809 (rank : 39)
Query Neighborhood Hits	42	Target Neighborhood Hits	1637	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

SYCP1_MOUSE
NC score	0.052926 (rank : 15)	θ value	0.0961366 (rank : 11)
Query Neighborhood Hits	42	Target Neighborhood Hits	1456	Shared Neighborhood Hits	32
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

SYNE1_HUMAN
NC score	0.052193 (rank : 16)	θ value	0.47712 (rank : 17)
Query Neighborhood Hits	42	Target Neighborhood Hits	1484	Shared Neighborhood Hits	29
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

CING_MOUSE
NC score	0.052188 (rank : 17)	θ value	0.62314 (rank : 18)
Query Neighborhood Hits	42	Target Neighborhood Hits	1432	Shared Neighborhood Hits	30
SwissProt Accessions	P59242	Gene names	Cgn
Domain Architecture
Description	Cingulin.

CAR14_MOUSE
NC score	0.052032 (rank : 18)	θ value	3.0926 (rank : 25)
Query Neighborhood Hits	42	Target Neighborhood Hits	526	Shared Neighborhood Hits	28
SwissProt Accessions	Q99KF0	Gene names	Card14, Bimp2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (Bcl10-interacting MAGUK protein 2) (Bimp2).

CP250_MOUSE
NC score	0.051922 (rank : 19)	θ value	0.163984 (rank : 12)
Query Neighborhood Hits	42	Target Neighborhood Hits	1583	Shared Neighborhood Hits	29
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

SYCP1_HUMAN
NC score	0.051198 (rank : 20)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	42	Target Neighborhood Hits	1313	Shared Neighborhood Hits	32
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

CYLN2_MOUSE
NC score	0.051021 (rank : 21)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	42	Target Neighborhood Hits	1002	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z0H8, Q7TSI9, Q8CHU1, Q9EP81	Gene names	Cyln2, Kiaa0291
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115).

CP135_MOUSE
NC score	0.050920 (rank : 22)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	42	Target Neighborhood Hits	1278	Shared Neighborhood Hits	28
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

CYLN2_HUMAN
NC score	0.050822 (rank : 23)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	42	Target Neighborhood Hits	1004	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UDT6, O14527, O43611	Gene names	CYLN2, KIAA0291, WBSCR4, WSCR4
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115) (Williams-Beuren syndrome chromosome region 4 protein).

GOGA4_MOUSE
NC score	0.049565 (rank : 24)	θ value	2.36792 (rank : 23)
Query Neighborhood Hits	42	Target Neighborhood Hits	1939	Shared Neighborhood Hits	31
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

RAD50_MOUSE
NC score	0.048367 (rank : 25)	θ value	5.27518 (rank : 33)
Query Neighborhood Hits	42	Target Neighborhood Hits	1366	Shared Neighborhood Hits	31
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

MYH14_MOUSE
NC score	0.047332 (rank : 26)	θ value	0.21417 (rank : 13)
Query Neighborhood Hits	42	Target Neighborhood Hits	1225	Shared Neighborhood Hits	29
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

GOGA4_HUMAN
NC score	0.046679 (rank : 27)	θ value	3.0926 (rank : 26)
Query Neighborhood Hits	42	Target Neighborhood Hits	2034	Shared Neighborhood Hits	29
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

SDCG8_HUMAN
NC score	0.046430 (rank : 28)	θ value	2.36792 (rank : 24)
Query Neighborhood Hits	42	Target Neighborhood Hits	1002	Shared Neighborhood Hits	28
SwissProt Accessions	Q86SQ7, O60527, Q3ZCR6, Q8N5F2, Q9P0F1	Gene names	SDCCAG8, CCCAP
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (hCCCAP) (Antigen NY-CO-8).

CENPF_HUMAN
NC score	0.044598 (rank : 29)	θ value	4.03905 (rank : 30)
Query Neighborhood Hits	42	Target Neighborhood Hits	1932	Shared Neighborhood Hits	28
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

MYH11_MOUSE
NC score	0.044585 (rank : 30)	θ value	0.813845 (rank : 20)
Query Neighborhood Hits	42	Target Neighborhood Hits	1777	Shared Neighborhood Hits	30
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

CENPE_HUMAN
NC score	0.044452 (rank : 31)	θ value	0.279714 (rank : 14)
Query Neighborhood Hits	42	Target Neighborhood Hits	2060	Shared Neighborhood Hits	32
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

MYH11_HUMAN
NC score	0.043219 (rank : 32)	θ value	1.06291 (rank : 21)
Query Neighborhood Hits	42	Target Neighborhood Hits	1806	Shared Neighborhood Hits	30
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH14_HUMAN
NC score	0.042854 (rank : 33)	θ value	5.27518 (rank : 32)
Query Neighborhood Hits	42	Target Neighborhood Hits	995	Shared Neighborhood Hits	29
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

KIF11_HUMAN
NC score	0.028602 (rank : 34)	θ value	6.88961 (rank : 35)
Query Neighborhood Hits	42	Target Neighborhood Hits	583	Shared Neighborhood Hits	25
SwissProt Accessions	P52732, Q15716, Q5VWX0	Gene names	KIF11, EG5, KNSL1
Domain Architecture
Description	Kinesin-like protein KIF11 (Kinesin-related motor protein Eg5) (Kinesin-like spindle protein HKSP) (Thyroid receptor-interacting protein 5) (TRIP5) (Kinesin-like protein 1).

CTF1_MOUSE
NC score	0.025638 (rank : 35)	θ value	4.03905 (rank : 31)
Query Neighborhood Hits	42	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q60753	Gene names	Ctf1
Domain Architecture	No domain graphic available
Description	Cardiotrophin-1 (CT-1).

ROCK1_MOUSE
NC score	0.022311 (rank : 36)	θ value	1.81305 (rank : 22)
Query Neighborhood Hits	42	Target Neighborhood Hits	2126	Shared Neighborhood Hits	32
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

TMC1_HUMAN
NC score	0.021011 (rank : 37)	θ value	3.0926 (rank : 29)
Query Neighborhood Hits	42	Target Neighborhood Hits	125	Shared Neighborhood Hits	12
SwissProt Accessions	Q8TDI8	Gene names	TMC1
Domain Architecture	No domain graphic available
Description	Transmembrane cochlear-expressed protein 1.

ROCK1_HUMAN
NC score	0.020307 (rank : 38)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	42	Target Neighborhood Hits	2000	Shared Neighborhood Hits	31
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

LAMC2_MOUSE
NC score	0.015160 (rank : 39)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	42	Target Neighborhood Hits	614	Shared Neighborhood Hits	20
SwissProt Accessions	Q61092	Gene names	Lamc2
Domain Architecture
Description	Laminin gamma-2 chain precursor (Laminin 5 gamma 2 subunit) (Kalinin/nicein/epiligrin 100 kDa subunit) (Laminin B2t chain).

ATE1_MOUSE
NC score	0.014299 (rank : 40)	θ value	8.99809 (rank : 38)
Query Neighborhood Hits	42	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z2A5, Q9Z2A4	Gene names	Ate1
Domain Architecture
Description	Arginyl-tRNA--protein transferase 1 (EC 2.3.2.8) (R-transferase 1) (Arginyltransferase 1) (Arginine-tRNA--protein transferase 1).

PRS10_HUMAN
NC score	0.013002 (rank : 41)	θ value	3.0926 (rank : 27)
Query Neighborhood Hits	42	Target Neighborhood Hits	95	Shared Neighborhood Hits	6
SwissProt Accessions	P62333, P49719, Q6IBU3, Q92524	Gene names	PSMC6, SUG2
Domain Architecture
Description	26S protease regulatory subunit S10B (Proteasome subunit p42) (Proteasome 26S subunit ATPase 6).

PRS10_MOUSE
NC score	0.013002 (rank : 42)	θ value	3.0926 (rank : 28)
Query Neighborhood Hits	42	Target Neighborhood Hits	95	Shared Neighborhood Hits	6
SwissProt Accessions	P62334, P49719, Q3TKK1, Q810A6, Q92524, Q9CXH9	Gene names	Psmc6, Sug2
Domain Architecture
Description	26S protease regulatory subunit S10B (Proteasome subunit p42) (Proteasome 26S subunit ATPase 6).

MFN1_HUMAN
NC score	0.012551 (rank : 43)	θ value	6.88961 (rank : 36)
Query Neighborhood Hits	42	Target Neighborhood Hits	71	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IWA4, O15323, O60639, Q9BZB5, Q9NWQ2	Gene names	MFN1
Domain Architecture
Description	Transmembrane GTPase MFN1 (EC 3.6.5.-) (Mitofusin-1) (Fzo homolog).

TAOK1_HUMAN
NC score	0.011711 (rank : 44)	θ value	6.88961 (rank : 37)
Query Neighborhood Hits	42	Target Neighborhood Hits	1734	Shared Neighborhood Hits	25
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

FANCM_HUMAN
NC score	0.011144 (rank : 45)	θ value	6.88961 (rank : 34)
Query Neighborhood Hits	42	Target Neighborhood Hits	210	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

MPIP3_HUMAN
NC score	0.009695 (rank : 46)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	42	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	P30307, Q96PL3, Q9H168, Q9H2E8, Q9H2E9, Q9H2F1	Gene names	CDC25C
Domain Architecture
Description	M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C).