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Network neighborhood for query Sequence : 4EBP1_MOUSE

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4EBP1_MOUSE
SwissProt Accessions	Q60876, Q3TDS8, Q9CZ40	Gene names	Eif4ebp1
Domain Architecture
Description	Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

4EBP1_MOUSE
θ value	7.47731e-63 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	Q60876, Q3TDS8, Q9CZ40	Gene names	Eif4ebp1
Domain Architecture
Description	Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I).

4EBP1_HUMAN
θ value	1.78386e-56 (rank : 2)	NC score	0.992704 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	10	Shared Neighborhood Hits	7
SwissProt Accessions	Q13541, Q6IBN3	Gene names	EIF4EBP1
Domain Architecture
Description	Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I).

4EBP2_MOUSE
θ value	1.28732e-30 (rank : 3)	NC score	0.959628 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	6	Shared Neighborhood Hits	6
SwissProt Accessions	P70445	Gene names	Eif4ebp2
Domain Architecture
Description	Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) (Phosphorylated heat- and acid-stable protein regulated by insulin 2) (PHAS-II).

4EBP2_HUMAN
θ value	3.74554e-30 (rank : 4)	NC score	0.958318 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	7	Shared Neighborhood Hits	6
SwissProt Accessions	Q13542	Gene names	EIF4EBP2
Domain Architecture
Description	Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2).

4EBP3_HUMAN
θ value	4.9032e-22 (rank : 5)	NC score	0.934221 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	6	Shared Neighborhood Hits	6
SwissProt Accessions	O60516	Gene names	EIF4EBP3
Domain Architecture
Description	Eukaryotic translation initiation factor 4E-binding protein 3 (4E-BP3) (eIF4E-binding protein 3).

4EBP3_MOUSE
θ value	4.15078e-21 (rank : 6)	NC score	0.922178 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	8	Shared Neighborhood Hits	6
SwissProt Accessions	Q80VV3, Q2TA53	Gene names	Eif4ebp3
Domain Architecture
Description	Eukaryotic translation initiation factor 4E-binding protein 3 (4E-BP3) (eIF4E-binding protein 3).

TRAK2_HUMAN
θ value	0.62314 (rank : 7)	NC score	0.038347 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	476	Shared Neighborhood Hits	4
SwissProt Accessions	O60296, Q8WVH7, Q96NS2, Q9C0K5, Q9C0K6	Gene names	TRAK2, ALS2CR3, KIAA0549
Domain Architecture
Description	Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein).

LYPD3_HUMAN
θ value	1.81305 (rank : 8)	NC score	0.035481 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	O95274, Q9UJ74	Gene names	LYPD3, C4.4A
Domain Architecture	No domain graphic available
Description	Ly6/PLAUR domain-containing protein 3 precursor (GPI-anchored metastasis-associated protein C4.4A homolog) (Matrigel-induced gene C4 protein) (MIG-C4).

ZN687_HUMAN
θ value	1.81305 (rank : 9)	NC score	0.007913 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	1244	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N1G0, Q68DQ8, Q9H937, Q9P2A7	Gene names	ZNF687, KIAA1441
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

IF4G3_HUMAN
θ value	2.36792 (rank : 10)	NC score	0.020722 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	247	Shared Neighborhood Hits	2
SwissProt Accessions	O43432, Q15597, Q8NEN1	Gene names	EIF4G3
Domain Architecture
Description	Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII).

NOLC1_HUMAN
θ value	2.36792 (rank : 11)	NC score	0.022613 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	452	Shared Neighborhood Hits	3
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

PELP1_HUMAN
θ value	3.0926 (rank : 12)	NC score	0.030079 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	596	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

IDE_MOUSE
θ value	4.03905 (rank : 13)	NC score	0.019639 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JHR7	Gene names	Ide
Domain Architecture
Description	Insulin-degrading enzyme (EC 3.4.24.56) (Insulysin) (Insulinase) (Insulin protease).

TFE2_MOUSE
θ value	4.03905 (rank : 14)	NC score	0.016529 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	118	Shared Neighborhood Hits	2
SwissProt Accessions	P15806, Q3U153, Q8CAH9, Q8VCY4, Q922S2, Q99MB8, Q9CYJ4	Gene names	Tcf3, Alf2, Me2, Tcfe2a
Domain Architecture	No domain graphic available
Description	Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Transcription factor A1).

CS016_HUMAN
θ value	5.27518 (rank : 15)	NC score	0.021527 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	310	Shared Neighborhood Hits	2
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

MINK1_HUMAN
θ value	5.27518 (rank : 16)	NC score	0.000933 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	1477	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

EP15R_MOUSE
θ value	6.88961 (rank : 17)	NC score	0.006533 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	1135	Shared Neighborhood Hits	8
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

FMNL_HUMAN
θ value	6.88961 (rank : 18)	NC score	0.010424 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	529	Shared Neighborhood Hits	3
SwissProt Accessions	O95466, Q6DKG5, Q6IBP3, Q86UH1, Q8N671, Q8TDH1, Q96H10	Gene names	FMNL1, C17orf1, C17orf1B, FMNL
Domain Architecture
Description	Formin-like protein 1 (Leukocyte formin) (CLL-associated antigen KW- 13).

GLU2B_HUMAN
θ value	6.88961 (rank : 19)	NC score	0.023843 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	377	Shared Neighborhood Hits	4
SwissProt Accessions	P14314, Q96BU9, Q96D06, Q9P0W9	Gene names	PRKCSH, G19P1
Domain Architecture	No domain graphic available
Description	Glucosidase 2 subunit beta precursor (Glucosidase II subunit beta) (Protein kinase C substrate, 60.1 kDa protein, heavy chain) (PKCSH) (80K-H protein).

GLU2B_MOUSE
θ value	6.88961 (rank : 20)	NC score	0.024199 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	357	Shared Neighborhood Hits	4
SwissProt Accessions	O08795, Q921X2	Gene names	Prkcsh
Domain Architecture	No domain graphic available
Description	Glucosidase 2 subunit beta precursor (Glucosidase II subunit beta) (Protein kinase C substrate, 60.1 kDa protein, heavy chain) (PKCSH) (80K-H protein).

PELP1_MOUSE
θ value	6.88961 (rank : 21)	NC score	0.027007 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	709	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

Hits sorted by NC score

4EBP1_MOUSE
NC score	0.999962 (rank : 1)	θ value	7.47731e-63 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	Q60876, Q3TDS8, Q9CZ40	Gene names	Eif4ebp1
Domain Architecture
Description	Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I).

4EBP1_HUMAN
NC score	0.992704 (rank : 2)	θ value	1.78386e-56 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	10	Shared Neighborhood Hits	7
SwissProt Accessions	Q13541, Q6IBN3	Gene names	EIF4EBP1
Domain Architecture
Description	Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I).

4EBP2_MOUSE
NC score	0.959628 (rank : 3)	θ value	1.28732e-30 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	6	Shared Neighborhood Hits	6
SwissProt Accessions	P70445	Gene names	Eif4ebp2
Domain Architecture
Description	Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) (Phosphorylated heat- and acid-stable protein regulated by insulin 2) (PHAS-II).

4EBP2_HUMAN
NC score	0.958318 (rank : 4)	θ value	3.74554e-30 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	7	Shared Neighborhood Hits	6
SwissProt Accessions	Q13542	Gene names	EIF4EBP2
Domain Architecture
Description	Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2).

4EBP3_HUMAN
NC score	0.934221 (rank : 5)	θ value	4.9032e-22 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	6	Shared Neighborhood Hits	6
SwissProt Accessions	O60516	Gene names	EIF4EBP3
Domain Architecture
Description	Eukaryotic translation initiation factor 4E-binding protein 3 (4E-BP3) (eIF4E-binding protein 3).

4EBP3_MOUSE
NC score	0.922178 (rank : 6)	θ value	4.15078e-21 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	8	Shared Neighborhood Hits	6
SwissProt Accessions	Q80VV3, Q2TA53	Gene names	Eif4ebp3
Domain Architecture
Description	Eukaryotic translation initiation factor 4E-binding protein 3 (4E-BP3) (eIF4E-binding protein 3).

TRAK2_HUMAN
NC score	0.038347 (rank : 7)	θ value	0.62314 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	476	Shared Neighborhood Hits	4
SwissProt Accessions	O60296, Q8WVH7, Q96NS2, Q9C0K5, Q9C0K6	Gene names	TRAK2, ALS2CR3, KIAA0549
Domain Architecture
Description	Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein).

LYPD3_HUMAN
NC score	0.035481 (rank : 8)	θ value	1.81305 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	O95274, Q9UJ74	Gene names	LYPD3, C4.4A
Domain Architecture	No domain graphic available
Description	Ly6/PLAUR domain-containing protein 3 precursor (GPI-anchored metastasis-associated protein C4.4A homolog) (Matrigel-induced gene C4 protein) (MIG-C4).

PELP1_HUMAN
NC score	0.030079 (rank : 9)	θ value	3.0926 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	596	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

PELP1_MOUSE
NC score	0.027007 (rank : 10)	θ value	6.88961 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	709	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

GLU2B_MOUSE
NC score	0.024199 (rank : 11)	θ value	6.88961 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	357	Shared Neighborhood Hits	4
SwissProt Accessions	O08795, Q921X2	Gene names	Prkcsh
Domain Architecture	No domain graphic available
Description	Glucosidase 2 subunit beta precursor (Glucosidase II subunit beta) (Protein kinase C substrate, 60.1 kDa protein, heavy chain) (PKCSH) (80K-H protein).

GLU2B_HUMAN
NC score	0.023843 (rank : 12)	θ value	6.88961 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	377	Shared Neighborhood Hits	4
SwissProt Accessions	P14314, Q96BU9, Q96D06, Q9P0W9	Gene names	PRKCSH, G19P1
Domain Architecture	No domain graphic available
Description	Glucosidase 2 subunit beta precursor (Glucosidase II subunit beta) (Protein kinase C substrate, 60.1 kDa protein, heavy chain) (PKCSH) (80K-H protein).

NOLC1_HUMAN
NC score	0.022613 (rank : 13)	θ value	2.36792 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	452	Shared Neighborhood Hits	3
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

CS016_HUMAN
NC score	0.021527 (rank : 14)	θ value	5.27518 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	310	Shared Neighborhood Hits	2
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

IF4G3_HUMAN
NC score	0.020722 (rank : 15)	θ value	2.36792 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	247	Shared Neighborhood Hits	2
SwissProt Accessions	O43432, Q15597, Q8NEN1	Gene names	EIF4G3
Domain Architecture
Description	Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII).

IDE_MOUSE
NC score	0.019639 (rank : 16)	θ value	4.03905 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JHR7	Gene names	Ide
Domain Architecture
Description	Insulin-degrading enzyme (EC 3.4.24.56) (Insulysin) (Insulinase) (Insulin protease).

TFE2_MOUSE
NC score	0.016529 (rank : 17)	θ value	4.03905 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	118	Shared Neighborhood Hits	2
SwissProt Accessions	P15806, Q3U153, Q8CAH9, Q8VCY4, Q922S2, Q99MB8, Q9CYJ4	Gene names	Tcf3, Alf2, Me2, Tcfe2a
Domain Architecture	No domain graphic available
Description	Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Transcription factor A1).

FMNL_HUMAN
NC score	0.010424 (rank : 18)	θ value	6.88961 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	529	Shared Neighborhood Hits	3
SwissProt Accessions	O95466, Q6DKG5, Q6IBP3, Q86UH1, Q8N671, Q8TDH1, Q96H10	Gene names	FMNL1, C17orf1, C17orf1B, FMNL
Domain Architecture
Description	Formin-like protein 1 (Leukocyte formin) (CLL-associated antigen KW- 13).

ZN687_HUMAN
NC score	0.007913 (rank : 19)	θ value	1.81305 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	1244	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N1G0, Q68DQ8, Q9H937, Q9P2A7	Gene names	ZNF687, KIAA1441
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

EP15R_MOUSE
NC score	0.006533 (rank : 20)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	1135	Shared Neighborhood Hits	8
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

MINK1_HUMAN
NC score	0.000933 (rank : 21)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	1477	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).