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Network neighborhood for query Sequence : SPSY_HUMAN

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SPSY_HUMAN
SwissProt Accessions	P52788, O00544, Q9UQS1	Gene names	SMS
Domain Architecture
Description	Spermine synthase (EC 2.5.1.22) (Spermidine aminopropyltransferase) (SPMSY).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SPSY_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	11	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	P52788, O00544, Q9UQS1	Gene names	SMS
Domain Architecture
Description	Spermine synthase (EC 2.5.1.22) (Spermidine aminopropyltransferase) (SPMSY).

SPSY_MOUSE
θ value	0 (rank : 2)	NC score	0.997273 (rank : 2)
Query Neighborhood Hits	11	Target Neighborhood Hits	13	Shared Neighborhood Hits	9
SwissProt Accessions	P97355, Q3TL65	Gene names	Sms
Domain Architecture
Description	Spermine synthase (EC 2.5.1.22) (Spermidine aminopropyltransferase) (SPMSY).

SPEE_MOUSE
θ value	7.59969e-07 (rank : 3)	NC score	0.393173 (rank : 3)
Query Neighborhood Hits	11	Target Neighborhood Hits	5	Shared Neighborhood Hits	4
SwissProt Accessions	Q64674	Gene names	Srm
Domain Architecture
Description	Spermidine synthase (EC 2.5.1.16) (Putrescine aminopropyltransferase) (SPDSY).

SPEE_HUMAN
θ value	9.92553e-07 (rank : 4)	NC score	0.391194 (rank : 4)
Query Neighborhood Hits	11	Target Neighborhood Hits	4	Shared Neighborhood Hits	4
SwissProt Accessions	P19623, Q15511	Gene names	SRM, SPS1
Domain Architecture
Description	Spermidine synthase (EC 2.5.1.16) (Putrescine aminopropyltransferase) (SPDSY).

EVPL_HUMAN
θ value	0.279714 (rank : 5)	NC score	0.037615 (rank : 5)
Query Neighborhood Hits	11	Target Neighborhood Hits	895	Shared Neighborhood Hits	6
SwissProt Accessions	Q92817	Gene names	EVPL
Domain Architecture
Description	Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) (210 kDa cornified envelope precursor protein).

EVPL_MOUSE
θ value	2.36792 (rank : 6)	NC score	0.028216 (rank : 7)
Query Neighborhood Hits	11	Target Neighborhood Hits	952	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

ECM29_MOUSE
θ value	5.27518 (rank : 7)	NC score	0.029298 (rank : 6)
Query Neighborhood Hits	11	Target Neighborhood Hits	65	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PDI5, Q6ZQC9, Q8BSW7, Q8CAH0, Q8R3M6	Gene names	Ecm29, Kiaa0368
Domain Architecture	No domain graphic available
Description	Proteasome-associated protein ECM29 homolog (Ecm29).

PITM1_HUMAN
θ value	6.88961 (rank : 8)	NC score	0.020759 (rank : 9)
Query Neighborhood Hits	11	Target Neighborhood Hits	129	Shared Neighborhood Hits	4
SwissProt Accessions	O00562, Q6T7X3, Q8TBN3, Q9BZ73	Gene names	PITPNM1, DRES9, NIR2, PITPNM
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 1 (Phosphatidylinositol transfer protein, membrane-associated 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) (Drosophila retinal degeneration B homolog).

PITM1_MOUSE
θ value	6.88961 (rank : 9)	NC score	0.020602 (rank : 10)
Query Neighborhood Hits	11	Target Neighborhood Hits	69	Shared Neighborhood Hits	4
SwissProt Accessions	O35954	Gene names	Pitpnm1, Dres9, Mpt1, Nir2, Pitpnm
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 1 (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Mpt-1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) (Drosophila retinal degeneration B homolog 1) (RdgB1).

DDX28_MOUSE
θ value	8.99809 (rank : 10)	NC score	0.010325 (rank : 11)
Query Neighborhood Hits	11	Target Neighborhood Hits	112	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CWT6, Q3TQM0	Gene names	Ddx28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

ECM29_HUMAN
θ value	8.99809 (rank : 11)	NC score	0.026771 (rank : 8)
Query Neighborhood Hits	11	Target Neighborhood Hits	46	Shared Neighborhood Hits	4
SwissProt Accessions	Q5VYK3, O15074, Q8WU82	Gene names	ECM29, KIAA0368
Domain Architecture	No domain graphic available
Description	Proteasome-associated protein ECM29 homolog (Ecm29).

Hits sorted by NC score

SPSY_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	11	Target Neighborhood Hits	11	Shared Neighborhood Hits	11
SwissProt Accessions	P52788, O00544, Q9UQS1	Gene names	SMS
Domain Architecture
Description	Spermine synthase (EC 2.5.1.22) (Spermidine aminopropyltransferase) (SPMSY).

SPSY_MOUSE
NC score	0.997273 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	11	Target Neighborhood Hits	13	Shared Neighborhood Hits	9
SwissProt Accessions	P97355, Q3TL65	Gene names	Sms
Domain Architecture
Description	Spermine synthase (EC 2.5.1.22) (Spermidine aminopropyltransferase) (SPMSY).

SPEE_MOUSE
NC score	0.393173 (rank : 3)	θ value	7.59969e-07 (rank : 3)
Query Neighborhood Hits	11	Target Neighborhood Hits	5	Shared Neighborhood Hits	4
SwissProt Accessions	Q64674	Gene names	Srm
Domain Architecture
Description	Spermidine synthase (EC 2.5.1.16) (Putrescine aminopropyltransferase) (SPDSY).

SPEE_HUMAN
NC score	0.391194 (rank : 4)	θ value	9.92553e-07 (rank : 4)
Query Neighborhood Hits	11	Target Neighborhood Hits	4	Shared Neighborhood Hits	4
SwissProt Accessions	P19623, Q15511	Gene names	SRM, SPS1
Domain Architecture
Description	Spermidine synthase (EC 2.5.1.16) (Putrescine aminopropyltransferase) (SPDSY).

EVPL_HUMAN
NC score	0.037615 (rank : 5)	θ value	0.279714 (rank : 5)
Query Neighborhood Hits	11	Target Neighborhood Hits	895	Shared Neighborhood Hits	6
SwissProt Accessions	Q92817	Gene names	EVPL
Domain Architecture
Description	Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) (210 kDa cornified envelope precursor protein).

ECM29_MOUSE
NC score	0.029298 (rank : 6)	θ value	5.27518 (rank : 7)
Query Neighborhood Hits	11	Target Neighborhood Hits	65	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PDI5, Q6ZQC9, Q8BSW7, Q8CAH0, Q8R3M6	Gene names	Ecm29, Kiaa0368
Domain Architecture	No domain graphic available
Description	Proteasome-associated protein ECM29 homolog (Ecm29).

EVPL_MOUSE
NC score	0.028216 (rank : 7)	θ value	2.36792 (rank : 6)
Query Neighborhood Hits	11	Target Neighborhood Hits	952	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

ECM29_HUMAN
NC score	0.026771 (rank : 8)	θ value	8.99809 (rank : 11)
Query Neighborhood Hits	11	Target Neighborhood Hits	46	Shared Neighborhood Hits	4
SwissProt Accessions	Q5VYK3, O15074, Q8WU82	Gene names	ECM29, KIAA0368
Domain Architecture	No domain graphic available
Description	Proteasome-associated protein ECM29 homolog (Ecm29).

PITM1_HUMAN
NC score	0.020759 (rank : 9)	θ value	6.88961 (rank : 8)
Query Neighborhood Hits	11	Target Neighborhood Hits	129	Shared Neighborhood Hits	4
SwissProt Accessions	O00562, Q6T7X3, Q8TBN3, Q9BZ73	Gene names	PITPNM1, DRES9, NIR2, PITPNM
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 1 (Phosphatidylinositol transfer protein, membrane-associated 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) (Drosophila retinal degeneration B homolog).

PITM1_MOUSE
NC score	0.020602 (rank : 10)	θ value	6.88961 (rank : 9)
Query Neighborhood Hits	11	Target Neighborhood Hits	69	Shared Neighborhood Hits	4
SwissProt Accessions	O35954	Gene names	Pitpnm1, Dres9, Mpt1, Nir2, Pitpnm
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 1 (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Mpt-1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) (Drosophila retinal degeneration B homolog 1) (RdgB1).

DDX28_MOUSE
NC score	0.010325 (rank : 11)	θ value	8.99809 (rank : 10)
Query Neighborhood Hits	11	Target Neighborhood Hits	112	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CWT6, Q3TQM0	Gene names	Ddx28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).