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Network neighborhood for query Sequence : BAXA_MOUSE

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BAXA_MOUSE
SwissProt Accessions	Q07813	Gene names	Bax
Domain Architecture
Description	Apoptosis regulator BAX, membrane isoform alpha.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

BAXA_MOUSE
θ value	2.6227e-108 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	26	Target Neighborhood Hits	26	Shared Neighborhood Hits	26
SwissProt Accessions	Q07813	Gene names	Bax
Domain Architecture
Description	Apoptosis regulator BAX, membrane isoform alpha.

BAXA_HUMAN
θ value	6.47494e-99 (rank : 2)	NC score	0.997869 (rank : 2)
Query Neighborhood Hits	26	Target Neighborhood Hits	29	Shared Neighborhood Hits	25
SwissProt Accessions	Q07812	Gene names	BAX
Domain Architecture
Description	Apoptosis regulator BAX, membrane isoform alpha.

BAXB_HUMAN
θ value	5.69867e-79 (rank : 3)	NC score	0.992545 (rank : 4)
Query Neighborhood Hits	26	Target Neighborhood Hits	26	Shared Neighborhood Hits	21
SwissProt Accessions	Q07814	Gene names	BAX
Domain Architecture
Description	Apoptosis regulator BAX, cytoplasmic isoform beta.

BAXD_HUMAN
θ value	5.00389e-67 (rank : 4)	NC score	0.992669 (rank : 3)
Query Neighborhood Hits	26	Target Neighborhood Hits	26	Shared Neighborhood Hits	24
SwissProt Accessions	P55269	Gene names	BAX
Domain Architecture
Description	BAX protein, cytoplasmic isoform delta.

BCL2_MOUSE
θ value	4.30538e-10 (rank : 5)	NC score	0.675909 (rank : 5)
Query Neighborhood Hits	26	Target Neighborhood Hits	24	Shared Neighborhood Hits	22
SwissProt Accessions	P10417, P10418	Gene names	Bcl2, Bcl-2
Domain Architecture
Description	Apoptosis regulator Bcl-2.

BCLX_HUMAN
θ value	4.30538e-10 (rank : 6)	NC score	0.661524 (rank : 8)
Query Neighborhood Hits	26	Target Neighborhood Hits	26	Shared Neighborhood Hits	22
SwissProt Accessions	Q07817, Q5TE65, Q92976	Gene names	BCL2L1, BCL2L, BCLX
Domain Architecture
Description	Apoptosis regulator Bcl-X (Bcl-2-like 1 protein).

BCLX_MOUSE
θ value	4.30538e-10 (rank : 7)	NC score	0.664567 (rank : 7)
Query Neighborhood Hits	26	Target Neighborhood Hits	24	Shared Neighborhood Hits	22
SwissProt Accessions	Q64373, O35844, Q60657, Q60658, Q61338	Gene names	Bcl2l1, Bcl2l, Bclx
Domain Architecture
Description	Apoptosis regulator Bcl-X (Bcl-2-like 1 protein).

BCL2_HUMAN
θ value	5.62301e-10 (rank : 8)	NC score	0.675902 (rank : 6)
Query Neighborhood Hits	26	Target Neighborhood Hits	28	Shared Neighborhood Hits	22
SwissProt Accessions	P10415, P10416, Q13842, Q16197	Gene names	BCL2
Domain Architecture
Description	Apoptosis regulator Bcl-2.

BCLW_MOUSE
θ value	3.64472e-09 (rank : 9)	NC score	0.659325 (rank : 9)
Query Neighborhood Hits	26	Target Neighborhood Hits	23	Shared Neighborhood Hits	22
SwissProt Accessions	P70345, Q545Q4, Q6A093, Q8CFR2, Q8CGL4, Q9CYW5	Gene names	Bcl2l2, Bclw, Kiaa0271
Domain Architecture
Description	Apoptosis regulator Bcl-W (Bcl-2-like 2 protein) (c98).

BCLW_HUMAN
θ value	4.76016e-09 (rank : 10)	NC score	0.656958 (rank : 10)
Query Neighborhood Hits	26	Target Neighborhood Hits	23	Shared Neighborhood Hits	22
SwissProt Accessions	Q92843, Q5U0H4	Gene names	BCL2L2, BCLW, KIAA0271
Domain Architecture
Description	Apoptosis regulator Bcl-W (Bcl-2-like 2 protein).

B2LA1_HUMAN
θ value	4.0297e-08 (rank : 11)	NC score	0.628369 (rank : 11)
Query Neighborhood Hits	26	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	Q16548, Q99524	Gene names	BCL2A1, BCL2L5, BFL1, GRS
Domain Architecture
Description	Bcl-2-related protein A1 (Protein BFL-1) (Hemopoietic-specific early response protein) (Protein GRS).

BAK2_HUMAN
θ value	6.87365e-08 (rank : 12)	NC score	0.599845 (rank : 13)
Query Neighborhood Hits	26	Target Neighborhood Hits	19	Shared Neighborhood Hits	19
SwissProt Accessions	Q13014	Gene names	BCL2L7P1, BAK2
Domain Architecture
Description	Putative Bcl-2 homologous antagonist/killer 2 (Apoptosis regulator BAK-2).

MCL1_MOUSE
θ value	6.87365e-08 (rank : 13)	NC score	0.618674 (rank : 12)
Query Neighborhood Hits	26	Target Neighborhood Hits	27	Shared Neighborhood Hits	20
SwissProt Accessions	P97287, Q3TUS0, Q792P0, Q9CRI4	Gene names	Mcl1
Domain Architecture	No domain graphic available
Description	Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Bcl-2-related protein EAT/mcl1).

MCL1_HUMAN
θ value	1.17247e-07 (rank : 14)	NC score	0.591325 (rank : 14)
Query Neighborhood Hits	26	Target Neighborhood Hits	35	Shared Neighborhood Hits	20
SwissProt Accessions	Q07820, Q9HD91, Q9NRQ3, Q9NRQ4, Q9UHR7, Q9UHR8, Q9UHR9, Q9UNJ1	Gene names	MCL1
Domain Architecture
Description	Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2- related protein EAT/mcl1) (mcl1/EAT).

BAK_HUMAN
θ value	1.53129e-07 (rank : 15)	NC score	0.591121 (rank : 15)
Query Neighborhood Hits	26	Target Neighborhood Hits	22	Shared Neighborhood Hits	19
SwissProt Accessions	Q16611, Q92533	Gene names	BAK1, BAK, BCL2L7
Domain Architecture
Description	Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2- like 7 protein).

BOK_HUMAN
θ value	3.77169e-06 (rank : 16)	NC score	0.578064 (rank : 16)
Query Neighborhood Hits	26	Target Neighborhood Hits	20	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UMX3	Gene names	BOK
Domain Architecture	No domain graphic available
Description	Bcl-2-related ovarian killer protein (Hbok).

BOK_MOUSE
θ value	4.92598e-06 (rank : 17)	NC score	0.573603 (rank : 18)
Query Neighborhood Hits	26	Target Neighborhood Hits	20	Shared Neighborhood Hits	19
SwissProt Accessions	O35425	Gene names	Bok, Mtd
Domain Architecture	No domain graphic available
Description	Bcl-2-related ovarian killer protein (Matador protein) (Apoptosis activator Mtd).

BAK_MOUSE
θ value	1.43324e-05 (rank : 18)	NC score	0.558765 (rank : 19)
Query Neighborhood Hits	26	Target Neighborhood Hits	24	Shared Neighborhood Hits	20
SwissProt Accessions	O08734	Gene names	Bak1, Bak
Domain Architecture
Description	Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK).

B2LA1_MOUSE
θ value	2.44474e-05 (rank : 19)	NC score	0.574890 (rank : 17)
Query Neighborhood Hits	26	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	Q07440	Gene names	Bcl2a1, A1, Bcl2a1a, Bfl1
Domain Architecture
Description	Bcl-2-related protein A1 (Protein BFL-1) (Hemopoietic-specific early response protein) (A1-A).

B2L14_MOUSE
θ value	0.0563607 (rank : 20)	NC score	0.210890 (rank : 21)
Query Neighborhood Hits	26	Target Neighborhood Hits	18	Shared Neighborhood Hits	11
SwissProt Accessions	Q9CPT0, Q3TVA7, Q8R141, Q9D3W3	Gene names	Bcl2l14
Domain Architecture	No domain graphic available
Description	Apoptosis facilitator Bcl-2-like protein 14.

B2L10_HUMAN
θ value	0.0961366 (rank : 21)	NC score	0.238352 (rank : 20)
Query Neighborhood Hits	26	Target Neighborhood Hits	15	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HD36, Q8TCS9	Gene names	BCL2L10, BCLB
Domain Architecture
Description	Apoptosis regulator Bcl-B (Bcl-2-like 10 protein) (Bcl2-L-10) (Anti- apoptotic protein NrH).

B2L14_HUMAN
θ value	0.125558 (rank : 22)	NC score	0.194479 (rank : 22)
Query Neighborhood Hits	26	Target Neighborhood Hits	23	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BZR8, Q96QR5, Q9BZR7	Gene names	BCL2L14, BCLG
Domain Architecture	No domain graphic available
Description	Apoptosis facilitator Bcl-2-like 14 protein (Apoptosis regulator Bcl- G).

B2L13_MOUSE
θ value	5.27518 (rank : 23)	NC score	0.043480 (rank : 25)
Query Neighborhood Hits	26	Target Neighborhood Hits	58	Shared Neighborhood Hits	8
SwissProt Accessions	P59017	Gene names	Bcl2l13, Mil1
Domain Architecture	No domain graphic available
Description	Bcl-2-like 13 protein (Protein Mil1) (Bcl-rambo).

PEX19_HUMAN
θ value	6.88961 (rank : 24)	NC score	0.016348 (rank : 26)
Query Neighborhood Hits	26	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	P40855, Q8NI97	Gene names	PEX19, HK33, PXF
Domain Architecture
Description	Peroxisomal biogenesis factor 19 (Peroxin-19) (Peroxisomal farnesylated protein) (33 kDa housekeeping protein).

CLD5_HUMAN
θ value	8.99809 (rank : 25)	NC score	0.015815 (rank : 27)
Query Neighborhood Hits	26	Target Neighborhood Hits	44	Shared Neighborhood Hits	5
SwissProt Accessions	O00501, Q53XW2, Q8WUW3	Gene names	CLDN5, TMVCF
Domain Architecture
Description	Claudin-5 (Transmembrane protein deleted in VCFS) (TMDVCF).

CLD5_MOUSE
θ value	8.99809 (rank : 26)	NC score	0.013878 (rank : 28)
Query Neighborhood Hits	26	Target Neighborhood Hits	42	Shared Neighborhood Hits	5
SwissProt Accessions	O54942, O88789	Gene names	Cldn5, Bec1
Domain Architecture
Description	Claudin-5 (Brain endothelial cell clone 1 protein) (Lung-specific membrane protein).

B2L10_MOUSE
θ value	θ > 10 (rank : 27)	NC score	0.083232 (rank : 23)
Query Neighborhood Hits	26	Target Neighborhood Hits	6	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z0F3	Gene names	Bcl2l10, Boo, Diva
Domain Architecture
Description	Apoptosis regulator Bcl-B (Bcl-2-like 10 protein) (Bcl2-L-10) (Anti- apoptotic protein Boo) (Bcl-2 homolog Diva).

BAXC_HUMAN
θ value	θ > 10 (rank : 28)	NC score	0.056978 (rank : 24)
Query Neighborhood Hits	26	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	Q07815	Gene names	BAX
Domain Architecture	No domain graphic available
Description	BAX protein, cytoplasmic isoform gamma.

Hits sorted by NC score

BAXA_MOUSE
NC score	0.999962 (rank : 1)	θ value	2.6227e-108 (rank : 1)
Query Neighborhood Hits	26	Target Neighborhood Hits	26	Shared Neighborhood Hits	26
SwissProt Accessions	Q07813	Gene names	Bax
Domain Architecture
Description	Apoptosis regulator BAX, membrane isoform alpha.

BAXA_HUMAN
NC score	0.997869 (rank : 2)	θ value	6.47494e-99 (rank : 2)
Query Neighborhood Hits	26	Target Neighborhood Hits	29	Shared Neighborhood Hits	25
SwissProt Accessions	Q07812	Gene names	BAX
Domain Architecture
Description	Apoptosis regulator BAX, membrane isoform alpha.

BAXD_HUMAN
NC score	0.992669 (rank : 3)	θ value	5.00389e-67 (rank : 4)
Query Neighborhood Hits	26	Target Neighborhood Hits	26	Shared Neighborhood Hits	24
SwissProt Accessions	P55269	Gene names	BAX
Domain Architecture
Description	BAX protein, cytoplasmic isoform delta.

BAXB_HUMAN
NC score	0.992545 (rank : 4)	θ value	5.69867e-79 (rank : 3)
Query Neighborhood Hits	26	Target Neighborhood Hits	26	Shared Neighborhood Hits	21
SwissProt Accessions	Q07814	Gene names	BAX
Domain Architecture
Description	Apoptosis regulator BAX, cytoplasmic isoform beta.

BCL2_MOUSE
NC score	0.675909 (rank : 5)	θ value	4.30538e-10 (rank : 5)
Query Neighborhood Hits	26	Target Neighborhood Hits	24	Shared Neighborhood Hits	22
SwissProt Accessions	P10417, P10418	Gene names	Bcl2, Bcl-2
Domain Architecture
Description	Apoptosis regulator Bcl-2.

BCL2_HUMAN
NC score	0.675902 (rank : 6)	θ value	5.62301e-10 (rank : 8)
Query Neighborhood Hits	26	Target Neighborhood Hits	28	Shared Neighborhood Hits	22
SwissProt Accessions	P10415, P10416, Q13842, Q16197	Gene names	BCL2
Domain Architecture
Description	Apoptosis regulator Bcl-2.

BCLX_MOUSE
NC score	0.664567 (rank : 7)	θ value	4.30538e-10 (rank : 7)
Query Neighborhood Hits	26	Target Neighborhood Hits	24	Shared Neighborhood Hits	22
SwissProt Accessions	Q64373, O35844, Q60657, Q60658, Q61338	Gene names	Bcl2l1, Bcl2l, Bclx
Domain Architecture
Description	Apoptosis regulator Bcl-X (Bcl-2-like 1 protein).

BCLX_HUMAN
NC score	0.661524 (rank : 8)	θ value	4.30538e-10 (rank : 6)
Query Neighborhood Hits	26	Target Neighborhood Hits	26	Shared Neighborhood Hits	22
SwissProt Accessions	Q07817, Q5TE65, Q92976	Gene names	BCL2L1, BCL2L, BCLX
Domain Architecture
Description	Apoptosis regulator Bcl-X (Bcl-2-like 1 protein).

BCLW_MOUSE
NC score	0.659325 (rank : 9)	θ value	3.64472e-09 (rank : 9)
Query Neighborhood Hits	26	Target Neighborhood Hits	23	Shared Neighborhood Hits	22
SwissProt Accessions	P70345, Q545Q4, Q6A093, Q8CFR2, Q8CGL4, Q9CYW5	Gene names	Bcl2l2, Bclw, Kiaa0271
Domain Architecture
Description	Apoptosis regulator Bcl-W (Bcl-2-like 2 protein) (c98).

BCLW_HUMAN
NC score	0.656958 (rank : 10)	θ value	4.76016e-09 (rank : 10)
Query Neighborhood Hits	26	Target Neighborhood Hits	23	Shared Neighborhood Hits	22
SwissProt Accessions	Q92843, Q5U0H4	Gene names	BCL2L2, BCLW, KIAA0271
Domain Architecture
Description	Apoptosis regulator Bcl-W (Bcl-2-like 2 protein).

B2LA1_HUMAN
NC score	0.628369 (rank : 11)	θ value	4.0297e-08 (rank : 11)
Query Neighborhood Hits	26	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	Q16548, Q99524	Gene names	BCL2A1, BCL2L5, BFL1, GRS
Domain Architecture
Description	Bcl-2-related protein A1 (Protein BFL-1) (Hemopoietic-specific early response protein) (Protein GRS).

MCL1_MOUSE
NC score	0.618674 (rank : 12)	θ value	6.87365e-08 (rank : 13)
Query Neighborhood Hits	26	Target Neighborhood Hits	27	Shared Neighborhood Hits	20
SwissProt Accessions	P97287, Q3TUS0, Q792P0, Q9CRI4	Gene names	Mcl1
Domain Architecture	No domain graphic available
Description	Induced myeloid leukemia cell differentiation protein Mcl-1 homolog (Bcl-2-related protein EAT/mcl1).

BAK2_HUMAN
NC score	0.599845 (rank : 13)	θ value	6.87365e-08 (rank : 12)
Query Neighborhood Hits	26	Target Neighborhood Hits	19	Shared Neighborhood Hits	19
SwissProt Accessions	Q13014	Gene names	BCL2L7P1, BAK2
Domain Architecture
Description	Putative Bcl-2 homologous antagonist/killer 2 (Apoptosis regulator BAK-2).

MCL1_HUMAN
NC score	0.591325 (rank : 14)	θ value	1.17247e-07 (rank : 14)
Query Neighborhood Hits	26	Target Neighborhood Hits	35	Shared Neighborhood Hits	20
SwissProt Accessions	Q07820, Q9HD91, Q9NRQ3, Q9NRQ4, Q9UHR7, Q9UHR8, Q9UHR9, Q9UNJ1	Gene names	MCL1
Domain Architecture
Description	Induced myeloid leukemia cell differentiation protein Mcl-1 (Bcl-2- related protein EAT/mcl1) (mcl1/EAT).

BAK_HUMAN
NC score	0.591121 (rank : 15)	θ value	1.53129e-07 (rank : 15)
Query Neighborhood Hits	26	Target Neighborhood Hits	22	Shared Neighborhood Hits	19
SwissProt Accessions	Q16611, Q92533	Gene names	BAK1, BAK, BCL2L7
Domain Architecture
Description	Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2- like 7 protein).

BOK_HUMAN
NC score	0.578064 (rank : 16)	θ value	3.77169e-06 (rank : 16)
Query Neighborhood Hits	26	Target Neighborhood Hits	20	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UMX3	Gene names	BOK
Domain Architecture	No domain graphic available
Description	Bcl-2-related ovarian killer protein (Hbok).

B2LA1_MOUSE
NC score	0.574890 (rank : 17)	θ value	2.44474e-05 (rank : 19)
Query Neighborhood Hits	26	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	Q07440	Gene names	Bcl2a1, A1, Bcl2a1a, Bfl1
Domain Architecture
Description	Bcl-2-related protein A1 (Protein BFL-1) (Hemopoietic-specific early response protein) (A1-A).

BOK_MOUSE
NC score	0.573603 (rank : 18)	θ value	4.92598e-06 (rank : 17)
Query Neighborhood Hits	26	Target Neighborhood Hits	20	Shared Neighborhood Hits	19
SwissProt Accessions	O35425	Gene names	Bok, Mtd
Domain Architecture	No domain graphic available
Description	Bcl-2-related ovarian killer protein (Matador protein) (Apoptosis activator Mtd).

BAK_MOUSE
NC score	0.558765 (rank : 19)	θ value	1.43324e-05 (rank : 18)
Query Neighborhood Hits	26	Target Neighborhood Hits	24	Shared Neighborhood Hits	20
SwissProt Accessions	O08734	Gene names	Bak1, Bak
Domain Architecture
Description	Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK).

B2L10_HUMAN
NC score	0.238352 (rank : 20)	θ value	0.0961366 (rank : 21)
Query Neighborhood Hits	26	Target Neighborhood Hits	15	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HD36, Q8TCS9	Gene names	BCL2L10, BCLB
Domain Architecture
Description	Apoptosis regulator Bcl-B (Bcl-2-like 10 protein) (Bcl2-L-10) (Anti- apoptotic protein NrH).

B2L14_MOUSE
NC score	0.210890 (rank : 21)	θ value	0.0563607 (rank : 20)
Query Neighborhood Hits	26	Target Neighborhood Hits	18	Shared Neighborhood Hits	11
SwissProt Accessions	Q9CPT0, Q3TVA7, Q8R141, Q9D3W3	Gene names	Bcl2l14
Domain Architecture	No domain graphic available
Description	Apoptosis facilitator Bcl-2-like protein 14.

B2L14_HUMAN
NC score	0.194479 (rank : 22)	θ value	0.125558 (rank : 22)
Query Neighborhood Hits	26	Target Neighborhood Hits	23	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BZR8, Q96QR5, Q9BZR7	Gene names	BCL2L14, BCLG
Domain Architecture	No domain graphic available
Description	Apoptosis facilitator Bcl-2-like 14 protein (Apoptosis regulator Bcl- G).

B2L10_MOUSE
NC score	0.083232 (rank : 23)	θ value	θ > 10 (rank : 27)
Query Neighborhood Hits	26	Target Neighborhood Hits	6	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z0F3	Gene names	Bcl2l10, Boo, Diva
Domain Architecture
Description	Apoptosis regulator Bcl-B (Bcl-2-like 10 protein) (Bcl2-L-10) (Anti- apoptotic protein Boo) (Bcl-2 homolog Diva).

BAXC_HUMAN
NC score	0.056978 (rank : 24)	θ value	θ > 10 (rank : 28)
Query Neighborhood Hits	26	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	Q07815	Gene names	BAX
Domain Architecture	No domain graphic available
Description	BAX protein, cytoplasmic isoform gamma.

B2L13_MOUSE
NC score	0.043480 (rank : 25)	θ value	5.27518 (rank : 23)
Query Neighborhood Hits	26	Target Neighborhood Hits	58	Shared Neighborhood Hits	8
SwissProt Accessions	P59017	Gene names	Bcl2l13, Mil1
Domain Architecture	No domain graphic available
Description	Bcl-2-like 13 protein (Protein Mil1) (Bcl-rambo).

PEX19_HUMAN
NC score	0.016348 (rank : 26)	θ value	6.88961 (rank : 24)
Query Neighborhood Hits	26	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	P40855, Q8NI97	Gene names	PEX19, HK33, PXF
Domain Architecture
Description	Peroxisomal biogenesis factor 19 (Peroxin-19) (Peroxisomal farnesylated protein) (33 kDa housekeeping protein).

CLD5_HUMAN
NC score	0.015815 (rank : 27)	θ value	8.99809 (rank : 25)
Query Neighborhood Hits	26	Target Neighborhood Hits	44	Shared Neighborhood Hits	5
SwissProt Accessions	O00501, Q53XW2, Q8WUW3	Gene names	CLDN5, TMVCF
Domain Architecture
Description	Claudin-5 (Transmembrane protein deleted in VCFS) (TMDVCF).

CLD5_MOUSE
NC score	0.013878 (rank : 28)	θ value	8.99809 (rank : 26)
Query Neighborhood Hits	26	Target Neighborhood Hits	42	Shared Neighborhood Hits	5
SwissProt Accessions	O54942, O88789	Gene names	Cldn5, Bec1
Domain Architecture
Description	Claudin-5 (Brain endothelial cell clone 1 protein) (Lung-specific membrane protein).