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Network neighborhood for query Sequence : CP240_MOUSE

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CP240_MOUSE
SwissProt Accessions	P56657	Gene names	Cyp2c40
Domain Architecture
Description	Cytochrome P450 2C40 (EC 1.14.14.1) (CYPIIC40).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CP237_MOUSE
θ value	0 (rank : 1)	NC score	0.998844 (rank : 2)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	P56654	Gene names	Cyp2c37
Domain Architecture
Description	Cytochrome P450 2C37 (EC 1.14.14.1) (CYPIIC37).

CP238_MOUSE
θ value	0 (rank : 2)	NC score	0.998513 (rank : 4)
Query Neighborhood Hits	111	Target Neighborhood Hits	112	Shared Neighborhood Hits	106
SwissProt Accessions	P56655	Gene names	Cyp2c38
Domain Architecture
Description	Cytochrome P450 2C38 (EC 1.14.14.1) (CYPIIC38).

CP239_MOUSE
θ value	0 (rank : 3)	NC score	0.998297 (rank : 6)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	P56656	Gene names	Cyp2c39
Domain Architecture
Description	Cytochrome P450 2C39 (EC 1.14.14.1) (CYPIIC39).

CP240_MOUSE
θ value	0 (rank : 4)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	111	Target Neighborhood Hits	111	Shared Neighborhood Hits	111
SwissProt Accessions	P56657	Gene names	Cyp2c40
Domain Architecture
Description	Cytochrome P450 2C40 (EC 1.14.14.1) (CYPIIC40).

CP2CT_MOUSE
θ value	0 (rank : 5)	NC score	0.998666 (rank : 3)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	Q64458, Q8WUN8	Gene names	Cyp2c29
Domain Architecture
Description	Cytochrome P450 2C29 (EC 1.14.14.1) (CYPIIC29) (P-450 MUT-2) (Aldehyde oxygenase).

CP2CI_HUMAN
θ value	3.24166e-183 (rank : 6)	NC score	0.998414 (rank : 5)
Query Neighborhood Hits	111	Target Neighborhood Hits	107	Shared Neighborhood Hits	106
SwissProt Accessions	P33260, Q16703, Q16751	Gene names	CYP2C18
Domain Architecture
Description	Cytochrome P450 2C18 (EC 1.14.14.1) (CYPIIC18) (P450-6B/29C).

CP2CJ_HUMAN
θ value	1.04281e-181 (rank : 7)	NC score	0.998022 (rank : 7)
Query Neighborhood Hits	111	Target Neighborhood Hits	112	Shared Neighborhood Hits	106
SwissProt Accessions	P33261, P33259, Q8WZB1, Q8WZB2	Gene names	CYP2C19
Domain Architecture
Description	Cytochrome P450 2C19 (EC 1.14.13.80) ((R)-limonene 6-monooxygenase) (EC 1.14.13.48) ((S)-limonene 6-monooxygenase) (EC 1.14.13.49) ((S)- limonene 7-monooxygenase) (CYPIIC19) (P450-11A) (Mephenytoin 4- hydroxylase) (CYPIIC17) (P450-254C).

CP2C9_HUMAN
θ value	1.40939e-178 (rank : 8)	NC score	0.997822 (rank : 9)
Query Neighborhood Hits	111	Target Neighborhood Hits	113	Shared Neighborhood Hits	106
SwissProt Accessions	P11712, P11713, Q16756, Q16872	Gene names	CYP2C9, CYP2C10
Domain Architecture
Description	Cytochrome P450 2C9 (EC 1.14.13.80) ((R)-limonene 6-monooxygenase) (EC 1.14.13.48) ((S)-limonene 6-monooxygenase) (EC 1.14.13.49) ((S)- limonene 7-monooxygenase) (CYPIIC9) (P450 PB-1) (P450 MP-4/MP-8) (S- mephenytoin 4-hydroxylase) (P-450MP).

CP2C8_HUMAN
θ value	3.24919e-175 (rank : 9)	NC score	0.997949 (rank : 8)
Query Neighborhood Hits	111	Target Neighborhood Hits	111	Shared Neighborhood Hits	106
SwissProt Accessions	P10632	Gene names	CYP2C8
Domain Architecture
Description	Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (P450 form 1) (P450 MP- 12/MP-20) (P450 IIC2) (S-mephenytoin 4-hydroxylase).

CP270_MOUSE
θ value	2.49938e-159 (rank : 10)	NC score	0.996600 (rank : 10)
Query Neighborhood Hits	111	Target Neighborhood Hits	112	Shared Neighborhood Hits	106
SwissProt Accessions	Q91W64, Q5GLY9, Q80VW0, Q8R120, Q8VC00	Gene names	Cyp2c70, Cyp2c-70, Cyp2c22
Domain Architecture	No domain graphic available
Description	Cytochrome P450 2C70 (EC 1.14.14.1) (CYPIIC70).

CP2E1_MOUSE
θ value	3.17642e-138 (rank : 11)	NC score	0.995806 (rank : 11)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	Q05421, Q9Z198	Gene names	Cyp2e1, Cyp2e, Cyp2e-1
Domain Architecture
Description	Cytochrome P450 2E1 (EC 1.14.14.1) (CYPIIE1) (P450-J) (P450-ALC).

CP2E1_HUMAN
θ value	2.51683e-135 (rank : 12)	NC score	0.995233 (rank : 12)
Query Neighborhood Hits	111	Target Neighborhood Hits	106	Shared Neighborhood Hits	106
SwissProt Accessions	P05181, Q9UK47	Gene names	CYP2E1, CYP2E
Domain Architecture
Description	Cytochrome P450 2E1 (EC 1.14.14.1) (CYPIIE1) (P450-J).

CP2AD_HUMAN
θ value	1.86652e-130 (rank : 13)	NC score	0.992605 (rank : 15)
Query Neighborhood Hits	111	Target Neighborhood Hits	105	Shared Neighborhood Hits	104
SwissProt Accessions	Q16696, Q53YR8, Q9H2X2	Gene names	CYP2A13
Domain Architecture
Description	Cytochrome P450 2A13 (EC 1.14.14.1) (CYPIIA13).

CP2F2_MOUSE
θ value	3.1838e-130 (rank : 14)	NC score	0.994445 (rank : 14)
Query Neighborhood Hits	111	Target Neighborhood Hits	106	Shared Neighborhood Hits	106
SwissProt Accessions	P33267	Gene names	Cyp2f2, Cyp2f-2
Domain Architecture
Description	Cytochrome P450 2F2 (EC 1.14.14.-) (CYPIIF2) (Naphthalene dehydrogenase) (Naphthalene hydroxylase) (P450-NAH-2).

CP2A7_HUMAN
θ value	1.63515e-126 (rank : 15)	NC score	0.992497 (rank : 17)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	106
SwissProt Accessions	P20853, Q13121	Gene names	CYP2A7
Domain Architecture
Description	Cytochrome P450 2A7 (EC 1.14.14.1) (CYPIIA7) (P450-IIA4).

CP2A4_MOUSE
θ value	2.78914e-126 (rank : 16)	NC score	0.992602 (rank : 16)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	105
SwissProt Accessions	P15392	Gene names	Cyp2a4, Cyp2a-4
Domain Architecture
Description	Cytochrome P450 2A4 (EC 1.14.14.1) (CYPIIA4) (Testosterone 15-alpha- hydroxylase) (P450-15-alpha) (P450-IIA3.1).

CP2A5_MOUSE
θ value	1.80787e-125 (rank : 17)	NC score	0.992009 (rank : 22)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	105
SwissProt Accessions	P20852	Gene names	Cyp2a5, Cyp2a-5
Domain Architecture
Description	Cytochrome P450 2A5 (EC 1.14.14.1) (CYPIIA5) (Coumarin 7-hydroxylase) (P450-15-COH) (P450-IIA3.2).

CP2A6_HUMAN
θ value	4.60808e-121 (rank : 18)	NC score	0.992176 (rank : 20)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	106
SwissProt Accessions	P11509, P00190, P10890, Q16803, Q4VAT9, Q4VAU0, Q4VAU1, Q9H1Z7, Q9UK48	Gene names	CYP2A6
Domain Architecture
Description	Cytochrome P450 2A6 (EC 1.14.14.1) (CYPIIA6) (Coumarin 7-hydroxylase) (P450 IIA3) (CYP2A3) (P450(I)).

CP2F1_HUMAN
θ value	5.09482e-120 (rank : 19)	NC score	0.994985 (rank : 13)
Query Neighborhood Hits	111	Target Neighborhood Hits	106	Shared Neighborhood Hits	106
SwissProt Accessions	P24903	Gene names	CYP2F1
Domain Architecture
Description	Cytochrome P450 2F1 (EC 1.14.14.1) (CYPIIF1).

CP2BJ_MOUSE
θ value	1.38745e-117 (rank : 20)	NC score	0.992083 (rank : 21)
Query Neighborhood Hits	111	Target Neighborhood Hits	114	Shared Neighborhood Hits	105
SwissProt Accessions	O55071	Gene names	Cyp2b19
Domain Architecture
Description	Cytochrome P450 2B19 (EC 1.14.14.1) (CYPIIB19).

CP2B6_HUMAN
θ value	2.2151e-115 (rank : 21)	NC score	0.992476 (rank : 18)
Query Neighborhood Hits	111	Target Neighborhood Hits	106	Shared Neighborhood Hits	105
SwissProt Accessions	P20813, Q2V565, Q9UK46	Gene names	CYP2B6
Domain Architecture
Description	Cytochrome P450 2B6 (EC 1.14.14.1) (CYPIIB6) (P450 IIB1).

CP2B9_MOUSE
θ value	1.8752e-114 (rank : 22)	NC score	0.992290 (rank : 19)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	105
SwissProt Accessions	P12790	Gene names	Cyp2b9, Cyp2b-9, Rip
Domain Architecture
Description	Cytochrome P450 2B9 (EC 1.14.14.1) (CYPIIB9) (Testosterone 16-alpha hydroxylase) (P450-16-alpha) (Clone PF26).

CP2BA_MOUSE
θ value	3.1986e-114 (rank : 23)	NC score	0.991898 (rank : 24)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	103
SwissProt Accessions	P12791	Gene names	Cyp2b10, Cyp2b-10
Domain Architecture
Description	Cytochrome P450 2B10 (EC 1.14.14.1) (CYPIIB10) (Testosterone 16-alpha hydroxylase) (P450-16-alpha) (Clone PF3/46).

CP2AC_MOUSE
θ value	8.71062e-112 (rank : 24)	NC score	0.991996 (rank : 23)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	105
SwissProt Accessions	P56593	Gene names	Cyp2a12
Domain Architecture	No domain graphic available
Description	Cytochrome P450 2A12 (EC 1.14.14.1) (CYPIIA12) (Steroid hormones 7- alpha-hydroxylase) (Testosterone 7-alpha-hydroxylase).

CP2J5_MOUSE
θ value	2.2254e-99 (rank : 25)	NC score	0.985355 (rank : 28)
Query Neighborhood Hits	111	Target Neighborhood Hits	113	Shared Neighborhood Hits	106
SwissProt Accessions	O54749	Gene names	Cyp2j5
Domain Architecture
Description	Cytochrome P450 2J5 (EC 1.14.14.1) (CYPIIJ5) (Arachidonic acid epoxygenase).

CP2J2_HUMAN
θ value	4.95767e-99 (rank : 26)	NC score	0.983898 (rank : 30)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	106
SwissProt Accessions	P51589	Gene names	CYP2J2
Domain Architecture
Description	Cytochrome P450 2J2 (EC 1.14.14.1) (CYPIIJ2) (Arachidonic acid epoxygenase).

CP2S1_HUMAN
θ value	6.27148e-94 (rank : 27)	NC score	0.990981 (rank : 25)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	106
SwissProt Accessions	Q96SQ9, Q9BZ66	Gene names	CYP2S1
Domain Architecture
Description	Cytochrome P450 2S1 (EC 1.14.14.1) (CYPIIS1).

CP2S1_MOUSE
θ value	6.27148e-94 (rank : 28)	NC score	0.990707 (rank : 26)
Query Neighborhood Hits	111	Target Neighborhood Hits	112	Shared Neighborhood Hits	104
SwissProt Accessions	Q9DBX6	Gene names	Cyp2s1
Domain Architecture
Description	Cytochrome P450 2S1 (EC 1.14.14.1) (CYPIIS1).

CP2J6_MOUSE
θ value	5.30912e-93 (rank : 29)	NC score	0.984222 (rank : 29)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	O54750	Gene names	Cyp2j6
Domain Architecture
Description	Cytochrome P450 2J6 (EC 1.14.14.1) (CYPIIJ6) (Arachidonic acid epoxygenase).

CP2W1_HUMAN
θ value	1.22395e-89 (rank : 30)	NC score	0.987178 (rank : 27)
Query Neighborhood Hits	111	Target Neighborhood Hits	104	Shared Neighborhood Hits	101
SwissProt Accessions	Q8TAV3	Gene names	CYP2W1
Domain Architecture	No domain graphic available
Description	Cytochrome P450 2W1 (EC 1.14.14.-) (CYPIIW1).

CP2D9_MOUSE
θ value	1.03855e-80 (rank : 31)	NC score	0.979826 (rank : 34)
Query Neighborhood Hits	111	Target Neighborhood Hits	107	Shared Neighborhood Hits	106
SwissProt Accessions	P11714, Q64489	Gene names	Cyp2d9, Cyp2d-9
Domain Architecture
Description	Cytochrome P450 2D9 (EC 1.14.14.1) (CYPIID9) (P450-16-alpha) (CA) (Testosterone 16-alpha hydroxylase).

CP2D6_HUMAN
θ value	1.26953e-78 (rank : 32)	NC score	0.980770 (rank : 32)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	104
SwissProt Accessions	P10635, Q16752, Q6B012	Gene names	CYP2D6
Domain Architecture
Description	Cytochrome P450 2D6 (EC 1.14.14.1) (CYPIID6) (P450-DB1) (Debrisoquine 4-hydroxylase).

CP2DQ_MOUSE
θ value	4.08394e-77 (rank : 33)	NC score	0.980968 (rank : 31)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	105
SwissProt Accessions	Q8CIM7, Q9DBJ5	Gene names	Cyp2d26, Cyp2d-26
Domain Architecture	No domain graphic available
Description	Cytochrome P450 2D26 (EC 1.14.14.1) (CYPIID26).

CP2DA_MOUSE
θ value	4.51533e-76 (rank : 34)	NC score	0.980019 (rank : 33)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	P24456, Q64490	Gene names	Cyp2d10, Cyp2d-10
Domain Architecture
Description	Cytochrome P450 2D10 (EC 1.14.14.1) (CYPIID10) (P450-16-alpha) (P450CB) (Testosterone 16-alpha hydroxylase).

CP2DB_MOUSE
θ value	7.45998e-71 (rank : 35)	NC score	0.977735 (rank : 35)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	105
SwissProt Accessions	P24457	Gene names	Cyp2d11, Cyp2d-11
Domain Architecture
Description	Cytochrome P450 2D11 (EC 1.14.14.1) (CYPIID11) (P450-16-alpha) (CC) (Testosterone 16-alpha hydroxylase).

CP2R1_HUMAN
θ value	1.5555e-68 (rank : 36)	NC score	0.977511 (rank : 37)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	106
SwissProt Accessions	Q6VVX0, Q5RT65	Gene names	CYP2R1
Domain Architecture	No domain graphic available
Description	Cytochrome P450 2R1 (EC 1.14.14.-) (Vitamin D 25-hydroxylase).

CP2R1_MOUSE
θ value	8.53533e-67 (rank : 37)	NC score	0.977580 (rank : 36)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	Q6VVW9	Gene names	Cyp2r1
Domain Architecture	No domain graphic available
Description	Cytochrome P450 2R1 (EC 1.14.14.-) (Vitamin D 25-hydroxylase).

CP1A1_MOUSE
θ value	6.99855e-61 (rank : 38)	NC score	0.962056 (rank : 41)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	106
SwissProt Accessions	P00184, Q61455	Gene names	Cyp1a1, Cyp1a-1
Domain Architecture
Description	Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (P450-P1).

CP1A1_HUMAN
θ value	2.03627e-60 (rank : 39)	NC score	0.962804 (rank : 40)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	106
SwissProt Accessions	P04798	Gene names	CYP1A1
Domain Architecture
Description	Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (P450-P1) (P450 form 6) (P450-C).

CP1B1_HUMAN
θ value	5.93839e-52 (rank : 40)	NC score	0.966627 (rank : 38)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	105
SwissProt Accessions	Q16678, Q93089, Q9H316	Gene names	CYP1B1
Domain Architecture
Description	Cytochrome P450 1B1 (EC 1.14.14.1) (CYPIB1).

CP1B1_MOUSE
θ value	2.49495e-50 (rank : 41)	NC score	0.966200 (rank : 39)
Query Neighborhood Hits	111	Target Neighborhood Hits	107	Shared Neighborhood Hits	105
SwissProt Accessions	Q64429, Q60593, Q64461	Gene names	Cyp1b1, Cyp1-b1
Domain Architecture
Description	Cytochrome P450 1B1 (EC 1.14.14.1) (CYPIB1) (P450CMEF) (P450EF).

CP1A2_MOUSE
θ value	1.04822e-48 (rank : 42)	NC score	0.958795 (rank : 42)
Query Neighborhood Hits	111	Target Neighborhood Hits	112	Shared Neighborhood Hits	105
SwissProt Accessions	P00186, Q9QWJ4	Gene names	Cyp1a2, Cyp1a-2
Domain Architecture
Description	Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (P450-P2/P450-P3).

CP17A_MOUSE
θ value	8.30557e-46 (rank : 43)	NC score	0.952433 (rank : 44)
Query Neighborhood Hits	111	Target Neighborhood Hits	106	Shared Neighborhood Hits	106
SwissProt Accessions	P27786	Gene names	Cyp17a1, Cyp17
Domain Architecture
Description	Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17) (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase).

CP1A2_HUMAN
θ value	1.32601e-43 (rank : 44)	NC score	0.953713 (rank : 43)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	106
SwissProt Accessions	P05177, Q16754, Q6NWU5, Q9BXX7, Q9UK49	Gene names	CYP1A2
Domain Architecture
Description	Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (P450-P3) (P(3)450) (P450 4).

CP17A_HUMAN
θ value	2.26182e-43 (rank : 45)	NC score	0.951427 (rank : 45)
Query Neighborhood Hits	111	Target Neighborhood Hits	115	Shared Neighborhood Hits	106
SwissProt Accessions	P05093, Q5TZV7	Gene names	CYP17A1, CYP17, S17AH
Domain Architecture
Description	Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17) (P450c17) (Steroid 17-alpha-monooxygenase) (Steroid 17-alpha-hydroxylase/17,20 lyase).

CP21A_HUMAN
θ value	3.99248e-40 (rank : 46)	NC score	0.946132 (rank : 46)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	106
SwissProt Accessions	P08686, P04033, Q01204, Q16749	Gene names	CYP21A2, CYP21, CYP21B
Domain Architecture
Description	Cytochrome P450 21 (EC 1.14.99.10) (Cytochrome P450 XXI) (Steroid 21- hydroxylase) (21-OHase) (P450-C21) (P-450c21) (P450-C21B).

CP21A_MOUSE
θ value	3.27365e-34 (rank : 47)	NC score	0.945719 (rank : 47)
Query Neighborhood Hits	111	Target Neighborhood Hits	112	Shared Neighborhood Hits	106
SwissProt Accessions	P03940, O88304, Q64510, Q9QX14	Gene names	Cyp21, Cyp21a-1, Cyp21a1
Domain Architecture
Description	Cytochrome P450 21 (EC 1.14.99.10) (Cytochrome P450 XXI) (Steroid 21- hydroxylase) (21-OHase) (P450-C21) (P-450c21).

CP341_MOUSE
θ value	1.73987e-27 (rank : 48)	NC score	0.811445 (rank : 53)
Query Neighborhood Hits	111	Target Neighborhood Hits	113	Shared Neighborhood Hits	106
SwissProt Accessions	Q9JMA7	Gene names	Cyp3a41
Domain Architecture
Description	Cytochrome P450 3A41 (EC 1.14.14.1).

CP3A4_HUMAN
θ value	1.16704e-23 (rank : 49)	NC score	0.804772 (rank : 58)
Query Neighborhood Hits	111	Target Neighborhood Hits	113	Shared Neighborhood Hits	106
SwissProt Accessions	P08684, Q16757, Q9UK50	Gene names	CYP3A4
Domain Architecture
Description	Cytochrome P450 3A4 (EC 1.14.13.67) (Quinine 3-monooxygenase) (CYPIIIA4) (Nifedipine oxidase) (Taurochenodeoxycholate 6-alpha- hydroxylase) (EC 1.14.13.97) (NF-25) (P450-PCN1).

CP3A3_HUMAN
θ value	1.6852e-22 (rank : 50)	NC score	0.802705 (rank : 61)
Query Neighborhood Hits	111	Target Neighborhood Hits	113	Shared Neighborhood Hits	106
SwissProt Accessions	P05184	Gene names	CYP3A3
Domain Architecture
Description	Cytochrome P450 3A3 (EC 1.14.14.1) (CYPIIIA3) (HLp).

CP3AG_MOUSE
θ value	2.20094e-22 (rank : 51)	NC score	0.803029 (rank : 59)
Query Neighborhood Hits	111	Target Neighborhood Hits	119	Shared Neighborhood Hits	106
SwissProt Accessions	Q64481	Gene names	Cyp3a16, Cyp3a-16
Domain Architecture
Description	Cytochrome P450 3A16 (EC 1.14.14.1) (CYPIIIA16).

CP4V2_HUMAN
θ value	6.40375e-22 (rank : 52)	NC score	0.811335 (rank : 54)
Query Neighborhood Hits	111	Target Neighborhood Hits	106	Shared Neighborhood Hits	106
SwissProt Accessions	Q6ZWL3, Q6ZTM4	Gene names	CYP4V2
Domain Architecture	No domain graphic available
Description	Cytochrome P450 4V2 (EC 1.14.-.-).

CP3A7_HUMAN
θ value	1.09232e-21 (rank : 53)	NC score	0.796687 (rank : 64)
Query Neighborhood Hits	111	Target Neighborhood Hits	115	Shared Neighborhood Hits	106
SwissProt Accessions	P24462	Gene names	CYP3A7
Domain Architecture
Description	Cytochrome P450 3A7 (EC 1.14.14.1) (CYPIIIA7) (P450-HFLA).

CP3AD_MOUSE
θ value	7.0802e-21 (rank : 54)	NC score	0.783133 (rank : 70)
Query Neighborhood Hits	111	Target Neighborhood Hits	112	Shared Neighborhood Hits	106
SwissProt Accessions	Q64464	Gene names	Cyp3a13, Cyp3a-13
Domain Architecture
Description	Cytochrome P450 3A13 (EC 1.14.14.1) (CYPIIIA13).

CP3AB_MOUSE
θ value	1.2077e-20 (rank : 55)	NC score	0.793276 (rank : 66)
Query Neighborhood Hits	111	Target Neighborhood Hits	111	Shared Neighborhood Hits	106
SwissProt Accessions	Q64459	Gene names	Cyp3a11, Cyp3a-11
Domain Architecture
Description	Cytochrome P450 3A11 (EC 1.14.14.1) (CYPIIIA11) (P-450IIIAM1) (P- 450UT).

CP4V3_MOUSE
θ value	2.27762e-19 (rank : 56)	NC score	0.815153 (rank : 51)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	106
SwissProt Accessions	Q9DBW0	Gene names	Cyp4v3
Domain Architecture	No domain graphic available
Description	Cytochrome P450 4V3 (EC 1.14.-.-).

CP4AA_MOUSE
θ value	2.5182e-18 (rank : 57)	NC score	0.723551 (rank : 80)
Query Neighborhood Hits	111	Target Neighborhood Hits	107	Shared Neighborhood Hits	106
SwissProt Accessions	O88833, Q9DCS5	Gene names	Cyp4a10, Cyp4a-10
Domain Architecture	No domain graphic available
Description	Cytochrome P450 4A10 (EC 1.14.15.3) (CYPIVA10) (Lauric acid omega- hydroxylase) (P450-LA-omega 1) (P452).

CP3A5_HUMAN
θ value	4.29542e-18 (rank : 58)	NC score	0.788612 (rank : 68)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	P20815, Q53WY8, Q75MV0, Q9HB56	Gene names	CYP3A5
Domain Architecture
Description	Cytochrome P450 3A5 (EC 1.14.14.1) (CYPIIIA5) (P450-PCN3) (HLp2).

CP4AC_MOUSE
θ value	5.60996e-18 (rank : 59)	NC score	0.725467 (rank : 78)
Query Neighborhood Hits	111	Target Neighborhood Hits	117	Shared Neighborhood Hits	106
SwissProt Accessions	Q91WL5, Q3UNE4, Q6P931, Q8N7N3	Gene names	Cyp4a12
Domain Architecture	No domain graphic available
Description	Cytochrome P450 4A12 (EC 1.14.14.1) (CYPIVA12).

CP343_HUMAN
θ value	1.24977e-17 (rank : 60)	NC score	0.791090 (rank : 67)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	Q9HB55, Q9HB52, Q9HB53, Q9HB54, Q9HB57	Gene names	CYP3A43
Domain Architecture
Description	Cytochrome P450 3A43 (EC 1.14.14.1).

CP24A_HUMAN
θ value	2.13179e-17 (rank : 61)	NC score	0.836461 (rank : 49)
Query Neighborhood Hits	111	Target Neighborhood Hits	116	Shared Neighborhood Hits	106
SwissProt Accessions	Q07973, Q15807	Gene names	CYP24A1, CYP24
Domain Architecture
Description	Cytochrome P450 24A1, mitochondrial precursor (EC 1.14.-.-) (P450- CC24) (Vitamin D(3) 24-hydroxylase) (1,25-dihydroxyvitamin D(3) 24- hydroxylase) (24-OHase).

CP24A_MOUSE
θ value	2.13179e-17 (rank : 62)	NC score	0.837586 (rank : 48)
Query Neighborhood Hits	111	Target Neighborhood Hits	116	Shared Neighborhood Hits	105
SwissProt Accessions	Q64441	Gene names	Cyp24a1, Cyp-24, Cyp24
Domain Architecture
Description	Cytochrome P450 24A1, mitochondrial precursor (EC 1.14.-.-) (P450- CC24) (Vitamin D(3) 24-hydroxylase) (1,25-dihydroxyvitamin D(3) 24- hydroxylase) (24-OHase).

CP4AB_HUMAN
θ value	1.38178e-16 (rank : 63)	NC score	0.723468 (rank : 81)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	106
SwissProt Accessions	Q02928, Q06766, Q16865, Q16866, Q8IWY5	Gene names	CYP4A11
Domain Architecture
Description	Cytochrome P450 4A11 precursor (EC 1.14.15.3) (CYPIVA11) (Fatty acid omega-hydroxylase) (P-450 HK omega) (Lauric acid omega-hydroxylase) (CYP4AII) (P450-HL-omega).

CP3AP_MOUSE
θ value	5.8054e-15 (rank : 64)	NC score	0.764584 (rank : 71)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	106
SwissProt Accessions	O09158	Gene names	Cyp3a25
Domain Architecture
Description	Cytochrome P450 3A25 (EC 1.14.14.1) (CYPIIIA25).

CP4X1_HUMAN
θ value	7.58209e-15 (rank : 65)	NC score	0.733073 (rank : 76)
Query Neighborhood Hits	111	Target Neighborhood Hits	112	Shared Neighborhood Hits	106
SwissProt Accessions	Q8N118	Gene names	CYP4X1
Domain Architecture
Description	Cytochrome P450 4X1 (EC 1.14.14.1) (CYPIVX1).

CP4AE_MOUSE
θ value	9.90251e-15 (rank : 66)	NC score	0.716540 (rank : 83)
Query Neighborhood Hits	111	Target Neighborhood Hits	114	Shared Neighborhood Hits	106
SwissProt Accessions	O35728, Q3UER2, Q5EBH0	Gene names	Cyp4a14
Domain Architecture	No domain graphic available
Description	Cytochrome P450 4A14 precursor (EC 1.14.15.3) (CYPIVA14) (Lauric acid omega-hydroxylase 3) (P450-LA-omega 3).

CP4F8_HUMAN
θ value	4.91457e-14 (rank : 67)	NC score	0.708124 (rank : 86)
Query Neighborhood Hits	111	Target Neighborhood Hits	107	Shared Neighborhood Hits	105
SwissProt Accessions	P98187	Gene names	CYP4F8
Domain Architecture
Description	Cytochrome P450 4F8 (EC 1.14.14.1) (CYPIVF8).

CP27B_HUMAN
θ value	6.41864e-14 (rank : 68)	NC score	0.799596 (rank : 62)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	106
SwissProt Accessions	O15528	Gene names	CYP27B1, CYP1ALPHA, CYP27B
Domain Architecture
Description	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor (EC 1.14.13.13) (Cytochrome P450 subfamily XXVIIB polypeptide 1) (Cytochrome p450 27B1) (Calcidiol 1-monooxygenase) (25-OHD-1 alpha- hydroxylase) (25-hydroxyvitamin D(3) 1-alpha-hydroxylase) (VD3 1A hydroxylase) (P450C1 alpha) (P450VD1-alpha).

CP27A_MOUSE
θ value	8.38298e-14 (rank : 69)	NC score	0.811946 (rank : 52)
Query Neighborhood Hits	111	Target Neighborhood Hits	112	Shared Neighborhood Hits	106
SwissProt Accessions	Q9DBG1	Gene names	Cyp27a1
Domain Architecture
Description	Cytochrome P450 27, mitochondrial precursor (EC 1.14.13.15) (Cytochrome P-450C27/25) (Sterol 26-hydroxylase) (Sterol 27- hydroxylase) (Vitamin D(3) 25-hydroxylase) (5-beta-cholestane-3- alpha,7-alpha,12-alpha-triol 27-hydroxylase).

CP27B_MOUSE
θ value	8.38298e-14 (rank : 70)	NC score	0.802749 (rank : 60)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	O35084	Gene names	Cyp27b1, Cyp27b, Cyp40
Domain Architecture
Description	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor (EC 1.14.13.13) (Cytochrome P450 subfamily XXVIIB polypeptide 1) (Cytochrome p450 27B1) (Calcidiol 1-monooxygenase) (25-OHD-1 alpha- hydroxylase) (25-hydroxyvitamin D(3) 1-alpha-hydroxylase) (VD3 1A hydroxylase) (P450C1 alpha) (P450VD1-alpha).

CP4FC_HUMAN
θ value	1.09485e-13 (rank : 71)	NC score	0.712754 (rank : 85)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	Q9HCS2, Q9HCS1	Gene names	CYP4F12
Domain Architecture
Description	Cytochrome P450 4F12 (EC 1.14.14.1) (CYPIVF12).

CP4FB_HUMAN
θ value	4.16044e-13 (rank : 72)	NC score	0.706528 (rank : 87)
Query Neighborhood Hits	111	Target Neighborhood Hits	114	Shared Neighborhood Hits	106
SwissProt Accessions	Q9HBI6, O75254, Q96AQ5	Gene names	CYP4F11
Domain Architecture
Description	Cytochrome P450 4F11 (EC 1.14.14.1) (CYPIVF11).

THAS_MOUSE
θ value	5.43371e-13 (rank : 73)	NC score	0.798735 (rank : 63)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	106
SwissProt Accessions	P36423, P97505	Gene names	Tbxas1, Cyp5, Cyp5a1
Domain Architecture
Description	Thromboxane-A synthase (EC 5.3.99.5) (TXA synthase) (TXS) (TS) (Cytochrome P450 5A1).

CP46A_MOUSE
θ value	7.09661e-13 (rank : 74)	NC score	0.805395 (rank : 57)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	105
SwissProt Accessions	Q9WVK8	Gene names	Cyp46a1, Cyp46
Domain Architecture
Description	Cytochrome p450 46A1 (EC 1.14.13.98) (Cholesterol 24-hydroxylase) (CH24H).

CP19A_MOUSE
θ value	9.26847e-13 (rank : 75)	NC score	0.823153 (rank : 50)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	106
SwissProt Accessions	P28649	Gene names	Cyp19a1, Arom, Cyp19
Domain Architecture
Description	Cytochrome P450 19A1 (EC 1.14.14.1) (Aromatase) (CYPXIX) (Estrogen synthetase) (P-450AROM).

CP4F2_HUMAN
θ value	2.69671e-12 (rank : 76)	NC score	0.705327 (rank : 89)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	P78329, Q16677, Q6NWT4, Q6NWT6, Q9NNZ0, Q9UIU8	Gene names	CYP4F2
Domain Architecture
Description	Cytochrome P450 4F2 (EC 1.14.13.30) (CYPIVF2) (Leukotriene-B(4) omega- hydroxylase) (Leukotriene-B(4) 20-monooxygenase) (Cytochrome P450-LTB- omega).

CP27A_HUMAN
θ value	6.00763e-12 (rank : 77)	NC score	0.795775 (rank : 65)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	Q02318, Q6LDB4, Q86YQ6	Gene names	CYP27A1, CYP27
Domain Architecture
Description	Cytochrome P450 27, mitochondrial precursor (EC 1.14.13.15) (Cytochrome P-450C27/25) (Sterol 26-hydroxylase) (Sterol 27- hydroxylase) (Vitamin D(3) 25-hydroxylase) (5-beta-cholestane-3- alpha,7-alpha,12-alpha-triol 27-hydroxylase).

CP4FE_MOUSE
θ value	6.00763e-12 (rank : 78)	NC score	0.687610 (rank : 92)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	105
SwissProt Accessions	Q9EP75, Q52L93	Gene names	Cyp4f14
Domain Architecture
Description	Cytochrome P450 4F14 (EC 1.14.13.30) (Leukotriene-B4 omega- hydroxylase) (Leukotriene-B4 20-monooxygenase) (Cytochrome P450-LTB- omega) (Cyp4f-14).

CP4Z1_HUMAN
θ value	1.02475e-11 (rank : 79)	NC score	0.739698 (rank : 75)
Query Neighborhood Hits	111	Target Neighborhood Hits	117	Shared Neighborhood Hits	105
SwissProt Accessions	Q86W10	Gene names	CYP4Z1
Domain Architecture
Description	Cytochrome P450 4Z1 (EC 1.14.14.1) (CYPIVZ1).

CP11A_MOUSE
θ value	2.28291e-11 (rank : 80)	NC score	0.744527 (rank : 74)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	104
SwissProt Accessions	Q9QZ82	Gene names	Cyp11a1, Cyp11a
Domain Architecture
Description	Cytochrome P450 11A1, mitochondrial precursor (EC 1.14.15.6) (CYPXIA1) (P450(scc)) (Cholesterol side-chain cleavage enzyme) (Cholesterol desmolase).

CP4F3_MOUSE
θ value	2.98157e-11 (rank : 81)	NC score	0.672296 (rank : 96)
Query Neighborhood Hits	111	Target Neighborhood Hits	111	Shared Neighborhood Hits	106
SwissProt Accessions	Q99N16, Q9D8N4	Gene names	Cyp4f3, Cyp4f18
Domain Architecture	No domain graphic available
Description	Cytochrome P450 4F3 (EC 1.14.13.30) (CYPIVF3) (Leukotriene-B(4) omega- hydroxylase) (Leukotriene-B(4) 20-monooxygenase) (Cytochrome P450-LTB- omega).

CP11A_HUMAN
θ value	3.89403e-11 (rank : 82)	NC score	0.719835 (rank : 82)
Query Neighborhood Hits	111	Target Neighborhood Hits	107	Shared Neighborhood Hits	104
SwissProt Accessions	P05108, Q15081, Q16805	Gene names	CYP11A1, CYP11A
Domain Architecture
Description	Cytochrome P450 11A1, mitochondrial precursor (EC 1.14.15.6) (CYPXIA1) (P450(scc)) (Cholesterol side-chain cleavage enzyme) (Cholesterol desmolase).

CP19A_HUMAN
θ value	5.08577e-11 (rank : 83)	NC score	0.808186 (rank : 56)
Query Neighborhood Hits	111	Target Neighborhood Hits	111	Shared Neighborhood Hits	106
SwissProt Accessions	P11511, Q16731, Q58FA0	Gene names	CYP19A1, ARO1, CYAR, CYP19
Domain Architecture
Description	Cytochrome P450 19A1 (EC 1.14.14.1) (Aromatase) (CYPXIX) (Estrogen synthetase) (P-450AROM).

CP4B1_MOUSE
θ value	5.08577e-11 (rank : 84)	NC score	0.685854 (rank : 93)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	106
SwissProt Accessions	Q64462	Gene names	Cyp4b1
Domain Architecture
Description	Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1).

CP26A_MOUSE
θ value	1.9326e-10 (rank : 85)	NC score	0.758275 (rank : 72)
Query Neighborhood Hits	111	Target Neighborhood Hits	111	Shared Neighborhood Hits	106
SwissProt Accessions	O55127, Q9R1F4	Gene names	Cyp26a1, Cyp26, P450ra
Domain Architecture
Description	Cytochrome P450 26A1 (EC 1.14.-.-) (Retinoic acid-metabolizing cytochrome) (P450RAI) (Retinoic acid 4-hydroxylase).

CP46A_HUMAN
θ value	1.9326e-10 (rank : 86)	NC score	0.808700 (rank : 55)
Query Neighborhood Hits	111	Target Neighborhood Hits	114	Shared Neighborhood Hits	105
SwissProt Accessions	Q9Y6A2	Gene names	CYP46A1, CYP46
Domain Architecture
Description	Cytochrome p450 46A1 (EC 1.14.13.98) (Cholesterol 24-hydroxylase) (CH24H).

CP4F3_HUMAN
θ value	1.9326e-10 (rank : 87)	NC score	0.694871 (rank : 91)
Query Neighborhood Hits	111	Target Neighborhood Hits	111	Shared Neighborhood Hits	106
SwissProt Accessions	Q08477, O60634, Q5U740	Gene names	CYP4F3, LTB4H
Domain Architecture
Description	Cytochrome P450 4F3 (EC 1.14.13.30) (CYPIVF3) (Leukotriene-B(4) omega- hydroxylase) (Leukotriene-B(4) 20-monooxygenase) (Cytochrome P450-LTB- omega).

THAS_HUMAN
θ value	4.30538e-10 (rank : 88)	NC score	0.786793 (rank : 69)
Query Neighborhood Hits	111	Target Neighborhood Hits	111	Shared Neighborhood Hits	106
SwissProt Accessions	P24557, Q16844, Q8IUN1, Q9GZW4, Q9HD77, Q9HD78, Q9HD79, Q9HD80, Q9HD81, Q9HD82, Q9HD83, Q9HD84	Gene names	TBXAS1, CYP5, CYP5A1
Domain Architecture
Description	Thromboxane-A synthase (EC 5.3.99.5) (TXA synthase) (TXS) (Cytochrome P450 5A1).

C11B2_HUMAN
θ value	5.62301e-10 (rank : 89)	NC score	0.724058 (rank : 79)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	106
SwissProt Accessions	P19099, Q16726	Gene names	CYP11B2
Domain Architecture
Description	Cytochrome P450 11B2, mitochondrial precursor (EC 1.14.15.4) (EC 1.14.15.5) (CYPXIB2) (P-450Aldo) (Aldosterone synthase) (ALDOS) (Aldosterone-synthesizing enzyme) (Steroid 18-hydroxylase) (P-450C18).

CP26A_HUMAN
θ value	5.62301e-10 (rank : 90)	NC score	0.744675 (rank : 73)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	106
SwissProt Accessions	O43174	Gene names	CYP26A1, CYP26, P450RAI1
Domain Architecture
Description	Cytochrome P450 26A1 (EC 1.14.-.-) (Retinoic acid-metabolizing cytochrome) (P450 retinoic acid-inactivating 1) (P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase).

C11B1_HUMAN
θ value	9.59137e-10 (rank : 91)	NC score	0.714683 (rank : 84)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	106
SwissProt Accessions	P15538, Q14095, Q9UML2	Gene names	CYP11B1, S11BH
Domain Architecture
Description	Cytochrome P450 11B1, mitochondrial precursor (EC 1.14.15.4) (CYPXIB1) (P450C11) (P-450c11) (Steroid 11-beta-hydroxylase).

CP26B_HUMAN
θ value	1.25267e-09 (rank : 92)	NC score	0.731376 (rank : 77)
Query Neighborhood Hits	111	Target Neighborhood Hits	114	Shared Neighborhood Hits	104
SwissProt Accessions	Q9NR63, Q53TW1, Q9NP41	Gene names	CYP26B1, CYP26A2, P450RAI2
Domain Architecture
Description	Cytochrome P450 26B1 (EC 1.14.-.-) (P450 26A2) (P450 retinoic acid- inactivating 2) (P450RAI-2) (Retinoic acid-metabolizing cytochrome).

CP4B1_HUMAN
θ value	2.36244e-08 (rank : 93)	NC score	0.684539 (rank : 94)
Query Neighborhood Hits	111	Target Neighborhood Hits	107	Shared Neighborhood Hits	106
SwissProt Accessions	P13584, Q8TD85, Q8WWU9, Q8WWV0	Gene names	CYP4B1
Domain Architecture
Description	Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1) (P450-HP).

CP8B1_HUMAN
θ value	5.26297e-08 (rank : 94)	NC score	0.574427 (rank : 99)
Query Neighborhood Hits	111	Target Neighborhood Hits	106	Shared Neighborhood Hits	106
SwissProt Accessions	Q9UNU6, O75958	Gene names	CYP8B1, CYP12
Domain Architecture
Description	Cytochrome P450 8B1 (EC 1.14.13.95) (CYPVIIIB1) (7-alpha- hydroxycholest-4-en-3-one 12-alpha-hydroxylase) (Sterol 12-alpha- hydroxylase) (7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase).

C11B2_MOUSE
θ value	3.41135e-07 (rank : 95)	NC score	0.674697 (rank : 95)
Query Neighborhood Hits	111	Target Neighborhood Hits	104	Shared Neighborhood Hits	99
SwissProt Accessions	P15539, Q64661	Gene names	Cyp11b2, Cyp11b-2
Domain Architecture
Description	Cytochrome P450 11B2, mitochondrial precursor (EC 1.14.15.4) (EC 1.14.15.5) (CYPXIB2) (P450C11) (Steroid 11-beta-hydroxylase) (Aldosterone synthase).

CP26C_HUMAN
θ value	1.29631e-06 (rank : 96)	NC score	0.698192 (rank : 90)
Query Neighborhood Hits	111	Target Neighborhood Hits	104	Shared Neighborhood Hits	104
SwissProt Accessions	Q6V0L0, Q5VXH6	Gene names	CYP26C1
Domain Architecture	No domain graphic available
Description	Cytochrome P450 26C1 (EC 1.14.-.-).

PTGIS_MOUSE
θ value	4.1701e-05 (rank : 97)	NC score	0.527794 (rank : 101)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	103
SwissProt Accessions	O35074	Gene names	Ptgis, Cyp8
Domain Architecture
Description	Prostacyclin synthase (EC 5.3.99.4) (Prostaglandin I2 synthase).

CP7B1_HUMAN
θ value	7.1131e-05 (rank : 98)	NC score	0.544570 (rank : 100)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	104
SwissProt Accessions	O75881, Q9UNF5	Gene names	CYP7B1
Domain Architecture
Description	Cytochrome P450 7B1 (EC 1.14.13.100) (25-hydroxycholesterol 7-alpha- hydroxylase) (Oxysterol 7-alpha-hydroxylase).

CP8B1_MOUSE
θ value	9.29e-05 (rank : 99)	NC score	0.518356 (rank : 102)
Query Neighborhood Hits	111	Target Neighborhood Hits	99	Shared Neighborhood Hits	99
SwissProt Accessions	O88962, Q9R217	Gene names	Cyp8b1, Cyp12
Domain Architecture
Description	Cytochrome P450 8B1 (EC 1.14.13.95) (CYPVIIIB1) (7-alpha- hydroxycholest-4-en-3-one 12-alpha-hydroxylase) (Sterol 12-alpha- hydroxylase) (7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase).

CP51A_HUMAN
θ value	0.000121331 (rank : 100)	NC score	0.705341 (rank : 88)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	Q16850, O00770, O00772, Q16784, Q8N1A8, Q99868	Gene names	CYP51A1, CYP51
Domain Architecture
Description	Cytochrome P450 51A1 (EC 1.14.13.70) (CYPLI) (P450LI) (Sterol 14-alpha demethylase) (Lanosterol 14-alpha demethylase) (LDM) (P450-14DM) (P45014DM).

CP39A_MOUSE
θ value	0.000602161 (rank : 101)	NC score	0.602221 (rank : 98)
Query Neighborhood Hits	111	Target Neighborhood Hits	116	Shared Neighborhood Hits	104
SwissProt Accessions	Q9JKJ9	Gene names	Cyp39a1
Domain Architecture
Description	Cytochrome P450 39A1 (EC 1.14.13.99) (24-hydroxycholesterol 7-alpha- hydroxylase) (Oxysterol 7-alpha-hydroxylase) (mCYP39A1).

CP7A1_MOUSE
θ value	0.00175202 (rank : 102)	NC score	0.481998 (rank : 105)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	104
SwissProt Accessions	Q64505	Gene names	Cyp7a1, Cyp7
Domain Architecture
Description	Cytochrome P450 7A1 (EC 1.14.13.17) (Cholesterol 7-alpha- monooxygenase) (CYPVII) (Cholesterol 7-alpha-hydroxylase).

CP7A1_HUMAN
θ value	0.00228821 (rank : 103)	NC score	0.484618 (rank : 104)
Query Neighborhood Hits	111	Target Neighborhood Hits	111	Shared Neighborhood Hits	104
SwissProt Accessions	P22680, P78454, Q7KZ19	Gene names	CYP7A1, CYP7
Domain Architecture
Description	Cytochrome P450 7A1 (Cholesterol 7-alpha-monooxygenase) (CYPVII) (EC 1.14.13.17) (Cholesterol 7-alpha-hydroxylase).

PTGIS_HUMAN
θ value	0.00390308 (rank : 104)	NC score	0.437616 (rank : 106)
Query Neighborhood Hits	111	Target Neighborhood Hits	102	Shared Neighborhood Hits	98
SwissProt Accessions	Q16647, Q9HAX2, Q9HAX3, Q9HAX4	Gene names	PTGIS, CYP8, CYP8A1
Domain Architecture
Description	Prostacyclin synthase (EC 5.3.99.4) (Prostaglandin I2 synthase).

CP39A_HUMAN
θ value	0.0148317 (rank : 105)	NC score	0.606121 (rank : 97)
Query Neighborhood Hits	111	Target Neighborhood Hits	113	Shared Neighborhood Hits	103
SwissProt Accessions	Q9NYL5, Q96FW5	Gene names	CYP39A1
Domain Architecture
Description	Cytochrome P450 39A1 (EC 1.14.13.99) (24-hydroxycholesterol 7-alpha- hydroxylase) (Oxysterol 7-alpha-hydroxylase) (hCYP39A1).

CP7B1_MOUSE
θ value	0.0330416 (rank : 106)	NC score	0.512209 (rank : 103)
Query Neighborhood Hits	111	Target Neighborhood Hits	106	Shared Neighborhood Hits	103
SwissProt Accessions	Q60991	Gene names	Cyp7b1
Domain Architecture
Description	Cytochrome P450 7B1 (EC 1.14.13.100) (25-hydroxycholesterol 7-alpha- hydroxylase) (Oxysterol 7-alpha-hydroxylase) (HCT-1).

MMAB_HUMAN
θ value	5.27518 (rank : 107)	NC score	0.006592 (rank : 107)
Query Neighborhood Hits	111	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	Q96EY8, Q9BSH0	Gene names	MMAB
Domain Architecture
Description	Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial precursor (EC 2.5.1.17) (Cob(I)alamin adenosyltransferase) (Methylmalonic aciduria type B protein).

RN123_MOUSE
θ value	6.88961 (rank : 108)	NC score	0.001937 (rank : 110)
Query Neighborhood Hits	111	Target Neighborhood Hits	174	Shared Neighborhood Hits	2
SwissProt Accessions	Q5XPI3, Q6PGE0	Gene names	Rnf123, Kpc1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

ROCK1_MOUSE
θ value	6.88961 (rank : 109)	NC score	-0.011992 (rank : 111)
Query Neighborhood Hits	111	Target Neighborhood Hits	2126	Shared Neighborhood Hits	2
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

HEMH_HUMAN
θ value	8.99809 (rank : 110)	NC score	0.005886 (rank : 108)
Query Neighborhood Hits	111	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	P22830, Q8IXN1	Gene names	FECH
Domain Architecture
Description	Ferrochelatase, mitochondrial precursor (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme synthetase).

HEMH_MOUSE
θ value	8.99809 (rank : 111)	NC score	0.005874 (rank : 109)
Query Neighborhood Hits	111	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	P22315	Gene names	Fech
Domain Architecture
Description	Ferrochelatase, mitochondrial precursor (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme synthetase).

Hits sorted by NC score

CP240_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 4)
Query Neighborhood Hits	111	Target Neighborhood Hits	111	Shared Neighborhood Hits	111
SwissProt Accessions	P56657	Gene names	Cyp2c40
Domain Architecture
Description	Cytochrome P450 2C40 (EC 1.14.14.1) (CYPIIC40).

CP237_MOUSE
NC score	0.998844 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	P56654	Gene names	Cyp2c37
Domain Architecture
Description	Cytochrome P450 2C37 (EC 1.14.14.1) (CYPIIC37).

CP2CT_MOUSE
NC score	0.998666 (rank : 3)	θ value	0 (rank : 5)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	Q64458, Q8WUN8	Gene names	Cyp2c29
Domain Architecture
Description	Cytochrome P450 2C29 (EC 1.14.14.1) (CYPIIC29) (P-450 MUT-2) (Aldehyde oxygenase).

CP238_MOUSE
NC score	0.998513 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	111	Target Neighborhood Hits	112	Shared Neighborhood Hits	106
SwissProt Accessions	P56655	Gene names	Cyp2c38
Domain Architecture
Description	Cytochrome P450 2C38 (EC 1.14.14.1) (CYPIIC38).

CP2CI_HUMAN
NC score	0.998414 (rank : 5)	θ value	3.24166e-183 (rank : 6)
Query Neighborhood Hits	111	Target Neighborhood Hits	107	Shared Neighborhood Hits	106
SwissProt Accessions	P33260, Q16703, Q16751	Gene names	CYP2C18
Domain Architecture
Description	Cytochrome P450 2C18 (EC 1.14.14.1) (CYPIIC18) (P450-6B/29C).

CP239_MOUSE
NC score	0.998297 (rank : 6)	θ value	0 (rank : 3)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	P56656	Gene names	Cyp2c39
Domain Architecture
Description	Cytochrome P450 2C39 (EC 1.14.14.1) (CYPIIC39).

CP2CJ_HUMAN
NC score	0.998022 (rank : 7)	θ value	1.04281e-181 (rank : 7)
Query Neighborhood Hits	111	Target Neighborhood Hits	112	Shared Neighborhood Hits	106
SwissProt Accessions	P33261, P33259, Q8WZB1, Q8WZB2	Gene names	CYP2C19
Domain Architecture
Description	Cytochrome P450 2C19 (EC 1.14.13.80) ((R)-limonene 6-monooxygenase) (EC 1.14.13.48) ((S)-limonene 6-monooxygenase) (EC 1.14.13.49) ((S)- limonene 7-monooxygenase) (CYPIIC19) (P450-11A) (Mephenytoin 4- hydroxylase) (CYPIIC17) (P450-254C).

CP2C8_HUMAN
NC score	0.997949 (rank : 8)	θ value	3.24919e-175 (rank : 9)
Query Neighborhood Hits	111	Target Neighborhood Hits	111	Shared Neighborhood Hits	106
SwissProt Accessions	P10632	Gene names	CYP2C8
Domain Architecture
Description	Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (P450 form 1) (P450 MP- 12/MP-20) (P450 IIC2) (S-mephenytoin 4-hydroxylase).

CP2C9_HUMAN
NC score	0.997822 (rank : 9)	θ value	1.40939e-178 (rank : 8)
Query Neighborhood Hits	111	Target Neighborhood Hits	113	Shared Neighborhood Hits	106
SwissProt Accessions	P11712, P11713, Q16756, Q16872	Gene names	CYP2C9, CYP2C10
Domain Architecture
Description	Cytochrome P450 2C9 (EC 1.14.13.80) ((R)-limonene 6-monooxygenase) (EC 1.14.13.48) ((S)-limonene 6-monooxygenase) (EC 1.14.13.49) ((S)- limonene 7-monooxygenase) (CYPIIC9) (P450 PB-1) (P450 MP-4/MP-8) (S- mephenytoin 4-hydroxylase) (P-450MP).

CP270_MOUSE
NC score	0.996600 (rank : 10)	θ value	2.49938e-159 (rank : 10)
Query Neighborhood Hits	111	Target Neighborhood Hits	112	Shared Neighborhood Hits	106
SwissProt Accessions	Q91W64, Q5GLY9, Q80VW0, Q8R120, Q8VC00	Gene names	Cyp2c70, Cyp2c-70, Cyp2c22
Domain Architecture	No domain graphic available
Description	Cytochrome P450 2C70 (EC 1.14.14.1) (CYPIIC70).

CP2E1_MOUSE
NC score	0.995806 (rank : 11)	θ value	3.17642e-138 (rank : 11)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	Q05421, Q9Z198	Gene names	Cyp2e1, Cyp2e, Cyp2e-1
Domain Architecture
Description	Cytochrome P450 2E1 (EC 1.14.14.1) (CYPIIE1) (P450-J) (P450-ALC).

CP2E1_HUMAN
NC score	0.995233 (rank : 12)	θ value	2.51683e-135 (rank : 12)
Query Neighborhood Hits	111	Target Neighborhood Hits	106	Shared Neighborhood Hits	106
SwissProt Accessions	P05181, Q9UK47	Gene names	CYP2E1, CYP2E
Domain Architecture
Description	Cytochrome P450 2E1 (EC 1.14.14.1) (CYPIIE1) (P450-J).

CP2F1_HUMAN
NC score	0.994985 (rank : 13)	θ value	5.09482e-120 (rank : 19)
Query Neighborhood Hits	111	Target Neighborhood Hits	106	Shared Neighborhood Hits	106
SwissProt Accessions	P24903	Gene names	CYP2F1
Domain Architecture
Description	Cytochrome P450 2F1 (EC 1.14.14.1) (CYPIIF1).

CP2F2_MOUSE
NC score	0.994445 (rank : 14)	θ value	3.1838e-130 (rank : 14)
Query Neighborhood Hits	111	Target Neighborhood Hits	106	Shared Neighborhood Hits	106
SwissProt Accessions	P33267	Gene names	Cyp2f2, Cyp2f-2
Domain Architecture
Description	Cytochrome P450 2F2 (EC 1.14.14.-) (CYPIIF2) (Naphthalene dehydrogenase) (Naphthalene hydroxylase) (P450-NAH-2).

CP2AD_HUMAN
NC score	0.992605 (rank : 15)	θ value	1.86652e-130 (rank : 13)
Query Neighborhood Hits	111	Target Neighborhood Hits	105	Shared Neighborhood Hits	104
SwissProt Accessions	Q16696, Q53YR8, Q9H2X2	Gene names	CYP2A13
Domain Architecture
Description	Cytochrome P450 2A13 (EC 1.14.14.1) (CYPIIA13).

CP2A4_MOUSE
NC score	0.992602 (rank : 16)	θ value	2.78914e-126 (rank : 16)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	105
SwissProt Accessions	P15392	Gene names	Cyp2a4, Cyp2a-4
Domain Architecture
Description	Cytochrome P450 2A4 (EC 1.14.14.1) (CYPIIA4) (Testosterone 15-alpha- hydroxylase) (P450-15-alpha) (P450-IIA3.1).

CP2A7_HUMAN
NC score	0.992497 (rank : 17)	θ value	1.63515e-126 (rank : 15)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	106
SwissProt Accessions	P20853, Q13121	Gene names	CYP2A7
Domain Architecture
Description	Cytochrome P450 2A7 (EC 1.14.14.1) (CYPIIA7) (P450-IIA4).

CP2B6_HUMAN
NC score	0.992476 (rank : 18)	θ value	2.2151e-115 (rank : 21)
Query Neighborhood Hits	111	Target Neighborhood Hits	106	Shared Neighborhood Hits	105
SwissProt Accessions	P20813, Q2V565, Q9UK46	Gene names	CYP2B6
Domain Architecture
Description	Cytochrome P450 2B6 (EC 1.14.14.1) (CYPIIB6) (P450 IIB1).

CP2B9_MOUSE
NC score	0.992290 (rank : 19)	θ value	1.8752e-114 (rank : 22)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	105
SwissProt Accessions	P12790	Gene names	Cyp2b9, Cyp2b-9, Rip
Domain Architecture
Description	Cytochrome P450 2B9 (EC 1.14.14.1) (CYPIIB9) (Testosterone 16-alpha hydroxylase) (P450-16-alpha) (Clone PF26).

CP2A6_HUMAN
NC score	0.992176 (rank : 20)	θ value	4.60808e-121 (rank : 18)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	106
SwissProt Accessions	P11509, P00190, P10890, Q16803, Q4VAT9, Q4VAU0, Q4VAU1, Q9H1Z7, Q9UK48	Gene names	CYP2A6
Domain Architecture
Description	Cytochrome P450 2A6 (EC 1.14.14.1) (CYPIIA6) (Coumarin 7-hydroxylase) (P450 IIA3) (CYP2A3) (P450(I)).

CP2BJ_MOUSE
NC score	0.992083 (rank : 21)	θ value	1.38745e-117 (rank : 20)
Query Neighborhood Hits	111	Target Neighborhood Hits	114	Shared Neighborhood Hits	105
SwissProt Accessions	O55071	Gene names	Cyp2b19
Domain Architecture
Description	Cytochrome P450 2B19 (EC 1.14.14.1) (CYPIIB19).

CP2A5_MOUSE
NC score	0.992009 (rank : 22)	θ value	1.80787e-125 (rank : 17)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	105
SwissProt Accessions	P20852	Gene names	Cyp2a5, Cyp2a-5
Domain Architecture
Description	Cytochrome P450 2A5 (EC 1.14.14.1) (CYPIIA5) (Coumarin 7-hydroxylase) (P450-15-COH) (P450-IIA3.2).

CP2AC_MOUSE
NC score	0.991996 (rank : 23)	θ value	8.71062e-112 (rank : 24)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	105
SwissProt Accessions	P56593	Gene names	Cyp2a12
Domain Architecture	No domain graphic available
Description	Cytochrome P450 2A12 (EC 1.14.14.1) (CYPIIA12) (Steroid hormones 7- alpha-hydroxylase) (Testosterone 7-alpha-hydroxylase).

CP2BA_MOUSE
NC score	0.991898 (rank : 24)	θ value	3.1986e-114 (rank : 23)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	103
SwissProt Accessions	P12791	Gene names	Cyp2b10, Cyp2b-10
Domain Architecture
Description	Cytochrome P450 2B10 (EC 1.14.14.1) (CYPIIB10) (Testosterone 16-alpha hydroxylase) (P450-16-alpha) (Clone PF3/46).

CP2S1_HUMAN
NC score	0.990981 (rank : 25)	θ value	6.27148e-94 (rank : 27)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	106
SwissProt Accessions	Q96SQ9, Q9BZ66	Gene names	CYP2S1
Domain Architecture
Description	Cytochrome P450 2S1 (EC 1.14.14.1) (CYPIIS1).

CP2S1_MOUSE
NC score	0.990707 (rank : 26)	θ value	6.27148e-94 (rank : 28)
Query Neighborhood Hits	111	Target Neighborhood Hits	112	Shared Neighborhood Hits	104
SwissProt Accessions	Q9DBX6	Gene names	Cyp2s1
Domain Architecture
Description	Cytochrome P450 2S1 (EC 1.14.14.1) (CYPIIS1).

CP2W1_HUMAN
NC score	0.987178 (rank : 27)	θ value	1.22395e-89 (rank : 30)
Query Neighborhood Hits	111	Target Neighborhood Hits	104	Shared Neighborhood Hits	101
SwissProt Accessions	Q8TAV3	Gene names	CYP2W1
Domain Architecture	No domain graphic available
Description	Cytochrome P450 2W1 (EC 1.14.14.-) (CYPIIW1).

CP2J5_MOUSE
NC score	0.985355 (rank : 28)	θ value	2.2254e-99 (rank : 25)
Query Neighborhood Hits	111	Target Neighborhood Hits	113	Shared Neighborhood Hits	106
SwissProt Accessions	O54749	Gene names	Cyp2j5
Domain Architecture
Description	Cytochrome P450 2J5 (EC 1.14.14.1) (CYPIIJ5) (Arachidonic acid epoxygenase).

CP2J6_MOUSE
NC score	0.984222 (rank : 29)	θ value	5.30912e-93 (rank : 29)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	O54750	Gene names	Cyp2j6
Domain Architecture
Description	Cytochrome P450 2J6 (EC 1.14.14.1) (CYPIIJ6) (Arachidonic acid epoxygenase).

CP2J2_HUMAN
NC score	0.983898 (rank : 30)	θ value	4.95767e-99 (rank : 26)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	106
SwissProt Accessions	P51589	Gene names	CYP2J2
Domain Architecture
Description	Cytochrome P450 2J2 (EC 1.14.14.1) (CYPIIJ2) (Arachidonic acid epoxygenase).

CP2DQ_MOUSE
NC score	0.980968 (rank : 31)	θ value	4.08394e-77 (rank : 33)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	105
SwissProt Accessions	Q8CIM7, Q9DBJ5	Gene names	Cyp2d26, Cyp2d-26
Domain Architecture	No domain graphic available
Description	Cytochrome P450 2D26 (EC 1.14.14.1) (CYPIID26).

CP2D6_HUMAN
NC score	0.980770 (rank : 32)	θ value	1.26953e-78 (rank : 32)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	104
SwissProt Accessions	P10635, Q16752, Q6B012	Gene names	CYP2D6
Domain Architecture
Description	Cytochrome P450 2D6 (EC 1.14.14.1) (CYPIID6) (P450-DB1) (Debrisoquine 4-hydroxylase).

CP2DA_MOUSE
NC score	0.980019 (rank : 33)	θ value	4.51533e-76 (rank : 34)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	P24456, Q64490	Gene names	Cyp2d10, Cyp2d-10
Domain Architecture
Description	Cytochrome P450 2D10 (EC 1.14.14.1) (CYPIID10) (P450-16-alpha) (P450CB) (Testosterone 16-alpha hydroxylase).

CP2D9_MOUSE
NC score	0.979826 (rank : 34)	θ value	1.03855e-80 (rank : 31)
Query Neighborhood Hits	111	Target Neighborhood Hits	107	Shared Neighborhood Hits	106
SwissProt Accessions	P11714, Q64489	Gene names	Cyp2d9, Cyp2d-9
Domain Architecture
Description	Cytochrome P450 2D9 (EC 1.14.14.1) (CYPIID9) (P450-16-alpha) (CA) (Testosterone 16-alpha hydroxylase).

CP2DB_MOUSE
NC score	0.977735 (rank : 35)	θ value	7.45998e-71 (rank : 35)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	105
SwissProt Accessions	P24457	Gene names	Cyp2d11, Cyp2d-11
Domain Architecture
Description	Cytochrome P450 2D11 (EC 1.14.14.1) (CYPIID11) (P450-16-alpha) (CC) (Testosterone 16-alpha hydroxylase).

CP2R1_MOUSE
NC score	0.977580 (rank : 36)	θ value	8.53533e-67 (rank : 37)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	Q6VVW9	Gene names	Cyp2r1
Domain Architecture	No domain graphic available
Description	Cytochrome P450 2R1 (EC 1.14.14.-) (Vitamin D 25-hydroxylase).

CP2R1_HUMAN
NC score	0.977511 (rank : 37)	θ value	1.5555e-68 (rank : 36)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	106
SwissProt Accessions	Q6VVX0, Q5RT65	Gene names	CYP2R1
Domain Architecture	No domain graphic available
Description	Cytochrome P450 2R1 (EC 1.14.14.-) (Vitamin D 25-hydroxylase).

CP1B1_HUMAN
NC score	0.966627 (rank : 38)	θ value	5.93839e-52 (rank : 40)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	105
SwissProt Accessions	Q16678, Q93089, Q9H316	Gene names	CYP1B1
Domain Architecture
Description	Cytochrome P450 1B1 (EC 1.14.14.1) (CYPIB1).

CP1B1_MOUSE
NC score	0.966200 (rank : 39)	θ value	2.49495e-50 (rank : 41)
Query Neighborhood Hits	111	Target Neighborhood Hits	107	Shared Neighborhood Hits	105
SwissProt Accessions	Q64429, Q60593, Q64461	Gene names	Cyp1b1, Cyp1-b1
Domain Architecture
Description	Cytochrome P450 1B1 (EC 1.14.14.1) (CYPIB1) (P450CMEF) (P450EF).

CP1A1_HUMAN
NC score	0.962804 (rank : 40)	θ value	2.03627e-60 (rank : 39)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	106
SwissProt Accessions	P04798	Gene names	CYP1A1
Domain Architecture
Description	Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (P450-P1) (P450 form 6) (P450-C).

CP1A1_MOUSE
NC score	0.962056 (rank : 41)	θ value	6.99855e-61 (rank : 38)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	106
SwissProt Accessions	P00184, Q61455	Gene names	Cyp1a1, Cyp1a-1
Domain Architecture
Description	Cytochrome P450 1A1 (EC 1.14.14.1) (CYPIA1) (P450-P1).

CP1A2_MOUSE
NC score	0.958795 (rank : 42)	θ value	1.04822e-48 (rank : 42)
Query Neighborhood Hits	111	Target Neighborhood Hits	112	Shared Neighborhood Hits	105
SwissProt Accessions	P00186, Q9QWJ4	Gene names	Cyp1a2, Cyp1a-2
Domain Architecture
Description	Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (P450-P2/P450-P3).

CP1A2_HUMAN
NC score	0.953713 (rank : 43)	θ value	1.32601e-43 (rank : 44)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	106
SwissProt Accessions	P05177, Q16754, Q6NWU5, Q9BXX7, Q9UK49	Gene names	CYP1A2
Domain Architecture
Description	Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (P450-P3) (P(3)450) (P450 4).

CP17A_MOUSE
NC score	0.952433 (rank : 44)	θ value	8.30557e-46 (rank : 43)
Query Neighborhood Hits	111	Target Neighborhood Hits	106	Shared Neighborhood Hits	106
SwissProt Accessions	P27786	Gene names	Cyp17a1, Cyp17
Domain Architecture
Description	Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17) (P450c17) (Steroid 17-alpha-hydroxylase/17,20 lyase).

CP17A_HUMAN
NC score	0.951427 (rank : 45)	θ value	2.26182e-43 (rank : 45)
Query Neighborhood Hits	111	Target Neighborhood Hits	115	Shared Neighborhood Hits	106
SwissProt Accessions	P05093, Q5TZV7	Gene names	CYP17A1, CYP17, S17AH
Domain Architecture
Description	Cytochrome P450 17A1 (EC 1.14.99.9) (CYPXVII) (P450-C17) (P450c17) (Steroid 17-alpha-monooxygenase) (Steroid 17-alpha-hydroxylase/17,20 lyase).

CP21A_HUMAN
NC score	0.946132 (rank : 46)	θ value	3.99248e-40 (rank : 46)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	106
SwissProt Accessions	P08686, P04033, Q01204, Q16749	Gene names	CYP21A2, CYP21, CYP21B
Domain Architecture
Description	Cytochrome P450 21 (EC 1.14.99.10) (Cytochrome P450 XXI) (Steroid 21- hydroxylase) (21-OHase) (P450-C21) (P-450c21) (P450-C21B).

CP21A_MOUSE
NC score	0.945719 (rank : 47)	θ value	3.27365e-34 (rank : 47)
Query Neighborhood Hits	111	Target Neighborhood Hits	112	Shared Neighborhood Hits	106
SwissProt Accessions	P03940, O88304, Q64510, Q9QX14	Gene names	Cyp21, Cyp21a-1, Cyp21a1
Domain Architecture
Description	Cytochrome P450 21 (EC 1.14.99.10) (Cytochrome P450 XXI) (Steroid 21- hydroxylase) (21-OHase) (P450-C21) (P-450c21).

CP24A_MOUSE
NC score	0.837586 (rank : 48)	θ value	2.13179e-17 (rank : 62)
Query Neighborhood Hits	111	Target Neighborhood Hits	116	Shared Neighborhood Hits	105
SwissProt Accessions	Q64441	Gene names	Cyp24a1, Cyp-24, Cyp24
Domain Architecture
Description	Cytochrome P450 24A1, mitochondrial precursor (EC 1.14.-.-) (P450- CC24) (Vitamin D(3) 24-hydroxylase) (1,25-dihydroxyvitamin D(3) 24- hydroxylase) (24-OHase).

CP24A_HUMAN
NC score	0.836461 (rank : 49)	θ value	2.13179e-17 (rank : 61)
Query Neighborhood Hits	111	Target Neighborhood Hits	116	Shared Neighborhood Hits	106
SwissProt Accessions	Q07973, Q15807	Gene names	CYP24A1, CYP24
Domain Architecture
Description	Cytochrome P450 24A1, mitochondrial precursor (EC 1.14.-.-) (P450- CC24) (Vitamin D(3) 24-hydroxylase) (1,25-dihydroxyvitamin D(3) 24- hydroxylase) (24-OHase).

CP19A_MOUSE
NC score	0.823153 (rank : 50)	θ value	9.26847e-13 (rank : 75)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	106
SwissProt Accessions	P28649	Gene names	Cyp19a1, Arom, Cyp19
Domain Architecture
Description	Cytochrome P450 19A1 (EC 1.14.14.1) (Aromatase) (CYPXIX) (Estrogen synthetase) (P-450AROM).

CP4V3_MOUSE
NC score	0.815153 (rank : 51)	θ value	2.27762e-19 (rank : 56)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	106
SwissProt Accessions	Q9DBW0	Gene names	Cyp4v3
Domain Architecture	No domain graphic available
Description	Cytochrome P450 4V3 (EC 1.14.-.-).

CP27A_MOUSE
NC score	0.811946 (rank : 52)	θ value	8.38298e-14 (rank : 69)
Query Neighborhood Hits	111	Target Neighborhood Hits	112	Shared Neighborhood Hits	106
SwissProt Accessions	Q9DBG1	Gene names	Cyp27a1
Domain Architecture
Description	Cytochrome P450 27, mitochondrial precursor (EC 1.14.13.15) (Cytochrome P-450C27/25) (Sterol 26-hydroxylase) (Sterol 27- hydroxylase) (Vitamin D(3) 25-hydroxylase) (5-beta-cholestane-3- alpha,7-alpha,12-alpha-triol 27-hydroxylase).

CP341_MOUSE
NC score	0.811445 (rank : 53)	θ value	1.73987e-27 (rank : 48)
Query Neighborhood Hits	111	Target Neighborhood Hits	113	Shared Neighborhood Hits	106
SwissProt Accessions	Q9JMA7	Gene names	Cyp3a41
Domain Architecture
Description	Cytochrome P450 3A41 (EC 1.14.14.1).

CP4V2_HUMAN
NC score	0.811335 (rank : 54)	θ value	6.40375e-22 (rank : 52)
Query Neighborhood Hits	111	Target Neighborhood Hits	106	Shared Neighborhood Hits	106
SwissProt Accessions	Q6ZWL3, Q6ZTM4	Gene names	CYP4V2
Domain Architecture	No domain graphic available
Description	Cytochrome P450 4V2 (EC 1.14.-.-).

CP46A_HUMAN
NC score	0.808700 (rank : 55)	θ value	1.9326e-10 (rank : 86)
Query Neighborhood Hits	111	Target Neighborhood Hits	114	Shared Neighborhood Hits	105
SwissProt Accessions	Q9Y6A2	Gene names	CYP46A1, CYP46
Domain Architecture
Description	Cytochrome p450 46A1 (EC 1.14.13.98) (Cholesterol 24-hydroxylase) (CH24H).

CP19A_HUMAN
NC score	0.808186 (rank : 56)	θ value	5.08577e-11 (rank : 83)
Query Neighborhood Hits	111	Target Neighborhood Hits	111	Shared Neighborhood Hits	106
SwissProt Accessions	P11511, Q16731, Q58FA0	Gene names	CYP19A1, ARO1, CYAR, CYP19
Domain Architecture
Description	Cytochrome P450 19A1 (EC 1.14.14.1) (Aromatase) (CYPXIX) (Estrogen synthetase) (P-450AROM).

CP46A_MOUSE
NC score	0.805395 (rank : 57)	θ value	7.09661e-13 (rank : 74)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	105
SwissProt Accessions	Q9WVK8	Gene names	Cyp46a1, Cyp46
Domain Architecture
Description	Cytochrome p450 46A1 (EC 1.14.13.98) (Cholesterol 24-hydroxylase) (CH24H).

CP3A4_HUMAN
NC score	0.804772 (rank : 58)	θ value	1.16704e-23 (rank : 49)
Query Neighborhood Hits	111	Target Neighborhood Hits	113	Shared Neighborhood Hits	106
SwissProt Accessions	P08684, Q16757, Q9UK50	Gene names	CYP3A4
Domain Architecture
Description	Cytochrome P450 3A4 (EC 1.14.13.67) (Quinine 3-monooxygenase) (CYPIIIA4) (Nifedipine oxidase) (Taurochenodeoxycholate 6-alpha- hydroxylase) (EC 1.14.13.97) (NF-25) (P450-PCN1).

CP3AG_MOUSE
NC score	0.803029 (rank : 59)	θ value	2.20094e-22 (rank : 51)
Query Neighborhood Hits	111	Target Neighborhood Hits	119	Shared Neighborhood Hits	106
SwissProt Accessions	Q64481	Gene names	Cyp3a16, Cyp3a-16
Domain Architecture
Description	Cytochrome P450 3A16 (EC 1.14.14.1) (CYPIIIA16).

CP27B_MOUSE
NC score	0.802749 (rank : 60)	θ value	8.38298e-14 (rank : 70)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	O35084	Gene names	Cyp27b1, Cyp27b, Cyp40
Domain Architecture
Description	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor (EC 1.14.13.13) (Cytochrome P450 subfamily XXVIIB polypeptide 1) (Cytochrome p450 27B1) (Calcidiol 1-monooxygenase) (25-OHD-1 alpha- hydroxylase) (25-hydroxyvitamin D(3) 1-alpha-hydroxylase) (VD3 1A hydroxylase) (P450C1 alpha) (P450VD1-alpha).

CP3A3_HUMAN
NC score	0.802705 (rank : 61)	θ value	1.6852e-22 (rank : 50)
Query Neighborhood Hits	111	Target Neighborhood Hits	113	Shared Neighborhood Hits	106
SwissProt Accessions	P05184	Gene names	CYP3A3
Domain Architecture
Description	Cytochrome P450 3A3 (EC 1.14.14.1) (CYPIIIA3) (HLp).

CP27B_HUMAN
NC score	0.799596 (rank : 62)	θ value	6.41864e-14 (rank : 68)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	106
SwissProt Accessions	O15528	Gene names	CYP27B1, CYP1ALPHA, CYP27B
Domain Architecture
Description	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor (EC 1.14.13.13) (Cytochrome P450 subfamily XXVIIB polypeptide 1) (Cytochrome p450 27B1) (Calcidiol 1-monooxygenase) (25-OHD-1 alpha- hydroxylase) (25-hydroxyvitamin D(3) 1-alpha-hydroxylase) (VD3 1A hydroxylase) (P450C1 alpha) (P450VD1-alpha).

THAS_MOUSE
NC score	0.798735 (rank : 63)	θ value	5.43371e-13 (rank : 73)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	106
SwissProt Accessions	P36423, P97505	Gene names	Tbxas1, Cyp5, Cyp5a1
Domain Architecture
Description	Thromboxane-A synthase (EC 5.3.99.5) (TXA synthase) (TXS) (TS) (Cytochrome P450 5A1).

CP3A7_HUMAN
NC score	0.796687 (rank : 64)	θ value	1.09232e-21 (rank : 53)
Query Neighborhood Hits	111	Target Neighborhood Hits	115	Shared Neighborhood Hits	106
SwissProt Accessions	P24462	Gene names	CYP3A7
Domain Architecture
Description	Cytochrome P450 3A7 (EC 1.14.14.1) (CYPIIIA7) (P450-HFLA).

CP27A_HUMAN
NC score	0.795775 (rank : 65)	θ value	6.00763e-12 (rank : 77)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	Q02318, Q6LDB4, Q86YQ6	Gene names	CYP27A1, CYP27
Domain Architecture
Description	Cytochrome P450 27, mitochondrial precursor (EC 1.14.13.15) (Cytochrome P-450C27/25) (Sterol 26-hydroxylase) (Sterol 27- hydroxylase) (Vitamin D(3) 25-hydroxylase) (5-beta-cholestane-3- alpha,7-alpha,12-alpha-triol 27-hydroxylase).

CP3AB_MOUSE
NC score	0.793276 (rank : 66)	θ value	1.2077e-20 (rank : 55)
Query Neighborhood Hits	111	Target Neighborhood Hits	111	Shared Neighborhood Hits	106
SwissProt Accessions	Q64459	Gene names	Cyp3a11, Cyp3a-11
Domain Architecture
Description	Cytochrome P450 3A11 (EC 1.14.14.1) (CYPIIIA11) (P-450IIIAM1) (P- 450UT).

CP343_HUMAN
NC score	0.791090 (rank : 67)	θ value	1.24977e-17 (rank : 60)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	Q9HB55, Q9HB52, Q9HB53, Q9HB54, Q9HB57	Gene names	CYP3A43
Domain Architecture
Description	Cytochrome P450 3A43 (EC 1.14.14.1).

CP3A5_HUMAN
NC score	0.788612 (rank : 68)	θ value	4.29542e-18 (rank : 58)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	P20815, Q53WY8, Q75MV0, Q9HB56	Gene names	CYP3A5
Domain Architecture
Description	Cytochrome P450 3A5 (EC 1.14.14.1) (CYPIIIA5) (P450-PCN3) (HLp2).

THAS_HUMAN
NC score	0.786793 (rank : 69)	θ value	4.30538e-10 (rank : 88)
Query Neighborhood Hits	111	Target Neighborhood Hits	111	Shared Neighborhood Hits	106
SwissProt Accessions	P24557, Q16844, Q8IUN1, Q9GZW4, Q9HD77, Q9HD78, Q9HD79, Q9HD80, Q9HD81, Q9HD82, Q9HD83, Q9HD84	Gene names	TBXAS1, CYP5, CYP5A1
Domain Architecture
Description	Thromboxane-A synthase (EC 5.3.99.5) (TXA synthase) (TXS) (Cytochrome P450 5A1).

CP3AD_MOUSE
NC score	0.783133 (rank : 70)	θ value	7.0802e-21 (rank : 54)
Query Neighborhood Hits	111	Target Neighborhood Hits	112	Shared Neighborhood Hits	106
SwissProt Accessions	Q64464	Gene names	Cyp3a13, Cyp3a-13
Domain Architecture
Description	Cytochrome P450 3A13 (EC 1.14.14.1) (CYPIIIA13).

CP3AP_MOUSE
NC score	0.764584 (rank : 71)	θ value	5.8054e-15 (rank : 64)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	106
SwissProt Accessions	O09158	Gene names	Cyp3a25
Domain Architecture
Description	Cytochrome P450 3A25 (EC 1.14.14.1) (CYPIIIA25).

CP26A_MOUSE
NC score	0.758275 (rank : 72)	θ value	1.9326e-10 (rank : 85)
Query Neighborhood Hits	111	Target Neighborhood Hits	111	Shared Neighborhood Hits	106
SwissProt Accessions	O55127, Q9R1F4	Gene names	Cyp26a1, Cyp26, P450ra
Domain Architecture
Description	Cytochrome P450 26A1 (EC 1.14.-.-) (Retinoic acid-metabolizing cytochrome) (P450RAI) (Retinoic acid 4-hydroxylase).

CP26A_HUMAN
NC score	0.744675 (rank : 73)	θ value	5.62301e-10 (rank : 90)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	106
SwissProt Accessions	O43174	Gene names	CYP26A1, CYP26, P450RAI1
Domain Architecture
Description	Cytochrome P450 26A1 (EC 1.14.-.-) (Retinoic acid-metabolizing cytochrome) (P450 retinoic acid-inactivating 1) (P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase).

CP11A_MOUSE
NC score	0.744527 (rank : 74)	θ value	2.28291e-11 (rank : 80)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	104
SwissProt Accessions	Q9QZ82	Gene names	Cyp11a1, Cyp11a
Domain Architecture
Description	Cytochrome P450 11A1, mitochondrial precursor (EC 1.14.15.6) (CYPXIA1) (P450(scc)) (Cholesterol side-chain cleavage enzyme) (Cholesterol desmolase).

CP4Z1_HUMAN
NC score	0.739698 (rank : 75)	θ value	1.02475e-11 (rank : 79)
Query Neighborhood Hits	111	Target Neighborhood Hits	117	Shared Neighborhood Hits	105
SwissProt Accessions	Q86W10	Gene names	CYP4Z1
Domain Architecture
Description	Cytochrome P450 4Z1 (EC 1.14.14.1) (CYPIVZ1).

CP4X1_HUMAN
NC score	0.733073 (rank : 76)	θ value	7.58209e-15 (rank : 65)
Query Neighborhood Hits	111	Target Neighborhood Hits	112	Shared Neighborhood Hits	106
SwissProt Accessions	Q8N118	Gene names	CYP4X1
Domain Architecture
Description	Cytochrome P450 4X1 (EC 1.14.14.1) (CYPIVX1).

CP26B_HUMAN
NC score	0.731376 (rank : 77)	θ value	1.25267e-09 (rank : 92)
Query Neighborhood Hits	111	Target Neighborhood Hits	114	Shared Neighborhood Hits	104
SwissProt Accessions	Q9NR63, Q53TW1, Q9NP41	Gene names	CYP26B1, CYP26A2, P450RAI2
Domain Architecture
Description	Cytochrome P450 26B1 (EC 1.14.-.-) (P450 26A2) (P450 retinoic acid- inactivating 2) (P450RAI-2) (Retinoic acid-metabolizing cytochrome).

CP4AC_MOUSE
NC score	0.725467 (rank : 78)	θ value	5.60996e-18 (rank : 59)
Query Neighborhood Hits	111	Target Neighborhood Hits	117	Shared Neighborhood Hits	106
SwissProt Accessions	Q91WL5, Q3UNE4, Q6P931, Q8N7N3	Gene names	Cyp4a12
Domain Architecture	No domain graphic available
Description	Cytochrome P450 4A12 (EC 1.14.14.1) (CYPIVA12).

C11B2_HUMAN
NC score	0.724058 (rank : 79)	θ value	5.62301e-10 (rank : 89)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	106
SwissProt Accessions	P19099, Q16726	Gene names	CYP11B2
Domain Architecture
Description	Cytochrome P450 11B2, mitochondrial precursor (EC 1.14.15.4) (EC 1.14.15.5) (CYPXIB2) (P-450Aldo) (Aldosterone synthase) (ALDOS) (Aldosterone-synthesizing enzyme) (Steroid 18-hydroxylase) (P-450C18).

CP4AA_MOUSE
NC score	0.723551 (rank : 80)	θ value	2.5182e-18 (rank : 57)
Query Neighborhood Hits	111	Target Neighborhood Hits	107	Shared Neighborhood Hits	106
SwissProt Accessions	O88833, Q9DCS5	Gene names	Cyp4a10, Cyp4a-10
Domain Architecture	No domain graphic available
Description	Cytochrome P450 4A10 (EC 1.14.15.3) (CYPIVA10) (Lauric acid omega- hydroxylase) (P450-LA-omega 1) (P452).

CP4AB_HUMAN
NC score	0.723468 (rank : 81)	θ value	1.38178e-16 (rank : 63)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	106
SwissProt Accessions	Q02928, Q06766, Q16865, Q16866, Q8IWY5	Gene names	CYP4A11
Domain Architecture
Description	Cytochrome P450 4A11 precursor (EC 1.14.15.3) (CYPIVA11) (Fatty acid omega-hydroxylase) (P-450 HK omega) (Lauric acid omega-hydroxylase) (CYP4AII) (P450-HL-omega).

CP11A_HUMAN
NC score	0.719835 (rank : 82)	θ value	3.89403e-11 (rank : 82)
Query Neighborhood Hits	111	Target Neighborhood Hits	107	Shared Neighborhood Hits	104
SwissProt Accessions	P05108, Q15081, Q16805	Gene names	CYP11A1, CYP11A
Domain Architecture
Description	Cytochrome P450 11A1, mitochondrial precursor (EC 1.14.15.6) (CYPXIA1) (P450(scc)) (Cholesterol side-chain cleavage enzyme) (Cholesterol desmolase).

CP4AE_MOUSE
NC score	0.716540 (rank : 83)	θ value	9.90251e-15 (rank : 66)
Query Neighborhood Hits	111	Target Neighborhood Hits	114	Shared Neighborhood Hits	106
SwissProt Accessions	O35728, Q3UER2, Q5EBH0	Gene names	Cyp4a14
Domain Architecture	No domain graphic available
Description	Cytochrome P450 4A14 precursor (EC 1.14.15.3) (CYPIVA14) (Lauric acid omega-hydroxylase 3) (P450-LA-omega 3).

C11B1_HUMAN
NC score	0.714683 (rank : 84)	θ value	9.59137e-10 (rank : 91)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	106
SwissProt Accessions	P15538, Q14095, Q9UML2	Gene names	CYP11B1, S11BH
Domain Architecture
Description	Cytochrome P450 11B1, mitochondrial precursor (EC 1.14.15.4) (CYPXIB1) (P450C11) (P-450c11) (Steroid 11-beta-hydroxylase).

CP4FC_HUMAN
NC score	0.712754 (rank : 85)	θ value	1.09485e-13 (rank : 71)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	Q9HCS2, Q9HCS1	Gene names	CYP4F12
Domain Architecture
Description	Cytochrome P450 4F12 (EC 1.14.14.1) (CYPIVF12).

CP4F8_HUMAN
NC score	0.708124 (rank : 86)	θ value	4.91457e-14 (rank : 67)
Query Neighborhood Hits	111	Target Neighborhood Hits	107	Shared Neighborhood Hits	105
SwissProt Accessions	P98187	Gene names	CYP4F8
Domain Architecture
Description	Cytochrome P450 4F8 (EC 1.14.14.1) (CYPIVF8).

CP4FB_HUMAN
NC score	0.706528 (rank : 87)	θ value	4.16044e-13 (rank : 72)
Query Neighborhood Hits	111	Target Neighborhood Hits	114	Shared Neighborhood Hits	106
SwissProt Accessions	Q9HBI6, O75254, Q96AQ5	Gene names	CYP4F11
Domain Architecture
Description	Cytochrome P450 4F11 (EC 1.14.14.1) (CYPIVF11).

CP51A_HUMAN
NC score	0.705341 (rank : 88)	θ value	0.000121331 (rank : 100)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	Q16850, O00770, O00772, Q16784, Q8N1A8, Q99868	Gene names	CYP51A1, CYP51
Domain Architecture
Description	Cytochrome P450 51A1 (EC 1.14.13.70) (CYPLI) (P450LI) (Sterol 14-alpha demethylase) (Lanosterol 14-alpha demethylase) (LDM) (P450-14DM) (P45014DM).

CP4F2_HUMAN
NC score	0.705327 (rank : 89)	θ value	2.69671e-12 (rank : 76)
Query Neighborhood Hits	111	Target Neighborhood Hits	110	Shared Neighborhood Hits	106
SwissProt Accessions	P78329, Q16677, Q6NWT4, Q6NWT6, Q9NNZ0, Q9UIU8	Gene names	CYP4F2
Domain Architecture
Description	Cytochrome P450 4F2 (EC 1.14.13.30) (CYPIVF2) (Leukotriene-B(4) omega- hydroxylase) (Leukotriene-B(4) 20-monooxygenase) (Cytochrome P450-LTB- omega).

CP26C_HUMAN
NC score	0.698192 (rank : 90)	θ value	1.29631e-06 (rank : 96)
Query Neighborhood Hits	111	Target Neighborhood Hits	104	Shared Neighborhood Hits	104
SwissProt Accessions	Q6V0L0, Q5VXH6	Gene names	CYP26C1
Domain Architecture	No domain graphic available
Description	Cytochrome P450 26C1 (EC 1.14.-.-).

CP4F3_HUMAN
NC score	0.694871 (rank : 91)	θ value	1.9326e-10 (rank : 87)
Query Neighborhood Hits	111	Target Neighborhood Hits	111	Shared Neighborhood Hits	106
SwissProt Accessions	Q08477, O60634, Q5U740	Gene names	CYP4F3, LTB4H
Domain Architecture
Description	Cytochrome P450 4F3 (EC 1.14.13.30) (CYPIVF3) (Leukotriene-B(4) omega- hydroxylase) (Leukotriene-B(4) 20-monooxygenase) (Cytochrome P450-LTB- omega).

CP4FE_MOUSE
NC score	0.687610 (rank : 92)	θ value	6.00763e-12 (rank : 78)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	105
SwissProt Accessions	Q9EP75, Q52L93	Gene names	Cyp4f14
Domain Architecture
Description	Cytochrome P450 4F14 (EC 1.14.13.30) (Leukotriene-B4 omega- hydroxylase) (Leukotriene-B4 20-monooxygenase) (Cytochrome P450-LTB- omega) (Cyp4f-14).

CP4B1_MOUSE
NC score	0.685854 (rank : 93)	θ value	5.08577e-11 (rank : 84)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	106
SwissProt Accessions	Q64462	Gene names	Cyp4b1
Domain Architecture
Description	Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1).

CP4B1_HUMAN
NC score	0.684539 (rank : 94)	θ value	2.36244e-08 (rank : 93)
Query Neighborhood Hits	111	Target Neighborhood Hits	107	Shared Neighborhood Hits	106
SwissProt Accessions	P13584, Q8TD85, Q8WWU9, Q8WWV0	Gene names	CYP4B1
Domain Architecture
Description	Cytochrome P450 4B1 (EC 1.14.14.1) (CYPIVB1) (P450-HP).

C11B2_MOUSE
NC score	0.674697 (rank : 95)	θ value	3.41135e-07 (rank : 95)
Query Neighborhood Hits	111	Target Neighborhood Hits	104	Shared Neighborhood Hits	99
SwissProt Accessions	P15539, Q64661	Gene names	Cyp11b2, Cyp11b-2
Domain Architecture
Description	Cytochrome P450 11B2, mitochondrial precursor (EC 1.14.15.4) (EC 1.14.15.5) (CYPXIB2) (P450C11) (Steroid 11-beta-hydroxylase) (Aldosterone synthase).

CP4F3_MOUSE
NC score	0.672296 (rank : 96)	θ value	2.98157e-11 (rank : 81)
Query Neighborhood Hits	111	Target Neighborhood Hits	111	Shared Neighborhood Hits	106
SwissProt Accessions	Q99N16, Q9D8N4	Gene names	Cyp4f3, Cyp4f18
Domain Architecture	No domain graphic available
Description	Cytochrome P450 4F3 (EC 1.14.13.30) (CYPIVF3) (Leukotriene-B(4) omega- hydroxylase) (Leukotriene-B(4) 20-monooxygenase) (Cytochrome P450-LTB- omega).

CP39A_HUMAN
NC score	0.606121 (rank : 97)	θ value	0.0148317 (rank : 105)
Query Neighborhood Hits	111	Target Neighborhood Hits	113	Shared Neighborhood Hits	103
SwissProt Accessions	Q9NYL5, Q96FW5	Gene names	CYP39A1
Domain Architecture
Description	Cytochrome P450 39A1 (EC 1.14.13.99) (24-hydroxycholesterol 7-alpha- hydroxylase) (Oxysterol 7-alpha-hydroxylase) (hCYP39A1).

CP39A_MOUSE
NC score	0.602221 (rank : 98)	θ value	0.000602161 (rank : 101)
Query Neighborhood Hits	111	Target Neighborhood Hits	116	Shared Neighborhood Hits	104
SwissProt Accessions	Q9JKJ9	Gene names	Cyp39a1
Domain Architecture
Description	Cytochrome P450 39A1 (EC 1.14.13.99) (24-hydroxycholesterol 7-alpha- hydroxylase) (Oxysterol 7-alpha-hydroxylase) (mCYP39A1).

CP8B1_HUMAN
NC score	0.574427 (rank : 99)	θ value	5.26297e-08 (rank : 94)
Query Neighborhood Hits	111	Target Neighborhood Hits	106	Shared Neighborhood Hits	106
SwissProt Accessions	Q9UNU6, O75958	Gene names	CYP8B1, CYP12
Domain Architecture
Description	Cytochrome P450 8B1 (EC 1.14.13.95) (CYPVIIIB1) (7-alpha- hydroxycholest-4-en-3-one 12-alpha-hydroxylase) (Sterol 12-alpha- hydroxylase) (7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase).

CP7B1_HUMAN
NC score	0.544570 (rank : 100)	θ value	7.1131e-05 (rank : 98)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	104
SwissProt Accessions	O75881, Q9UNF5	Gene names	CYP7B1
Domain Architecture
Description	Cytochrome P450 7B1 (EC 1.14.13.100) (25-hydroxycholesterol 7-alpha- hydroxylase) (Oxysterol 7-alpha-hydroxylase).

PTGIS_MOUSE
NC score	0.527794 (rank : 101)	θ value	4.1701e-05 (rank : 97)
Query Neighborhood Hits	111	Target Neighborhood Hits	108	Shared Neighborhood Hits	103
SwissProt Accessions	O35074	Gene names	Ptgis, Cyp8
Domain Architecture
Description	Prostacyclin synthase (EC 5.3.99.4) (Prostaglandin I2 synthase).

CP8B1_MOUSE
NC score	0.518356 (rank : 102)	θ value	9.29e-05 (rank : 99)
Query Neighborhood Hits	111	Target Neighborhood Hits	99	Shared Neighborhood Hits	99
SwissProt Accessions	O88962, Q9R217	Gene names	Cyp8b1, Cyp12
Domain Architecture
Description	Cytochrome P450 8B1 (EC 1.14.13.95) (CYPVIIIB1) (7-alpha- hydroxycholest-4-en-3-one 12-alpha-hydroxylase) (Sterol 12-alpha- hydroxylase) (7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase).

CP7B1_MOUSE
NC score	0.512209 (rank : 103)	θ value	0.0330416 (rank : 106)
Query Neighborhood Hits	111	Target Neighborhood Hits	106	Shared Neighborhood Hits	103
SwissProt Accessions	Q60991	Gene names	Cyp7b1
Domain Architecture
Description	Cytochrome P450 7B1 (EC 1.14.13.100) (25-hydroxycholesterol 7-alpha- hydroxylase) (Oxysterol 7-alpha-hydroxylase) (HCT-1).

CP7A1_HUMAN
NC score	0.484618 (rank : 104)	θ value	0.00228821 (rank : 103)
Query Neighborhood Hits	111	Target Neighborhood Hits	111	Shared Neighborhood Hits	104
SwissProt Accessions	P22680, P78454, Q7KZ19	Gene names	CYP7A1, CYP7
Domain Architecture
Description	Cytochrome P450 7A1 (Cholesterol 7-alpha-monooxygenase) (CYPVII) (EC 1.14.13.17) (Cholesterol 7-alpha-hydroxylase).

CP7A1_MOUSE
NC score	0.481998 (rank : 105)	θ value	0.00175202 (rank : 102)
Query Neighborhood Hits	111	Target Neighborhood Hits	109	Shared Neighborhood Hits	104
SwissProt Accessions	Q64505	Gene names	Cyp7a1, Cyp7
Domain Architecture
Description	Cytochrome P450 7A1 (EC 1.14.13.17) (Cholesterol 7-alpha- monooxygenase) (CYPVII) (Cholesterol 7-alpha-hydroxylase).

PTGIS_HUMAN
NC score	0.437616 (rank : 106)	θ value	0.00390308 (rank : 104)
Query Neighborhood Hits	111	Target Neighborhood Hits	102	Shared Neighborhood Hits	98
SwissProt Accessions	Q16647, Q9HAX2, Q9HAX3, Q9HAX4	Gene names	PTGIS, CYP8, CYP8A1
Domain Architecture
Description	Prostacyclin synthase (EC 5.3.99.4) (Prostaglandin I2 synthase).

MMAB_HUMAN
NC score	0.006592 (rank : 107)	θ value	5.27518 (rank : 107)
Query Neighborhood Hits	111	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	Q96EY8, Q9BSH0	Gene names	MMAB
Domain Architecture
Description	Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial precursor (EC 2.5.1.17) (Cob(I)alamin adenosyltransferase) (Methylmalonic aciduria type B protein).

HEMH_HUMAN
NC score	0.005886 (rank : 108)	θ value	8.99809 (rank : 110)
Query Neighborhood Hits	111	Target Neighborhood Hits	6	Shared Neighborhood Hits	3
SwissProt Accessions	P22830, Q8IXN1	Gene names	FECH
Domain Architecture
Description	Ferrochelatase, mitochondrial precursor (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme synthetase).

HEMH_MOUSE
NC score	0.005874 (rank : 109)	θ value	8.99809 (rank : 111)
Query Neighborhood Hits	111	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	P22315	Gene names	Fech
Domain Architecture
Description	Ferrochelatase, mitochondrial precursor (EC 4.99.1.1) (Protoheme ferro-lyase) (Heme synthetase).

RN123_MOUSE
NC score	0.001937 (rank : 110)	θ value	6.88961 (rank : 108)
Query Neighborhood Hits	111	Target Neighborhood Hits	174	Shared Neighborhood Hits	2
SwissProt Accessions	Q5XPI3, Q6PGE0	Gene names	Rnf123, Kpc1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

ROCK1_MOUSE
NC score	-0.011992 (rank : 111)	θ value	6.88961 (rank : 109)
Query Neighborhood Hits	111	Target Neighborhood Hits	2126	Shared Neighborhood Hits	2
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).