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Network neighborhood for query Sequence : ACLY_HUMAN

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ACLY_HUMAN
SwissProt Accessions	P53396, Q13037, Q9BRL0	Gene names	ACLY
Domain Architecture
Description	ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ACLY_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	P53396, Q13037, Q9BRL0	Gene names	ACLY
Domain Architecture
Description	ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme).

ACLY_MOUSE
θ value	0 (rank : 2)	NC score	0.999350 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	21	Shared Neighborhood Hits	16
SwissProt Accessions	Q91V92	Gene names	Acly
Domain Architecture
Description	ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme).

SUCA_MOUSE
θ value	5.07402e-19 (rank : 3)	NC score	0.598400 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WUM5, Q8C2C3, Q9DBA3, Q9DCI8	Gene names	Suclg1
Domain Architecture
Description	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial precursor (EC 6.2.1.4) (Succinyl-CoA synthetase subunit alpha) (SCS- alpha).

SUCA_HUMAN
θ value	6.20254e-17 (rank : 4)	NC score	0.581236 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	7	Shared Neighborhood Hits	4
SwissProt Accessions	P53597, Q9BWB0, Q9UNP6	Gene names	SUCLG1
Domain Architecture
Description	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial precursor (EC 6.2.1.4) (Succinyl-CoA synthetase subunit alpha) (SCS- alpha).

SUCB2_MOUSE
θ value	1.53129e-07 (rank : 5)	NC score	0.347230 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	7	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z2I8, Q3T9B8, Q3TJQ5, Q3TK63, Q66JT3, Q7TMY3, Q80VV1, Q8K2K9	Gene names	Suclg2
Domain Architecture	No domain graphic available
Description	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial precursor (EC 6.2.1.4) (Succinyl-CoA synthetase, betaG chain) (SCS-betaG) (GTP- specific succinyl-CoA synthetase subunit beta).

SUCB1_MOUSE
θ value	5.81887e-07 (rank : 6)	NC score	0.328701 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z2I9, Q3TVH1, Q8BGS6	Gene names	Sucla2
Domain Architecture	No domain graphic available
Description	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial precursor (EC 6.2.1.5) (Succinyl-CoA synthetase, betaA chain) (SCS-betaA) (ATP- specific succinyl-CoA synthetase subunit beta).

SUCB2_HUMAN
θ value	5.81887e-07 (rank : 7)	NC score	0.340327 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	8	Shared Neighborhood Hits	6
SwissProt Accessions	Q96I99, O95195, Q6NUH7, Q86VX8, Q8WUQ1	Gene names	SUCLG2
Domain Architecture	No domain graphic available
Description	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial precursor (EC 6.2.1.4) (Succinyl-CoA synthetase, betaG chain) (SCS-betaG) (GTP- specific succinyl-CoA synthetase subunit beta).

SUCB1_HUMAN
θ value	6.43352e-06 (rank : 8)	NC score	0.317199 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	9	Shared Neighborhood Hits	6
SwissProt Accessions	Q9P2R7, O95194, Q9NV21, Q9NVP7	Gene names	SUCLA2
Domain Architecture
Description	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial precursor (EC 6.2.1.5) (Succinyl-CoA synthetase, betaA chain) (SCS-betaA) (ATP- specific succinyl-CoA synthetase subunit beta) (NY-REN-39 antigen).

SP3_HUMAN
θ value	0.163984 (rank : 9)	NC score	0.018176 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	737	Shared Neighborhood Hits	4
SwissProt Accessions	Q02447, Q8TD56, Q9BQR1	Gene names	SP3
Domain Architecture
Description	Transcription factor Sp3 (SPR-2).

CACP_HUMAN
θ value	0.21417 (rank : 10)	NC score	0.044237 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	P43155, Q9BW16	Gene names	CRAT, CAT1
Domain Architecture
Description	Carnitine O-acetyltransferase (EC 2.3.1.7) (Carnitine acetylase) (CAT) (Carnitine acetyltransferase) (CrAT).

SP3_MOUSE
θ value	0.62314 (rank : 11)	NC score	0.015560 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	731	Shared Neighborhood Hits	4
SwissProt Accessions	O70494, Q68FF2, Q8CF64, Q8K378	Gene names	Sp3
Domain Architecture	No domain graphic available
Description	Transcription factor Sp3.

SMC3_HUMAN
θ value	4.03905 (rank : 12)	NC score	0.018593 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	1186	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

SMC3_MOUSE
θ value	4.03905 (rank : 13)	NC score	0.018613 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	1187	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

BMP5_HUMAN
θ value	5.27518 (rank : 14)	NC score	0.011017 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	72	Shared Neighborhood Hits	3
SwissProt Accessions	P22003, Q9H547, Q9NTM5	Gene names	BMP5
Domain Architecture
Description	Bone morphogenetic protein 5 precursor (BMP-5).

FREM1_HUMAN
θ value	8.99809 (rank : 15)	NC score	0.006131 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	170	Shared Neighborhood Hits	2
SwissProt Accessions	Q5H8C1, Q5VV00, Q5VV01, Q6MZI4, Q8NEG9, Q96LI3	Gene names	FREM1, C9orf154
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 1 precursor (Protein QBRICK).

KSYK_HUMAN
θ value	8.99809 (rank : 16)	NC score	0.000982 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	901	Shared Neighborhood Hits	3
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	8.99809 (rank : 17)	NC score	0.002172 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	944	Shared Neighborhood Hits	4
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

PPBT_HUMAN
θ value	8.99809 (rank : 18)	NC score	0.013558 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	P05186, Q8WU32, Q9UBK0	Gene names	ALPL
Domain Architecture
Description	Alkaline phosphatase, tissue-nonspecific isozyme precursor (EC 3.1.3.1) (AP-TNAP) (Liver/bone/kidney isozyme) (TNSALP).

Hits sorted by NC score

ACLY_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	P53396, Q13037, Q9BRL0	Gene names	ACLY
Domain Architecture
Description	ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme).

ACLY_MOUSE
NC score	0.999350 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	21	Shared Neighborhood Hits	16
SwissProt Accessions	Q91V92	Gene names	Acly
Domain Architecture
Description	ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme).

SUCA_MOUSE
NC score	0.598400 (rank : 3)	θ value	5.07402e-19 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	8	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WUM5, Q8C2C3, Q9DBA3, Q9DCI8	Gene names	Suclg1
Domain Architecture
Description	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial precursor (EC 6.2.1.4) (Succinyl-CoA synthetase subunit alpha) (SCS- alpha).

SUCA_HUMAN
NC score	0.581236 (rank : 4)	θ value	6.20254e-17 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	7	Shared Neighborhood Hits	4
SwissProt Accessions	P53597, Q9BWB0, Q9UNP6	Gene names	SUCLG1
Domain Architecture
Description	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial precursor (EC 6.2.1.4) (Succinyl-CoA synthetase subunit alpha) (SCS- alpha).

SUCB2_MOUSE
NC score	0.347230 (rank : 5)	θ value	1.53129e-07 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	7	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z2I8, Q3T9B8, Q3TJQ5, Q3TK63, Q66JT3, Q7TMY3, Q80VV1, Q8K2K9	Gene names	Suclg2
Domain Architecture	No domain graphic available
Description	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial precursor (EC 6.2.1.4) (Succinyl-CoA synthetase, betaG chain) (SCS-betaG) (GTP- specific succinyl-CoA synthetase subunit beta).

SUCB2_HUMAN
NC score	0.340327 (rank : 6)	θ value	5.81887e-07 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	8	Shared Neighborhood Hits	6
SwissProt Accessions	Q96I99, O95195, Q6NUH7, Q86VX8, Q8WUQ1	Gene names	SUCLG2
Domain Architecture	No domain graphic available
Description	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial precursor (EC 6.2.1.4) (Succinyl-CoA synthetase, betaG chain) (SCS-betaG) (GTP- specific succinyl-CoA synthetase subunit beta).

SUCB1_MOUSE
NC score	0.328701 (rank : 7)	θ value	5.81887e-07 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Z2I9, Q3TVH1, Q8BGS6	Gene names	Sucla2
Domain Architecture	No domain graphic available
Description	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial precursor (EC 6.2.1.5) (Succinyl-CoA synthetase, betaA chain) (SCS-betaA) (ATP- specific succinyl-CoA synthetase subunit beta).

SUCB1_HUMAN
NC score	0.317199 (rank : 8)	θ value	6.43352e-06 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	9	Shared Neighborhood Hits	6
SwissProt Accessions	Q9P2R7, O95194, Q9NV21, Q9NVP7	Gene names	SUCLA2
Domain Architecture
Description	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial precursor (EC 6.2.1.5) (Succinyl-CoA synthetase, betaA chain) (SCS-betaA) (ATP- specific succinyl-CoA synthetase subunit beta) (NY-REN-39 antigen).

CACP_HUMAN
NC score	0.044237 (rank : 9)	θ value	0.21417 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	P43155, Q9BW16	Gene names	CRAT, CAT1
Domain Architecture
Description	Carnitine O-acetyltransferase (EC 2.3.1.7) (Carnitine acetylase) (CAT) (Carnitine acetyltransferase) (CrAT).

SMC3_MOUSE
NC score	0.018613 (rank : 10)	θ value	4.03905 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	1187	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

SMC3_HUMAN
NC score	0.018593 (rank : 11)	θ value	4.03905 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	1186	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

SP3_HUMAN
NC score	0.018176 (rank : 12)	θ value	0.163984 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	737	Shared Neighborhood Hits	4
SwissProt Accessions	Q02447, Q8TD56, Q9BQR1	Gene names	SP3
Domain Architecture
Description	Transcription factor Sp3 (SPR-2).

SP3_MOUSE
NC score	0.015560 (rank : 13)	θ value	0.62314 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	731	Shared Neighborhood Hits	4
SwissProt Accessions	O70494, Q68FF2, Q8CF64, Q8K378	Gene names	Sp3
Domain Architecture	No domain graphic available
Description	Transcription factor Sp3.

PPBT_HUMAN
NC score	0.013558 (rank : 14)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	P05186, Q8WU32, Q9UBK0	Gene names	ALPL
Domain Architecture
Description	Alkaline phosphatase, tissue-nonspecific isozyme precursor (EC 3.1.3.1) (AP-TNAP) (Liver/bone/kidney isozyme) (TNSALP).

BMP5_HUMAN
NC score	0.011017 (rank : 15)	θ value	5.27518 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	72	Shared Neighborhood Hits	3
SwissProt Accessions	P22003, Q9H547, Q9NTM5	Gene names	BMP5
Domain Architecture
Description	Bone morphogenetic protein 5 precursor (BMP-5).

FREM1_HUMAN
NC score	0.006131 (rank : 16)	θ value	8.99809 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	170	Shared Neighborhood Hits	2
SwissProt Accessions	Q5H8C1, Q5VV00, Q5VV01, Q6MZI4, Q8NEG9, Q96LI3	Gene names	FREM1, C9orf154
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 1 precursor (Protein QBRICK).

KSYK_MOUSE
NC score	0.002172 (rank : 17)	θ value	8.99809 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	944	Shared Neighborhood Hits	4
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_HUMAN
NC score	0.000982 (rank : 18)	θ value	8.99809 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	901	Shared Neighborhood Hits	3
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).