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Network neighborhood for query Sequence : VPS39_HUMAN

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VPS39_HUMAN
SwissProt Accessions	Q96JC1, O94869, Q96B93, Q96RM0	Gene names	VPS39, KIAA0770
Domain Architecture
Description	Vam6/Vps39-like protein (hVam6p).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

VPS39_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	Q96JC1, O94869, Q96B93, Q96RM0	Gene names	VPS39, KIAA0770
Domain Architecture
Description	Vam6/Vps39-like protein (hVam6p).

VPS39_MOUSE
θ value	0 (rank : 2)	NC score	0.995783 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	20	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R5L3, Q922I3	Gene names	Vps39, Pldn
Domain Architecture
Description	Vam6/Vps39-like protein (Vps39 protein).

MRCKB_MOUSE
θ value	2.44474e-05 (rank : 3)	NC score	0.061070 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	2180	Shared Neighborhood Hits	16
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MRCKB_HUMAN
θ value	3.19293e-05 (rank : 4)	NC score	0.060036 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	2239	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

TNIK_HUMAN
θ value	0.00102713 (rank : 5)	NC score	0.056681 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	1570	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

MINK1_HUMAN
θ value	0.00390308 (rank : 6)	NC score	0.058464 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	1477	Shared Neighborhood Hits	15
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_MOUSE
θ value	0.00390308 (rank : 7)	NC score	0.058762 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	1451	Shared Neighborhood Hits	15
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

M4K4_HUMAN
θ value	0.00509761 (rank : 8)	NC score	0.055403 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	1589	Shared Neighborhood Hits	14
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

M4K4_MOUSE
θ value	0.00665767 (rank : 9)	NC score	0.056574 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	1560	Shared Neighborhood Hits	13
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

CR034_HUMAN
θ value	0.0113563 (rank : 10)	NC score	0.066256 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	538	Shared Neighborhood Hits	11
SwissProt Accessions	Q5BJE1, Q6ZP67, Q6ZU20	Gene names	C18orf34
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34.

MRCKA_HUMAN
θ value	0.0148317 (rank : 11)	NC score	0.051478 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	1999	Shared Neighborhood Hits	15
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

TRAF5_HUMAN
θ value	0.21417 (rank : 12)	NC score	0.045311 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	396	Shared Neighborhood Hits	7
SwissProt Accessions	O00463	Gene names	TRAF5, RNF84
Domain Architecture
Description	TNF receptor-associated factor 5 (RING finger protein 84).

SHOC2_MOUSE
θ value	1.38821 (rank : 13)	NC score	0.024112 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	308	Shared Neighborhood Hits	5
SwissProt Accessions	O88520, Q3UJH6, Q8BVL0	Gene names	Shoc2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat protein SHOC-2 (Ras-binding protein Sur-8).

SHOC2_HUMAN
θ value	1.81305 (rank : 14)	NC score	0.023054 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	330	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UQ13, O76063	Gene names	SHOC2, KIAA0862
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat protein SHOC-2 (Ras-binding protein Sur-8).

TLR12_MOUSE
θ value	3.0926 (rank : 15)	NC score	0.014882 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	268	Shared Neighborhood Hits	4
SwissProt Accessions	Q6QNU9	Gene names	Tlr12
Domain Architecture	No domain graphic available
Description	Toll-like receptor 12 precursor.

CCD39_HUMAN
θ value	6.88961 (rank : 16)	NC score	0.025171 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	868	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

CTRO_MOUSE
θ value	6.88961 (rank : 17)	NC score	0.031865 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	2344	Shared Neighborhood Hits	16
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

MRCKG_MOUSE
θ value	6.88961 (rank : 18)	NC score	0.040032 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	1466	Shared Neighborhood Hits	15
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

NU133_HUMAN
θ value	6.88961 (rank : 19)	NC score	0.017119 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WUM0, Q9H9W2, Q9NV71, Q9NVC4	Gene names	NUP133
Domain Architecture
Description	Nuclear pore complex protein Nup133 (Nucleoporin Nup133) (133 kDa nucleoporin).

DCP2_MOUSE
θ value	8.99809 (rank : 20)	NC score	0.022774 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CYC6	Gene names	Dcp2
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 2 (EC 3.-.-.-).

SM1L2_MOUSE
θ value	8.99809 (rank : 21)	NC score	0.022890 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	918	Shared Neighborhood Hits	16
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

Hits sorted by NC score

VPS39_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	Q96JC1, O94869, Q96B93, Q96RM0	Gene names	VPS39, KIAA0770
Domain Architecture
Description	Vam6/Vps39-like protein (hVam6p).

VPS39_MOUSE
NC score	0.995783 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	20	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R5L3, Q922I3	Gene names	Vps39, Pldn
Domain Architecture
Description	Vam6/Vps39-like protein (Vps39 protein).

CR034_HUMAN
NC score	0.066256 (rank : 3)	θ value	0.0113563 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	538	Shared Neighborhood Hits	11
SwissProt Accessions	Q5BJE1, Q6ZP67, Q6ZU20	Gene names	C18orf34
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34.

MRCKB_MOUSE
NC score	0.061070 (rank : 4)	θ value	2.44474e-05 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	2180	Shared Neighborhood Hits	16
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MRCKB_HUMAN
NC score	0.060036 (rank : 5)	θ value	3.19293e-05 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	2239	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MINK1_MOUSE
NC score	0.058762 (rank : 6)	θ value	0.00390308 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	1451	Shared Neighborhood Hits	15
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_HUMAN
NC score	0.058464 (rank : 7)	θ value	0.00390308 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	1477	Shared Neighborhood Hits	15
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

TNIK_HUMAN
NC score	0.056681 (rank : 8)	θ value	0.00102713 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	1570	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

M4K4_MOUSE
NC score	0.056574 (rank : 9)	θ value	0.00665767 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	1560	Shared Neighborhood Hits	13
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

M4K4_HUMAN
NC score	0.055403 (rank : 10)	θ value	0.00509761 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	1589	Shared Neighborhood Hits	14
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MRCKA_HUMAN
NC score	0.051478 (rank : 11)	θ value	0.0148317 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	1999	Shared Neighborhood Hits	15
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

TRAF5_HUMAN
NC score	0.045311 (rank : 12)	θ value	0.21417 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	396	Shared Neighborhood Hits	7
SwissProt Accessions	O00463	Gene names	TRAF5, RNF84
Domain Architecture
Description	TNF receptor-associated factor 5 (RING finger protein 84).

MRCKG_MOUSE
NC score	0.040032 (rank : 13)	θ value	6.88961 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	1466	Shared Neighborhood Hits	15
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

CTRO_MOUSE
NC score	0.031865 (rank : 14)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	2344	Shared Neighborhood Hits	16
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CCD39_HUMAN
NC score	0.025171 (rank : 15)	θ value	6.88961 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	868	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

SHOC2_MOUSE
NC score	0.024112 (rank : 16)	θ value	1.38821 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	308	Shared Neighborhood Hits	5
SwissProt Accessions	O88520, Q3UJH6, Q8BVL0	Gene names	Shoc2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat protein SHOC-2 (Ras-binding protein Sur-8).

SHOC2_HUMAN
NC score	0.023054 (rank : 17)	θ value	1.81305 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	330	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UQ13, O76063	Gene names	SHOC2, KIAA0862
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat protein SHOC-2 (Ras-binding protein Sur-8).

SM1L2_MOUSE
NC score	0.022890 (rank : 18)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	918	Shared Neighborhood Hits	16
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

DCP2_MOUSE
NC score	0.022774 (rank : 19)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CYC6	Gene names	Dcp2
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 2 (EC 3.-.-.-).

NU133_HUMAN
NC score	0.017119 (rank : 20)	θ value	6.88961 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WUM0, Q9H9W2, Q9NV71, Q9NVC4	Gene names	NUP133
Domain Architecture
Description	Nuclear pore complex protein Nup133 (Nucleoporin Nup133) (133 kDa nucleoporin).

TLR12_MOUSE
NC score	0.014882 (rank : 21)	θ value	3.0926 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	268	Shared Neighborhood Hits	4
SwissProt Accessions	Q6QNU9	Gene names	Tlr12
Domain Architecture	No domain graphic available
Description	Toll-like receptor 12 precursor.