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Network neighborhood for query Sequence : IZUM1_HUMAN

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IZUM1_HUMAN
SwissProt Accessions	Q8IYV9, Q6Q8P6, Q6Q8P7	Gene names	IZUMO1
Domain Architecture	No domain graphic available
Description	Izumo sperm-egg fusion protein 1 precursor (Sperm-specific protein izumo).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

IZUM1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IYV9, Q6Q8P6, Q6Q8P7	Gene names	IZUMO1
Domain Architecture	No domain graphic available
Description	Izumo sperm-egg fusion protein 1 precursor (Sperm-specific protein izumo).

IZUM1_MOUSE
θ value	1.88829e-90 (rank : 2)	NC score	0.945207 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	41	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D9J7	Gene names	Izumo1
Domain Architecture	No domain graphic available
Description	Izumo sperm-egg fusion protein 1 precursor (Sperm-specific protein izumo).

OBSCN_HUMAN
θ value	0.0563607 (rank : 3)	NC score	0.033106 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	1931	Shared Neighborhood Hits	17
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

TITIN_HUMAN
θ value	0.279714 (rank : 4)	NC score	0.034521 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	2923	Shared Neighborhood Hits	17
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

CD22_HUMAN
θ value	0.62314 (rank : 5)	NC score	0.064618 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	365	Shared Neighborhood Hits	16
SwissProt Accessions	P20273, O95699, O95701, O95702, O95703, Q01665, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6	Gene names	CD22
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

AMGO1_HUMAN
θ value	1.81305 (rank : 6)	NC score	0.025318 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	353	Shared Neighborhood Hits	7
SwissProt Accessions	Q86WK6, Q8IW71, Q9ULQ7	Gene names	AMIGO1, ALI2, AMIGO, KIAA1163
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 1 precursor (AMIGO-1) (Alivin-2).

KIRR2_HUMAN
θ value	1.81305 (rank : 7)	NC score	0.041222 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	321	Shared Neighborhood Hits	14
SwissProt Accessions	Q6UWL6, Q6P1R1, Q7Z5P1, Q7Z5P2, Q96IQ8, Q9H0T1	Gene names	KIRREL2, NEPH3
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3).

MYPC3_HUMAN
θ value	1.81305 (rank : 8)	NC score	0.042261 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	318	Shared Neighborhood Hits	13
SwissProt Accessions	Q14896, Q16410, Q6R2F7, Q9UE27, Q9UM53	Gene names	MYBPC3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

ICAM5_MOUSE
θ value	2.36792 (rank : 9)	NC score	0.039995 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	308	Shared Neighborhood Hits	14
SwissProt Accessions	Q60625	Gene names	Icam5, Tlcn
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

ATS20_MOUSE
θ value	3.0926 (rank : 10)	NC score	0.011288 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	225	Shared Neighborhood Hits	4
SwissProt Accessions	P59511	Gene names	Adamts20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

CD22_MOUSE
θ value	4.03905 (rank : 11)	NC score	0.056414 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	331	Shared Neighborhood Hits	14
SwissProt Accessions	P35329, Q9JHL2, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51	Gene names	Cd22, Lyb-8
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

TIE2_HUMAN
θ value	4.03905 (rank : 12)	NC score	0.006573 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	1192	Shared Neighborhood Hits	8
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

MDGA1_HUMAN
θ value	5.27518 (rank : 13)	NC score	0.033408 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	358	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NFP4, Q8NBE3	Gene names	MDGA1, MAMDC3
Domain Architecture
Description	MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor (MAM domain-containing protein 3) (GPI and MAM protein) (Glycosylphosphatidylinositol-MAM) (GPIM).

OBSL1_HUMAN
θ value	5.27518 (rank : 14)	NC score	0.052330 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	354	Shared Neighborhood Hits	14
SwissProt Accessions	O75147, Q96IW3	Gene names	OBSL1, KIAA0657
Domain Architecture	No domain graphic available
Description	Obscurin-like protein 1 precursor.

PGBM_HUMAN
θ value	5.27518 (rank : 15)	NC score	0.030040 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	1113	Shared Neighborhood Hits	15
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

TREM2_HUMAN
θ value	5.27518 (rank : 16)	NC score	0.031889 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	60	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZC2, Q8N5H8, Q8WYN6	Gene names	TREM2
Domain Architecture	No domain graphic available
Description	Triggering receptor expressed on myeloid cells 2 precursor (Triggering receptor expressed on monocytes 2) (TREM-2).

BMP10_MOUSE
θ value	8.99809 (rank : 17)	NC score	0.007661 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	75	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R229, Q9Z1V8	Gene names	Bmp10
Domain Architecture
Description	Bone morphogenetic protein 10 precursor (BMP-10).

HMCN1_HUMAN
θ value	8.99809 (rank : 18)	NC score	0.030976 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	983	Shared Neighborhood Hits	18
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

L1CAM_HUMAN
θ value	8.99809 (rank : 19)	NC score	0.024216 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	457	Shared Neighborhood Hits	15
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

LRCH1_MOUSE
θ value	8.99809 (rank : 20)	NC score	0.007110 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	264	Shared Neighborhood Hits	2
SwissProt Accessions	P62046	Gene names	Lrch1, Chdc1, Kiaa1016
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1).

MAG_HUMAN
θ value	8.99809 (rank : 21)	NC score	0.034861 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	278	Shared Neighborhood Hits	14
SwissProt Accessions	P20916	Gene names	MAG
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

Hits sorted by NC score

IZUM1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IYV9, Q6Q8P6, Q6Q8P7	Gene names	IZUMO1
Domain Architecture	No domain graphic available
Description	Izumo sperm-egg fusion protein 1 precursor (Sperm-specific protein izumo).

IZUM1_MOUSE
NC score	0.945207 (rank : 2)	θ value	1.88829e-90 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	41	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D9J7	Gene names	Izumo1
Domain Architecture	No domain graphic available
Description	Izumo sperm-egg fusion protein 1 precursor (Sperm-specific protein izumo).

CD22_HUMAN
NC score	0.064618 (rank : 3)	θ value	0.62314 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	365	Shared Neighborhood Hits	16
SwissProt Accessions	P20273, O95699, O95701, O95702, O95703, Q01665, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6	Gene names	CD22
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

CD22_MOUSE
NC score	0.056414 (rank : 4)	θ value	4.03905 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	331	Shared Neighborhood Hits	14
SwissProt Accessions	P35329, Q9JHL2, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51	Gene names	Cd22, Lyb-8
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

OBSL1_HUMAN
NC score	0.052330 (rank : 5)	θ value	5.27518 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	354	Shared Neighborhood Hits	14
SwissProt Accessions	O75147, Q96IW3	Gene names	OBSL1, KIAA0657
Domain Architecture	No domain graphic available
Description	Obscurin-like protein 1 precursor.

MYPC3_HUMAN
NC score	0.042261 (rank : 6)	θ value	1.81305 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	318	Shared Neighborhood Hits	13
SwissProt Accessions	Q14896, Q16410, Q6R2F7, Q9UE27, Q9UM53	Gene names	MYBPC3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

KIRR2_HUMAN
NC score	0.041222 (rank : 7)	θ value	1.81305 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	321	Shared Neighborhood Hits	14
SwissProt Accessions	Q6UWL6, Q6P1R1, Q7Z5P1, Q7Z5P2, Q96IQ8, Q9H0T1	Gene names	KIRREL2, NEPH3
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3).

ICAM5_MOUSE
NC score	0.039995 (rank : 8)	θ value	2.36792 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	308	Shared Neighborhood Hits	14
SwissProt Accessions	Q60625	Gene names	Icam5, Tlcn
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

MAG_HUMAN
NC score	0.034861 (rank : 9)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	278	Shared Neighborhood Hits	14
SwissProt Accessions	P20916	Gene names	MAG
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

TITIN_HUMAN
NC score	0.034521 (rank : 10)	θ value	0.279714 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	2923	Shared Neighborhood Hits	17
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

MDGA1_HUMAN
NC score	0.033408 (rank : 11)	θ value	5.27518 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	358	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NFP4, Q8NBE3	Gene names	MDGA1, MAMDC3
Domain Architecture
Description	MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor (MAM domain-containing protein 3) (GPI and MAM protein) (Glycosylphosphatidylinositol-MAM) (GPIM).

OBSCN_HUMAN
NC score	0.033106 (rank : 12)	θ value	0.0563607 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	1931	Shared Neighborhood Hits	17
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

TREM2_HUMAN
NC score	0.031889 (rank : 13)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	60	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NZC2, Q8N5H8, Q8WYN6	Gene names	TREM2
Domain Architecture	No domain graphic available
Description	Triggering receptor expressed on myeloid cells 2 precursor (Triggering receptor expressed on monocytes 2) (TREM-2).

HMCN1_HUMAN
NC score	0.030976 (rank : 14)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	983	Shared Neighborhood Hits	18
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

PGBM_HUMAN
NC score	0.030040 (rank : 15)	θ value	5.27518 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	1113	Shared Neighborhood Hits	15
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

AMGO1_HUMAN
NC score	0.025318 (rank : 16)	θ value	1.81305 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	353	Shared Neighborhood Hits	7
SwissProt Accessions	Q86WK6, Q8IW71, Q9ULQ7	Gene names	AMIGO1, ALI2, AMIGO, KIAA1163
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 1 precursor (AMIGO-1) (Alivin-2).

L1CAM_HUMAN
NC score	0.024216 (rank : 17)	θ value	8.99809 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	457	Shared Neighborhood Hits	15
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

ATS20_MOUSE
NC score	0.011288 (rank : 18)	θ value	3.0926 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	225	Shared Neighborhood Hits	4
SwissProt Accessions	P59511	Gene names	Adamts20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

BMP10_MOUSE
NC score	0.007661 (rank : 19)	θ value	8.99809 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	75	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R229, Q9Z1V8	Gene names	Bmp10
Domain Architecture
Description	Bone morphogenetic protein 10 precursor (BMP-10).

LRCH1_MOUSE
NC score	0.007110 (rank : 20)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	264	Shared Neighborhood Hits	2
SwissProt Accessions	P62046	Gene names	Lrch1, Chdc1, Kiaa1016
Domain Architecture
Description	Leucine-rich repeats and calponin homology domain-containing protein 1 (Calponin homology domain-containing protein 1).

TIE2_HUMAN
NC score	0.006573 (rank : 21)	θ value	4.03905 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	1192	Shared Neighborhood Hits	8
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).