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Network neighborhood for query Sequence : ADH7_HUMAN

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ADH7_HUMAN
SwissProt Accessions	P40394, Q13713	Gene names	ADH7
Domain Architecture
Description	Alcohol dehydrogenase class 4 mu/sigma chain (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Retinol dehydrogenase) (Gastric alcohol dehydrogenase).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ADH7_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	31	Target Neighborhood Hits	31	Shared Neighborhood Hits	31
SwissProt Accessions	P40394, Q13713	Gene names	ADH7
Domain Architecture
Description	Alcohol dehydrogenase class 4 mu/sigma chain (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Retinol dehydrogenase) (Gastric alcohol dehydrogenase).

ADH7_MOUSE
θ value	0 (rank : 2)	NC score	0.998682 (rank : 2)
Query Neighborhood Hits	31	Target Neighborhood Hits	26	Shared Neighborhood Hits	23
SwissProt Accessions	Q64437	Gene names	Adh7, Adh-3, Adh3
Domain Architecture
Description	Alcohol dehydrogenase class 4 mu/sigma chain (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Retinol dehydrogenase) (Gastric alcohol dehydrogenase) (ADH-C2) (Alcohol dehydrogenase 7).

ADH1B_HUMAN
θ value	1.05009e-157 (rank : 3)	NC score	0.995298 (rank : 5)
Query Neighborhood Hits	31	Target Neighborhood Hits	29	Shared Neighborhood Hits	25
SwissProt Accessions	P00325, Q13711, Q4ZGI9, Q96KI7	Gene names	ADH1B, ADH2
Domain Architecture
Description	Alcohol dehydrogenase 1B (EC 1.1.1.1) (Alcohol dehydrogenase beta subunit).

ADH1A_HUMAN
θ value	8.32034e-155 (rank : 4)	NC score	0.994834 (rank : 6)
Query Neighborhood Hits	31	Target Neighborhood Hits	28	Shared Neighborhood Hits	25
SwissProt Accessions	P07327	Gene names	ADH1A, ADH1
Domain Architecture
Description	Alcohol dehydrogenase 1A (EC 1.1.1.1) (Alcohol dehydrogenase alpha subunit).

ADH1G_HUMAN
θ value	6.82227e-149 (rank : 5)	NC score	0.995909 (rank : 3)
Query Neighborhood Hits	31	Target Neighborhood Hits	28	Shared Neighborhood Hits	26
SwissProt Accessions	P00326, Q4PJ18, Q5WRV0, Q6LBW4, Q6NWV0, Q6NZA7	Gene names	ADH1C, ADH3
Domain Architecture
Description	Alcohol dehydrogenase 1C (EC 1.1.1.1) (Alcohol dehydrogenase gamma subunit).

ADH1_MOUSE
θ value	4.13891e-146 (rank : 6)	NC score	0.995772 (rank : 4)
Query Neighborhood Hits	31	Target Neighborhood Hits	32	Shared Neighborhood Hits	26
SwissProt Accessions	P00329	Gene names	Adh1, Adh-1
Domain Architecture
Description	Alcohol dehydrogenase 1 (EC 1.1.1.1) (Alcohol dehydrogenase A subunit) (ADH-A2).

ADH4_HUMAN
θ value	9.92011e-124 (rank : 7)	NC score	0.990993 (rank : 10)
Query Neighborhood Hits	31	Target Neighborhood Hits	30	Shared Neighborhood Hits	25
SwissProt Accessions	P08319, Q8TCD7	Gene names	ADH4
Domain Architecture
Description	Alcohol dehydrogenase 4 (EC 1.1.1.1) (Alcohol dehydrogenase class II pi chain).

ADHX_HUMAN
θ value	3.76964e-123 (rank : 8)	NC score	0.992321 (rank : 8)
Query Neighborhood Hits	31	Target Neighborhood Hits	28	Shared Neighborhood Hits	25
SwissProt Accessions	P11766, Q6FHR2	Gene names	ADH5, ADHX, FDH
Domain Architecture
Description	Alcohol dehydrogenase class 3 chi chain (EC 1.1.1.1) (Alcohol dehydrogenase class III chi chain) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) (Glutathione-dependent formaldehyde dehydrogenase) (FDH).

ADHX_MOUSE
θ value	1.87085e-122 (rank : 9)	NC score	0.991334 (rank : 9)
Query Neighborhood Hits	31	Target Neighborhood Hits	26	Shared Neighborhood Hits	24
SwissProt Accessions	P28474, Q3TW83, Q8C662	Gene names	Adh5, Adh-2, Adh2
Domain Architecture
Description	Alcohol dehydrogenase class 3 (EC 1.1.1.1) (Alcohol dehydrogenase class III) (Alcohol dehydrogenase 2) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) (Glutathione-dependent formaldehyde dehydrogenase) (FDH) (FALDH) (Alcohol dehydrogenase-B2) (ADH-B2).

ADH6_HUMAN
θ value	2.70151e-121 (rank : 10)	NC score	0.994212 (rank : 7)
Query Neighborhood Hits	31	Target Neighborhood Hits	29	Shared Neighborhood Hits	24
SwissProt Accessions	P28332, Q58F53	Gene names	ADH6
Domain Architecture
Description	Alcohol dehydrogenase 6 (EC 1.1.1.1).

ADH4_MOUSE
θ value	2.1455e-110 (rank : 11)	NC score	0.990806 (rank : 11)
Query Neighborhood Hits	31	Target Neighborhood Hits	25	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QYY9	Gene names	Adh4
Domain Architecture
Description	Alcohol dehydrogenase 4 (EC 1.1.1.1) (Alcohol dehydrogenase class II) (Alcohol dehydrogenase II) (ADH2).

DHSO_HUMAN
θ value	3.40345e-15 (rank : 12)	NC score	0.792087 (rank : 12)
Query Neighborhood Hits	31	Target Neighborhood Hits	30	Shared Neighborhood Hits	24
SwissProt Accessions	Q00796, Q16682, Q9UMD6	Gene names	SORD
Domain Architecture
Description	Sorbitol dehydrogenase (EC 1.1.1.14) (L-iditol 2-dehydrogenase).

QOR_HUMAN
θ value	1.69304e-06 (rank : 13)	NC score	0.417252 (rank : 14)
Query Neighborhood Hits	31	Target Neighborhood Hits	35	Shared Neighborhood Hits	27
SwissProt Accessions	Q08257, Q53FT0, Q59EU7, Q6NSK9	Gene names	CRYZ
Domain Architecture
Description	Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta- crystallin).

MECR_HUMAN
θ value	1.09739e-05 (rank : 14)	NC score	0.456622 (rank : 13)
Query Neighborhood Hits	31	Target Neighborhood Hits	39	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BV79, Q5SYU0, Q5SYU1, Q5SYU2, Q6IBU9, Q9Y373	Gene names	MECR, NBRF1
Domain Architecture	No domain graphic available
Description	Trans-2-enoyl-CoA reductase, mitochondrial precursor (EC 1.3.1.38) (HsNrbf-1) (NRBF-1).

MECR_MOUSE
θ value	5.44631e-05 (rank : 15)	NC score	0.412869 (rank : 15)
Query Neighborhood Hits	31	Target Neighborhood Hits	36	Shared Neighborhood Hits	27
SwissProt Accessions	Q9DCS3, Q99L39	Gene names	Mecr, Nrbf1
Domain Architecture	No domain graphic available
Description	Trans-2-enoyl-CoA reductase, mitochondrial precursor (EC 1.3.1.38).

QOR_MOUSE
θ value	0.00175202 (rank : 16)	NC score	0.352372 (rank : 16)
Query Neighborhood Hits	31	Target Neighborhood Hits	35	Shared Neighborhood Hits	27
SwissProt Accessions	P47199, Q62508, Q99L63	Gene names	Cryz
Domain Architecture
Description	Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta- crystallin).

ZADH2_HUMAN
θ value	0.00390308 (rank : 17)	NC score	0.203031 (rank : 21)
Query Neighborhood Hits	31	Target Neighborhood Hits	33	Shared Neighborhood Hits	23
SwissProt Accessions	Q8N4Q0	Gene names	ZADH2
Domain Architecture	No domain graphic available
Description	Zinc-binding alcohol dehydrogenase domain-containing protein 2 (EC 1.-.-.-).

K1576_HUMAN
θ value	0.0193708 (rank : 18)	NC score	0.224276 (rank : 20)
Query Neighborhood Hits	31	Target Neighborhood Hits	30	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HCJ6, Q8IYW8	Gene names	KIAA1576
Domain Architecture	No domain graphic available
Description	Probable oxidoreductase KIAA1576 (EC 1.-.-.-).

K1576_MOUSE
θ value	0.0193708 (rank : 19)	NC score	0.224907 (rank : 19)
Query Neighborhood Hits	31	Target Neighborhood Hits	30	Shared Neighborhood Hits	27
SwissProt Accessions	Q80TB8, Q6PGM9	Gene names	Kiaa1576
Domain Architecture	No domain graphic available
Description	Probable oxidoreductase KIAA1576 (EC 1.-.-.-).

ZADH2_MOUSE
θ value	0.279714 (rank : 20)	NC score	0.188166 (rank : 23)
Query Neighborhood Hits	31	Target Neighborhood Hits	32	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BGC4	Gene names	Zadh2
Domain Architecture	No domain graphic available
Description	Zinc-binding alcohol dehydrogenase domain-containing protein 2 (EC 1.-.-.-).

ECHP_HUMAN
θ value	0.47712 (rank : 21)	NC score	0.051754 (rank : 32)
Query Neighborhood Hits	31	Target Neighborhood Hits	28	Shared Neighborhood Hits	6
SwissProt Accessions	Q08426	Gene names	EHHADH, ECHD
Domain Architecture
Description	Peroxisomal bifunctional enzyme (PBE) (PBFE) [Includes: Enoyl-CoA hydratase (EC 4.2.1.17); 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)].

FAS_HUMAN
θ value	0.62314 (rank : 22)	NC score	0.131131 (rank : 26)
Query Neighborhood Hits	31	Target Neighborhood Hits	66	Shared Neighborhood Hits	24
SwissProt Accessions	P49327, Q13479, Q16702, Q6P4U5, Q6SS02, Q969R1, Q96C68, Q96IT0	Gene names	FASN, FAS
Domain Architecture
Description	Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S- acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S- malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.10); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)].

VAT1_HUMAN
θ value	0.62314 (rank : 23)	NC score	0.247030 (rank : 17)
Query Neighborhood Hits	31	Target Neighborhood Hits	33	Shared Neighborhood Hits	26
SwissProt Accessions	Q99536, Q13035, Q96A39, Q9BUT8	Gene names	VAT1
Domain Architecture
Description	Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-).

VAT1_MOUSE
θ value	1.38821 (rank : 24)	NC score	0.227515 (rank : 18)
Query Neighborhood Hits	31	Target Neighborhood Hits	41	Shared Neighborhood Hits	26
SwissProt Accessions	Q62465, Q8R3G0, Q8R3T8	Gene names	Vat1, Vat-1
Domain Architecture	No domain graphic available
Description	Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-).

QORL_MOUSE
θ value	1.81305 (rank : 25)	NC score	0.159474 (rank : 24)
Query Neighborhood Hits	31	Target Neighborhood Hits	37	Shared Neighborhood Hits	25
SwissProt Accessions	Q921W4, Q3UKX2, Q8VCS1, Q9CWR9	Gene names	Cryzl1
Domain Architecture
Description	Quinone oxidoreductase-like 1 (EC 1.-.-.-) (QOH-1) (Zeta-crystallin homolog).

QORL_HUMAN
θ value	2.36792 (rank : 26)	NC score	0.153152 (rank : 25)
Query Neighborhood Hits	31	Target Neighborhood Hits	39	Shared Neighborhood Hits	25
SwissProt Accessions	O95825, Q96DY0, Q9NVY7	Gene names	CRYZL1
Domain Architecture
Description	Quinone oxidoreductase-like 1 (EC 1.-.-.-) (QOH-1) (Zeta-crystallin homolog) (4P11).

FLNB_MOUSE
θ value	4.03905 (rank : 27)	NC score	0.004966 (rank : 35)
Query Neighborhood Hits	31	Target Neighborhood Hits	126	Shared Neighborhood Hits	2
SwissProt Accessions	Q80X90, Q8VHX4, Q8VHX7, Q99KY3	Gene names	Flnb
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (ABP- 280-like protein).

GDE1_HUMAN
θ value	6.88961 (rank : 28)	NC score	0.008871 (rank : 34)
Query Neighborhood Hits	31	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NZC3, O43334, Q6PKF7, Q7KYR4	Gene names	GDE1, MIR16
Domain Architecture	No domain graphic available
Description	Glycerophosphodiester phosphodiesterase 1 (EC 3.1.4.44) (Membrane interacting protein of RGS16) (RGS16-interacting membrane protein).

RT4I1_HUMAN
θ value	6.88961 (rank : 29)	NC score	0.112268 (rank : 27)
Query Neighborhood Hits	31	Target Neighborhood Hits	31	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WWV3, Q8N9B3, Q8WZ66, Q9BRA4	Gene names	RTN4IP1, NIMP
Domain Architecture	No domain graphic available
Description	Reticulon-4-interacting protein 1, mitochondrial precursor (NOGO- interacting mitochondrial protein).

RT4I1_MOUSE
θ value	8.99809 (rank : 30)	NC score	0.098751 (rank : 28)
Query Neighborhood Hits	31	Target Neighborhood Hits	32	Shared Neighborhood Hits	20
SwissProt Accessions	Q924D0, Q8R1T0	Gene names	Rtn4ip1, Nimp
Domain Architecture	No domain graphic available
Description	Reticulon-4-interacting protein 1, mitochondrial precursor (NOGO- interacting mitochondrial protein).

SOCS6_HUMAN
θ value	8.99809 (rank : 31)	NC score	0.010964 (rank : 33)
Query Neighborhood Hits	31	Target Neighborhood Hits	126	Shared Neighborhood Hits	3
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

FAS_MOUSE
θ value	θ > 10 (rank : 32)	NC score	0.070247 (rank : 29)
Query Neighborhood Hits	31	Target Neighborhood Hits	76	Shared Neighborhood Hits	17
SwissProt Accessions	P19096, Q6PB72, Q8C4Z0, Q9EQR0	Gene names	Fasn
Domain Architecture	No domain graphic available
Description	Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S- acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S- malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.10); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)].

LTB4D_HUMAN
θ value	θ > 10 (rank : 33)	NC score	0.053815 (rank : 31)
Query Neighborhood Hits	31	Target Neighborhood Hits	23	Shared Neighborhood Hits	15
SwissProt Accessions	Q14914, Q8IYQ0, Q9H1X6	Gene names	LTB4DH
Domain Architecture
Description	NADP-dependent leukotriene B4 12-hydroxydehydrogenase (EC 1.3.1.74) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48).

LTB4D_MOUSE
θ value	θ > 10 (rank : 34)	NC score	0.068970 (rank : 30)
Query Neighborhood Hits	31	Target Neighborhood Hits	26	Shared Neighborhood Hits	15
SwissProt Accessions	Q91YR9, Q3TKT6, Q9CPS1	Gene names	Ltb4dh
Domain Architecture	No domain graphic available
Description	NADP-dependent leukotriene B4 12-hydroxydehydrogenase (EC 1.3.1.74) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48).

QORX_HUMAN
θ value	θ > 10 (rank : 35)	NC score	0.202623 (rank : 22)
Query Neighborhood Hits	31	Target Neighborhood Hits	35	Shared Neighborhood Hits	24
SwissProt Accessions	Q53FA7, O14679, O14685, Q38G78, Q6JLE7, Q9BWB8	Gene names	TP53I3, PIG3
Domain Architecture	No domain graphic available
Description	Putative quinone oxidoreductase (EC 1.-.-.-) (Tumor protein p53- inducible protein 3) (p53-induced protein 3).

Hits sorted by NC score

ADH7_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	31	Target Neighborhood Hits	31	Shared Neighborhood Hits	31
SwissProt Accessions	P40394, Q13713	Gene names	ADH7
Domain Architecture
Description	Alcohol dehydrogenase class 4 mu/sigma chain (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Retinol dehydrogenase) (Gastric alcohol dehydrogenase).

ADH7_MOUSE
NC score	0.998682 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	31	Target Neighborhood Hits	26	Shared Neighborhood Hits	23
SwissProt Accessions	Q64437	Gene names	Adh7, Adh-3, Adh3
Domain Architecture
Description	Alcohol dehydrogenase class 4 mu/sigma chain (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Retinol dehydrogenase) (Gastric alcohol dehydrogenase) (ADH-C2) (Alcohol dehydrogenase 7).

ADH1G_HUMAN
NC score	0.995909 (rank : 3)	θ value	6.82227e-149 (rank : 5)
Query Neighborhood Hits	31	Target Neighborhood Hits	28	Shared Neighborhood Hits	26
SwissProt Accessions	P00326, Q4PJ18, Q5WRV0, Q6LBW4, Q6NWV0, Q6NZA7	Gene names	ADH1C, ADH3
Domain Architecture
Description	Alcohol dehydrogenase 1C (EC 1.1.1.1) (Alcohol dehydrogenase gamma subunit).

ADH1_MOUSE
NC score	0.995772 (rank : 4)	θ value	4.13891e-146 (rank : 6)
Query Neighborhood Hits	31	Target Neighborhood Hits	32	Shared Neighborhood Hits	26
SwissProt Accessions	P00329	Gene names	Adh1, Adh-1
Domain Architecture
Description	Alcohol dehydrogenase 1 (EC 1.1.1.1) (Alcohol dehydrogenase A subunit) (ADH-A2).

ADH1B_HUMAN
NC score	0.995298 (rank : 5)	θ value	1.05009e-157 (rank : 3)
Query Neighborhood Hits	31	Target Neighborhood Hits	29	Shared Neighborhood Hits	25
SwissProt Accessions	P00325, Q13711, Q4ZGI9, Q96KI7	Gene names	ADH1B, ADH2
Domain Architecture
Description	Alcohol dehydrogenase 1B (EC 1.1.1.1) (Alcohol dehydrogenase beta subunit).

ADH1A_HUMAN
NC score	0.994834 (rank : 6)	θ value	8.32034e-155 (rank : 4)
Query Neighborhood Hits	31	Target Neighborhood Hits	28	Shared Neighborhood Hits	25
SwissProt Accessions	P07327	Gene names	ADH1A, ADH1
Domain Architecture
Description	Alcohol dehydrogenase 1A (EC 1.1.1.1) (Alcohol dehydrogenase alpha subunit).

ADH6_HUMAN
NC score	0.994212 (rank : 7)	θ value	2.70151e-121 (rank : 10)
Query Neighborhood Hits	31	Target Neighborhood Hits	29	Shared Neighborhood Hits	24
SwissProt Accessions	P28332, Q58F53	Gene names	ADH6
Domain Architecture
Description	Alcohol dehydrogenase 6 (EC 1.1.1.1).

ADHX_HUMAN
NC score	0.992321 (rank : 8)	θ value	3.76964e-123 (rank : 8)
Query Neighborhood Hits	31	Target Neighborhood Hits	28	Shared Neighborhood Hits	25
SwissProt Accessions	P11766, Q6FHR2	Gene names	ADH5, ADHX, FDH
Domain Architecture
Description	Alcohol dehydrogenase class 3 chi chain (EC 1.1.1.1) (Alcohol dehydrogenase class III chi chain) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) (Glutathione-dependent formaldehyde dehydrogenase) (FDH).

ADHX_MOUSE
NC score	0.991334 (rank : 9)	θ value	1.87085e-122 (rank : 9)
Query Neighborhood Hits	31	Target Neighborhood Hits	26	Shared Neighborhood Hits	24
SwissProt Accessions	P28474, Q3TW83, Q8C662	Gene names	Adh5, Adh-2, Adh2
Domain Architecture
Description	Alcohol dehydrogenase class 3 (EC 1.1.1.1) (Alcohol dehydrogenase class III) (Alcohol dehydrogenase 2) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) (Glutathione-dependent formaldehyde dehydrogenase) (FDH) (FALDH) (Alcohol dehydrogenase-B2) (ADH-B2).

ADH4_HUMAN
NC score	0.990993 (rank : 10)	θ value	9.92011e-124 (rank : 7)
Query Neighborhood Hits	31	Target Neighborhood Hits	30	Shared Neighborhood Hits	25
SwissProt Accessions	P08319, Q8TCD7	Gene names	ADH4
Domain Architecture
Description	Alcohol dehydrogenase 4 (EC 1.1.1.1) (Alcohol dehydrogenase class II pi chain).

ADH4_MOUSE
NC score	0.990806 (rank : 11)	θ value	2.1455e-110 (rank : 11)
Query Neighborhood Hits	31	Target Neighborhood Hits	25	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QYY9	Gene names	Adh4
Domain Architecture
Description	Alcohol dehydrogenase 4 (EC 1.1.1.1) (Alcohol dehydrogenase class II) (Alcohol dehydrogenase II) (ADH2).

DHSO_HUMAN
NC score	0.792087 (rank : 12)	θ value	3.40345e-15 (rank : 12)
Query Neighborhood Hits	31	Target Neighborhood Hits	30	Shared Neighborhood Hits	24
SwissProt Accessions	Q00796, Q16682, Q9UMD6	Gene names	SORD
Domain Architecture
Description	Sorbitol dehydrogenase (EC 1.1.1.14) (L-iditol 2-dehydrogenase).

MECR_HUMAN
NC score	0.456622 (rank : 13)	θ value	1.09739e-05 (rank : 14)
Query Neighborhood Hits	31	Target Neighborhood Hits	39	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BV79, Q5SYU0, Q5SYU1, Q5SYU2, Q6IBU9, Q9Y373	Gene names	MECR, NBRF1
Domain Architecture	No domain graphic available
Description	Trans-2-enoyl-CoA reductase, mitochondrial precursor (EC 1.3.1.38) (HsNrbf-1) (NRBF-1).

QOR_HUMAN
NC score	0.417252 (rank : 14)	θ value	1.69304e-06 (rank : 13)
Query Neighborhood Hits	31	Target Neighborhood Hits	35	Shared Neighborhood Hits	27
SwissProt Accessions	Q08257, Q53FT0, Q59EU7, Q6NSK9	Gene names	CRYZ
Domain Architecture
Description	Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta- crystallin).

MECR_MOUSE
NC score	0.412869 (rank : 15)	θ value	5.44631e-05 (rank : 15)
Query Neighborhood Hits	31	Target Neighborhood Hits	36	Shared Neighborhood Hits	27
SwissProt Accessions	Q9DCS3, Q99L39	Gene names	Mecr, Nrbf1
Domain Architecture	No domain graphic available
Description	Trans-2-enoyl-CoA reductase, mitochondrial precursor (EC 1.3.1.38).

QOR_MOUSE
NC score	0.352372 (rank : 16)	θ value	0.00175202 (rank : 16)
Query Neighborhood Hits	31	Target Neighborhood Hits	35	Shared Neighborhood Hits	27
SwissProt Accessions	P47199, Q62508, Q99L63	Gene names	Cryz
Domain Architecture
Description	Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta- crystallin).

VAT1_HUMAN
NC score	0.247030 (rank : 17)	θ value	0.62314 (rank : 23)
Query Neighborhood Hits	31	Target Neighborhood Hits	33	Shared Neighborhood Hits	26
SwissProt Accessions	Q99536, Q13035, Q96A39, Q9BUT8	Gene names	VAT1
Domain Architecture
Description	Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-).

VAT1_MOUSE
NC score	0.227515 (rank : 18)	θ value	1.38821 (rank : 24)
Query Neighborhood Hits	31	Target Neighborhood Hits	41	Shared Neighborhood Hits	26
SwissProt Accessions	Q62465, Q8R3G0, Q8R3T8	Gene names	Vat1, Vat-1
Domain Architecture	No domain graphic available
Description	Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-).

K1576_MOUSE
NC score	0.224907 (rank : 19)	θ value	0.0193708 (rank : 19)
Query Neighborhood Hits	31	Target Neighborhood Hits	30	Shared Neighborhood Hits	27
SwissProt Accessions	Q80TB8, Q6PGM9	Gene names	Kiaa1576
Domain Architecture	No domain graphic available
Description	Probable oxidoreductase KIAA1576 (EC 1.-.-.-).

K1576_HUMAN
NC score	0.224276 (rank : 20)	θ value	0.0193708 (rank : 18)
Query Neighborhood Hits	31	Target Neighborhood Hits	30	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HCJ6, Q8IYW8	Gene names	KIAA1576
Domain Architecture	No domain graphic available
Description	Probable oxidoreductase KIAA1576 (EC 1.-.-.-).

ZADH2_HUMAN
NC score	0.203031 (rank : 21)	θ value	0.00390308 (rank : 17)
Query Neighborhood Hits	31	Target Neighborhood Hits	33	Shared Neighborhood Hits	23
SwissProt Accessions	Q8N4Q0	Gene names	ZADH2
Domain Architecture	No domain graphic available
Description	Zinc-binding alcohol dehydrogenase domain-containing protein 2 (EC 1.-.-.-).

QORX_HUMAN
NC score	0.202623 (rank : 22)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	31	Target Neighborhood Hits	35	Shared Neighborhood Hits	24
SwissProt Accessions	Q53FA7, O14679, O14685, Q38G78, Q6JLE7, Q9BWB8	Gene names	TP53I3, PIG3
Domain Architecture	No domain graphic available
Description	Putative quinone oxidoreductase (EC 1.-.-.-) (Tumor protein p53- inducible protein 3) (p53-induced protein 3).

ZADH2_MOUSE
NC score	0.188166 (rank : 23)	θ value	0.279714 (rank : 20)
Query Neighborhood Hits	31	Target Neighborhood Hits	32	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BGC4	Gene names	Zadh2
Domain Architecture	No domain graphic available
Description	Zinc-binding alcohol dehydrogenase domain-containing protein 2 (EC 1.-.-.-).

QORL_MOUSE
NC score	0.159474 (rank : 24)	θ value	1.81305 (rank : 25)
Query Neighborhood Hits	31	Target Neighborhood Hits	37	Shared Neighborhood Hits	25
SwissProt Accessions	Q921W4, Q3UKX2, Q8VCS1, Q9CWR9	Gene names	Cryzl1
Domain Architecture
Description	Quinone oxidoreductase-like 1 (EC 1.-.-.-) (QOH-1) (Zeta-crystallin homolog).

QORL_HUMAN
NC score	0.153152 (rank : 25)	θ value	2.36792 (rank : 26)
Query Neighborhood Hits	31	Target Neighborhood Hits	39	Shared Neighborhood Hits	25
SwissProt Accessions	O95825, Q96DY0, Q9NVY7	Gene names	CRYZL1
Domain Architecture
Description	Quinone oxidoreductase-like 1 (EC 1.-.-.-) (QOH-1) (Zeta-crystallin homolog) (4P11).

FAS_HUMAN
NC score	0.131131 (rank : 26)	θ value	0.62314 (rank : 22)
Query Neighborhood Hits	31	Target Neighborhood Hits	66	Shared Neighborhood Hits	24
SwissProt Accessions	P49327, Q13479, Q16702, Q6P4U5, Q6SS02, Q969R1, Q96C68, Q96IT0	Gene names	FASN, FAS
Domain Architecture
Description	Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S- acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S- malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.10); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)].

RT4I1_HUMAN
NC score	0.112268 (rank : 27)	θ value	6.88961 (rank : 29)
Query Neighborhood Hits	31	Target Neighborhood Hits	31	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WWV3, Q8N9B3, Q8WZ66, Q9BRA4	Gene names	RTN4IP1, NIMP
Domain Architecture	No domain graphic available
Description	Reticulon-4-interacting protein 1, mitochondrial precursor (NOGO- interacting mitochondrial protein).

RT4I1_MOUSE
NC score	0.098751 (rank : 28)	θ value	8.99809 (rank : 30)
Query Neighborhood Hits	31	Target Neighborhood Hits	32	Shared Neighborhood Hits	20
SwissProt Accessions	Q924D0, Q8R1T0	Gene names	Rtn4ip1, Nimp
Domain Architecture	No domain graphic available
Description	Reticulon-4-interacting protein 1, mitochondrial precursor (NOGO- interacting mitochondrial protein).

FAS_MOUSE
NC score	0.070247 (rank : 29)	θ value	θ > 10 (rank : 32)
Query Neighborhood Hits	31	Target Neighborhood Hits	76	Shared Neighborhood Hits	17
SwissProt Accessions	P19096, Q6PB72, Q8C4Z0, Q9EQR0	Gene names	Fasn
Domain Architecture	No domain graphic available
Description	Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S- acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S- malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.10); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)].

LTB4D_MOUSE
NC score	0.068970 (rank : 30)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	31	Target Neighborhood Hits	26	Shared Neighborhood Hits	15
SwissProt Accessions	Q91YR9, Q3TKT6, Q9CPS1	Gene names	Ltb4dh
Domain Architecture	No domain graphic available
Description	NADP-dependent leukotriene B4 12-hydroxydehydrogenase (EC 1.3.1.74) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48).

LTB4D_HUMAN
NC score	0.053815 (rank : 31)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	31	Target Neighborhood Hits	23	Shared Neighborhood Hits	15
SwissProt Accessions	Q14914, Q8IYQ0, Q9H1X6	Gene names	LTB4DH
Domain Architecture
Description	NADP-dependent leukotriene B4 12-hydroxydehydrogenase (EC 1.3.1.74) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48).

ECHP_HUMAN
NC score	0.051754 (rank : 32)	θ value	0.47712 (rank : 21)
Query Neighborhood Hits	31	Target Neighborhood Hits	28	Shared Neighborhood Hits	6
SwissProt Accessions	Q08426	Gene names	EHHADH, ECHD
Domain Architecture
Description	Peroxisomal bifunctional enzyme (PBE) (PBFE) [Includes: Enoyl-CoA hydratase (EC 4.2.1.17); 3,2-trans-enoyl-CoA isomerase (EC 5.3.3.8); 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35)].

SOCS6_HUMAN
NC score	0.010964 (rank : 33)	θ value	8.99809 (rank : 31)
Query Neighborhood Hits	31	Target Neighborhood Hits	126	Shared Neighborhood Hits	3
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

GDE1_HUMAN
NC score	0.008871 (rank : 34)	θ value	6.88961 (rank : 28)
Query Neighborhood Hits	31	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NZC3, O43334, Q6PKF7, Q7KYR4	Gene names	GDE1, MIR16
Domain Architecture	No domain graphic available
Description	Glycerophosphodiester phosphodiesterase 1 (EC 3.1.4.44) (Membrane interacting protein of RGS16) (RGS16-interacting membrane protein).

FLNB_MOUSE
NC score	0.004966 (rank : 35)	θ value	4.03905 (rank : 27)
Query Neighborhood Hits	31	Target Neighborhood Hits	126	Shared Neighborhood Hits	2
SwissProt Accessions	Q80X90, Q8VHX4, Q8VHX7, Q99KY3	Gene names	Flnb
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (ABP- 280-like protein).