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Network neighborhood for query Sequence : CDCA5_HUMAN

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CDCA5_HUMAN
SwissProt Accessions	Q96FF9	Gene names	CDCA5
Domain Architecture	No domain graphic available
Description	Sororin (Cell division cycle-associated protein 5) (p35).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CDCA5_HUMAN
θ value	2.5344e-111 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	25	Target Neighborhood Hits	25	Shared Neighborhood Hits	25
SwissProt Accessions	Q96FF9	Gene names	CDCA5
Domain Architecture	No domain graphic available
Description	Sororin (Cell division cycle-associated protein 5) (p35).

CDCA5_MOUSE
θ value	2.84138e-62 (rank : 2)	NC score	0.959934 (rank : 2)
Query Neighborhood Hits	25	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CPY3, Q78HI6	Gene names	Cdca5
Domain Architecture	No domain graphic available
Description	Sororin (Cell division cycle-associated protein 5).

ZN750_MOUSE
θ value	0.163984 (rank : 3)	NC score	0.101140 (rank : 3)
Query Neighborhood Hits	25	Target Neighborhood Hits	346	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BH05, Q66JP3, Q8C0L1	Gene names	Znf750
Domain Architecture	No domain graphic available
Description	Protein ZNF750.

MYO15_HUMAN
θ value	0.62314 (rank : 4)	NC score	0.021517 (rank : 21)
Query Neighborhood Hits	25	Target Neighborhood Hits	671	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

MINT_MOUSE
θ value	1.06291 (rank : 5)	NC score	0.047761 (rank : 5)
Query Neighborhood Hits	25	Target Neighborhood Hits	1514	Shared Neighborhood Hits	17
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

ZN750_HUMAN
θ value	1.06291 (rank : 6)	NC score	0.098507 (rank : 4)
Query Neighborhood Hits	25	Target Neighborhood Hits	183	Shared Neighborhood Hits	7
SwissProt Accessions	Q32MQ0, Q9H899	Gene names	ZNF750
Domain Architecture	No domain graphic available
Description	Protein ZNF750.

DYNA_HUMAN
θ value	1.81305 (rank : 7)	NC score	0.017334 (rank : 23)
Query Neighborhood Hits	25	Target Neighborhood Hits	1194	Shared Neighborhood Hits	6
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

SFRIP_HUMAN
θ value	1.81305 (rank : 8)	NC score	0.042714 (rank : 6)
Query Neighborhood Hits	25	Target Neighborhood Hits	530	Shared Neighborhood Hits	7
SwissProt Accessions	Q99590, Q8IW59	Gene names	SFRS2IP, CASP11, SIP1
Domain Architecture	No domain graphic available
Description	SFRS2-interacting protein (Splicing factor, arginine/serine-rich 2- interacting protein) (SC35-interacting protein 1) (CTD-associated SR protein 11) (Splicing regulatory protein 129) (SRrp129) (NY-REN-40 antigen).

SMOO_HUMAN
θ value	1.81305 (rank : 9)	NC score	0.032853 (rank : 12)
Query Neighborhood Hits	25	Target Neighborhood Hits	391	Shared Neighborhood Hits	7
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

MKL2_MOUSE
θ value	2.36792 (rank : 10)	NC score	0.031559 (rank : 14)
Query Neighborhood Hits	25	Target Neighborhood Hits	269	Shared Neighborhood Hits	5
SwissProt Accessions	P59759	Gene names	Mkl2, Mrtfb
Domain Architecture
Description	MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B).

SRGP2_HUMAN
θ value	2.36792 (rank : 11)	NC score	0.026609 (rank : 18)
Query Neighborhood Hits	25	Target Neighborhood Hits	331	Shared Neighborhood Hits	4
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

CASC3_MOUSE
θ value	3.0926 (rank : 12)	NC score	0.033904 (rank : 10)
Query Neighborhood Hits	25	Target Neighborhood Hits	333	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K3W3, Q8K219, Q99NF0	Gene names	Casc3, Mln51
Domain Architecture	No domain graphic available
Description	Protein CASC3 (Cancer susceptibility candidate gene 3 protein homolog) (Metastatic lymph node protein 51 homolog) (Protein MLN 51 homolog) (Protein barentsz) (Btz).

CMTA1_HUMAN
θ value	4.03905 (rank : 13)	NC score	0.032890 (rank : 11)
Query Neighborhood Hits	25	Target Neighborhood Hits	217	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6Y1, Q5VUE1	Gene names	CAMTA1, KIAA0833
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 1.

NACAM_MOUSE
θ value	4.03905 (rank : 14)	NC score	0.034252 (rank : 9)
Query Neighborhood Hits	25	Target Neighborhood Hits	1866	Shared Neighborhood Hits	22
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

MINT_HUMAN
θ value	5.27518 (rank : 15)	NC score	0.041406 (rank : 8)
Query Neighborhood Hits	25	Target Neighborhood Hits	1291	Shared Neighborhood Hits	15
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

SRGP2_MOUSE
θ value	5.27518 (rank : 16)	NC score	0.024555 (rank : 19)
Query Neighborhood Hits	25	Target Neighborhood Hits	324	Shared Neighborhood Hits	4
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

MAVS_HUMAN
θ value	6.88961 (rank : 17)	NC score	0.031525 (rank : 15)
Query Neighborhood Hits	25	Target Neighborhood Hits	271	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z434, Q3I0Y2, Q5T7I6, Q86VY7, Q9H1H3, Q9H4Y1, Q9H8D3, Q9ULE9	Gene names	MAVS, IPS1, KIAA1271, VISA
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif) (Putative NF-kappa-B- activating protein 031N).

NELFA_HUMAN
θ value	6.88961 (rank : 18)	NC score	0.028133 (rank : 17)
Query Neighborhood Hits	25	Target Neighborhood Hits	161	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H3P2, O95392	Gene names	WHSC2, NELFA
Domain Architecture	No domain graphic available
Description	Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein).

NOVA2_HUMAN
θ value	6.88961 (rank : 19)	NC score	0.018700 (rank : 22)
Query Neighborhood Hits	25	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UNW9, O43267, Q9UEA1	Gene names	NOVA2, ANOVA, NOVA3
Domain Architecture
Description	RNA-binding protein Nova-2 (Neuro-oncological ventral antigen 2) (Astrocytic NOVA1-like RNA-binding protein).

S6OS1_HUMAN
θ value	6.88961 (rank : 20)	NC score	0.023561 (rank : 20)
Query Neighborhood Hits	25	Target Neighborhood Hits	134	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N1H7	Gene names	SIX6OS1, C14orf39
Domain Architecture	No domain graphic available
Description	Protein SIX6OS1 (Six6 opposite strand transcript 1).

SNPC2_MOUSE
θ value	6.88961 (rank : 21)	NC score	0.031937 (rank : 13)
Query Neighborhood Hits	25	Target Neighborhood Hits	83	Shared Neighborhood Hits	5
SwissProt Accessions	Q91XA5, Q3UK17, Q8CBS9	Gene names	Snapc2
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 2 (SNAPc subunit 2) (snRNA- activating protein complex 45 kDa subunit) (SNAPc 45 kDa subunit) (Small nuclear RNA-activating complex polypeptide 2).

ERRFI_MOUSE
θ value	8.99809 (rank : 22)	NC score	0.041578 (rank : 7)
Query Neighborhood Hits	25	Target Neighborhood Hits	72	Shared Neighborhood Hits	5
SwissProt Accessions	Q99JZ7	Gene names	Errfi1, Mig6
Domain Architecture	No domain graphic available
Description	ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein homolog) (Mig-6).

IC1_MOUSE
θ value	8.99809 (rank : 23)	NC score	0.008491 (rank : 25)
Query Neighborhood Hits	25	Target Neighborhood Hits	164	Shared Neighborhood Hits	4
SwissProt Accessions	P97290, O88330, Q99M43, Q9QX09	Gene names	Serping1, C1nh
Domain Architecture
Description	Plasma protease C1 inhibitor precursor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor).

SFRS8_HUMAN
θ value	8.99809 (rank : 24)	NC score	0.028616 (rank : 16)
Query Neighborhood Hits	25	Target Neighborhood Hits	166	Shared Neighborhood Hits	5
SwissProt Accessions	Q12872	Gene names	SFRS8, SWAP
Domain Architecture
Description	Splicing factor, arginine/serine-rich 8 (Suppressor of white apricot protein homolog).

SIA7A_MOUSE
θ value	8.99809 (rank : 25)	NC score	0.015821 (rank : 24)
Query Neighborhood Hits	25	Target Neighborhood Hits	203	Shared Neighborhood Hits	7
SwissProt Accessions	Q9QZ39, Q9JJP5	Gene names	St6galnac1, Siat7a
Domain Architecture
Description	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC 2.4.99.3) (GalNAc alpha-2,6-sialyltransferase I) (ST6GalNAc I) (Sialyltransferase 7A).

Hits sorted by NC score

CDCA5_HUMAN
NC score	0.999962 (rank : 1)	θ value	2.5344e-111 (rank : 1)
Query Neighborhood Hits	25	Target Neighborhood Hits	25	Shared Neighborhood Hits	25
SwissProt Accessions	Q96FF9	Gene names	CDCA5
Domain Architecture	No domain graphic available
Description	Sororin (Cell division cycle-associated protein 5) (p35).

CDCA5_MOUSE
NC score	0.959934 (rank : 2)	θ value	2.84138e-62 (rank : 2)
Query Neighborhood Hits	25	Target Neighborhood Hits	12	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CPY3, Q78HI6	Gene names	Cdca5
Domain Architecture	No domain graphic available
Description	Sororin (Cell division cycle-associated protein 5).

ZN750_MOUSE
NC score	0.101140 (rank : 3)	θ value	0.163984 (rank : 3)
Query Neighborhood Hits	25	Target Neighborhood Hits	346	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BH05, Q66JP3, Q8C0L1	Gene names	Znf750
Domain Architecture	No domain graphic available
Description	Protein ZNF750.

ZN750_HUMAN
NC score	0.098507 (rank : 4)	θ value	1.06291 (rank : 6)
Query Neighborhood Hits	25	Target Neighborhood Hits	183	Shared Neighborhood Hits	7
SwissProt Accessions	Q32MQ0, Q9H899	Gene names	ZNF750
Domain Architecture	No domain graphic available
Description	Protein ZNF750.

MINT_MOUSE
NC score	0.047761 (rank : 5)	θ value	1.06291 (rank : 5)
Query Neighborhood Hits	25	Target Neighborhood Hits	1514	Shared Neighborhood Hits	17
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

SFRIP_HUMAN
NC score	0.042714 (rank : 6)	θ value	1.81305 (rank : 8)
Query Neighborhood Hits	25	Target Neighborhood Hits	530	Shared Neighborhood Hits	7
SwissProt Accessions	Q99590, Q8IW59	Gene names	SFRS2IP, CASP11, SIP1
Domain Architecture	No domain graphic available
Description	SFRS2-interacting protein (Splicing factor, arginine/serine-rich 2- interacting protein) (SC35-interacting protein 1) (CTD-associated SR protein 11) (Splicing regulatory protein 129) (SRrp129) (NY-REN-40 antigen).

ERRFI_MOUSE
NC score	0.041578 (rank : 7)	θ value	8.99809 (rank : 22)
Query Neighborhood Hits	25	Target Neighborhood Hits	72	Shared Neighborhood Hits	5
SwissProt Accessions	Q99JZ7	Gene names	Errfi1, Mig6
Domain Architecture	No domain graphic available
Description	ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein homolog) (Mig-6).

MINT_HUMAN
NC score	0.041406 (rank : 8)	θ value	5.27518 (rank : 15)
Query Neighborhood Hits	25	Target Neighborhood Hits	1291	Shared Neighborhood Hits	15
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

NACAM_MOUSE
NC score	0.034252 (rank : 9)	θ value	4.03905 (rank : 14)
Query Neighborhood Hits	25	Target Neighborhood Hits	1866	Shared Neighborhood Hits	22
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

CASC3_MOUSE
NC score	0.033904 (rank : 10)	θ value	3.0926 (rank : 12)
Query Neighborhood Hits	25	Target Neighborhood Hits	333	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K3W3, Q8K219, Q99NF0	Gene names	Casc3, Mln51
Domain Architecture	No domain graphic available
Description	Protein CASC3 (Cancer susceptibility candidate gene 3 protein homolog) (Metastatic lymph node protein 51 homolog) (Protein MLN 51 homolog) (Protein barentsz) (Btz).

CMTA1_HUMAN
NC score	0.032890 (rank : 11)	θ value	4.03905 (rank : 13)
Query Neighborhood Hits	25	Target Neighborhood Hits	217	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6Y1, Q5VUE1	Gene names	CAMTA1, KIAA0833
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 1.

SMOO_HUMAN
NC score	0.032853 (rank : 12)	θ value	1.81305 (rank : 9)
Query Neighborhood Hits	25	Target Neighborhood Hits	391	Shared Neighborhood Hits	7
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

SNPC2_MOUSE
NC score	0.031937 (rank : 13)	θ value	6.88961 (rank : 21)
Query Neighborhood Hits	25	Target Neighborhood Hits	83	Shared Neighborhood Hits	5
SwissProt Accessions	Q91XA5, Q3UK17, Q8CBS9	Gene names	Snapc2
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 2 (SNAPc subunit 2) (snRNA- activating protein complex 45 kDa subunit) (SNAPc 45 kDa subunit) (Small nuclear RNA-activating complex polypeptide 2).

MKL2_MOUSE
NC score	0.031559 (rank : 14)	θ value	2.36792 (rank : 10)
Query Neighborhood Hits	25	Target Neighborhood Hits	269	Shared Neighborhood Hits	5
SwissProt Accessions	P59759	Gene names	Mkl2, Mrtfb
Domain Architecture
Description	MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B).

MAVS_HUMAN
NC score	0.031525 (rank : 15)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	25	Target Neighborhood Hits	271	Shared Neighborhood Hits	8
SwissProt Accessions	Q7Z434, Q3I0Y2, Q5T7I6, Q86VY7, Q9H1H3, Q9H4Y1, Q9H8D3, Q9ULE9	Gene names	MAVS, IPS1, KIAA1271, VISA
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif) (Putative NF-kappa-B- activating protein 031N).

SFRS8_HUMAN
NC score	0.028616 (rank : 16)	θ value	8.99809 (rank : 24)
Query Neighborhood Hits	25	Target Neighborhood Hits	166	Shared Neighborhood Hits	5
SwissProt Accessions	Q12872	Gene names	SFRS8, SWAP
Domain Architecture
Description	Splicing factor, arginine/serine-rich 8 (Suppressor of white apricot protein homolog).

NELFA_HUMAN
NC score	0.028133 (rank : 17)	θ value	6.88961 (rank : 18)
Query Neighborhood Hits	25	Target Neighborhood Hits	161	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H3P2, O95392	Gene names	WHSC2, NELFA
Domain Architecture	No domain graphic available
Description	Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein).

SRGP2_HUMAN
NC score	0.026609 (rank : 18)	θ value	2.36792 (rank : 11)
Query Neighborhood Hits	25	Target Neighborhood Hits	331	Shared Neighborhood Hits	4
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
NC score	0.024555 (rank : 19)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	25	Target Neighborhood Hits	324	Shared Neighborhood Hits	4
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

S6OS1_HUMAN
NC score	0.023561 (rank : 20)	θ value	6.88961 (rank : 20)
Query Neighborhood Hits	25	Target Neighborhood Hits	134	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N1H7	Gene names	SIX6OS1, C14orf39
Domain Architecture	No domain graphic available
Description	Protein SIX6OS1 (Six6 opposite strand transcript 1).

MYO15_HUMAN
NC score	0.021517 (rank : 21)	θ value	0.62314 (rank : 4)
Query Neighborhood Hits	25	Target Neighborhood Hits	671	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

NOVA2_HUMAN
NC score	0.018700 (rank : 22)	θ value	6.88961 (rank : 19)
Query Neighborhood Hits	25	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UNW9, O43267, Q9UEA1	Gene names	NOVA2, ANOVA, NOVA3
Domain Architecture
Description	RNA-binding protein Nova-2 (Neuro-oncological ventral antigen 2) (Astrocytic NOVA1-like RNA-binding protein).

DYNA_HUMAN
NC score	0.017334 (rank : 23)	θ value	1.81305 (rank : 7)
Query Neighborhood Hits	25	Target Neighborhood Hits	1194	Shared Neighborhood Hits	6
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

SIA7A_MOUSE
NC score	0.015821 (rank : 24)	θ value	8.99809 (rank : 25)
Query Neighborhood Hits	25	Target Neighborhood Hits	203	Shared Neighborhood Hits	7
SwissProt Accessions	Q9QZ39, Q9JJP5	Gene names	St6galnac1, Siat7a
Domain Architecture
Description	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC 2.4.99.3) (GalNAc alpha-2,6-sialyltransferase I) (ST6GalNAc I) (Sialyltransferase 7A).

IC1_MOUSE
NC score	0.008491 (rank : 25)	θ value	8.99809 (rank : 23)
Query Neighborhood Hits	25	Target Neighborhood Hits	164	Shared Neighborhood Hits	4
SwissProt Accessions	P97290, O88330, Q99M43, Q9QX09	Gene names	Serping1, C1nh
Domain Architecture
Description	Plasma protease C1 inhibitor precursor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor).