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Network neighborhood for query Sequence : PSN2_MOUSE

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PSN2_MOUSE
SwissProt Accessions	Q61144, O54977, P97934, P97935, Q91VS3, Q9D616	Gene names	Psen2, Ad4h, Alg3, Ps-2, Psnl2
Domain Architecture
Description	Presenilin-2 (EC 3.4.23.-) (PS-2) [Contains: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PSN2_HUMAN
θ value	0 (rank : 1)	NC score	0.996671 (rank : 2)
Query Neighborhood Hits	29	Target Neighborhood Hits	29	Shared Neighborhood Hits	16
SwissProt Accessions	P49810, Q96P32	Gene names	PSEN2, AD4, PS2, PSNL2, STM2
Domain Architecture
Description	Presenilin-2 (EC 3.4.23.-) (PS-2) (STM-2) (E5-1) (AD3LP) (AD5) [Contains: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit].

PSN2_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	29	Target Neighborhood Hits	29	Shared Neighborhood Hits	29
SwissProt Accessions	Q61144, O54977, P97934, P97935, Q91VS3, Q9D616	Gene names	Psen2, Ad4h, Alg3, Ps-2, Psnl2
Domain Architecture
Description	Presenilin-2 (EC 3.4.23.-) (PS-2) [Contains: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit].

PSN1_MOUSE
θ value	3.64273e-126 (rank : 3)	NC score	0.978301 (rank : 3)
Query Neighborhood Hits	29	Target Neighborhood Hits	22	Shared Neighborhood Hits	8
SwissProt Accessions	P49769, Q91WK6, Q9JLP9	Gene names	Psen1, Ad3h, Psnl1
Domain Architecture
Description	Presenilin-1 (EC 3.4.23.-) (PS-1) (Protein S182) [Contains: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)].

PSN1_HUMAN
θ value	1.05987e-125 (rank : 4)	NC score	0.977730 (rank : 4)
Query Neighborhood Hits	29	Target Neighborhood Hits	24	Shared Neighborhood Hits	7
SwissProt Accessions	P49768, O95465, Q14762, Q15719, Q15720, Q96P33, Q9UIF0	Gene names	PSEN1, AD3, PS1, PSNL1
Domain Architecture
Description	Presenilin-1 (EC 3.4.23.-) (PS-1) (Protein S182) [Contains: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)].

HM13_MOUSE
θ value	0.0563607 (rank : 5)	NC score	0.123479 (rank : 5)
Query Neighborhood Hits	29	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D8V0, O19444, Q542R3, Q811Z6, Q9CQA4, Q9CSK9	Gene names	Hm13, H13, Psl3
Domain Architecture
Description	Minor histocompatibility antigen H13 (EC 3.4.99.-) (Signal peptide peptidase) (Presenilin-like protein 3).

HM13_HUMAN
θ value	0.125558 (rank : 6)	NC score	0.113436 (rank : 6)
Query Neighborhood Hits	29	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TCT9, Q540H8, Q5JWP2, Q5JWP3, Q5JWP4, Q5JWP5, Q7Z4F2, Q86Y35, Q95H87, Q9H110, Q9H111	Gene names	HM13, H13, IMP1, PSL3, SPP
Domain Architecture
Description	Minor histocompatibility antigen H13 (EC 3.4.99.-) (Signal peptide peptidase) (Presenilin-like protein 3) (hIMP1 protein).

TR135_MOUSE
θ value	0.125558 (rank : 7)	NC score	0.063489 (rank : 10)
Query Neighborhood Hits	29	Target Neighborhood Hits	78	Shared Neighborhood Hits	5
SwissProt Accessions	Q7TQA9, Q7M705	Gene names	Tas2r135, T2r38, Tas2r35
Domain Architecture
Description	Taste receptor type 2 member 135 (T2R135) (Taste receptor type 2 member 35) (T2R35) (mT2r38).

APBB1_MOUSE
θ value	0.163984 (rank : 8)	NC score	0.071493 (rank : 8)
Query Neighborhood Hits	29	Target Neighborhood Hits	75	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QXJ1, O08642, Q3TPU0, Q8BNF4, Q8BSR9	Gene names	Apbb1, Fe65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

AP3B1_HUMAN
θ value	0.21417 (rank : 9)	NC score	0.031562 (rank : 19)
Query Neighborhood Hits	29	Target Neighborhood Hits	283	Shared Neighborhood Hits	4
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

CHIC1_HUMAN
θ value	0.21417 (rank : 10)	NC score	0.074832 (rank : 7)
Query Neighborhood Hits	29	Target Neighborhood Hits	48	Shared Neighborhood Hits	4
SwissProt Accessions	Q5VXU3	Gene names	CHIC1, BRX
Domain Architecture	No domain graphic available
Description	Cysteine-rich hydrophobic domain 1 protein (Brain X-linked protein).

SCN3A_HUMAN
θ value	0.21417 (rank : 11)	NC score	0.041427 (rank : 12)
Query Neighborhood Hits	29	Target Neighborhood Hits	115	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

APBB1_HUMAN
θ value	0.279714 (rank : 12)	NC score	0.068050 (rank : 9)
Query Neighborhood Hits	29	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	O00213, Q96A93	Gene names	APBB1, FE65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

SCN2A_HUMAN
θ value	1.38821 (rank : 13)	NC score	0.036269 (rank : 13)
Query Neighborhood Hits	29	Target Neighborhood Hits	157	Shared Neighborhood Hits	8
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

CHIC1_MOUSE
θ value	1.81305 (rank : 14)	NC score	0.060507 (rank : 11)
Query Neighborhood Hits	29	Target Neighborhood Hits	50	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CBW7, O08904, Q8K3S5	Gene names	Chic1, Brx
Domain Architecture	No domain graphic available
Description	Cysteine-rich hydrophobic domain 1 protein (Brain X-linked protein).

SCN1A_HUMAN
θ value	3.0926 (rank : 15)	NC score	0.033352 (rank : 16)
Query Neighborhood Hits	29	Target Neighborhood Hits	148	Shared Neighborhood Hits	7
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SCN9A_HUMAN
θ value	3.0926 (rank : 16)	NC score	0.033432 (rank : 15)
Query Neighborhood Hits	29	Target Neighborhood Hits	157	Shared Neighborhood Hits	7
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

KCNA6_MOUSE
θ value	4.03905 (rank : 17)	NC score	0.008731 (rank : 24)
Query Neighborhood Hits	29	Target Neighborhood Hits	106	Shared Neighborhood Hits	3
SwissProt Accessions	Q61923	Gene names	Kcna6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (MK1.6).

TERF1_HUMAN
θ value	4.03905 (rank : 18)	NC score	0.034549 (rank : 14)
Query Neighborhood Hits	29	Target Neighborhood Hits	83	Shared Neighborhood Hits	3
SwissProt Accessions	P54274, Q15553, Q93029	Gene names	TERF1, PIN2, TRF, TRF1
Domain Architecture
Description	Telomeric repeat-binding factor 1 (TTAGGG repeat-binding factor 1) (NIMA-interacting protein 2) (Telomeric protein Pin2/TRF1).

DDX4_HUMAN
θ value	5.27518 (rank : 19)	NC score	0.004880 (rank : 28)
Query Neighborhood Hits	29	Target Neighborhood Hits	123	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NQI0, Q86VX0, Q9NT92, Q9NYB1	Gene names	DDX4, VASA
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog).

DYR_MOUSE
θ value	5.27518 (rank : 20)	NC score	0.023196 (rank : 20)
Query Neighborhood Hits	29	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	P00375, P70693, Q61485, Q61487, Q61579	Gene names	Dhfr
Domain Architecture
Description	Dihydrofolate reductase (EC 1.5.1.3).

SCN8A_HUMAN
θ value	5.27518 (rank : 21)	NC score	0.032172 (rank : 18)
Query Neighborhood Hits	29	Target Neighborhood Hits	135	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN8A_MOUSE
θ value	5.27518 (rank : 22)	NC score	0.032571 (rank : 17)
Query Neighborhood Hits	29	Target Neighborhood Hits	136	Shared Neighborhood Hits	7
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

WDR22_MOUSE
θ value	5.27518 (rank : 23)	NC score	0.009543 (rank : 23)
Query Neighborhood Hits	29	Target Neighborhood Hits	302	Shared Neighborhood Hits	2
SwissProt Accessions	Q80T85, Q80VT3, Q80ZW6, Q8BIP8, Q8BVK5, Q8K0Q6	Gene names	Wdr22, Kiaa1824
Domain Architecture
Description	WD repeat protein 22.

FOXM1_HUMAN
θ value	6.88961 (rank : 24)	NC score	0.014161 (rank : 22)
Query Neighborhood Hits	29	Target Neighborhood Hits	167	Shared Neighborhood Hits	3
SwissProt Accessions	Q08050, O43258, O43259, O43260, Q4ZGG7, Q9BRL2	Gene names	FOXM1, FKHL16, HFH11, MPP2, WIN
Domain Architecture
Description	Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HNF-3/fork-head homolog 11) (HFH-11) (Winged helix factor from INS-1 cells) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident).

TLR1_HUMAN
θ value	6.88961 (rank : 25)	NC score	0.005477 (rank : 27)
Query Neighborhood Hits	29	Target Neighborhood Hits	280	Shared Neighborhood Hits	2
SwissProt Accessions	Q15399, O15452, Q9UG90	Gene names	TLR1, KIAA0012
Domain Architecture
Description	Toll-like receptor 1 precursor (Toll/interleukin-1 receptor-like protein) (TIL) (CD281 antigen).

AN32E_HUMAN
θ value	8.99809 (rank : 26)	NC score	0.006125 (rank : 26)
Query Neighborhood Hits	29	Target Neighborhood Hits	291	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BTT0, Q8N1S4, Q8WWW9	Gene names	ANP32E
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member E (LANP- like protein) (LANP-L).

CD2L2_HUMAN
θ value	8.99809 (rank : 27)	NC score	-0.000867 (rank : 29)
Query Neighborhood Hits	29	Target Neighborhood Hits	1439	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

DYR_HUMAN
θ value	8.99809 (rank : 28)	NC score	0.019819 (rank : 21)
Query Neighborhood Hits	29	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	P00374, Q14130, Q6IRW8	Gene names	DHFR
Domain Architecture
Description	Dihydrofolate reductase (EC 1.5.1.3).

G3BP2_MOUSE
θ value	8.99809 (rank : 29)	NC score	0.007260 (rank : 25)
Query Neighborhood Hits	29	Target Neighborhood Hits	258	Shared Neighborhood Hits	2
SwissProt Accessions	P97379, Q9R1B8	Gene names	G3bp2
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 2 (GAP SH3-domain- binding protein 2) (G3BP-2).

Hits sorted by NC score

PSN2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	29	Target Neighborhood Hits	29	Shared Neighborhood Hits	29
SwissProt Accessions	Q61144, O54977, P97934, P97935, Q91VS3, Q9D616	Gene names	Psen2, Ad4h, Alg3, Ps-2, Psnl2
Domain Architecture
Description	Presenilin-2 (EC 3.4.23.-) (PS-2) [Contains: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit].

PSN2_HUMAN
NC score	0.996671 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	29	Target Neighborhood Hits	29	Shared Neighborhood Hits	16
SwissProt Accessions	P49810, Q96P32	Gene names	PSEN2, AD4, PS2, PSNL2, STM2
Domain Architecture
Description	Presenilin-2 (EC 3.4.23.-) (PS-2) (STM-2) (E5-1) (AD3LP) (AD5) [Contains: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit].

PSN1_MOUSE
NC score	0.978301 (rank : 3)	θ value	3.64273e-126 (rank : 3)
Query Neighborhood Hits	29	Target Neighborhood Hits	22	Shared Neighborhood Hits	8
SwissProt Accessions	P49769, Q91WK6, Q9JLP9	Gene names	Psen1, Ad3h, Psnl1
Domain Architecture
Description	Presenilin-1 (EC 3.4.23.-) (PS-1) (Protein S182) [Contains: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)].

PSN1_HUMAN
NC score	0.977730 (rank : 4)	θ value	1.05987e-125 (rank : 4)
Query Neighborhood Hits	29	Target Neighborhood Hits	24	Shared Neighborhood Hits	7
SwissProt Accessions	P49768, O95465, Q14762, Q15719, Q15720, Q96P33, Q9UIF0	Gene names	PSEN1, AD3, PS1, PSNL1
Domain Architecture
Description	Presenilin-1 (EC 3.4.23.-) (PS-1) (Protein S182) [Contains: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)].

HM13_MOUSE
NC score	0.123479 (rank : 5)	θ value	0.0563607 (rank : 5)
Query Neighborhood Hits	29	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D8V0, O19444, Q542R3, Q811Z6, Q9CQA4, Q9CSK9	Gene names	Hm13, H13, Psl3
Domain Architecture
Description	Minor histocompatibility antigen H13 (EC 3.4.99.-) (Signal peptide peptidase) (Presenilin-like protein 3).

HM13_HUMAN
NC score	0.113436 (rank : 6)	θ value	0.125558 (rank : 6)
Query Neighborhood Hits	29	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TCT9, Q540H8, Q5JWP2, Q5JWP3, Q5JWP4, Q5JWP5, Q7Z4F2, Q86Y35, Q95H87, Q9H110, Q9H111	Gene names	HM13, H13, IMP1, PSL3, SPP
Domain Architecture
Description	Minor histocompatibility antigen H13 (EC 3.4.99.-) (Signal peptide peptidase) (Presenilin-like protein 3) (hIMP1 protein).

CHIC1_HUMAN
NC score	0.074832 (rank : 7)	θ value	0.21417 (rank : 10)
Query Neighborhood Hits	29	Target Neighborhood Hits	48	Shared Neighborhood Hits	4
SwissProt Accessions	Q5VXU3	Gene names	CHIC1, BRX
Domain Architecture	No domain graphic available
Description	Cysteine-rich hydrophobic domain 1 protein (Brain X-linked protein).

APBB1_MOUSE
NC score	0.071493 (rank : 8)	θ value	0.163984 (rank : 8)
Query Neighborhood Hits	29	Target Neighborhood Hits	75	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QXJ1, O08642, Q3TPU0, Q8BNF4, Q8BSR9	Gene names	Apbb1, Fe65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

APBB1_HUMAN
NC score	0.068050 (rank : 9)	θ value	0.279714 (rank : 12)
Query Neighborhood Hits	29	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	O00213, Q96A93	Gene names	APBB1, FE65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

TR135_MOUSE
NC score	0.063489 (rank : 10)	θ value	0.125558 (rank : 7)
Query Neighborhood Hits	29	Target Neighborhood Hits	78	Shared Neighborhood Hits	5
SwissProt Accessions	Q7TQA9, Q7M705	Gene names	Tas2r135, T2r38, Tas2r35
Domain Architecture
Description	Taste receptor type 2 member 135 (T2R135) (Taste receptor type 2 member 35) (T2R35) (mT2r38).

CHIC1_MOUSE
NC score	0.060507 (rank : 11)	θ value	1.81305 (rank : 14)
Query Neighborhood Hits	29	Target Neighborhood Hits	50	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CBW7, O08904, Q8K3S5	Gene names	Chic1, Brx
Domain Architecture	No domain graphic available
Description	Cysteine-rich hydrophobic domain 1 protein (Brain X-linked protein).

SCN3A_HUMAN
NC score	0.041427 (rank : 12)	θ value	0.21417 (rank : 11)
Query Neighborhood Hits	29	Target Neighborhood Hits	115	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

SCN2A_HUMAN
NC score	0.036269 (rank : 13)	θ value	1.38821 (rank : 13)
Query Neighborhood Hits	29	Target Neighborhood Hits	157	Shared Neighborhood Hits	8
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

TERF1_HUMAN
NC score	0.034549 (rank : 14)	θ value	4.03905 (rank : 18)
Query Neighborhood Hits	29	Target Neighborhood Hits	83	Shared Neighborhood Hits	3
SwissProt Accessions	P54274, Q15553, Q93029	Gene names	TERF1, PIN2, TRF, TRF1
Domain Architecture
Description	Telomeric repeat-binding factor 1 (TTAGGG repeat-binding factor 1) (NIMA-interacting protein 2) (Telomeric protein Pin2/TRF1).

SCN9A_HUMAN
NC score	0.033432 (rank : 15)	θ value	3.0926 (rank : 16)
Query Neighborhood Hits	29	Target Neighborhood Hits	157	Shared Neighborhood Hits	7
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

SCN1A_HUMAN
NC score	0.033352 (rank : 16)	θ value	3.0926 (rank : 15)
Query Neighborhood Hits	29	Target Neighborhood Hits	148	Shared Neighborhood Hits	7
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SCN8A_MOUSE
NC score	0.032571 (rank : 17)	θ value	5.27518 (rank : 22)
Query Neighborhood Hits	29	Target Neighborhood Hits	136	Shared Neighborhood Hits	7
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN8A_HUMAN
NC score	0.032172 (rank : 18)	θ value	5.27518 (rank : 21)
Query Neighborhood Hits	29	Target Neighborhood Hits	135	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

AP3B1_HUMAN
NC score	0.031562 (rank : 19)	θ value	0.21417 (rank : 9)
Query Neighborhood Hits	29	Target Neighborhood Hits	283	Shared Neighborhood Hits	4
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

DYR_MOUSE
NC score	0.023196 (rank : 20)	θ value	5.27518 (rank : 20)
Query Neighborhood Hits	29	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	P00375, P70693, Q61485, Q61487, Q61579	Gene names	Dhfr
Domain Architecture
Description	Dihydrofolate reductase (EC 1.5.1.3).

DYR_HUMAN
NC score	0.019819 (rank : 21)	θ value	8.99809 (rank : 28)
Query Neighborhood Hits	29	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	P00374, Q14130, Q6IRW8	Gene names	DHFR
Domain Architecture
Description	Dihydrofolate reductase (EC 1.5.1.3).

FOXM1_HUMAN
NC score	0.014161 (rank : 22)	θ value	6.88961 (rank : 24)
Query Neighborhood Hits	29	Target Neighborhood Hits	167	Shared Neighborhood Hits	3
SwissProt Accessions	Q08050, O43258, O43259, O43260, Q4ZGG7, Q9BRL2	Gene names	FOXM1, FKHL16, HFH11, MPP2, WIN
Domain Architecture
Description	Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HNF-3/fork-head homolog 11) (HFH-11) (Winged helix factor from INS-1 cells) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident).

WDR22_MOUSE
NC score	0.009543 (rank : 23)	θ value	5.27518 (rank : 23)
Query Neighborhood Hits	29	Target Neighborhood Hits	302	Shared Neighborhood Hits	2
SwissProt Accessions	Q80T85, Q80VT3, Q80ZW6, Q8BIP8, Q8BVK5, Q8K0Q6	Gene names	Wdr22, Kiaa1824
Domain Architecture
Description	WD repeat protein 22.

KCNA6_MOUSE
NC score	0.008731 (rank : 24)	θ value	4.03905 (rank : 17)
Query Neighborhood Hits	29	Target Neighborhood Hits	106	Shared Neighborhood Hits	3
SwissProt Accessions	Q61923	Gene names	Kcna6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (MK1.6).

G3BP2_MOUSE
NC score	0.007260 (rank : 25)	θ value	8.99809 (rank : 29)
Query Neighborhood Hits	29	Target Neighborhood Hits	258	Shared Neighborhood Hits	2
SwissProt Accessions	P97379, Q9R1B8	Gene names	G3bp2
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 2 (GAP SH3-domain- binding protein 2) (G3BP-2).

AN32E_HUMAN
NC score	0.006125 (rank : 26)	θ value	8.99809 (rank : 26)
Query Neighborhood Hits	29	Target Neighborhood Hits	291	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BTT0, Q8N1S4, Q8WWW9	Gene names	ANP32E
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member E (LANP- like protein) (LANP-L).

TLR1_HUMAN
NC score	0.005477 (rank : 27)	θ value	6.88961 (rank : 25)
Query Neighborhood Hits	29	Target Neighborhood Hits	280	Shared Neighborhood Hits	2
SwissProt Accessions	Q15399, O15452, Q9UG90	Gene names	TLR1, KIAA0012
Domain Architecture
Description	Toll-like receptor 1 precursor (Toll/interleukin-1 receptor-like protein) (TIL) (CD281 antigen).

DDX4_HUMAN
NC score	0.004880 (rank : 28)	θ value	5.27518 (rank : 19)
Query Neighborhood Hits	29	Target Neighborhood Hits	123	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NQI0, Q86VX0, Q9NT92, Q9NYB1	Gene names	DDX4, VASA
Domain Architecture
Description	Probable ATP-dependent RNA helicase DDX4 (EC 3.6.1.-) (DEAD box protein 4) (VASA homolog).

CD2L2_HUMAN
NC score	-0.000867 (rank : 29)	θ value	8.99809 (rank : 27)
Query Neighborhood Hits	29	Target Neighborhood Hits	1439	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).