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Network neighborhood for query Sequence : DSCR6_HUMAN

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DSCR6_HUMAN
SwissProt Accessions	P57055	Gene names	DSCR6, RIPPLY3
Domain Architecture	No domain graphic available
Description	Down syndrome critical region protein 6.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DSCR6_HUMAN
θ value	5.34618e-69 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	P57055	Gene names	DSCR6, RIPPLY3
Domain Architecture	No domain graphic available
Description	Down syndrome critical region protein 6.

ASXL1_HUMAN
θ value	0.0736092 (rank : 2)	NC score	0.118850 (rank : 2)
Query Neighborhood Hits	22	Target Neighborhood Hits	260	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IXJ9, Q5JWS9, Q8IYY7, Q9H466, Q9NQF8, Q9UFJ0, Q9UFP8, Q9Y2I4	Gene names	ASXL1, KIAA0978
Domain Architecture	No domain graphic available
Description	Putative Polycomb group protein ASXL1 (Additional sex combs-like protein 1).

LPPRC_HUMAN
θ value	0.813845 (rank : 3)	NC score	0.106817 (rank : 3)
Query Neighborhood Hits	22	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	P42704	Gene names	LRPPRC, LRP130
Domain Architecture	No domain graphic available
Description	130 kDa leucine-rich protein (LRP 130) (GP130) (Leucine-rich PPR motif-containing protein).

FUS_HUMAN
θ value	1.38821 (rank : 4)	NC score	0.079153 (rank : 5)
Query Neighborhood Hits	22	Target Neighborhood Hits	179	Shared Neighborhood Hits	4
SwissProt Accessions	P35637	Gene names	FUS, TLS
Domain Architecture
Description	RNA-binding protein FUS (Oncogene FUS) (Oncogene TLS) (Translocated in liposarcoma protein) (POMp75) (75 kDa DNA-pairing protein).

FUS_MOUSE
θ value	1.38821 (rank : 5)	NC score	0.079389 (rank : 4)
Query Neighborhood Hits	22	Target Neighborhood Hits	154	Shared Neighborhood Hits	4
SwissProt Accessions	P56959	Gene names	Fus
Domain Architecture
Description	RNA-binding protein FUS (Pigpen protein).

SNRK_MOUSE
θ value	1.38821 (rank : 6)	NC score	0.009630 (rank : 21)
Query Neighborhood Hits	22	Target Neighborhood Hits	849	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

K22E_HUMAN
θ value	1.81305 (rank : 7)	NC score	0.018627 (rank : 17)
Query Neighborhood Hits	22	Target Neighborhood Hits	515	Shared Neighborhood Hits	4
SwissProt Accessions	P35908	Gene names	KRT2A, KRT2E
Domain Architecture
Description	Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (K2e) (CK 2e).

NEIL1_MOUSE
θ value	1.81305 (rank : 8)	NC score	0.067757 (rank : 7)
Query Neighborhood Hits	22	Target Neighborhood Hits	52	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K4Q6, Q80V58, Q9CYT9	Gene names	Neil1, Nei1
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (Nei-like 1) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (NEH1).

PRD16_HUMAN
θ value	1.81305 (rank : 9)	NC score	0.010823 (rank : 20)
Query Neighborhood Hits	22	Target Neighborhood Hits	832	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HAZ2, Q8WYJ9, Q9C0I8	Gene names	PRDM16, KIAA1675, MEL1, PFM13
Domain Architecture
Description	PR domain zinc finger protein 16 (PR domain-containing protein 16) (Transcription factor MEL1).

HNRLL_MOUSE
θ value	3.0926 (rank : 10)	NC score	0.034269 (rank : 13)
Query Neighborhood Hits	22	Target Neighborhood Hits	63	Shared Neighborhood Hits	2
SwissProt Accessions	Q921F4, Q8BIP6, Q99J40	Gene names	Hnrpll
Domain Architecture	No domain graphic available
Description	Heterogeneous nuclear ribonucleoprotein L-like.

RRS1_HUMAN
θ value	3.0926 (rank : 11)	NC score	0.057114 (rank : 9)
Query Neighborhood Hits	22	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	Q15050, Q9BUX8	Gene names	RRS1, KIAA0112, RRR
Domain Architecture
Description	Ribosome biogenesis regulatory protein homolog.

CI079_HUMAN
θ value	4.03905 (rank : 12)	NC score	0.052660 (rank : 10)
Query Neighborhood Hits	22	Target Neighborhood Hits	288	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZUB1, Q5SQC9, Q8NA41, Q8ND27	Gene names	C9orf79
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf79.

GCP6_HUMAN
θ value	4.03905 (rank : 13)	NC score	0.044676 (rank : 11)
Query Neighborhood Hits	22	Target Neighborhood Hits	295	Shared Neighborhood Hits	2
SwissProt Accessions	Q96RT7, Q5JZ80, Q6PJ40, Q86YE9, Q9BY91, Q9UGX3, Q9UGX4	Gene names	TUBGCP6, GCP6, KIAA1669
Domain Architecture
Description	Gamma-tubulin complex component 6 (GCP-6).

APXL_HUMAN
θ value	5.27518 (rank : 14)	NC score	0.033345 (rank : 14)
Query Neighborhood Hits	22	Target Neighborhood Hits	553	Shared Neighborhood Hits	2
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

FBRL_MOUSE
θ value	5.27518 (rank : 15)	NC score	0.043990 (rank : 12)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	P35550, Q99L58	Gene names	Fbl
Domain Architecture
Description	rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) (Nucleolar protein 1).

PRDM8_HUMAN
θ value	5.27518 (rank : 16)	NC score	0.030209 (rank : 15)
Query Neighborhood Hits	22	Target Neighborhood Hits	591	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NQV8, Q6IQ36	Gene names	PRDM8, PFM5
Domain Architecture	No domain graphic available
Description	PR domain zinc finger protein 8 (PR domain-containing protein 8).

ZN696_HUMAN
θ value	5.27518 (rank : 17)	NC score	0.004169 (rank : 23)
Query Neighborhood Hits	22	Target Neighborhood Hits	743	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H7X3	Gene names	ZNF696
Domain Architecture	No domain graphic available
Description	Zinc finger protein 696.

K1C10_MOUSE
θ value	8.99809 (rank : 18)	NC score	0.012220 (rank : 19)
Query Neighborhood Hits	22	Target Neighborhood Hits	466	Shared Neighborhood Hits	5
SwissProt Accessions	P02535, P08731, Q8BUX3, Q8BV09, Q8BVU3, Q9CXH6, Q9JKB4	Gene names	Krt10, Krt1-10
Domain Architecture
Description	Keratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Keratin-10) (K10) (56 kDa cytokeratin) (Keratin, type I cytoskeletal 59 kDa).

K2C1B_HUMAN
θ value	8.99809 (rank : 19)	NC score	0.015219 (rank : 18)
Query Neighborhood Hits	22	Target Neighborhood Hits	542	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z794, Q7RTS8	Gene names	KRT1B
Domain Architecture	No domain graphic available
Description	Keratin, type II cytoskeletal 1b.

RBP56_HUMAN
θ value	8.99809 (rank : 20)	NC score	0.062935 (rank : 8)
Query Neighborhood Hits	22	Target Neighborhood Hits	157	Shared Neighborhood Hits	4
SwissProt Accessions	Q92804, Q92751	Gene names	TAF15, RBP56, TAF2N
Domain Architecture
Description	TATA-binding protein-associated factor 2N (RNA-binding protein 56) (TAFII68) (TAF(II)68).

TRIO_HUMAN
θ value	8.99809 (rank : 21)	NC score	0.006601 (rank : 22)
Query Neighborhood Hits	22	Target Neighborhood Hits	1580	Shared Neighborhood Hits	4
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

USBP1_HUMAN
θ value	8.99809 (rank : 22)	NC score	0.027029 (rank : 16)
Query Neighborhood Hits	22	Target Neighborhood Hits	188	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N6Y0, Q8NBX7, Q96KH3, Q9BYI8	Gene names	USHBP1, AIEBP, MCC2
Domain Architecture	No domain graphic available
Description	USH1C-binding protein 1 (Usher syndrome type-1C protein-binding protein 1) (MCC-2) (AIE-75 binding protein).

ASXL1_MOUSE
θ value	θ > 10 (rank : 23)	NC score	0.075287 (rank : 6)
Query Neighborhood Hits	22	Target Neighborhood Hits	182	Shared Neighborhood Hits	1
SwissProt Accessions	P59598	Gene names	Asxl1, Kiaa0978
Domain Architecture	No domain graphic available
Description	Putative Polycomb group protein ASXL1 (Additional sex combs-like protein 1).

Hits sorted by NC score

DSCR6_HUMAN
NC score	0.999962 (rank : 1)	θ value	5.34618e-69 (rank : 1)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	22
SwissProt Accessions	P57055	Gene names	DSCR6, RIPPLY3
Domain Architecture	No domain graphic available
Description	Down syndrome critical region protein 6.

ASXL1_HUMAN
NC score	0.118850 (rank : 2)	θ value	0.0736092 (rank : 2)
Query Neighborhood Hits	22	Target Neighborhood Hits	260	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IXJ9, Q5JWS9, Q8IYY7, Q9H466, Q9NQF8, Q9UFJ0, Q9UFP8, Q9Y2I4	Gene names	ASXL1, KIAA0978
Domain Architecture	No domain graphic available
Description	Putative Polycomb group protein ASXL1 (Additional sex combs-like protein 1).

LPPRC_HUMAN
NC score	0.106817 (rank : 3)	θ value	0.813845 (rank : 3)
Query Neighborhood Hits	22	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	P42704	Gene names	LRPPRC, LRP130
Domain Architecture	No domain graphic available
Description	130 kDa leucine-rich protein (LRP 130) (GP130) (Leucine-rich PPR motif-containing protein).

FUS_MOUSE
NC score	0.079389 (rank : 4)	θ value	1.38821 (rank : 5)
Query Neighborhood Hits	22	Target Neighborhood Hits	154	Shared Neighborhood Hits	4
SwissProt Accessions	P56959	Gene names	Fus
Domain Architecture
Description	RNA-binding protein FUS (Pigpen protein).

FUS_HUMAN
NC score	0.079153 (rank : 5)	θ value	1.38821 (rank : 4)
Query Neighborhood Hits	22	Target Neighborhood Hits	179	Shared Neighborhood Hits	4
SwissProt Accessions	P35637	Gene names	FUS, TLS
Domain Architecture
Description	RNA-binding protein FUS (Oncogene FUS) (Oncogene TLS) (Translocated in liposarcoma protein) (POMp75) (75 kDa DNA-pairing protein).

ASXL1_MOUSE
NC score	0.075287 (rank : 6)	θ value	θ > 10 (rank : 23)
Query Neighborhood Hits	22	Target Neighborhood Hits	182	Shared Neighborhood Hits	1
SwissProt Accessions	P59598	Gene names	Asxl1, Kiaa0978
Domain Architecture	No domain graphic available
Description	Putative Polycomb group protein ASXL1 (Additional sex combs-like protein 1).

NEIL1_MOUSE
NC score	0.067757 (rank : 7)	θ value	1.81305 (rank : 8)
Query Neighborhood Hits	22	Target Neighborhood Hits	52	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K4Q6, Q80V58, Q9CYT9	Gene names	Neil1, Nei1
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (Nei-like 1) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (NEH1).

RBP56_HUMAN
NC score	0.062935 (rank : 8)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	22	Target Neighborhood Hits	157	Shared Neighborhood Hits	4
SwissProt Accessions	Q92804, Q92751	Gene names	TAF15, RBP56, TAF2N
Domain Architecture
Description	TATA-binding protein-associated factor 2N (RNA-binding protein 56) (TAFII68) (TAF(II)68).

RRS1_HUMAN
NC score	0.057114 (rank : 9)	θ value	3.0926 (rank : 11)
Query Neighborhood Hits	22	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	Q15050, Q9BUX8	Gene names	RRS1, KIAA0112, RRR
Domain Architecture
Description	Ribosome biogenesis regulatory protein homolog.

CI079_HUMAN
NC score	0.052660 (rank : 10)	θ value	4.03905 (rank : 12)
Query Neighborhood Hits	22	Target Neighborhood Hits	288	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZUB1, Q5SQC9, Q8NA41, Q8ND27	Gene names	C9orf79
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf79.

GCP6_HUMAN
NC score	0.044676 (rank : 11)	θ value	4.03905 (rank : 13)
Query Neighborhood Hits	22	Target Neighborhood Hits	295	Shared Neighborhood Hits	2
SwissProt Accessions	Q96RT7, Q5JZ80, Q6PJ40, Q86YE9, Q9BY91, Q9UGX3, Q9UGX4	Gene names	TUBGCP6, GCP6, KIAA1669
Domain Architecture
Description	Gamma-tubulin complex component 6 (GCP-6).

FBRL_MOUSE
NC score	0.043990 (rank : 12)	θ value	5.27518 (rank : 15)
Query Neighborhood Hits	22	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	P35550, Q99L58	Gene names	Fbl
Domain Architecture
Description	rRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-) (Nucleolar protein 1).

HNRLL_MOUSE
NC score	0.034269 (rank : 13)	θ value	3.0926 (rank : 10)
Query Neighborhood Hits	22	Target Neighborhood Hits	63	Shared Neighborhood Hits	2
SwissProt Accessions	Q921F4, Q8BIP6, Q99J40	Gene names	Hnrpll
Domain Architecture	No domain graphic available
Description	Heterogeneous nuclear ribonucleoprotein L-like.

APXL_HUMAN
NC score	0.033345 (rank : 14)	θ value	5.27518 (rank : 14)
Query Neighborhood Hits	22	Target Neighborhood Hits	553	Shared Neighborhood Hits	2
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

PRDM8_HUMAN
NC score	0.030209 (rank : 15)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	22	Target Neighborhood Hits	591	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NQV8, Q6IQ36	Gene names	PRDM8, PFM5
Domain Architecture	No domain graphic available
Description	PR domain zinc finger protein 8 (PR domain-containing protein 8).

USBP1_HUMAN
NC score	0.027029 (rank : 16)	θ value	8.99809 (rank : 22)
Query Neighborhood Hits	22	Target Neighborhood Hits	188	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N6Y0, Q8NBX7, Q96KH3, Q9BYI8	Gene names	USHBP1, AIEBP, MCC2
Domain Architecture	No domain graphic available
Description	USH1C-binding protein 1 (Usher syndrome type-1C protein-binding protein 1) (MCC-2) (AIE-75 binding protein).

K22E_HUMAN
NC score	0.018627 (rank : 17)	θ value	1.81305 (rank : 7)
Query Neighborhood Hits	22	Target Neighborhood Hits	515	Shared Neighborhood Hits	4
SwissProt Accessions	P35908	Gene names	KRT2A, KRT2E
Domain Architecture
Description	Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (K2e) (CK 2e).

K2C1B_HUMAN
NC score	0.015219 (rank : 18)	θ value	8.99809 (rank : 19)
Query Neighborhood Hits	22	Target Neighborhood Hits	542	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z794, Q7RTS8	Gene names	KRT1B
Domain Architecture	No domain graphic available
Description	Keratin, type II cytoskeletal 1b.

K1C10_MOUSE
NC score	0.012220 (rank : 19)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	22	Target Neighborhood Hits	466	Shared Neighborhood Hits	5
SwissProt Accessions	P02535, P08731, Q8BUX3, Q8BV09, Q8BVU3, Q9CXH6, Q9JKB4	Gene names	Krt10, Krt1-10
Domain Architecture
Description	Keratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Keratin-10) (K10) (56 kDa cytokeratin) (Keratin, type I cytoskeletal 59 kDa).

PRD16_HUMAN
NC score	0.010823 (rank : 20)	θ value	1.81305 (rank : 9)
Query Neighborhood Hits	22	Target Neighborhood Hits	832	Shared Neighborhood Hits	4
SwissProt Accessions	Q9HAZ2, Q8WYJ9, Q9C0I8	Gene names	PRDM16, KIAA1675, MEL1, PFM13
Domain Architecture
Description	PR domain zinc finger protein 16 (PR domain-containing protein 16) (Transcription factor MEL1).

SNRK_MOUSE
NC score	0.009630 (rank : 21)	θ value	1.38821 (rank : 6)
Query Neighborhood Hits	22	Target Neighborhood Hits	849	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

TRIO_HUMAN
NC score	0.006601 (rank : 22)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	22	Target Neighborhood Hits	1580	Shared Neighborhood Hits	4
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

ZN696_HUMAN
NC score	0.004169 (rank : 23)	θ value	5.27518 (rank : 17)
Query Neighborhood Hits	22	Target Neighborhood Hits	743	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H7X3	Gene names	ZNF696
Domain Architecture	No domain graphic available
Description	Zinc finger protein 696.