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Network neighborhood for query Sequence : TRADD_HUMAN

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TRADD_HUMAN
SwissProt Accessions	Q15628	Gene names	TRADD
Domain Architecture
Description	Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TRADD_HUMAN
θ value	3.62588e-142 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	7	Target Neighborhood Hits	7	Shared Neighborhood Hits	7
SwissProt Accessions	Q15628	Gene names	TRADD
Domain Architecture
Description	Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain).

RIPK1_HUMAN
θ value	0.00020696 (rank : 2)	NC score	0.060255 (rank : 5)
Query Neighborhood Hits	7	Target Neighborhood Hits	891	Shared Neighborhood Hits	5
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK1_MOUSE
θ value	0.00020696 (rank : 3)	NC score	0.062198 (rank : 4)
Query Neighborhood Hits	7	Target Neighborhood Hits	874	Shared Neighborhood Hits	5
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

THOC1_MOUSE
θ value	0.00509761 (rank : 4)	NC score	0.243353 (rank : 2)
Query Neighborhood Hits	7	Target Neighborhood Hits	30	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R3N6, Q8BWD5, Q8BXY3	Gene names	Thoc1
Domain Architecture
Description	THO complex subunit 1 (Tho1) (Nuclear matrix protein p84).

THOC1_HUMAN
θ value	0.0193708 (rank : 5)	NC score	0.233279 (rank : 3)
Query Neighborhood Hits	7	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q96FV9, Q15219	Gene names	THOC1, HPR1
Domain Architecture
Description	THO complex subunit 1 (Tho1) (Nuclear matrix protein p84).

MLL4_HUMAN
θ value	3.0926 (rank : 6)	NC score	0.024802 (rank : 7)
Query Neighborhood Hits	7	Target Neighborhood Hits	722	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

CAH3_HUMAN
θ value	4.03905 (rank : 7)	NC score	0.015682 (rank : 8)
Query Neighborhood Hits	7	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	P07451, O60842	Gene names	CA3
Domain Architecture
Description	Carbonic anhydrase 3 (EC 4.2.1.1) (Carbonic anhydrase III) (Carbonate dehydratase III) (CA-III).

FADD_MOUSE
θ value	θ > 10 (rank : 8)	NC score	0.051117 (rank : 6)
Query Neighborhood Hits	7	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	Q61160, Q3TC37, Q61082	Gene names	Fadd, Mort1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

Hits sorted by NC score

TRADD_HUMAN
NC score	0.999962 (rank : 1)	θ value	3.62588e-142 (rank : 1)
Query Neighborhood Hits	7	Target Neighborhood Hits	7	Shared Neighborhood Hits	7
SwissProt Accessions	Q15628	Gene names	TRADD
Domain Architecture
Description	Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain).

THOC1_MOUSE
NC score	0.243353 (rank : 2)	θ value	0.00509761 (rank : 4)
Query Neighborhood Hits	7	Target Neighborhood Hits	30	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R3N6, Q8BWD5, Q8BXY3	Gene names	Thoc1
Domain Architecture
Description	THO complex subunit 1 (Tho1) (Nuclear matrix protein p84).

THOC1_HUMAN
NC score	0.233279 (rank : 3)	θ value	0.0193708 (rank : 5)
Query Neighborhood Hits	7	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q96FV9, Q15219	Gene names	THOC1, HPR1
Domain Architecture
Description	THO complex subunit 1 (Tho1) (Nuclear matrix protein p84).

RIPK1_MOUSE
NC score	0.062198 (rank : 4)	θ value	0.00020696 (rank : 3)
Query Neighborhood Hits	7	Target Neighborhood Hits	874	Shared Neighborhood Hits	5
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RIPK1_HUMAN
NC score	0.060255 (rank : 5)	θ value	0.00020696 (rank : 2)
Query Neighborhood Hits	7	Target Neighborhood Hits	891	Shared Neighborhood Hits	5
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

FADD_MOUSE
NC score	0.051117 (rank : 6)	θ value	θ > 10 (rank : 8)
Query Neighborhood Hits	7	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	Q61160, Q3TC37, Q61082	Gene names	Fadd, Mort1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

MLL4_HUMAN
NC score	0.024802 (rank : 7)	θ value	3.0926 (rank : 6)
Query Neighborhood Hits	7	Target Neighborhood Hits	722	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

CAH3_HUMAN
NC score	0.015682 (rank : 8)	θ value	4.03905 (rank : 7)
Query Neighborhood Hits	7	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	P07451, O60842	Gene names	CA3
Domain Architecture
Description	Carbonic anhydrase 3 (EC 4.2.1.1) (Carbonic anhydrase III) (Carbonate dehydratase III) (CA-III).