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Network neighborhood for query Sequence : DOPO_HUMAN

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DOPO_HUMAN
SwissProt Accessions	P09172, Q5T381, Q96AG2	Gene names	DBH
Domain Architecture
Description	Dopamine beta-hydroxylase precursor (EC 1.14.17.1) (Dopamine beta- monooxygenase).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DOPO_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	13
SwissProt Accessions	P09172, Q5T381, Q96AG2	Gene names	DBH
Domain Architecture
Description	Dopamine beta-hydroxylase precursor (EC 1.14.17.1) (Dopamine beta- monooxygenase).

DOPO_MOUSE
θ value	0 (rank : 2)	NC score	0.996252 (rank : 2)
Query Neighborhood Hits	13	Target Neighborhood Hits	9	Shared Neighborhood Hits	5
SwissProt Accessions	Q64237	Gene names	Dbh
Domain Architecture
Description	Dopamine beta-hydroxylase precursor (EC 1.14.17.1) (Dopamine beta- monooxygenase).

AMD_MOUSE
θ value	9.24701e-21 (rank : 3)	NC score	0.558485 (rank : 3)
Query Neighborhood Hits	13	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	P97467	Gene names	Pam
Domain Architecture
Description	Peptidyl-glycine alpha-amidating monooxygenase precursor (PAM) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase (EC 1.14.17.3) (PHM); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)].

AMD_HUMAN
θ value	5.07402e-19 (rank : 4)	NC score	0.539653 (rank : 4)
Query Neighborhood Hits	13	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	P19021, O95080, Q16252, Q16253, Q86U53, Q8WVC7, Q9UCG0	Gene names	PAM
Domain Architecture
Description	Peptidyl-glycine alpha-amidating monooxygenase precursor (PAM) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase (EC 1.14.17.3) (PHM); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)].

CT102_HUMAN
θ value	1.38821 (rank : 5)	NC score	0.039227 (rank : 5)
Query Neighborhood Hits	13	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	Q96N03, Q5JWZ5, Q8ND45, Q9BR37	Gene names	C20orf102
Domain Architecture
Description	Protein C20orf102 precursor.

HSP74_MOUSE
θ value	3.0926 (rank : 6)	NC score	0.016121 (rank : 7)
Query Neighborhood Hits	13	Target Neighborhood Hits	257	Shared Neighborhood Hits	3
SwissProt Accessions	Q61316	Gene names	Hspa4, Hsp110
Domain Architecture
Description	Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2).

HSP74_HUMAN
θ value	4.03905 (rank : 7)	NC score	0.015832 (rank : 8)
Query Neighborhood Hits	13	Target Neighborhood Hits	154	Shared Neighborhood Hits	3
SwissProt Accessions	P34932, O95756	Gene names	HSPA4
Domain Architecture
Description	Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2) (HSP70RY).

BFAR_MOUSE
θ value	6.88961 (rank : 8)	NC score	0.012754 (rank : 9)
Query Neighborhood Hits	13	Target Neighborhood Hits	232	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R079, Q8C1A7, Q9CXY3	Gene names	Bfar
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator.

CDK7_MOUSE
θ value	6.88961 (rank : 9)	NC score	0.003725 (rank : 12)
Query Neighborhood Hits	13	Target Neighborhood Hits	835	Shared Neighborhood Hits	3
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

ST14_HUMAN
θ value	6.88961 (rank : 10)	NC score	0.002918 (rank : 13)
Query Neighborhood Hits	13	Target Neighborhood Hits	409	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y5Y6, Q9BS01, Q9H3S0, Q9HB36, Q9HCA3	Gene names	ST14, PRSS14, SNC19, TADG15
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein).

TRPC4_HUMAN
θ value	6.88961 (rank : 11)	NC score	0.011835 (rank : 10)
Query Neighborhood Hits	13	Target Neighborhood Hits	140	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UBN4, Q15721, Q9UIB0, Q9UIB1, Q9UIB2	Gene names	TRPC4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (trp-related protein 4) (hTrp-4) (hTrp4).

TRPC4_MOUSE
θ value	6.88961 (rank : 12)	NC score	0.011834 (rank : 11)
Query Neighborhood Hits	13	Target Neighborhood Hits	141	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QUQ5, Q62350, Q9QUQ9, Q9QZC0	Gene names	Trpc4, Trrp4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (Receptor- activated cation channel TRP4) (Capacitative calcium entry channel Trp4).

TCL1B_HUMAN
θ value	8.99809 (rank : 13)	NC score	0.017804 (rank : 6)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	O95988	Gene names	TCL1B
Domain Architecture
Description	T-cell leukemia/lymphoma protein 1B (TCL1B oncogene) (Syncytiotrophoblast-specific protein) (SYN-1).

Hits sorted by NC score

DOPO_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	13
SwissProt Accessions	P09172, Q5T381, Q96AG2	Gene names	DBH
Domain Architecture
Description	Dopamine beta-hydroxylase precursor (EC 1.14.17.1) (Dopamine beta- monooxygenase).

DOPO_MOUSE
NC score	0.996252 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	13	Target Neighborhood Hits	9	Shared Neighborhood Hits	5
SwissProt Accessions	Q64237	Gene names	Dbh
Domain Architecture
Description	Dopamine beta-hydroxylase precursor (EC 1.14.17.1) (Dopamine beta- monooxygenase).

AMD_MOUSE
NC score	0.558485 (rank : 3)	θ value	9.24701e-21 (rank : 3)
Query Neighborhood Hits	13	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	P97467	Gene names	Pam
Domain Architecture
Description	Peptidyl-glycine alpha-amidating monooxygenase precursor (PAM) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase (EC 1.14.17.3) (PHM); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)].

AMD_HUMAN
NC score	0.539653 (rank : 4)	θ value	5.07402e-19 (rank : 4)
Query Neighborhood Hits	13	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	P19021, O95080, Q16252, Q16253, Q86U53, Q8WVC7, Q9UCG0	Gene names	PAM
Domain Architecture
Description	Peptidyl-glycine alpha-amidating monooxygenase precursor (PAM) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase (EC 1.14.17.3) (PHM); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)].

CT102_HUMAN
NC score	0.039227 (rank : 5)	θ value	1.38821 (rank : 5)
Query Neighborhood Hits	13	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	Q96N03, Q5JWZ5, Q8ND45, Q9BR37	Gene names	C20orf102
Domain Architecture
Description	Protein C20orf102 precursor.

TCL1B_HUMAN
NC score	0.017804 (rank : 6)	θ value	8.99809 (rank : 13)
Query Neighborhood Hits	13	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	O95988	Gene names	TCL1B
Domain Architecture
Description	T-cell leukemia/lymphoma protein 1B (TCL1B oncogene) (Syncytiotrophoblast-specific protein) (SYN-1).

HSP74_MOUSE
NC score	0.016121 (rank : 7)	θ value	3.0926 (rank : 6)
Query Neighborhood Hits	13	Target Neighborhood Hits	257	Shared Neighborhood Hits	3
SwissProt Accessions	Q61316	Gene names	Hspa4, Hsp110
Domain Architecture
Description	Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2).

HSP74_HUMAN
NC score	0.015832 (rank : 8)	θ value	4.03905 (rank : 7)
Query Neighborhood Hits	13	Target Neighborhood Hits	154	Shared Neighborhood Hits	3
SwissProt Accessions	P34932, O95756	Gene names	HSPA4
Domain Architecture
Description	Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2) (HSP70RY).

BFAR_MOUSE
NC score	0.012754 (rank : 9)	θ value	6.88961 (rank : 8)
Query Neighborhood Hits	13	Target Neighborhood Hits	232	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R079, Q8C1A7, Q9CXY3	Gene names	Bfar
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator.

TRPC4_HUMAN
NC score	0.011835 (rank : 10)	θ value	6.88961 (rank : 11)
Query Neighborhood Hits	13	Target Neighborhood Hits	140	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UBN4, Q15721, Q9UIB0, Q9UIB1, Q9UIB2	Gene names	TRPC4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (trp-related protein 4) (hTrp-4) (hTrp4).

TRPC4_MOUSE
NC score	0.011834 (rank : 11)	θ value	6.88961 (rank : 12)
Query Neighborhood Hits	13	Target Neighborhood Hits	141	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QUQ5, Q62350, Q9QUQ9, Q9QZC0	Gene names	Trpc4, Trrp4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (Receptor- activated cation channel TRP4) (Capacitative calcium entry channel Trp4).

CDK7_MOUSE
NC score	0.003725 (rank : 12)	θ value	6.88961 (rank : 9)
Query Neighborhood Hits	13	Target Neighborhood Hits	835	Shared Neighborhood Hits	3
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

ST14_HUMAN
NC score	0.002918 (rank : 13)	θ value	6.88961 (rank : 10)
Query Neighborhood Hits	13	Target Neighborhood Hits	409	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y5Y6, Q9BS01, Q9H3S0, Q9HB36, Q9HCA3	Gene names	ST14, PRSS14, SNC19, TADG15
Domain Architecture
Description	Suppressor of tumorigenicity protein 14 (EC 3.4.21.-) (Serine protease 14) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein).